Paul Bieniasz

Summary

Affiliation: Aaron Diamond AIDS Research Center
Country: USA

Publications

  1. doi request reprint An overview of intracellular interactions between immunodeficiency viruses and their hosts
    Paul D Bieniasz
    Laboratory of Retrovirology, Howard Hughes Medical Institute, Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    AIDS 26:1243-54. 2012
  2. ncbi request reprint Restriction factors: a defense against retroviral infection
    Paul D Bieniasz
    Aaron Diamond AIDS Research Center, 455 First Avenue, New York, NY 10016, USA
    Trends Microbiol 11:286-91. 2003
  3. ncbi request reprint Late budding domains and host proteins in enveloped virus release
    Paul D Bieniasz
    Aaron Diamond AIDS Research Center and Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Virology 344:55-63. 2006
  4. ncbi request reprint Intrinsic immunity: a front-line defense against viral attack
    Paul D Bieniasz
    Aaron Diamond AIDS Research Center, New York, New York 10016, USA
    Nat Immunol 5:1109-15. 2004
  5. pmc An intrinsic host defense against HIV-1 integration?
    Paul D Bieniasz
    Aaron Diamond AIDS Research Center and Laboratory of Retrovirology, The Rockefeller University, New York, New York 10016, USA
    J Clin Invest 117:302-4. 2007
  6. pmc The cell biology of HIV-1 virion genesis
    Paul D Bieniasz
    Howard Hughes Medical Institute, Aaron Diamond AIDS Research Center, New York, NY 10016, USA
    Cell Host Microbe 5:550-8. 2009
  7. doi request reprint Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu
    Stuart J D Neil
    Aaron Diamond AIDS Research Center and Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, New York 10016, USA
    Nature 451:425-30. 2008
  8. pmc Restriction of human immunodeficiency virus type 1 by TRIM-CypA occurs with rapid kinetics and independently of cytoplasmic bodies, ubiquitin, and proteasome activity
    David Perez-Caballero
    Aaron Diamond AIDS Research Center, 455 First Avenue, New York, NY 10016, USA
    J Virol 79:15567-72. 2005
  9. pmc HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein-sorting pathway
    Juan Martin-Serrano
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10021, USA
    J Cell Biol 168:89-101. 2005
  10. ncbi request reprint Comparative analysis of the antiretroviral activity of APOBEC3G and APOBEC3F from primates
    Veronique Zennou
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA
    Virology 349:31-40. 2006

Research Grants

  1. DETERMINANTS OF INFECTIOUS HIV-1 PARTICLE PRODUCTION
    Paul Bieniasz; Fiscal Year: 2005
  2. Mechanism of Action of Retroviral Late-Budding Domains
    Paul Bieniasz; Fiscal Year: 2006
  3. Late Events in Retrovirus Assembly
    Paul Bieniasz; Fiscal Year: 2007
  4. DETERMINANTS OF INFECTIOUS HIV-1 PARTICLE PRODUCTION
    Paul Bieniasz; Fiscal Year: 2007
  5. Retrovirus Restriction by Trima5alpha
    Paul Bieniasz; Fiscal Year: 2009
  6. DETERMINANTS OF INFECTIOUS HIV-1 PARTICLE PRODUCTION
    Paul D Bieniasz; Fiscal Year: 2010
  7. Late Events in Retrovirus Assembly
    Paul D Bieniasz; Fiscal Year: 2010

Collaborators

  • Juan Martin-Serrano
  • Stephen Goff
  • Marc C Johnson
  • Jeremy Luban
  • Michael H Malim
  • Greg J Towers
  • D D Ho
  • D Derse
  • WESLEY IAN SUNDQUIST
  • BRYAN CULLEN
  • Theodora Hatziioannou
  • David Perez-Caballero
  • Simone Cowan
  • Stuart J D Neil
  • Nolwenn Jouvenet
  • Fengwen Zhang
  • Cesar A Virgen
  • Young Nam Lee
  • Veronique Zennou
  • Trinity Zang
  • Zerina Kratovac
  • Scott W Eastman
  • Maria Zhadina
  • Sanford M Simon
  • Zandrea Ambrose
  • Matthew J Evans
  • Aliza G Lloyd
  • Myra O McClure
  • Brian P Doehle
  • Gillian S Patton
  • Wayne Chung
  • Annie Yang
  • Mark A Muesing
  • Yi Jun Zhang
  • Beatrice H Hahn
  • Frederick Bibollet-Ruche
  • Thomas von Hahn
  • Vineet N Kewalramani
  • Maryline Panis
  • Donna M Tscherne
  • Jane A McKeating
  • Benno Wölk
  • Charles M Rice
  • Andrew J Syder
  • Virginie Sandrin
  • Lubbertus C F Mulder
  • Jeffrey D Lifson
  • Michael Princiotta
  • Heather L Wiegand
  • Cameron Bess
  • Masaru Yamaizumi
  • Satoshi Tateishi
  • Eric Hunter
  • Hal P Bogerd
  • Michael Piatak
  • Fang Yuan
  • Stephen A Morris
  • Uta K von Schwedler
  • Heinrich Gottlinger
  • Douglas Braaten
  • Tshaka Cunningham
  • Heinrich G Gottlinger

Detail Information

Publications46

  1. doi request reprint An overview of intracellular interactions between immunodeficiency viruses and their hosts
    Paul D Bieniasz
    Laboratory of Retrovirology, Howard Hughes Medical Institute, Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    AIDS 26:1243-54. 2012
    ..Here, I present an overview of how HIV-1 interacts with some key host cell factors during its replication cycle...
  2. ncbi request reprint Restriction factors: a defense against retroviral infection
    Paul D Bieniasz
    Aaron Diamond AIDS Research Center, 455 First Avenue, New York, NY 10016, USA
    Trends Microbiol 11:286-91. 2003
    ..Primate- and murine-retrovirus restriction factors have diverse and overlapping specificities, and some variants of Lv1, as well as Ref1, apparently recognize and inhibit infection by widely divergent retroviruses...
  3. ncbi request reprint Late budding domains and host proteins in enveloped virus release
    Paul D Bieniasz
    Aaron Diamond AIDS Research Center and Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Virology 344:55-63. 2006
  4. ncbi request reprint Intrinsic immunity: a front-line defense against viral attack
    Paul D Bieniasz
    Aaron Diamond AIDS Research Center, New York, New York 10016, USA
    Nat Immunol 5:1109-15. 2004
    ..Additional, less well characterized activities also inhibit viral replication. Here, the present understanding of these 'intrinsic' immune mechanisms is reviewed and their role in protection from retroviral infection is discussed...
  5. pmc An intrinsic host defense against HIV-1 integration?
    Paul D Bieniasz
    Aaron Diamond AIDS Research Center and Laboratory of Retrovirology, The Rockefeller University, New York, New York 10016, USA
    J Clin Invest 117:302-4. 2007
    ..Strikingly, p21 appears to alter the fate of nuclear HIV-1 DNA, promoting the formation of circular viral DNA forms rather than functional proviruses...
  6. pmc The cell biology of HIV-1 virion genesis
    Paul D Bieniasz
    Howard Hughes Medical Institute, Aaron Diamond AIDS Research Center, New York, NY 10016, USA
    Cell Host Microbe 5:550-8. 2009
    ..Here, I review recent progress in these three areas...
  7. doi request reprint Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu
    Stuart J D Neil
    Aaron Diamond AIDS Research Center and Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, New York 10016, USA
    Nature 451:425-30. 2008
    ..Vpu co-localized with CD317 and inhibited these effects. Inhibition of Vpu function and consequent mobilization of tetherin's antiviral activity is a potential therapeutic strategy in HIV/AIDS...
  8. pmc Restriction of human immunodeficiency virus type 1 by TRIM-CypA occurs with rapid kinetics and independently of cytoplasmic bodies, ubiquitin, and proteasome activity
    David Perez-Caballero
    Aaron Diamond AIDS Research Center, 455 First Avenue, New York, NY 10016, USA
    J Virol 79:15567-72. 2005
    ..Moreover, tagged TRIM-CypA proteins can be fully active as restriction factors without forming cytoplasmic bodies...
  9. pmc HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein-sorting pathway
    Juan Martin-Serrano
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10021, USA
    J Cell Biol 168:89-101. 2005
    ..These data indicate that specific HECT ubiquitin ligases can link PPXY motifs to the VPS pathway to induce viral budding...
  10. ncbi request reprint Comparative analysis of the antiretroviral activity of APOBEC3G and APOBEC3F from primates
    Veronique Zennou
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA
    Virology 349:31-40. 2006
    ..Overall, highly efficient and species-specific neutralization of APOBEC3G, and less efficient neutralization of APOBEC3F, appears to be a general property of Vif proteins...
  11. pmc Effect of DNA repair protein Rad18 on viral infection
    Aliza G Lloyd
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York, USA
    PLoS Pathog 2:e40. 2006
    ..Furthermore, considering data published recently, it appears that the interactions between DNA repair components with incoming viruses, often result in inhibition of the infection rather than cooperation toward its establishment...
  12. ncbi request reprint Antiretroviral potential of human tripartite motif-5 and related proteins
    Fengwen Zhang
    Aaron Diamond AIDS Research Center and the Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Virology 353:396-409. 2006
    ..However, endogenous owl monkey TRIMCyp potently inhibited an SIV(AGM) strain. Overall, sporadic examples of intrinsic antiretroviral activity exist in this panel of TRIM proteins...
  13. doi request reprint HIV-1 at 25
    David D Ho
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    Cell 133:561-5. 2008
    ..Today, 33 million persons are living with infection by the human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS, while another 25 million have already died of this disease...
  14. pmc Reconstitution of an infectious human endogenous retrovirus
    Young Nam Lee
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York, United States of America
    PLoS Pathog 3:e10. 2007
    ..Overall, the resurrection of this extinct infectious agent in a functional form from molecular fossils should enable studies of the molecular virology and pathogenic potential of this ancient human retrovirus...
  15. doi request reprint No effect of endogenous TRIM5alpha on HIV-1 production
    Fengwen Zhang
    Nat Med 14:235-6; author reply 236-8. 2008
  16. ncbi request reprint Generation of simian-tropic HIV-1 by restriction factor evasion
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center and Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Science 314:95. 2006
    ....
  17. ncbi request reprint Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding
    Scott W Eastman
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York 10016, USA
    J Biol Chem 280:628-36. 2005
    ..Thus, this study identifies VPS37C as a functional component of mammalian ESCRT-I...
  18. pmc APOBEC3G incorporation into human immunodeficiency virus type 1 particles
    Veronique Zennou
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA
    J Virol 78:12058-61. 2004
    ..Because it is, therefore, difficult to evolve specific sequences that confer escape from APOBEC3G, these findings may explain why lentiviruses evolved an activity that induces its destruction...
  19. pmc Context-dependent effects of L domains and ubiquitination on viral budding
    Juan Martin-Serrano
    Aaron Diamond AIDS Research Center, 455 First Ave, New York, NY 10021, USA
    J Virol 78:5554-63. 2004
    ..Moreover, context-dependent L-domain function may reflect distinct requirements for host functions during the morphogenesis of different viral particles or the underlying presence of additional, as yet undiscovered L domains...
  20. pmc Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism
    Simone Cowan
    Aaron Diamond AIDS Research Center, Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 99:11914-9. 2002
    ..These data indicate the existence of one or more saturable inhibitors that are polymorphic in primates and prevent HIV and SIV infection by targeting the capsid of the incoming lentivirus particle...
  21. pmc A bipartite late-budding domain in human immunodeficiency virus type 1
    Juan Martin-Serrano
    Aaron Diamond AIDS Research Center, New York, New York, USA
    J Virol 77:12373-7. 2003
    ..These studies suggest that Tsg101 recruitment is necessary but not sufficient to account for late-budding activity exhibited by HIV-1 p6...
  22. pmc Restriction of multiple divergent retroviruses by Lv1 and Ref1
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center and The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    EMBO J 22:385-94. 2003
    ..These data suggest that restriction factors in human and non-human primate cells are able to recognize and block infection by multiple, widely divergent retroviruses and that the factors themselves may be related...
  23. pmc Capsid-dependent and -independent postentry restriction of primate lentivirus tropism in rodent cells
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York 10021, USA
    J Virol 78:1006-11. 2004
    ..Overall, these findings indicate that novel restriction factors in rodents can modulate sensitivity to specific primate lentiviruses...
  24. pmc Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center and Rockefeller University, New York, New York 10021, USA
    J Virol 79:176-83. 2005
    ..We speculate that CypA and/or CypA-related proteins affect the fate of incoming HIV-1 capsid either directly or by modulating interactions with unidentified host cell factors...
  25. ncbi request reprint HIV/AIDS: in search of an animal model
    Zandrea Ambrose
    HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA
    Trends Biotechnol 25:333-7. 2007
    ..Here, we discuss the uses and limitations of existing models and recent advances that might lead to better animal models for HIV/AIDS...
  26. pmc Ubiquitin-dependent virus particle budding without viral protein ubiquitination
    Maria Zhadina
    Aaron Diamond AIDS Research Center and Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 104:20031-6. 2007
    ..Thus, in this model system, ubiquitin conjugation to transacting factors, not viral proteins, appears critical for ubiquitin-dependent enveloped viral particle release...
  27. pmc Role of ESCRT-I in retroviral budding
    Juan Martin-Serrano
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York 10016, USA
    J Virol 77:4794-804. 2003
    ..However, the PTAP-type L domain appears to be unique in its requirement for an intact, or nearly intact, ESCRT-I complex...
  28. pmc Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate species
    Cesar A Virgen
    Aaron Diamond AIDS Research Center and Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 105:3563-8. 2008
    ..Overall, an intuitively unlikely evolutionary event has, in fact, occurred at least twice in primates and represents a striking example of convergent evolution in divergent species...
  29. pmc Primate lentivirus capsid sensitivity to TRIM5 proteins
    Zerina Kratovac
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA
    J Virol 82:6772-7. 2008
    ..TRIM5alpha proteins from other primates exhibited distinct restriction specificities for primate lentivirus capsids. Finally, we identified novel primate lentiviral capsids that are targeted by TRIMCyp proteins...
  30. pmc Imaging the biogenesis of individual HIV-1 virions in live cells
    Nolwenn Jouvenet
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10065, USA
    Nature 454:236-40. 2008
    ..These approaches allow a previously unobserved view of the genesis of individual virions and the determination of parameters of viral assembly that are inaccessible with conventional techniques...
  31. pmc Hypermutation of an ancient human retrovirus by APOBEC3G
    Young Nam Lee
    Aaron Diamond AIDS Research Center, Laboratory of Retrovirology, The Rockefeller University, New York, New York 10016, USA
    J Virol 82:8762-70. 2008
    ....
  32. pmc Envelope-dependent, cyclophilin-independent effects of glycosaminoglycans on human immunodeficiency virus type 1 attachment and infection
    Yi Jun Zhang
    Aaron Diamond AIDS Research Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Virol 76:6332-43. 2002
    ..Overall, these data exclude a major role for GAGs in mediating the attachment of many HIV-1 strains to target cells via interactions with virion-associated gp120 or CypA...
  33. ncbi request reprint Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
    Matthew J Evans
    Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA
    Nature 446:801-5. 2007
    ..With CLDN1 we have identified a novel key factor for HCV entry and a new target for antiviral drug development...
  34. ncbi request reprint Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors
    Greg J Towers
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nat Med 9:1138-43. 2003
    ..Manipulation of HIV-1 CA recognition by restriction factors promises to advance animal models and new therapeutic strategies for HIV-1 and AIDS...
  35. pmc Identification of domains in gag important for prototypic foamy virus egress
    Gillian S Patton
    Jefferiss Research Trust Laboratories, Wright Fleming Institute, Division of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, United Kingdom
    J Virol 79:6392-9. 2005
    ....
  36. pmc Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity
    David Perez-Caballero
    Aaron Diamond AIDS Research Center, 455 First Ave, New York, NY 10021, USA
    J Virol 79:8969-78. 2005
    ..However, localization in large cytoplasmic bodies is not required for inhibition of N-MLV by huTRIM5alpha or for inhibition of HIV-1 by chimeric or rhTRIM5alpha...
  37. pmc Human immunodeficiency virus type 1 matrix inhibits and confers cooperativity on gag precursor-membrane interactions
    David Perez-Caballero
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York 10016, USA
    J Virol 78:9560-3. 2004
    ..MA-mediated inhibition is relieved by concentration-dependent Gag multimerization and imparts a high degree of cooperativity on Gag-membrane association. This cooperativity may confer temporal and spatial regulation on HIV-1 assembly...
  38. pmc Matrix-induced inhibition of membrane binding contributes to human immunodeficiency virus type 1 particle assembly defects in murine cells
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center, 455 First Avenue, New York, NY 10016, USA
    J Virol 79:15586-9. 2005
    ..Expression level and autoinhibition can be important confounding variables in studies of HIV-1 assembly and contribute to defects encountered in murine cells...
  39. pmc Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 101:10774-9. 2004
    ..These data indicate that TRIM5alpha can confer broad innate immunity to retrovirus infection in primate cells and is likely to be an important natural barrier to cross-species retrovirus transmission...
  40. pmc Species-specific tropism determinants in the human immunodeficiency virus type 1 capsid
    Theodora Hatziioannou
    AIDS Research Center, 455 First Ave, New York, NY 10021, USA
    J Virol 78:6005-12. 2004
    ....
  41. pmc HIV-1 Vpu promotes release and prevents endocytosis of nascent retrovirus particles from the plasma membrane
    Stuart J D Neil
    Aaron Diamond AIDS Research Center, Laboratory of Retrovirology, Rockefeller University, New York, New York, USA
    PLoS Pathog 2:e39. 2006
    ..This entrapment leads to subsequent endocytosis by a Rab5a- and clathrin-dependent mechanism and intracellular sequestration of virions in endosomes...
  42. pmc Cyclin T1 expression is mediated by a complex and constitutively active promoter and does not limit human immunodeficiency virus type 1 Tat function in unstimulated primary lymphocytes
    Juan Martin-Serrano
    Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York 10016, USA
    J Virol 76:208-19. 2002
    ..These results strongly suggest that CycT1 expression levels in unstimulated primary lymphocytes do not profoundly limit HIV-1 gene expression or provide an adequate mechanistic explanation for proviral latency in vivo...
  43. pmc The betaretrovirus Mason-Pfizer monkey virus selectively excludes simian APOBEC3G from virion particles
    Brian P Doehle
    Duke University Medical Center, Box 3025, Durham, NC 27710, USA
    J Virol 80:12102-8. 2006
    ....
  44. pmc Plasma membrane is the site of productive HIV-1 particle assembly
    Nolwenn Jouvenet
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York, United States of America
    PLoS Biol 4:e435. 2006
    ..We conclude that HIV-1 assembly is initiated and completed at the PM, and not at endosomal membranes...
  45. pmc Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins
    Juan Martin-Serrano
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:12414-9. 2003
    ....
  46. pmc An interferon-alpha-induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by the HIV-1 Vpu protein
    Stuart J D Neil
    Aaron Diamond AIDS Research Center and the Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Cell Host Microbe 2:193-203. 2007
    ..Thus, we propose that HIV-1 expresses Vpu to counteract an IFNalpha-induced, general host defense that inhibits dissemination of enveloped virions from the surface of infected cells...

Research Grants24

  1. DETERMINANTS OF INFECTIOUS HIV-1 PARTICLE PRODUCTION
    Paul Bieniasz; Fiscal Year: 2005
    ..These studies have the potential to reveal new targets for chemotherapeutic intervention in HIV disease and may make a rodent model of HIV infection feasible. ..
  2. Mechanism of Action of Retroviral Late-Budding Domains
    Paul Bieniasz; Fiscal Year: 2006
    ..These studies have the potential to reveal completely novel, host-cell targets for therapeutic blockade of the replication of HIV-1, and possibly other viruses. ..
  3. Late Events in Retrovirus Assembly
    Paul Bieniasz; Fiscal Year: 2007
    ..To spread from cell to cell they make use of cellular proteins to facilitate the release of accurately assembled virus particles. Understanding how this system works could give opportunities to intervene with targeted therapeutics. ..
  4. DETERMINANTS OF INFECTIOUS HIV-1 PARTICLE PRODUCTION
    Paul Bieniasz; Fiscal Year: 2007
    ..The experiments proposed herein should provide greater clarity as to how Gag proteins behave during assembly in cells. ..
  5. Retrovirus Restriction by Trima5alpha
    Paul Bieniasz; Fiscal Year: 2009
    ....
  6. DETERMINANTS OF INFECTIOUS HIV-1 PARTICLE PRODUCTION
    Paul D Bieniasz; Fiscal Year: 2010
    ..The experiments proposed herein should provide greater clarity as to how Gag proteins behave during assembly in cells. ..
  7. Late Events in Retrovirus Assembly
    Paul D Bieniasz; Fiscal Year: 2010
    ..To spread from cell to cell they make use of cellular proteins to facilitate the release of accurately assembled virus particles. Understanding how this system works could give opportunities to intervene with targeted therapeutics. ..