Research Topics
Genomes and Genes | Theodora HatziioannouSummaryAffiliation: Aaron Diamond AIDS Research Center Country: USA Publications
Research Grants
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Detail Information
Publications
Animal models for HIV/AIDS researchTheodora Hatziioannou
Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York, New York 10016, USA
Nat Rev Microbiol 10:852-67. 2012..Understanding the advantages and limitations of each of these models is essential for the design of animal studies to guide the development of vaccines and antiretroviral therapies for the prevention and treatment of HIV-1 infection...
A macaque model of HIV-1 infectionTheodora Hatziioannou
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 106:4425-9. 2009....- Primate lentivirus capsid sensitivity to TRIM5 proteinsZerina Kratovac
Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA
J Virol 82:6772-7. 2008..TRIM5alpha proteins from other primates exhibited distinct restriction specificities for primate lentivirus capsids. Finally, we identified novel primate lentiviral capsids that are targeted by TRIMCyp proteins... - Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cellsTheodora Hatziioannou
Aaron Diamond AIDS Research Center and Rockefeller University, New York, New York 10021, USA
J Virol 79:176-83. 2005..We speculate that CypA and/or CypA-related proteins affect the fate of incoming HIV-1 capsid either directly or by modulating interactions with unidentified host cell factors... - Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificityDavid Perez-Caballero
Aaron Diamond AIDS Research Center, 455 First Ave, New York, NY 10021, USA
J Virol 79:8969-78. 2005..However, localization in large cytoplasmic bodies is not required for inhibition of N-MLV by huTRIM5alpha or for inhibition of HIV-1 by chimeric or rhTRIM5alpha... 
Generation of simian-tropic HIV-1 by restriction factor evasionTheodora Hatziioannou
Aaron Diamond AIDS Research Center and Rockefeller University, 455 First Avenue, New York, NY 10016, USA
Science 314:95. 2006....- Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variantsMatthew W McNatt
Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York, United States of America
PLoS Pathog 5:e1000300. 2009.... - Broad-spectrum inhibition of retroviral and filoviral particle release by tetherinNolwenn Jouvenet
Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York, USA
J Virol 83:1837-44. 2009..Overall, tetherin is potentially active against many enveloped viruses and likely to be an important component of the antiviral innate immune defense... - Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factorsGreg J Towers
Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Nat Med 9:1138-43. 2003..Manipulation of HIV-1 CA recognition by restriction factors promises to advance animal models and new therapeutic strategies for HIV-1 and AIDS... - SIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion releaseFengwen Zhang
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York, United States of America
PLoS Pathog 7:e1002039. 2011..Accordingly, depletion of AP-2 using RNA interference impairs the ability of Nef to antagonize Tetherin, demonstrating that AP-2 recruitment is required for Nef proteins to counteract this antiviral protein... - Antiretroviral potential of human tripartite motif-5 and related proteinsFengwen Zhang
Aaron Diamond AIDS Research Center and the Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
Virology 353:396-409. 2006..However, endogenous owl monkey TRIMCyp potently inhibited an SIV(AGM) strain. Overall, sporadic examples of intrinsic antiretroviral activity exist in this panel of TRIM proteins... - Matrix-induced inhibition of membrane binding contributes to human immunodeficiency virus type 1 particle assembly defects in murine cellsTheodora Hatziioannou
Aaron Diamond AIDS Research Center, 455 First Avenue, New York, NY 10016, USA
J Virol 79:15586-9. 2005..Expression level and autoinhibition can be important confounding variables in studies of HIV-1 assembly and contribute to defects encountered in murine cells... - Nef proteins from simian immunodeficiency viruses are tetherin antagonistsFengwen Zhang
Aaron Diamond AIDS Research Center, Laboratory of Retrovirology, The Rockefeller University, New York, NY 10016, USA
Cell Host Microbe 6:54-67. 2009.... - Moesin regulates stable microtubule formation and limits retroviral infection in cultured cellsMojgan H Naghavi
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
EMBO J 26:41-52. 2007..Together, these results suggest that moesin negatively regulates stable microtubule networks and is a natural determinant of cellular sensitivity to retroviral infection... - Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate speciesCesar A Virgen
Aaron Diamond AIDS Research Center and Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
Proc Natl Acad Sci U S A 105:3563-8. 2008..Overall, an intuitively unlikely evolutionary event has, in fact, occurred at least twice in primates and represents a striking example of convergent evolution in divergent species... - Restriction of human immunodeficiency virus type 1 by TRIM-CypA occurs with rapid kinetics and independently of cytoplasmic bodies, ubiquitin, and proteasome activityDavid Perez-Caballero
Aaron Diamond AIDS Research Center, 455 First Avenue, New York, NY 10016, USA
J Virol 79:15567-72. 2005..Moreover, tagged TRIM-CypA proteins can be fully active as restriction factors without forming cytoplasmic bodies... - Restriction of multiple divergent retroviruses by Lv1 and Ref1Theodora Hatziioannou
Aaron Diamond AIDS Research Center and The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
EMBO J 22:385-94. 2003..These data suggest that restriction factors in human and non-human primate cells are able to recognize and block infection by multiple, widely divergent retroviruses and that the factors themselves may be related... - Capsid-dependent and -independent postentry restriction of primate lentivirus tropism in rodent cellsTheodora Hatziioannou
Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York 10021, USA
J Virol 78:1006-11. 2004..Overall, these findings indicate that novel restriction factors in rodents can modulate sensitivity to specific primate lentiviruses... - Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alphaTheodora Hatziioannou
Aaron Diamond AIDS Research Center, New York, NY 10016, USA
Proc Natl Acad Sci U S A 101:10774-9. 2004..These data indicate that TRIM5alpha can confer broad innate immunity to retrovirus infection in primate cells and is likely to be an important natural barrier to cross-species retrovirus transmission... - Species-specific tropism determinants in the human immunodeficiency virus type 1 capsidTheodora Hatziioannou
AIDS Research Center, 455 First Ave, New York, NY 10021, USA
J Virol 78:6005-12. 2004.... - Antiretroviral restriction factorsTheodora Hatziioannou
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, United States
Curr Opin Virol 1:526-32. 2011..Potentially, this recently revealed intrinsic system of antiviral immunity might be mobilized for therapeutic benefit... - Antiretroviral activity and Vif sensitivity of rhesus macaque APOBEC3 proteinsCesar A Virgen
Aaron Diamond AIDS Research Center, 455 1st Avenue, New York, NY 10016, USA
J Virol 81:13932-7. 2007..These findings suggest that multiple APOBEC3 proteins can contribute to primate lentivirus species tropism... - Human immunodeficiency virus type 1 matrix inhibits and confers cooperativity on gag precursor-membrane interactionsDavid Perez-Caballero
Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York 10016, USA
J Virol 78:9560-3. 2004..MA-mediated inhibition is relieved by concentration-dependent Gag multimerization and imparts a high degree of cooperativity on Gag-membrane association. This cooperativity may confer temporal and spatial regulation on HIV-1 assembly... - Claudin-1 is a hepatitis C virus co-receptor required for a late step in entryMatthew J Evans
Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA
Nature 446:801-5. 2007..With CLDN1 we have identified a novel key factor for HCV entry and a new target for antiviral drug development... - Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropismSimone Cowan
Aaron Diamond AIDS Research Center, Rockefeller University, 455 First Avenue, New York, NY 10016, USA
Proc Natl Acad Sci U S A 99:11914-9. 2002..These data indicate the existence of one or more saturable inhibitors that are polymorphic in primates and prevent HIV and SIV infection by targeting the capsid of the incoming lentivirus particle... - Overexpression of fasciculation and elongation protein zeta-1 (FEZ1) induces a post-entry block to retroviruses in cultured cellsMojgan H Naghavi
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Genes Dev 19:1105-15. 2005..Thus, our data suggest that FEZ1 overexpression is sufficient to explain the resistant phenotype of R3-2 cells and identify FEZ1 as a new gene capable of causing retrovirus resistance... - Adaptation to the interferon-induced antiviral state by human and simian immunodeficiency virusesJulia Bitzegeio
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY, USA
J Virol 87:3549-60. 2013.... - Envelope-dependent, cyclophilin-independent effects of glycosaminoglycans on human immunodeficiency virus type 1 attachment and infectionYi Jun Zhang
Aaron Diamond AIDS Research Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
J Virol 76:6332-43. 2002..Overall, these data exclude a major role for GAGs in mediating the attachment of many HIV-1 strains to target cells via interactions with virion-associated gp120 or CypA...
Research Grants
- Overcoming Host Restriction Factors to Develop Better Animal Models for HIV/AIDS.Theodora Hatziioannou; Fiscal Year: 2009..If successful, this proposal will lead to improved animal models for HIV-1 infection and will considerably facilitate the development and testing of drug and vaccine interventions. ..
- Overcoming blocks to HIV-1 replication in rhesus macaques.Theodora Hatziioannou; Fiscal Year: 2007..If successful, this proposal will lead to improved animal models for HIV-1 infection and will considerably facilitate the development and testing of drug and vaccine interventions. ..
- Overcoming Host Restriction Factors to Develop Better Animal Models for HIV/AIDS.Theodora Hatziioannou; Fiscal Year: 2010..If successful, this proposal will lead to improved animal models for HIV-1 infection and will considerably facilitate the development and testing of drug and vaccine interventions. ..