Bruno Manta

Summary

Country: Uruguay

Publications

  1. doi request reprint Trypanothione: a unique bis-glutathionyl derivative in trypanosomatids
    Bruno Manta
    Institut Pasteur de Montevideo, Montevideo, Uruguay
    Biochim Biophys Acta 1830:3199-216. 2013
  2. doi request reprint Factors affecting protein thiol reactivity and specificity in peroxide reduction
    Gerardo Ferrer-Sueta
    Laboratorio de Fisicoquímica Biológica, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
    Chem Res Toxicol 24:434-50. 2011
  3. pmc Iron-sulfur cluster binding by mitochondrial monothiol glutaredoxin-1 of Trypanosoma brucei: molecular basis of iron-sulfur cluster coordination and relevance for parasite infectivity
    Bruno Manta
    Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay
    Antioxid Redox Signal 19:665-82. 2013
  4. doi request reprint Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics
    Martín Hugo
    Departamento de Bioqumica, Facultad de Medicina, Center for Free Radical and Biomedical Research, Universidad de la Republica, Montevideo, Uruguay
    Biochemistry 48:9416-26. 2009

Collaborators

Detail Information

Publications4

  1. doi request reprint Trypanothione: a unique bis-glutathionyl derivative in trypanosomatids
    Bruno Manta
    Institut Pasteur de Montevideo, Montevideo, Uruguay
    Biochim Biophys Acta 1830:3199-216. 2013
    ..Notably, the trypanothione system is capable to sustain several cellular functions mediated by thiol-dependent (redox) processes...
  2. doi request reprint Factors affecting protein thiol reactivity and specificity in peroxide reduction
    Gerardo Ferrer-Sueta
    Laboratorio de Fisicoquímica Biológica, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
    Chem Res Toxicol 24:434-50. 2011
    ..The extraordinary thiol reactivity and specificity toward H(2)O(2) combined with their ubiquity and abundance place peroxiredoxins, along with glutathione peroxidases, as obligate hydroperoxide cellular sensors...
  3. pmc Iron-sulfur cluster binding by mitochondrial monothiol glutaredoxin-1 of Trypanosoma brucei: molecular basis of iron-sulfur cluster coordination and relevance for parasite infectivity
    Bruno Manta
    Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay
    Antioxid Redox Signal 19:665-82. 2013
    ..We here report on the functional and structural analysis of 1-C-Grx1 in relation to its ISC-binding properties...
  4. doi request reprint Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics
    Martín Hugo
    Departamento de Bioqumica, Facultad de Medicina, Center for Free Radical and Biomedical Research, Universidad de la Republica, Montevideo, Uruguay
    Biochemistry 48:9416-26. 2009
    ..Taken together, our results indicate that MtAhpE is a relevant component in the antioxidant repertoire of M. tuberculosis probably involved in peroxide and specially peroxynitrite detoxification...