Patricia Cassina

Summary

Affiliation: Facultad de Medicina
Country: Uruguay

Publications

  1. pmc Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants
    Patricia Cassina
    Departamento de Histologia, and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, 11800 Montevideo, Uruguay
    J Neurosci 28:4115-22. 2008
  2. ncbi request reprint Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis
    Marcelo R Vargas
    Departamento de Neurobiologia Celular y Molecular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    J Neurochem 97:687-96. 2006
  3. ncbi request reprint Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis
    Patricia Cassina
    Departamento de Histologia, Facultad de Medicina, Universidad de la República Montevideo, Uruguay
    J Neurochem 93:38-46. 2005
  4. pmc Lead exposure stimulates VEGF expression in the spinal cord and extends survival in a mouse model of ALS
    Ana G Barbeito
    Departamento de Histologia y Embriologia, Facultad de Medicina, Universidad de la Republica, Avenida General Flores 2125, 11800, Montevideo, Uruguay
    Neurobiol Dis 37:574-80. 2010
  5. ncbi request reprint Complexity of astrocyte-motor neuron interactions in amyotrophic lateral sclerosis
    Mariana Pehar
    Departamento de Neurobiologia Celular y Molecular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    Neurodegener Dis 2:139-46. 2005
  6. pmc Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis
    Mandi Gandelman
    Institut Pasteur, Montevideo, Uruguay
    J Neuroinflammation 7:33. 2010
  7. ncbi request reprint Involvement of nitric oxide on kainate-induced toxicity in oligodendrocyte precursors
    Laura Martinez-Palma
    Departamento de Histologia, Facultad de Veterinaria y Facultad de Medicina, Universidad de la Republica, Montevideo 11600, Uruguay
    Neurotox Res 5:399-406. 2003
  8. ncbi request reprint Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis
    Mariana Pehar
    Departamento de Neurobiología Celular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    J Neurochem 89:464-73. 2004
  9. pmc Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis
    Ernesto Miquel
    Departamento de Histologia y Embriologia, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    PLoS ONE 7:e34776. 2012
  10. ncbi request reprint A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis
    Luis H Barbeito
    Departamento de Neurobiologia Celular y Molecular, Instituto de Investigaciones Biologicas Clemente Estable, Avenida Italia 3318 CP 11600, Montevideo, Uruguay
    Brain Res Brain Res Rev 47:263-74. 2004

Collaborators

Detail Information

Publications16

  1. pmc Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants
    Patricia Cassina
    Departamento de Histologia, and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, 11800 Montevideo, Uruguay
    J Neurosci 28:4115-22. 2008
    ..Together, our results indicate that mitochondrial dysfunction in astrocytes critically influences motor neuron survival and support the potential pharmacological utility of mitochondrial-targeted antioxidants in ALS treatment...
  2. ncbi request reprint Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis
    Marcelo R Vargas
    Departamento de Neurobiologia Celular y Molecular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    J Neurochem 97:687-96. 2006
    ..These results suggest that activation of Nrf2 in astrocytes can reduce NO-dependent toxicity to motor neurons by increasing GSH biosynthesis...
  3. ncbi request reprint Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis
    Patricia Cassina
    Departamento de Histologia, Facultad de Medicina, Universidad de la República Montevideo, Uruguay
    J Neurochem 93:38-46. 2005
    ..These results suggest that FGF-1 released by oxidative stress from motor neurons might have a role in activating astrocytes, which could in turn initiate motor neuron apoptosis in ALS through a p75(NTR)-dependent mechanism...
  4. pmc Lead exposure stimulates VEGF expression in the spinal cord and extends survival in a mouse model of ALS
    Ana G Barbeito
    Departamento de Histologia y Embriologia, Facultad de Medicina, Universidad de la Republica, Avenida General Flores 2125, 11800, Montevideo, Uruguay
    Neurobiol Dis 37:574-80. 2010
    ..Understanding how Pb stimulates astrocytic VEGF production and reduces neuroinflammation may yield a new therapeutic approach for treating ALS...
  5. ncbi request reprint Complexity of astrocyte-motor neuron interactions in amyotrophic lateral sclerosis
    Mariana Pehar
    Departamento de Neurobiologia Celular y Molecular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    Neurodegener Dis 2:139-46. 2005
    ..Consequently, astrocyte activation in ALS may have a complex pathogenic role...
  6. pmc Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis
    Mandi Gandelman
    Institut Pasteur, Montevideo, Uruguay
    J Neuroinflammation 7:33. 2010
    ..Here we studied the role of extracellular ATP acting through P2X(7) receptors as an initiator of a neurotoxic phenotype that leads to astrocyte-mediated motor neuron death in non-transgenic and SOD1G93A astrocytes...
  7. ncbi request reprint Involvement of nitric oxide on kainate-induced toxicity in oligodendrocyte precursors
    Laura Martinez-Palma
    Departamento de Histologia, Facultad de Veterinaria y Facultad de Medicina, Universidad de la Republica, Montevideo 11600, Uruguay
    Neurotox Res 5:399-406. 2003
    ....
  8. ncbi request reprint Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis
    Mariana Pehar
    Departamento de Neurobiología Celular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    J Neurochem 89:464-73. 2004
    ..Thus, reactive astrocytes might contribute to the progressive motor neuron degeneration characterizing ALS...
  9. pmc Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis
    Ernesto Miquel
    Departamento de Histologia y Embriologia, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    PLoS ONE 7:e34776. 2012
    ..Taken together, our results indicate that improvement of the mitochondrial redox status by DCA leads to a disease-modifying effect, further supporting the therapeutic potential of mitochondria-targeted drugs in ALS...
  10. ncbi request reprint A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis
    Luis H Barbeito
    Departamento de Neurobiologia Celular y Molecular, Instituto de Investigaciones Biologicas Clemente Estable, Avenida Italia 3318 CP 11600, Montevideo, Uruguay
    Brain Res Brain Res Rev 47:263-74. 2004
    ..The comprehensive understanding of the interactions between motor neurons and glia in ALS may lead to a more accurate theory of the pathogenesis of the disease...
  11. ncbi request reprint Stimulation of nerve growth factor expression in astrocytes by peroxynitrite
    Marcelo R Vargas
    Departamento de Neurobiologia Celular y Molecular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    In Vivo 18:269-74. 2004
    ..In the present study, we investigated whether peroxynitrite stimulated nerve growth factor (NGF) expression in spinal cord astrocytes...
  12. pmc P2X7 receptor-induced death of motor neurons by a peroxynitrite/FAS-dependent pathway
    Mandi Gandelman
    Neurodegeneration Laboratory, Institut Pasteur, Montevideo, Uruguay
    J Neurochem 126:382-8. 2013
    ..Taken together, our results indicate that motor neurons are highly sensitive to P2X7 activation, which triggers apoptosis by activation of the well-established peroxynitrite/FAS death pathway in motor neurons. ..
  13. doi request reprint Astrocytic proliferation and mitochondrial dysfunction induced by accumulated glutaric acidemia I (GAI) metabolites: possible implications for GAI pathogenesis
    Silvia Olivera
    Cellular and Molecular Neurobiology Department, Instituto Clemente Estable IIBCE, Montevideo, Uruguay
    Neurobiol Dis 32:528-34. 2008
    ....
  14. ncbi request reprint Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis
    Patricia Cassina
    Departamento de Histologia y Embriologia, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    J Neurosci Res 67:21-9. 2002
    ..Thus, spinal cord astrocytes respond to extracellular peroxynitrite by adopting a phenotype that is cytotoxic to motor neurons through peroxynitrite-dependent mechanisms...
  15. ncbi request reprint Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis
    Ernesto Miquel
    Departamento de Histologia y Embriologia, Facultad de Medicina, Universidad de la Republica, 11800 Montevideo, Uruguay
    Free Radic Biol Med 70:204-13. 2014
    ..Our results support a role for mitochondrial nitroxidative damage and dysfunction in the pathogenesis of ALS and suggest that mitochondria-targeted antioxidants may be of pharmacological use for ALS treatment...
  16. pmc FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels
    Juan M Garré
    Facultad de Medicina, Universidad de la República Oriental del Uruguay, C P 11800 Montevideo, Uruguay
    Proc Natl Acad Sci U S A 107:22659-64. 2010
    ..These changes in HCs and gap junction channels may promote inflammation and deprive neurons of astrocyte-mediated protection in spinal cord trauma and neurodegenerative disease...