Patricia Cassina

Summary

Affiliation: Facultad de Medicina
Country: Uruguay

Publications

  1. doi request reprint Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants
    Patricia Cassina
    Departamento de Histologia, and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, 11800 Montevideo, Uruguay
    J Neurosci 28:4115-22. 2008
  2. pmc Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis
    Mandi Gandelman
    Institut Pasteur, Montevideo, Uruguay
    J Neuroinflammation 7:33. 2010
  3. ncbi request reprint Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis
    Patricia Cassina
    Departamento de Histologia, Facultad de Medicina, Universidad de la República Montevideo, Uruguay
    J Neurochem 93:38-46. 2005
  4. pmc Lead exposure stimulates VEGF expression in the spinal cord and extends survival in a mouse model of ALS
    Ana G Barbeito
    Departamento de Histologia y Embriologia, Facultad de Medicina, Universidad de la Republica, Avenida General Flores 2125, 11800, Montevideo, Uruguay
    Neurobiol Dis 37:574-80. 2010
  5. ncbi request reprint Involvement of nitric oxide on kainate-induced toxicity in oligodendrocyte precursors
    Laura Martinez-Palma
    Departamento de Histologia, Facultad de Veterinaria y Facultad de Medicina, Universidad de la Republica, Montevideo 11600, Uruguay
    Neurotox Res 5:399-406. 2003
  6. pmc Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis
    Ernesto Miquel
    Departamento de Histologia y Embriologia, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    PLoS ONE 7:e34776. 2012
  7. ncbi request reprint Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis
    Patricia Cassina
    Departamento de Histologia y Embriologia, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    J Neurosci Res 67:21-9. 2002
  8. pmc FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels
    Juan M Garré
    Facultad de Medicina, Universidad de la República Oriental del Uruguay, C P 11800 Montevideo, Uruguay
    Proc Natl Acad Sci U S A 107:22659-64. 2010

Collaborators

Detail Information

Publications8

  1. doi request reprint Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants
    Patricia Cassina
    Departamento de Histologia, and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, 11800 Montevideo, Uruguay
    J Neurosci 28:4115-22. 2008
    ..Together, our results indicate that mitochondrial dysfunction in astrocytes critically influences motor neuron survival and support the potential pharmacological utility of mitochondrial-targeted antioxidants in ALS treatment...
  2. pmc Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis
    Mandi Gandelman
    Institut Pasteur, Montevideo, Uruguay
    J Neuroinflammation 7:33. 2010
    ..Here we studied the role of extracellular ATP acting through P2X(7) receptors as an initiator of a neurotoxic phenotype that leads to astrocyte-mediated motor neuron death in non-transgenic and SOD1G93A astrocytes...
  3. ncbi request reprint Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis
    Patricia Cassina
    Departamento de Histologia, Facultad de Medicina, Universidad de la República Montevideo, Uruguay
    J Neurochem 93:38-46. 2005
    ..These results suggest that FGF-1 released by oxidative stress from motor neurons might have a role in activating astrocytes, which could in turn initiate motor neuron apoptosis in ALS through a p75(NTR)-dependent mechanism...
  4. pmc Lead exposure stimulates VEGF expression in the spinal cord and extends survival in a mouse model of ALS
    Ana G Barbeito
    Departamento de Histologia y Embriologia, Facultad de Medicina, Universidad de la Republica, Avenida General Flores 2125, 11800, Montevideo, Uruguay
    Neurobiol Dis 37:574-80. 2010
    ..Understanding how Pb stimulates astrocytic VEGF production and reduces neuroinflammation may yield a new therapeutic approach for treating ALS...
  5. ncbi request reprint Involvement of nitric oxide on kainate-induced toxicity in oligodendrocyte precursors
    Laura Martinez-Palma
    Departamento de Histologia, Facultad de Veterinaria y Facultad de Medicina, Universidad de la Republica, Montevideo 11600, Uruguay
    Neurotox Res 5:399-406. 2003
    ....
  6. pmc Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis
    Ernesto Miquel
    Departamento de Histologia y Embriologia, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    PLoS ONE 7:e34776. 2012
    ..Taken together, our results indicate that improvement of the mitochondrial redox status by DCA leads to a disease-modifying effect, further supporting the therapeutic potential of mitochondria-targeted drugs in ALS...
  7. ncbi request reprint Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis
    Patricia Cassina
    Departamento de Histologia y Embriologia, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    J Neurosci Res 67:21-9. 2002
    ..Thus, spinal cord astrocytes respond to extracellular peroxynitrite by adopting a phenotype that is cytotoxic to motor neurons through peroxynitrite-dependent mechanisms...
  8. pmc FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels
    Juan M Garré
    Facultad de Medicina, Universidad de la República Oriental del Uruguay, C P 11800 Montevideo, Uruguay
    Proc Natl Acad Sci U S A 107:22659-64. 2010
    ..These changes in HCs and gap junction channels may promote inflammation and deprive neurons of astrocyte-mediated protection in spinal cord trauma and neurodegenerative disease...