Gustavo Javier Rodrigo

Summary

Affiliation: Departamento de Emergencia
Country: Uruguay

Publications

  1. ncbi request reprint [Critical analysis of asthma guidelines: are they really evidence-based?]
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Facultad de Medicina, Centro Latinoamericano de Economía Humana del Uruguay CLAEH, Punta del Este, Uruguay
    Arch Bronconeumol 44:81-6. 2008
  2. doi request reprint Safety of long-acting β agonists for the treatment of asthma: clearing the air
    Gustavo J Rodrigo
    Department of Emergency, Hospital Central de las Fuerzas Armadas, Av 8 de octubre 3020, Montevideo 11600, Uruguay
    Thorax 67:342-9. 2012
  3. doi request reprint Comparison of three combined pharmacological approaches with tiotropium monotherapy in stable moderate to severe COPD: a systematic review
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Av 8 de octubre 3020, Montevideo 11300, Uruguay
    Pulm Pharmacol Ther 25:40-7. 2012
  4. doi request reprint Reliability and factor analysis of the Spanish version of the asthma control test
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
    Ann Allergy Asthma Immunol 100:17-22. 2008
  5. doi request reprint Safety of long-acting beta-agonists in stable COPD: a systematic review
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Av 8 de octubre 3020, Montevideo 11600, Uruguay
    Chest 133:1079-87. 2008
  6. ncbi request reprint Factors associated with mortality in patients hospitalized in Spain and Latin America for acute severe asthma in 1994, 1999, and 2004
    Gustavo Javier Rodrigo
    Departamento de Emergencia, Hospital Central de Fuerzas Armadas, Montevideo, Uruguay
    J Bras Pneumol 34:546-51. 2008
  7. doi request reprint Safety of regular use of long-acting beta agonists as monotherapy or added to inhaled corticosteroids in asthma. A systematic review
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Av 8 de octubre 3020, Montevideo 11600, Uruguay
    Pulm Pharmacol Ther 22:9-19. 2009
  8. doi request reprint Predicting response to therapy in acute asthma
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
    Curr Opin Pulm Med 15:35-8. 2009
  9. doi request reprint Tiotropium and risk for fatal and nonfatal cardiovascular events in patients with chronic obstructive pulmonary disease: systematic review with meta-analysis
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Av 8 de octubre 3020, Montevideo 11600, Uruguay
    Respir Med 103:1421-9. 2009
  10. doi request reprint Safety and efficacy of combined long-acting beta-agonists and inhaled corticosteroids vs long-acting beta-agonists monotherapy for stable COPD: a systematic review
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo 11600, Uruguay
    Chest 136:1029-38. 2009

Detail Information

Publications35

  1. ncbi request reprint [Critical analysis of asthma guidelines: are they really evidence-based?]
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Facultad de Medicina, Centro Latinoamericano de Economía Humana del Uruguay CLAEH, Punta del Este, Uruguay
    Arch Bronconeumol 44:81-6. 2008
    ..Our main sources of information should therefore be those that apply the best research designs, namely randomized controlled trials or meta-analyses of such trials with consistent results and a low probability of bias...
  2. doi request reprint Safety of long-acting β agonists for the treatment of asthma: clearing the air
    Gustavo J Rodrigo
    Department of Emergency, Hospital Central de las Fuerzas Armadas, Av 8 de octubre 3020, Montevideo 11600, Uruguay
    Thorax 67:342-9. 2012
    ....
  3. doi request reprint Comparison of three combined pharmacological approaches with tiotropium monotherapy in stable moderate to severe COPD: a systematic review
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Av 8 de octubre 3020, Montevideo 11300, Uruguay
    Pulm Pharmacol Ther 25:40-7. 2012
    ..Guidelines recommend the use of inhaled long-acting bronchodilators, inhaled corticosteroids (ICS) and their combinations for maintenance treatment of moderate to severe COPD. However, there are limited data supporting combination therapy...
  4. doi request reprint Reliability and factor analysis of the Spanish version of the asthma control test
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
    Ann Allergy Asthma Immunol 100:17-22. 2008
    ..The Asthma Control Test (ACT) has been developed to evaluate asthma control and to reflect its nature. A Spanish version of the test has been widely disseminated to physicians, but it has not yet been validated...
  5. doi request reprint Safety of long-acting beta-agonists in stable COPD: a systematic review
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Av 8 de octubre 3020, Montevideo 11600, Uruguay
    Chest 133:1079-87. 2008
    ..The purpose of this review was to assess the safety, and secondarily the efficacy of LABAs...
  6. ncbi request reprint Factors associated with mortality in patients hospitalized in Spain and Latin America for acute severe asthma in 1994, 1999, and 2004
    Gustavo Javier Rodrigo
    Departamento de Emergencia, Hospital Central de Fuerzas Armadas, Montevideo, Uruguay
    J Bras Pneumol 34:546-51. 2008
    ..To evaluate, for the first time, the characteristics of patients with acute asthma who died during hospitalization in Spain and Latin America, as well as to evaluate factors associated with asthma mortality...
  7. doi request reprint Safety of regular use of long-acting beta agonists as monotherapy or added to inhaled corticosteroids in asthma. A systematic review
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Av 8 de octubre 3020, Montevideo 11600, Uruguay
    Pulm Pharmacol Ther 22:9-19. 2009
    ..Safety of long-acting beta agonists (LABA) has been questioned and recent evidence suggested a detrimental effect on asthma control as well as an increased risk of death...
  8. doi request reprint Predicting response to therapy in acute asthma
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
    Curr Opin Pulm Med 15:35-8. 2009
    ..To analyze the prediction of response of therapy into the context of acute adult asthma assessment in the emergency department (ED) setting...
  9. doi request reprint Tiotropium and risk for fatal and nonfatal cardiovascular events in patients with chronic obstructive pulmonary disease: systematic review with meta-analysis
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Av 8 de octubre 3020, Montevideo 11600, Uruguay
    Respir Med 103:1421-9. 2009
    ..The purpose of this review was to evaluate the cardiovascular risk of regular use of inhaled tiotropium bromide in patients with COPD of any severity...
  10. doi request reprint Safety and efficacy of combined long-acting beta-agonists and inhaled corticosteroids vs long-acting beta-agonists monotherapy for stable COPD: a systematic review
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo 11600, Uruguay
    Chest 136:1029-38. 2009
    ..However, the evidence has been inconclusive. The aim of this review was to assess the safety and efficacy of LABAs/ICSs compared with LABA monotherapy for patients with moderate-to-very severe COPD...
  11. ncbi request reprint The study of severe asthma in Latin America and Spain (1994-2004): characteristics of patients hospitalized with acute severe asthma
    Gustavo Javier Rodrigo
    Department of Emergency Services, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
    J Bras Pneumol 35:635-44. 2009
    ..The present study evaluated long-term changes among hospitalized asthma patients at a large number of facilities...
  12. doi request reprint Relationship between the characteristics of hospitalised acute asthma patients and the severity of their asthma. A case-control study
    G J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
    Allergol Immunopathol (Madr) 37:225-9. 2009
    ..The EAGLE project database was analysed to assess the characteristics of patients with severe (SA) who required hospitalisation as a result of an acute episode during the period 1994-2004, and the relationship with asthma severity...
  13. doi request reprint Formoterol for acute asthma in the emergency department: a systematic review with meta-analysis
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
    Ann Allergy Asthma Immunol 104:247-52. 2010
    ..Although several published studies have suggested that formoterol fumarate could be equivalent to short-acting beta2-agonists (SABAs) for the treatment of asthma exacerbations, its role in acute asthma treatment remains undefined...
  14. ncbi request reprint Inhaled corticosteroids as rescue medication in acute severe asthma
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Avenue 8 de Octubre 3020, Montevideo 11600, Uruguay and Facultad de Medicina Claeh, Prado y Salt Lake, Parada 16, Avenue Roosevelt, Punta del Este, Maldonado, Uruguay
    Expert Rev Clin Immunol 4:723-9. 2008
    ....
  15. doi request reprint Efficacy and safety of subcutaneous omalizumab vs placebo as add-on therapy to corticosteroids for children and adults with asthma: a systematic review
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Av 8 de octubre 3020, Montevideo 11600, Uruguay
    Chest 139:28-35. 2011
    ..Omalizumab is a humanized monoclonal anti-IgE for the treatment of severe allergic asthma. Because omalizumab targets an immune system molecule, there has been particular interest in the drug's safety...
  16. doi request reprint Efficacy of fluticasone furoate nasal spray vs. placebo for the treatment of ocular and nasal symptoms of allergic rhinitis: a systematic review
    G J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay Unidad de Medicina Respiratoria, Hospital de Niños O Alassia, Santa Fe, Argentina
    Clin Exp Allergy 41:160-70. 2011
    ..Therefore, an independent systematic review with meta-analysis is required to confirm and clarify the magnitude of the effect of FF...
  17. ncbi request reprint Body mass index and response to emergency department treatment in adults with severe asthma exacerbations: a prospective cohort study
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las FF AA, Av 8 de octubre 3020, Montevideo 11600, Uruguay
    Chest 132:1513-9. 2007
    ..In acute asthma (AA), overweight/obesity (body mass index [BMI]>or=25 kg/m2) have been related to poorer outcomes and higher risk of complications...
  18. ncbi request reprint Rapid effects of inhaled corticosteroids in acute asthma: an evidence-based evaluation
    Gustavo J Rodrigo
    Clinica Respirar, Benito Nardone 2310, Montevideo 11300, Uruguay
    Chest 130:1301-11. 2006
    ..Current reviews on the use of inhaled corticosteroids (ICS) for acute asthma underestimated their early (minutes) clinical impact and produced conclusions of questionable validity...
  19. ncbi request reprint [Inhaled corticosteroids in the treatment of asthma exacerbations: essential concepts]
    Gustavo Javier Rodrigo
    Clinica Respirar, Montevideo, Uruguay
    Arch Bronconeumol 42:533-40. 2006
    ..This review considers the biological basis for the effects of inhaled corticosteroids and analyzes the best data available on the use and therapeutic implications of inhaled corticosteroids for the treatment of asthma exacerbations...
  20. ncbi request reprint Aerosol and inhaled therapy in treatment of acute adult airway obstruction in the emergency department
    G J Rodrigo
    Departmento de Emergencia, Hospital Central de las FF AA, Montevideo, Uruguay
    Respir Care Clin N Am 7:215-31, v. 2001
    ..Factors influencing lower respiratory deposition of aerosols are summarized. The use of inhaled beta2-adrenergic agonists, anticholinergic drugs, corticosteroids, and heliox are discussed...
  21. ncbi request reprint The role of anticholinergics in acute asthma treatment: an evidence-based evaluation
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
    Chest 121:1977-87. 2002
    ..In patients with mild-to-moderate acute asthma, there is no apparent benefit from adding a single dose of an anticholinergic medication...
  22. ncbi request reprint Continuous vs intermittent beta-agonists in the treatment of acute adult asthma: a systematic review with meta-analysis
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
    Chest 122:160-5. 2002
    ..These studies have suggested that this therapy is safe, is at least as effective as intermittent nebulization, and may be superior to intermittent nebulization in patients with the most severely impaired pulmonary function...
  23. ncbi request reprint Use of helium-oxygen mixtures in the treatment of acute asthma: a systematic review
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
    Chest 123:891-6. 2003
    ..To determine the effect of the addition of heliox to standard medical care on the course of acute asthma...
  24. ncbi request reprint Triple inhaled drug protocol for the treatment of acute severe asthma
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
    Chest 123:1908-15. 2003
    ....
  25. ncbi request reprint Inhaled therapy for acute adult asthma
    Gustavo J Rodrigo
    Emergency Department, Hospital Central de las Fuerzas Armadas, Uruguay
    Curr Opin Allergy Clin Immunol 3:169-75. 2003
    ..To evaluate recent developments on emergency department inhalotherapy in non-intubated acute adult asthma patients...
  26. ncbi request reprint Effects of short-term 28% and 100% oxygen on PaCO2 and peak expiratory flow rate in acute asthma: a randomized trial
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uraguay
    Chest 124:1312-7. 2003
    ..We conducted the first randomized controlled study to assess the effects of short-term 28% and 100% oxygen on PaCO(2) and peak expiratory flow rate (PEFR) in patients with acute severe asthma...
  27. ncbi request reprint [Fatal or near-fatal asthma: clinical entity or incorrect management?]
    G J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
    Arch Bronconeumol 40:24-33. 2004
  28. ncbi request reprint Acute asthma in adults: a review
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
    Chest 125:1081-102. 2004
    ..This review describes the epidemiology, costs, pathophysiology, mortality, and management of adult AA in the ED and in the ICU...
  29. ncbi request reprint Comparison of inhaled fluticasone with intravenous hydrocortisone in the treatment of adult acute asthma
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Av 8 de octubre 3020, Montevideo 11600, Uruguay
    Am J Respir Crit Care Med 171:1231-6. 2005
    ..Several studies published in the second half of the 1990s have shown a therapeutic early effect of inhaled corticosteroids in acute asthma. However, systemic corticosteroids are considered the standard of care...
  30. pmc Elevated plasma lactate level associated with high dose inhaled albuterol therapy in acute severe asthma
    G J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Av 8 de octubre 3020, Montevideo 11600, Uruguay
    Emerg Med J 22:404-8. 2005
    ..Lactic acidosis is a recognised event in adult patients with status asthmaticus, particularly in the setting of intensive care. However, it has been infrequently studied in patients attending the emergency departments (ED)...
  31. pmc Anticholinergics in the treatment of children and adults with acute asthma: a systematic review with meta-analysis
    G J Rodrigo
    Departamento de Emergencia, Hospital Central de las FF AA, Av 8 de octubre 3020, Montevideo 11600, Uruguay
    Thorax 60:740-6. 2005
    ....
  32. ncbi request reprint The role of antileukotriene therapy in seasonal allergic rhinitis: a systematic review of randomized trials
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, and Clinica Respirar, Benito Nardone, Montevideo, Uruguay
    Ann Allergy Asthma Immunol 96:779-86. 2006
    ..To evaluate the effect of oral leukotriene receptor antagonists as monotherapy or combined with other drugs in the treatment of seasonal allergic rhinitis...
  33. ncbi request reprint First-line therapy for adult patients with acute asthma receiving a multiple-dose protocol of ipratropium bromide plus albuterol in the emergency department
    G J Rodrigo
    Departamento de Emergencia, Hospital Central de las FF AA, Asociación Española 1 a de Socorros Mutuos, Montevideo, Uruguay
    Am J Respir Crit Care Med 161:1862-8. 2000
    ....
  34. ncbi request reprint Rapid-onset asthma attack: a prospective cohort study about characteristics and response to emergency department treatment
    G J Rodrigo
    Departamento de Emergencia, Hospital Central de las FF AA, Montevideo, Uruguay
    Chest 118:1547-52. 2000
    ..All patients were treated with albuterol, four puffs at 10-min intervals (100 microg per actuation), delivered by metered-dose inhaler with a spacer device during 3 h...
  35. ncbi request reprint [Controversies in the use of beta-agonists in the treatment of acute asthma]
    G J Rodrigo
    Departamento de Emergencia, Hospital Central de las FF AA, Montevideo, Uruguay
    Arch Bronconeumol 38:322-8. 2002