Theodora Hatziioannou

Summary

Affiliation: Aaron Diamond AIDS Research Center
Country: USA

Publications

  1. ncbi request reprint HIV-1-induced AIDS in monkeys
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center, 455 First Avenue, New York, NY 10016, USA
    Science 344:1401-5. 2014
  2. doi request reprint Animal models for HIV/AIDS research
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York, New York 10016, USA
    Nat Rev Microbiol 10:852-67. 2012
  3. pmc A macaque model of HIV-1 infection
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 106:4425-9. 2009
  4. pmc Primate lentivirus capsid sensitivity to TRIM5 proteins
    Zerina Kratovac
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA
    J Virol 82:6772-7. 2008
  5. pmc Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center and Rockefeller University, New York, New York 10021, USA
    J Virol 79:176-83. 2005
  6. pmc Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variants
    Matthew W McNatt
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York, United States of America
    PLoS Pathog 5:e1000300. 2009
  7. pmc Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity
    David Perez-Caballero
    Aaron Diamond AIDS Research Center, 455 First Ave, New York, NY 10021, USA
    J Virol 79:8969-78. 2005
  8. ncbi request reprint Generation of simian-tropic HIV-1 by restriction factor evasion
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center and Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Science 314:95. 2006
  9. pmc Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin
    Nolwenn Jouvenet
    Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York, USA
    J Virol 83:1837-44. 2009
  10. ncbi request reprint Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors
    Greg J Towers
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nat Med 9:1138-43. 2003

Collaborators

Detail Information

Publications31

  1. ncbi request reprint HIV-1-induced AIDS in monkeys
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center, 455 First Avenue, New York, NY 10016, USA
    Science 344:1401-5. 2014
    ..Thus, an adapted HIV-1 can cause AIDS in macaques, and stark differences in outcome can be determined by immunological perturbations during early infection. ..
  2. doi request reprint Animal models for HIV/AIDS research
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York, New York 10016, USA
    Nat Rev Microbiol 10:852-67. 2012
    ..Understanding the advantages and limitations of each of these models is essential for the design of animal studies to guide the development of vaccines and antiretroviral therapies for the prevention and treatment of HIV-1 infection...
  3. pmc A macaque model of HIV-1 infection
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 106:4425-9. 2009
    ....
  4. pmc Primate lentivirus capsid sensitivity to TRIM5 proteins
    Zerina Kratovac
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA
    J Virol 82:6772-7. 2008
    ..TRIM5alpha proteins from other primates exhibited distinct restriction specificities for primate lentivirus capsids. Finally, we identified novel primate lentiviral capsids that are targeted by TRIMCyp proteins...
  5. pmc Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center and Rockefeller University, New York, New York 10021, USA
    J Virol 79:176-83. 2005
    ..We speculate that CypA and/or CypA-related proteins affect the fate of incoming HIV-1 capsid either directly or by modulating interactions with unidentified host cell factors...
  6. pmc Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variants
    Matthew W McNatt
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York, United States of America
    PLoS Pathog 5:e1000300. 2009
    ....
  7. pmc Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity
    David Perez-Caballero
    Aaron Diamond AIDS Research Center, 455 First Ave, New York, NY 10021, USA
    J Virol 79:8969-78. 2005
    ..However, localization in large cytoplasmic bodies is not required for inhibition of N-MLV by huTRIM5alpha or for inhibition of HIV-1 by chimeric or rhTRIM5alpha...
  8. ncbi request reprint Generation of simian-tropic HIV-1 by restriction factor evasion
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center and Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Science 314:95. 2006
    ....
  9. pmc Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin
    Nolwenn Jouvenet
    Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York, USA
    J Virol 83:1837-44. 2009
    ..Overall, tetherin is potentially active against many enveloped viruses and likely to be an important component of the antiviral innate immune defense...
  10. ncbi request reprint Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors
    Greg J Towers
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nat Med 9:1138-43. 2003
    ..Manipulation of HIV-1 CA recognition by restriction factors promises to advance animal models and new therapeutic strategies for HIV-1 and AIDS...
  11. pmc Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate species
    Cesar A Virgen
    Aaron Diamond AIDS Research Center and Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 105:3563-8. 2008
    ..Overall, an intuitively unlikely evolutionary event has, in fact, occurred at least twice in primates and represents a striking example of convergent evolution in divergent species...
  12. pmc MX2 is an interferon-induced inhibitor of HIV-1 infection
    Melissa Kane
    1 Aaron Diamond AIDS Research Center, New York, New York 10016, USA 2 Laboratory of Retrovirology, The Rockefeller University, New York, New York 10065, USA
    Nature 502:563-6. 2013
    ..Overall, these findings indicate that MX2 is an effector of the anti-HIV-1 activity of type-I IFN, and suggest that MX2 inhibits HIV-1 infection by inhibiting capsid-dependent nuclear import of subviral complexes. ..
  13. pmc SIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion release
    Fengwen Zhang
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York, United States of America
    PLoS Pathog 7:e1002039. 2011
    ..Accordingly, depletion of AP-2 using RNA interference impairs the ability of Nef to antagonize Tetherin, demonstrating that AP-2 recruitment is required for Nef proteins to counteract this antiviral protein...
  14. pmc Matrix-induced inhibition of membrane binding contributes to human immunodeficiency virus type 1 particle assembly defects in murine cells
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center, 455 First Avenue, New York, NY 10016, USA
    J Virol 79:15586-9. 2005
    ..Expression level and autoinhibition can be important confounding variables in studies of HIV-1 assembly and contribute to defects encountered in murine cells...
  15. ncbi request reprint Antiretroviral potential of human tripartite motif-5 and related proteins
    Fengwen Zhang
    Aaron Diamond AIDS Research Center and the Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Virology 353:396-409. 2006
    ..However, endogenous owl monkey TRIMCyp potently inhibited an SIV(AGM) strain. Overall, sporadic examples of intrinsic antiretroviral activity exist in this panel of TRIM proteins...
  16. pmc Nef proteins from simian immunodeficiency viruses are tetherin antagonists
    Fengwen Zhang
    Aaron Diamond AIDS Research Center, Laboratory of Retrovirology, The Rockefeller University, New York, NY 10016, USA
    Cell Host Microbe 6:54-67. 2009
    ....
  17. pmc Moesin regulates stable microtubule formation and limits retroviral infection in cultured cells
    Mojgan H Naghavi
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    EMBO J 26:41-52. 2007
    ..Together, these results suggest that moesin negatively regulates stable microtubule networks and is a natural determinant of cellular sensitivity to retroviral infection...
  18. pmc Assisted evolution enables HIV-1 to overcome a high TRIM5α-imposed genetic barrier to rhesus macaque tropism
    Steven J Soll
    Laboratory of Retrovirology, The Rockefeller University, New York, New York, United States of America Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York, United States of America Howard Hughes Medical Institute, The Rockefeller University, New York, New York, United States of America
    PLoS Pathog 9:e1003667. 2013
    ..These findings demonstrate that rhTRIM5α is difficult to but not impossible to evade, and doing so should facilitate the development of primate models of HIV-1 infection...
  19. pmc Restriction of human immunodeficiency virus type 1 by TRIM-CypA occurs with rapid kinetics and independently of cytoplasmic bodies, ubiquitin, and proteasome activity
    David Perez-Caballero
    Aaron Diamond AIDS Research Center, 455 First Avenue, New York, NY 10016, USA
    J Virol 79:15567-72. 2005
    ..Moreover, tagged TRIM-CypA proteins can be fully active as restriction factors without forming cytoplasmic bodies...
  20. pmc Adaptation to the interferon-induced antiviral state by human and simian immunodeficiency viruses
    Julia Bitzegeio
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY, USA
    J Virol 87:3549-60. 2013
    ....
  21. pmc Restriction of multiple divergent retroviruses by Lv1 and Ref1
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center and The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    EMBO J 22:385-94. 2003
    ..These data suggest that restriction factors in human and non-human primate cells are able to recognize and block infection by multiple, widely divergent retroviruses and that the factors themselves may be related...
  22. pmc Capsid-dependent and -independent postentry restriction of primate lentivirus tropism in rodent cells
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York 10021, USA
    J Virol 78:1006-11. 2004
    ..Overall, these findings indicate that novel restriction factors in rodents can modulate sensitivity to specific primate lentiviruses...
  23. pmc Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 101:10774-9. 2004
    ..These data indicate that TRIM5alpha can confer broad innate immunity to retrovirus infection in primate cells and is likely to be an important natural barrier to cross-species retrovirus transmission...
  24. pmc Species-specific tropism determinants in the human immunodeficiency virus type 1 capsid
    Theodora Hatziioannou
    AIDS Research Center, 455 First Ave, New York, NY 10021, USA
    J Virol 78:6005-12. 2004
    ....
  25. pmc Antiretroviral restriction factors
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, United States
    Curr Opin Virol 1:526-32. 2011
    ..Potentially, this recently revealed intrinsic system of antiviral immunity might be mobilized for therapeutic benefit...
  26. pmc Human immunodeficiency virus type 1 matrix inhibits and confers cooperativity on gag precursor-membrane interactions
    David Perez-Caballero
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York 10016, USA
    J Virol 78:9560-3. 2004
    ..MA-mediated inhibition is relieved by concentration-dependent Gag multimerization and imparts a high degree of cooperativity on Gag-membrane association. This cooperativity may confer temporal and spatial regulation on HIV-1 assembly...
  27. pmc Antiretroviral activity and Vif sensitivity of rhesus macaque APOBEC3 proteins
    Cesar A Virgen
    Aaron Diamond AIDS Research Center, 455 1st Avenue, New York, NY 10016, USA
    J Virol 81:13932-7. 2007
    ..These findings suggest that multiple APOBEC3 proteins can contribute to primate lentivirus species tropism...
  28. pmc Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism
    Simone Cowan
    Aaron Diamond AIDS Research Center, Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 99:11914-9. 2002
    ..These data indicate the existence of one or more saturable inhibitors that are polymorphic in primates and prevent HIV and SIV infection by targeting the capsid of the incoming lentivirus particle...
  29. ncbi request reprint Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
    Matthew J Evans
    Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA
    Nature 446:801-5. 2007
    ..With CLDN1 we have identified a novel key factor for HCV entry and a new target for antiviral drug development...
  30. pmc Overexpression of fasciculation and elongation protein zeta-1 (FEZ1) induces a post-entry block to retroviruses in cultured cells
    Mojgan H Naghavi
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Genes Dev 19:1105-15. 2005
    ..Thus, our data suggest that FEZ1 overexpression is sufficient to explain the resistant phenotype of R3-2 cells and identify FEZ1 as a new gene capable of causing retrovirus resistance...
  31. pmc Envelope-dependent, cyclophilin-independent effects of glycosaminoglycans on human immunodeficiency virus type 1 attachment and infection
    Yi Jun Zhang
    Aaron Diamond AIDS Research Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Virol 76:6332-43. 2002
    ..Overall, these data exclude a major role for GAGs in mediating the attachment of many HIV-1 strains to target cells via interactions with virion-associated gp120 or CypA...

Research Grants5

  1. Overcoming Host Restriction Factors to Develop Better Animal Models for HIV/AIDS.
    Theodora Hatziioannou; Fiscal Year: 2009
    ..If successful, this proposal will lead to improved animal models for HIV-1 infection and will considerably facilitate the development and testing of drug and vaccine interventions. ..
  2. Overcoming blocks to HIV-1 replication in rhesus macaques.
    Theodora Hatziioannou; Fiscal Year: 2007
    ..If successful, this proposal will lead to improved animal models for HIV-1 infection and will considerably facilitate the development and testing of drug and vaccine interventions. ..
  3. Overcoming Host Restriction Factors to Develop Better Animal Models for HIV/AIDS.
    Theodora Hatziioannou; Fiscal Year: 2009
    ..If successful, this proposal will lead to improved animal models for HIV-1 infection and will considerably facilitate the development and testing of drug and vaccine interventions. ..
  4. Overcoming Host Restriction Factors to Develop Better Animal Models for HIV/AIDS.
    Theodora Hatziioannou; Fiscal Year: 2010
    ..If successful, this proposal will lead to improved animal models for HIV-1 infection and will considerably facilitate the development and testing of drug and vaccine interventions. ..