Patricia Cassina

Summary

Affiliation: Facultad de Medicina
Country: Uruguay

Publications

  1. pmc Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis
    Ernesto Miquel
    Departamento de Histologia y Embriologia, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    PLoS ONE 7:e34776. 2012
  2. pmc Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants
    Patricia Cassina
    Departamento de Histologia, and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, 11800 Montevideo, Uruguay
    J Neurosci 28:4115-22. 2008
  3. ncbi request reprint Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis
    Marcelo R Vargas
    Departamento de Neurobiologia Celular y Molecular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    J Neurochem 97:687-96. 2006
  4. ncbi request reprint Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis
    Patricia Cassina
    Departamento de Histologia, Facultad de Medicina, Universidad de la República Montevideo, Uruguay
    J Neurochem 93:38-46. 2005
  5. pmc Lead exposure stimulates VEGF expression in the spinal cord and extends survival in a mouse model of ALS
    Ana G Barbeito
    Departamento de Histologia y Embriologia, Facultad de Medicina, Universidad de la Republica, Avenida General Flores 2125, 11800, Montevideo, Uruguay
    Neurobiol Dis 37:574-80. 2010
  6. ncbi request reprint Complexity of astrocyte-motor neuron interactions in amyotrophic lateral sclerosis
    Mariana Pehar
    Departamento de Neurobiologia Celular y Molecular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    Neurodegener Dis 2:139-46. 2005
  7. ncbi request reprint Involvement of nitric oxide on kainate-induced toxicity in oligodendrocyte precursors
    Laura Martinez-Palma
    Departamento de Histologia, Facultad de Veterinaria y Facultad de Medicina, Universidad de la Republica, Montevideo 11600, Uruguay
    Neurotox Res 5:399-406. 2003
  8. pmc Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis
    Mandi Gandelman
    Institut Pasteur, Montevideo, Uruguay
    J Neuroinflammation 7:33. 2010
  9. ncbi request reprint Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis
    Mariana Pehar
    Departamento de Neurobiología Celular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    J Neurochem 89:464-73. 2004
  10. ncbi request reprint A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis
    Luis H Barbeito
    Departamento de Neurobiologia Celular y Molecular, Instituto de Investigaciones Biologicas Clemente Estable, Avenida Italia 3318 CP 11600, Montevideo, Uruguay
    Brain Res Brain Res Rev 47:263-74. 2004

Collaborators

Detail Information

Publications16

  1. pmc Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis
    Ernesto Miquel
    Departamento de Histologia y Embriologia, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    PLoS ONE 7:e34776. 2012
    ..Taken together, our results indicate that improvement of the mitochondrial redox status by DCA leads to a disease-modifying effect, further supporting the therapeutic potential of mitochondria-targeted drugs in ALS...
  2. pmc Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants
    Patricia Cassina
    Departamento de Histologia, and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, 11800 Montevideo, Uruguay
    J Neurosci 28:4115-22. 2008
    ..Together, our results indicate that mitochondrial dysfunction in astrocytes critically influences motor neuron survival and support the potential pharmacological utility of mitochondrial-targeted antioxidants in ALS treatment...
  3. ncbi request reprint Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis
    Marcelo R Vargas
    Departamento de Neurobiologia Celular y Molecular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    J Neurochem 97:687-96. 2006
    ..These results suggest that activation of Nrf2 in astrocytes can reduce NO-dependent toxicity to motor neurons by increasing GSH biosynthesis...
  4. ncbi request reprint Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis
    Patricia Cassina
    Departamento de Histologia, Facultad de Medicina, Universidad de la República Montevideo, Uruguay
    J Neurochem 93:38-46. 2005
    ..These results suggest that FGF-1 released by oxidative stress from motor neurons might have a role in activating astrocytes, which could in turn initiate motor neuron apoptosis in ALS through a p75(NTR)-dependent mechanism...
  5. pmc Lead exposure stimulates VEGF expression in the spinal cord and extends survival in a mouse model of ALS
    Ana G Barbeito
    Departamento de Histologia y Embriologia, Facultad de Medicina, Universidad de la Republica, Avenida General Flores 2125, 11800, Montevideo, Uruguay
    Neurobiol Dis 37:574-80. 2010
    ..Understanding how Pb stimulates astrocytic VEGF production and reduces neuroinflammation may yield a new therapeutic approach for treating ALS...
  6. ncbi request reprint Complexity of astrocyte-motor neuron interactions in amyotrophic lateral sclerosis
    Mariana Pehar
    Departamento de Neurobiologia Celular y Molecular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    Neurodegener Dis 2:139-46. 2005
    ..Consequently, astrocyte activation in ALS may have a complex pathogenic role...
  7. ncbi request reprint Involvement of nitric oxide on kainate-induced toxicity in oligodendrocyte precursors
    Laura Martinez-Palma
    Departamento de Histologia, Facultad de Veterinaria y Facultad de Medicina, Universidad de la Republica, Montevideo 11600, Uruguay
    Neurotox Res 5:399-406. 2003
    ....
  8. pmc Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis
    Mandi Gandelman
    Institut Pasteur, Montevideo, Uruguay
    J Neuroinflammation 7:33. 2010
    ..Here we studied the role of extracellular ATP acting through P2X(7) receptors as an initiator of a neurotoxic phenotype that leads to astrocyte-mediated motor neuron death in non-transgenic and SOD1G93A astrocytes...
  9. ncbi request reprint Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis
    Mariana Pehar
    Departamento de Neurobiología Celular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    J Neurochem 89:464-73. 2004
    ..Thus, reactive astrocytes might contribute to the progressive motor neuron degeneration characterizing ALS...
  10. ncbi request reprint A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis
    Luis H Barbeito
    Departamento de Neurobiologia Celular y Molecular, Instituto de Investigaciones Biologicas Clemente Estable, Avenida Italia 3318 CP 11600, Montevideo, Uruguay
    Brain Res Brain Res Rev 47:263-74. 2004
    ..The comprehensive understanding of the interactions between motor neurons and glia in ALS may lead to a more accurate theory of the pathogenesis of the disease...
  11. ncbi request reprint Stimulation of nerve growth factor expression in astrocytes by peroxynitrite
    Marcelo R Vargas
    Departamento de Neurobiologia Celular y Molecular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    In Vivo 18:269-74. 2004
    ..In the present study, we investigated whether peroxynitrite stimulated nerve growth factor (NGF) expression in spinal cord astrocytes...
  12. pmc P2X7 receptor-induced death of motor neurons by a peroxynitrite/FAS-dependent pathway
    Mandi Gandelman
    Neurodegeneration Laboratory, Institut Pasteur, Montevideo, Uruguay
    J Neurochem 126:382-8. 2013
    ..Taken together, our results indicate that motor neurons are highly sensitive to P2X7 activation, which triggers apoptosis by activation of the well-established peroxynitrite/FAS death pathway in motor neurons. ..
  13. doi request reprint Astrocytic proliferation and mitochondrial dysfunction induced by accumulated glutaric acidemia I (GAI) metabolites: possible implications for GAI pathogenesis
    Silvia Olivera
    Cellular and Molecular Neurobiology Department, Instituto Clemente Estable IIBCE, Montevideo, Uruguay
    Neurobiol Dis 32:528-34. 2008
    ....
  14. ncbi request reprint Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis
    Patricia Cassina
    Departamento de Histologia y Embriologia, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    J Neurosci Res 67:21-9. 2002
    ..Thus, spinal cord astrocytes respond to extracellular peroxynitrite by adopting a phenotype that is cytotoxic to motor neurons through peroxynitrite-dependent mechanisms...
  15. doi request reprint Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis
    Ernesto Miquel
    Departamento de Histologia y Embriologia, Facultad de Medicina, Universidad de la Republica, 11800 Montevideo, Uruguay
    Free Radic Biol Med 70:204-13. 2014
    ..Our results support a role for mitochondrial nitroxidative damage and dysfunction in the pathogenesis of ALS and suggest that mitochondria-targeted antioxidants may be of pharmacological use for ALS treatment. ..
  16. pmc FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels
    Juan M Garré
    Facultad de Medicina, Universidad de la República Oriental del Uruguay, C P 11800 Montevideo, Uruguay
    Proc Natl Acad Sci U S A 107:22659-64. 2010
    ..These changes in HCs and gap junction channels may promote inflammation and deprive neurons of astrocyte-mediated protection in spinal cord trauma and neurodegenerative disease...