Cecilia Cheng-Mayer

Summary

Affiliation: Aaron Diamond AIDS Research Center
Country: USA

Publications

  1. pmc Adoption of an "open" envelope conformation facilitating CD4 binding and structural remodeling precedes coreceptor switch in R5 SHIV-infected macaques
    Ke Zhuang
    Aaron Diamond AIDS Research Center, New York, New York, United States of America
    PLoS ONE 6:e21350. 2011
  2. pmc The number and genetic relatedness of transmitted/founder virus impact clinical outcome in vaginal R5 SHIVSF162P3N infection
    Lily Tsai
    Aaron Diamond AIDS Research Center, Aaron Diamond Professor at the Rockefeller University, New York, NY, USA
    Retrovirology 11:22. 2014
  3. pmc Delay of simian human immunodeficiency virus infection and control of viral replication in vaccinated macaques challenged in the presence of a topical microbicide
    Cecilia Cheng-Mayer
    Aaron Diamond AIDS Research Center, New York, New York 10016, USA
    AIDS 25:1833-41. 2011
  4. ncbi request reprint Coreceptor switch in infection of nonhuman primates
    Cecilia Cheng-Mayer
    Aaron Diamond AIDS Research Center, The Rockefeller University, USA
    Curr HIV Res 7:30-8. 2009
  5. pmc Selection for neutralization resistance of the simian/human immunodeficiency virus SHIVSF33A variant in vivo by virtue of sequence changes in the extracellular envelope glycoprotein that modify N-linked glycosylation
    C Cheng-Mayer
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 73:5294-300. 1999
  6. pmc Coreceptor switch in R5-tropic simian/human immunodeficiency virus-infected macaques
    Siu hong Ho
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    J Virol 81:8621-33. 2007
  7. pmc Efficient repeated low-dose intravaginal infection with X4 and R5 SHIVs in rhesus macaque: implications for HIV-1 transmission in humans
    Lily Tsai
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Floor, New York, NY 10016, USA
    Virology 362:207-16. 2007
  8. pmc R5X4 viruses are evolutionary, functional, and antigenic intermediates in the pathway of a simian-human immunodeficiency virus coreceptor switch
    Silvana Tasca
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, New York, NY 10016, USA
    J Virol 82:7089-99. 2008
  9. pmc Different tempo and anatomic location of dual-tropic and X4 virus emergence in a model of R5 simian-human immunodeficiency virus infection
    Wuze Ren
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    J Virol 84:340-51. 2010
  10. pmc V3 loop-determined coreceptor preference dictates the dynamics of CD4+-T-cell loss in simian-human immunodeficiency virus-infected macaques
    Siu hong Ho
    Rockefeller University, Aaron Diamond AIDS Research Center, 455 First Ave, 7th Floor, New York, NY 10016, USA
    J Virol 79:12296-303. 2005

Research Grants

  1. TRANSMISSION & PATHOGENESIS OF X4 & R5 SHIVS
    Cecilia Cheng Mayer; Fiscal Year: 2006
  2. STRUCTURE/FUNCTION RELATIONSHIP OF HIV-1
    Cecilia Cheng Mayer; Fiscal Year: 2002
  3. TRANSMISSION & PATHOGENESIS OF X4 & R5 SHIVS
    Cecilia Cheng Mayer; Fiscal Year: 2007
  4. Assessment of vaccine/microbicide combination efficacy in the macaque model
    Cecilia Cheng Mayer; Fiscal Year: 2007
  5. PHENOTYPIC AND GENETIC DETERMINANTS OF SHIV PATHOGENESIS
    Cecilia Cheng Mayer; Fiscal Year: 2007
  6. Assessment of vaccine/microbicide combination efficacy in the macaque model
    Cecilia Cheng Mayer; Fiscal Year: 2009
  7. R5 SHIV/Macaque Models for the Evaluation of T and B Cell-Based HIV-1 Vaccines
    Cecilia Cheng Mayer; Fiscal Year: 2009
  8. Assessment of vaccine/microbicide combination efficacy in the macaque model
    CECILIA C CHENG MAYER; Fiscal Year: 2010
  9. TRANSMISSION & PATHOGENESIS OF X4 & R5 SHIVS
    Cecilia Cheng Mayer; Fiscal Year: 2005
  10. STRUCTURE/FUNCTION RELATIONSHIP OF HIV-1
    Cecilia Cheng Mayer; Fiscal Year: 2004

Collaborators

Detail Information

Publications33

  1. pmc Adoption of an "open" envelope conformation facilitating CD4 binding and structural remodeling precedes coreceptor switch in R5 SHIV-infected macaques
    Ke Zhuang
    Aaron Diamond AIDS Research Center, New York, New York, United States of America
    PLoS ONE 6:e21350. 2011
    ..These observations in a simian model of R5-to-X4 evolution provide a mechanistic basis for the HIV-1 coreceptor switch...
  2. pmc The number and genetic relatedness of transmitted/founder virus impact clinical outcome in vaginal R5 SHIVSF162P3N infection
    Lily Tsai
    Aaron Diamond AIDS Research Center, Aaron Diamond Professor at the Rockefeller University, New York, NY, USA
    Retrovirology 11:22. 2014
    ....
  3. pmc Delay of simian human immunodeficiency virus infection and control of viral replication in vaccinated macaques challenged in the presence of a topical microbicide
    Cecilia Cheng-Mayer
    Aaron Diamond AIDS Research Center, New York, New York 10016, USA
    AIDS 25:1833-41. 2011
    ..Using a nonhuman primate model of heterosexual HIV-1 transmission, we tested whether a topical microbicide that reduces viral infectivity can potentiate the efficacy of a T-cell-based HIV vaccine...
  4. ncbi request reprint Coreceptor switch in infection of nonhuman primates
    Cecilia Cheng-Mayer
    Aaron Diamond AIDS Research Center, The Rockefeller University, USA
    Curr HIV Res 7:30-8. 2009
    ..Further studies in this animal model should enhance our understanding of the mechanistic basis for, and obstacles to, coreceptor switch...
  5. pmc Selection for neutralization resistance of the simian/human immunodeficiency virus SHIVSF33A variant in vivo by virtue of sequence changes in the extracellular envelope glycoprotein that modify N-linked glycosylation
    C Cheng-Mayer
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 73:5294-300. 1999
    ....
  6. pmc Coreceptor switch in R5-tropic simian/human immunodeficiency virus-infected macaques
    Siu hong Ho
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    J Virol 81:8621-33. 2007
    ....
  7. pmc Efficient repeated low-dose intravaginal infection with X4 and R5 SHIVs in rhesus macaque: implications for HIV-1 transmission in humans
    Lily Tsai
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Floor, New York, NY 10016, USA
    Virology 362:207-16. 2007
    ..These data have implications for HIV-1 transmission and infection in humans...
  8. pmc R5X4 viruses are evolutionary, functional, and antigenic intermediates in the pathway of a simian-human immunodeficiency virus coreceptor switch
    Silvana Tasca
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, New York, NY 10016, USA
    J Virol 82:7089-99. 2008
    ..The data further support a model linking an open envelope gp120 conformation, better CD4 binding, and expansion to CXCR4 usage...
  9. pmc Different tempo and anatomic location of dual-tropic and X4 virus emergence in a model of R5 simian-human immunodeficiency virus infection
    Wuze Ren
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    J Virol 84:340-51. 2010
    ..These findings help define R5 SHIV(SF162P3N) infection of rhesus macaques as a model to study the mechanistic basis, dynamics, and sites of HIV-1 coreceptor switch...
  10. pmc V3 loop-determined coreceptor preference dictates the dynamics of CD4+-T-cell loss in simian-human immunodeficiency virus-infected macaques
    Siu hong Ho
    Rockefeller University, Aaron Diamond AIDS Research Center, 455 First Ave, 7th Floor, New York, NY 10016, USA
    J Virol 79:12296-303. 2005
    ..These findings in a unique isogenic system illustrate that coreceptor usage is the principal determinant of tissue and target cell specificity of the virus in vivo and dictates the dynamics of CD4+-T-cell depletion during SHIV infection...
  11. ncbi request reprint A CCR5-tropic simian-HIV molecular clone capable of inducing AIDS in rhesus macaques
    Mayla Hsu
    Aaron Diamond AIDS Research Center, Rockefeller University, New York, NY 10016, USA
    J Acquir Immune Defic Syndr 40:383-7. 2005
    ..The availability of an infectious R5 SHIV molecular clone that can be transmitted mucosally and causes disease provides an important reagent for studies of lentiviral pathogenesis and AIDS vaccine research...
  12. pmc Induction of potent local cellular immunity with low dose X4 SHIV(SF33A) vaginal exposure
    Silvana Tasca
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Floor, New York, NY 10016, USA
    Virology 367:196-211. 2007
    ..These studies identify the gut and lymphoid tissues proximal to the genital tract as sites of robust CD8 T lymphocyte responses that contribute to containment of virus spread following vaginal transmission...
  13. pmc Mucosal transmissibility, disease induction and coreceptor switching of R5 SHIVSF162P3N molecular clones in rhesus macaques
    Wuze Ren
    Aaron Diamond AIDS Research Center, 455 First Ave, 7th Floor, New York, NY 10016, USA
    Retrovirology 10:9. 2013
    ....
  14. pmc Fitness disadvantage of transitional intermediates contributes to dynamic change in the infecting-virus population during coreceptor switch in R5 simian/human immunodeficiency virus-infected macaques
    Madina Shakirzyanova
    Aaron Diamond AIDS Research Center, 455 First Avenue, 7th Floor, New York, NY 10065, USA
    J Virol 84:12862-71. 2010
    ..Similar observations were made in two infected macaques with coreceptor switch, providing in vivo evidence that fitness disadvantage is an obstacle to X4 emergence and expansion...
  15. ncbi request reprint Progestin-based contraceptive suppresses cellular immune responses in SHIV-infected rhesus macaques
    Nataliya Trunova
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Floor, New York, NY 10016, USA
    Virology 352:169-77. 2006
    ....
  16. pmc Identification of interdependent variables that influence coreceptor switch in R5 SHIV(SF162P3N)-infected macaques
    Ke Zhuang
    Aaron Diamond AIDS Research Center, New York, NY, USA
    Retrovirology 9:106. 2012
    ..Here we extended these studies to two additional RP monkeys with coreceptor switch and three without to confirm and identify additional factors that facilitated the process of phenotypic conversion...
  17. pmc Pathogenic consequences of vaginal infection with CCR5-tropic simian-human immunodeficiency virus SHIVSF162P3N
    Madina Shakirzyanova
    Aaron Diamond AIDS Research Center, New York, New York, USA
    J Virol 86:9432-42. 2012
    ..However, the administered dose appears to impact SHIV(SF162P3N) vaginal infection outcome in an unexpected manner...
  18. pmc Effect of B-cell depletion on coreceptor switching in R5 simian-human immunodeficiency virus infection of rhesus macaques
    Silvana Tasca
    Aaron Diamond AIDS Research Center, 455 First Avenue, 7th Floor, New York, NY 10016, USA
    J Virol 85:3086-94. 2011
    ..These results demonstrate that the absence or diminution of humoral immune responses by itself is insufficient to drive the R5-to-X4 switch and the neutralization susceptibility of the evolving viruses...
  19. pmc CD8+ T cell-mediated CXC chemokine receptor 4-simian/human immunodeficiency virus suppression in dually infected rhesus macaques
    Janet M Harouse
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, 7th Floor, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 100:10977-82. 2003
    ..These findings provide critical insights into a key question related to HIV pathogenesis and have important implications for the development and testing of antiviral vaccines and therapeutics...
  20. ncbi request reprint Expansion of quasispecies diversity but no evidence for adaptive evolution of SHIV during rapid serial transfers among seronegative macaques
    Peter Balfe
    Aaron Diamond AIDS Research Center, New York, NY 10016, USA
    Virology 318:267-79. 2004
    ..Envelope sequence changes accumulate principally in response to immune pressure exerted by the host, generating viral variants that can persist in the presence of a strong host immune response...
  21. pmc Generation of lineage-related, mucosally transmissible subtype C R5 simian-human immunodeficiency viruses capable of AIDS development, induction of neurological disease, and coreceptor switching in rhesus macaques
    Wuze Ren
    Aaron Diamond AIDS Research Center, New York, New York, USA
    J Virol 87:6137-49. 2013
    ..These findings support the use of these new SHIVC109F.PB4-derived viruses to study the immunopathology of HIV-1 clade C infection and to evaluate envelope-based AIDS vaccines in nonhuman primates...
  22. ncbi request reprint Cellulose acetate 1,2-benzenedicarboxylate protects against challenge with pathogenic X4 and R5 simian/human immunodeficiency virus
    Tina Boadi
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    AIDS 19:1587-94. 2005
    ....
  23. pmc Different mutational pathways to CXCR4 coreceptor switch of CCR5-using simian-human immunodeficiency virus
    Siu hong Ho
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Floor, New York, NY 10016, USA
    J Virol 82:5653-6. 2008
    ....
  24. pmc Efficient mucosal transmissibility but limited pathogenicity of R5 SHIV SF162P3N in Chinese-origin rhesus macaques
    Alexandra Mumbauer
    Aaron Diamond AIDS Research Center, New York, NY 10065, USA
    J Acquir Immune Defic Syndr 62:496-504. 2013
    ..In developing alternative nonhuman primate AIDS models for the CCR5 (R5)-tropic SHIVSF162P3N, we characterized virus transmission and infection in Chinese-origin RMs...
  25. pmc Recombinant extracellular domains of tetraspanin proteins are potent inhibitors of the infection of macrophages by human immunodeficiency virus type 1
    Siu hong Ho
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, 7th Floor, New York, NY 10016, USA
    J Virol 80:6487-96. 2006
    ....
  26. ncbi request reprint Long-acting integrase inhibitor protects macaques from intrarectal simian/human immunodeficiency virus
    Chasity D Andrews
    Aaron Diamond AIDS Research Center, Rockefeller University, New York, NY 10016, USA
    Science 343:1151-4. 2014
    ..With a quarterly dosing schedule in humans, our results suggest that GSK744 LA could potentially decrease adherence problems associated with daily preexposure prophylaxis (PrEP). ..
  27. pmc Addition of a single gp120 glycan confers increased binding to dendritic cell-specific ICAM-3-grabbing nonintegrin and neutralization escape to human immunodeficiency virus type 1
    James Lue
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    J Virol 76:10299-306. 2002
    ..Our data suggest that more-efficient binding of envelope gp120 to DC-SIGN could be relevant to the enhanced mucosal transmissibility of SHIV(SF162P3) compared to that of parental SHIV(SF162)...
  28. pmc Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
    Mayla Hsu
    Aaron Diamond AIDS Research Center and Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:7271-6. 2003
    ..However, HIV-HCV pseudotype infectivity was inhibited by a recombinant soluble form of CD81 and a mAb specific for CD81, suggesting that CD81 may be a component of a receptor complex...
  29. pmc Increased mucosal transmission but not enhanced pathogenicity of the CCR5-tropic, simian AIDS-inducing simian/human immunodeficiency virus SHIV(SF162P3) maps to envelope gp120
    Mayla Hsu
    Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York 10016, USA
    J Virol 77:989-98. 2003
    ....
  30. ncbi request reprint Multiple human immunodeficiency virus type 1 Nef functions contribute to efficient replication in primary human macrophages
    Amanda Brown
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, 7th Floor, New York, NY 10016, USA
    J Gen Virol 85:1463-9. 2004
    ..These data suggest that efficient HIV-1 replication is dependent on the ability of Nef to interact with cellular kinases and remove CD4 from the surface of infected macrophages...
  31. pmc Properties of the surface envelope glycoprotein associated with virulence of simian-human immunodeficiency virus SHIV(SF33A) molecular clones
    Lisa A Chakrabarti
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 76:1588-99. 2002
    ....
  32. ncbi request reprint HTLV-1 Tax-associated hTid-1, a human DnaJ protein, is a repressor of Ikappa B kinase beta subunit
    Hua Cheng
    Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York 10021, USA
    J Biol Chem 277:20605-10. 2002
    ..Collectively, our data suggest that hTid-1, in association with heat shock proteins, exerts a negative regulatory effect on the NF-kappaB activity induced by various extracellular and intracellular activators including HTLV-1 Tax...
  33. pmc Coreceptor use in nonhuman primate models of HIV infection
    Silvana Tasca Sina
    Aaron Diamond AIDS Research Center, 455 First Ave, 7th Floor, New York, New York, USA
    J Transl Med 9:S7. 2011
    ....

Research Grants26

  1. TRANSMISSION & PATHOGENESIS OF X4 & R5 SHIVS
    Cecilia Cheng Mayer; Fiscal Year: 2006
    ..abstract_text> ..
  2. STRUCTURE/FUNCTION RELATIONSHIP OF HIV-1
    Cecilia Cheng Mayer; Fiscal Year: 2002
    ..Since the outcome of SHIV infection via the mucosal route appears to be attenuated, it is possible that the type or extent of immune responses elicited by these two routes of immunization may differ. ..
  3. TRANSMISSION & PATHOGENESIS OF X4 & R5 SHIVS
    Cecilia Cheng Mayer; Fiscal Year: 2007
    ..abstract_text> ..
  4. Assessment of vaccine/microbicide combination efficacy in the macaque model
    Cecilia Cheng Mayer; Fiscal Year: 2007
    ..We believe that information gained from the proposed studies will be invaluable for the design, testing and interpretation of preventive strategies against HIV infection in women. ..
  5. PHENOTYPIC AND GENETIC DETERMINANTS OF SHIV PATHOGENESIS
    Cecilia Cheng Mayer; Fiscal Year: 2007
    ..Furthermore, the findings should provide insight on the mechanism for Env-mediated immunopathogenesis and the impact of coreceptor use on these mechanistic processes. ..
  6. Assessment of vaccine/microbicide combination efficacy in the macaque model
    Cecilia Cheng Mayer; Fiscal Year: 2009
    ..We believe that information gained from the proposed studies will be invaluable for the design, testing and interpretation of preventive strategies against HIV infection in women. ..
  7. R5 SHIV/Macaque Models for the Evaluation of T and B Cell-Based HIV-1 Vaccines
    Cecilia Cheng Mayer; Fiscal Year: 2009
    ..Research efforts to establish a set of biologically relevant and extensively-characterized models should broaden the applications, and improve the predictive value of NHP studies. ..
  8. Assessment of vaccine/microbicide combination efficacy in the macaque model
    CECILIA C CHENG MAYER; Fiscal Year: 2010
    ..We believe that information gained from the proposed studies will be invaluable for the design, testing and interpretation of preventive strategies against HIV infection in women. ..
  9. TRANSMISSION & PATHOGENESIS OF X4 & R5 SHIVS
    Cecilia Cheng Mayer; Fiscal Year: 2005
    ..abstract_text> ..
  10. STRUCTURE/FUNCTION RELATIONSHIP OF HIV-1
    Cecilia Cheng Mayer; Fiscal Year: 2004
    ..Since the outcome of SHIV infection via the mucosal route appears to be attenuated, it is possible that the type or extent of immune responses elicited by these two routes of immunization may differ. ..
  11. TRANSMISSION & PATHOGENESIS OF X4 & R5 SHIVS
    Cecilia Cheng Mayer; Fiscal Year: 2004
    ..4) Identify the first site and target cell of virus replication, and characterize the route of viral dissemination in R5 and X4 infected animals. ..
  12. STRUCTURE/FUNCTION RELATIONSHIP OF HIV-1
    Cecilia Cheng Mayer; Fiscal Year: 2003
    ..Since the outcome of SHIV infection via the mucosal route appears to be attenuated, it is possible that the type or extent of immune responses elicited by these two routes of immunization may differ. ..
  13. STRUCTURE/FUNCTION RELATIONSHIP OF HIV 1
    Cecilia Cheng Mayer; Fiscal Year: 1999
    ..An understanding of the mechanism by which HIV-1 infects cells, and the cellular factor(s) involved, may lead to the identification of new targets for anti-viral and vaccine developments. ..
  14. TRANSMISSION & PATHOGENESIS OF X4 & R5 SHIVS
    Cecilia Cheng Mayer; Fiscal Year: 2009
    ..abstract_text> ..
  15. STRUCTURE/FUNCTION RELATIONSHIP OF HIV-1
    Cecilia Cheng Mayer; Fiscal Year: 2000
    ..Since the outcome of SHIV infection via the mucosal route appears to be attenuated, it is possible that the type or extent of immune responses elicited by these two routes of immunization may differ. ..
  16. TRANSMISSION & PATHOGENESIS OF X4 & R5 SHIVS
    Cecilia Cheng Mayer; Fiscal Year: 2001
    ..4) Identify the first site and target cell of virus replication, and characterize the route of viral dissemination in R5 and X4 infected animals. ..
  17. STRUCTURE/FUNCTION RELATIONSHIP OF HIV-1
    Cecilia Cheng Mayer; Fiscal Year: 2001
    ..Since the outcome of SHIV infection via the mucosal route appears to be attenuated, it is possible that the type or extent of immune responses elicited by these two routes of immunization may differ. ..
  18. TRANSMISSION & PATHOGENESIS OF X4 & R5 SHIVS
    Cecilia Cheng Mayer; Fiscal Year: 2002
    ..4) Identify the first site and target cell of virus replication, and characterize the route of viral dissemination in R5 and X4 infected animals. ..
  19. TRANSMISSION & PATHOGENESIS OF X4 & R5 SHIVS
    Cecilia Cheng Mayer; Fiscal Year: 2003
    ..4) Identify the first site and target cell of virus replication, and characterize the route of viral dissemination in R5 and X4 infected animals. ..
  20. R5 SHIV/Macaque Models for the Evaluation of T and B Cell-Based HIV-1 Vaccines
    CECILIA C CHENG MAYER; Fiscal Year: 2010
    ..Research efforts to establish a set of biologically relevant and extensively-characterized models should broaden the applications, and improve the predictive value of NHP studies. ..