J M Harouse
Affiliation: Aaron Diamond AIDS Research Center
- Increased mucosal transmission but not enhanced pathogenicity of the CCR5-tropic, simian AIDS-inducing simian/human immunodeficiency virus SHIV(SF162P3) maps to envelope gp120Mayla Hsu
Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York 10016, USA
J Virol 77:989-98. 2003....
- CD8+ T cell-mediated CXC chemokine receptor 4-simian/human immunodeficiency virus suppression in dually infected rhesus macaquesJanet M Harouse
Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, 7th Floor, New York, NY 10016, USA
Proc Natl Acad Sci U S A 100:10977-82. 2003..These findings provide critical insights into a key question related to HIV pathogenesis and have important implications for the development and testing of antiviral vaccines and therapeutics...
- Expansion of quasispecies diversity but no evidence for adaptive evolution of SHIV during rapid serial transfers among seronegative macaquesPeter Balfe
Aaron Diamond AIDS Research Center, New York, NY 10016, USA
Virology 318:267-79. 2004..Envelope sequence changes accumulate principally in response to immune pressure exerted by the host, generating viral variants that can persist in the presence of a strong host immune response...
- Mucosal transmission and induction of simian AIDS by CCR5-specific simian/human immunodeficiency virus SHIV(SF162P3)J M Harouse
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
J Virol 75:1990-5. 2001..Furthermore, this controlled model provides the setting to investigate immunologic responses and putative host-specific susceptibility factors that alter viral transmission and subsequent disease progression...
- Pathogenic determinants of the mucosally transmissible CXCR4-specific SHIV(SF33A2) map to env regionJ M Harouse
Aaron Diamond AIDS Research Center, The Rockefeller University, New York City, New York 10016, USA
J Acquir Immune Defic Syndr 27:222-8. 2001..These data indicate that domains within the HIV-1 envelope protein are sufficient to define pathogenic potential in the context of the SIVmac239 genome...
- Infection of macaques with a molecular clone, SHIVSF33A2, provides evidence for tissue specific variantsC M Buckner
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY, USA
J Med Primatol 31:164-70. 2002..As the inoculating virus is a molecular clone, the variants generated are likely due to the presence of tissue specific selective forces rather than a founder's effect...
- Induction of simian AIDS in infant rhesus macaques infected with CCR5- or CXCR4-utilizing simian-human immunodeficiency viruses is associated with distinct lesions of the thymusR A Reyes
Center for Comparative Medicine, University of California, Davis, California 95616, USA
J Virol 78:2121-30. 2004..Furthermore, these findings could help explain the rapid progression of disease observed in some HIV-1-infected children...