Marcelo A Comini

Summary

Country: Uruguay

Publications

  1. doi Monothiol glutaredoxin-1 is an essential iron-sulfur protein in the mitochondrion of African trypanosomes
    Marcelo A Comini
    Centre of Biochemistry, Heidelberg University, Im Neuenheimer Feld 504, D 69120 Heidelberg, Germany
    J Biol Chem 283:27785-98. 2008
  2. ncbi Cloning, functional analysis, and mitochondrial localization of Trypanosoma brucei monothiol glutaredoxin-1
    Michael Filser
    Biochemie Zentrum der Universitat Heidelberg, Im Neuenheimer Feld 504, D 69120 Heidelberg, Germany
    Biol Chem 389:21-32. 2008
  3. doi Preparative enzymatic synthesis of trypanothione and trypanothione analogues
    Marcelo A Comini
    Biochemie Zentrum der Universitat Heidelberg, Im Neuenheimer Feld 504, 69120 Heidelberg, Germany
    Int J Parasitol 39:1059-62. 2009
  4. doi Cytotoxic interactions of methylene blue with trypanosomatid-specific disulfide reductases and their dithiol products
    Kathrin Buchholz
    Biochemie Zentrum der Universitat Heidelberg, INF 504, D 69120 Heidelberg, Germany
    Mol Biochem Parasitol 160:65-9. 2008
  5. pmc Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes
    Marcelo A Comini
    Centre of Biochemistry, Heidelberg University, Im Neuenheimer Feld 504, D 69120, Heidelberg, Germany
    Biochem J 402:43-9. 2007
  6. pmc Catalytic mechanism of the glutathione peroxidase-type tryparedoxin peroxidase of Trypanosoma brucei
    Tanja Schlecker
    Biochemie Zentrum der Universitat Heidelberg, Im Neuenheimer Feld 504, 69120 Heidelberg, Germany
    Biochem J 405:445-54. 2007
  7. ncbi Validation of Trypanosoma brucei trypanothione synthetase as drug target
    Marcelo A Comini
    Department of Biochemistry, Technical University of Braunschweig, Braunschweig, Germany
    Free Radic Biol Med 36:1289-302. 2004
  8. ncbi The trypanothione system
    Luise R Krauth-Siegel
    Biochemie Zentrum der Universitat Heidelberg, Germany
    Subcell Biochem 44:231-51. 2007
  9. doi Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification
    Florencia Irigoín
    Departmento de Histología y Embriología, Facultad de Medicina, Universidad de la Republica, Uruguay
    Free Radic Biol Med 45:733-42. 2008

Collaborators

Detail Information

Publications9

  1. doi Monothiol glutaredoxin-1 is an essential iron-sulfur protein in the mitochondrion of African trypanosomes
    Marcelo A Comini
    Centre of Biochemistry, Heidelberg University, Im Neuenheimer Feld 504, D 69120 Heidelberg, Germany
    J Biol Chem 283:27785-98. 2008
    ..The results point to an essential role of the mitochondrial 1-C-Grx1 in the iron metabolism of these parasites...
  2. ncbi Cloning, functional analysis, and mitochondrial localization of Trypanosoma brucei monothiol glutaredoxin-1
    Michael Filser
    Biochemie Zentrum der Universitat Heidelberg, Im Neuenheimer Feld 504, D 69120 Heidelberg, Germany
    Biol Chem 389:21-32. 2008
    ..This is surprising because even bacterial and plant 1-Cys-glutaredoxins efficiently revert the defects, and may be due to the lack of two basic residues conserved in all but the trypanosomatid proteins...
  3. doi Preparative enzymatic synthesis of trypanothione and trypanothione analogues
    Marcelo A Comini
    Biochemie Zentrum der Universitat Heidelberg, Im Neuenheimer Feld 504, 69120 Heidelberg, Germany
    Int J Parasitol 39:1059-62. 2009
    ..The protocol also allows the synthesis of related glutathione conjugates. It will greatly facilitate the thorough analysis of this parasite's metabolism and drug screening approaches against trypanothione-dependent enzymes...
  4. doi Cytotoxic interactions of methylene blue with trypanosomatid-specific disulfide reductases and their dithiol products
    Kathrin Buchholz
    Biochemie Zentrum der Universitat Heidelberg, INF 504, D 69120 Heidelberg, Germany
    Mol Biochem Parasitol 160:65-9. 2008
    ..Since MB is an affordable, available, and accessible drug it might be tested--alone or in drug combinations--against trypanosomatid-caused diseases of animal and man...
  5. pmc Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes
    Marcelo A Comini
    Centre of Biochemistry, Heidelberg University, Im Neuenheimer Feld 504, D 69120, Heidelberg, Germany
    Biochem J 402:43-9. 2007
    ..5-fold, the sensitivity against exogenously generated H2O2 was significantly enhanced. The results prove the essential role of the cTXN and its pivotal function in the parasite defence against oxidative stress...
  6. pmc Catalytic mechanism of the glutathione peroxidase-type tryparedoxin peroxidase of Trypanosoma brucei
    Tanja Schlecker
    Biochemie Zentrum der Universitat Heidelberg, Im Neuenheimer Feld 504, 69120 Heidelberg, Germany
    Biochem J 405:445-54. 2007
    ..The catalytic mechanism of the Tpx peroxidase resembles that of atypical 2-Cys-peroxiredoxins but is distinct from that of the selenoenzymes...
  7. ncbi Validation of Trypanosoma brucei trypanothione synthetase as drug target
    Marcelo A Comini
    Department of Biochemistry, Technical University of Braunschweig, Braunschweig, Germany
    Free Radic Biol Med 36:1289-302. 2004
    ....
  8. ncbi The trypanothione system
    Luise R Krauth-Siegel
    Biochemie Zentrum der Universitat Heidelberg, Germany
    Subcell Biochem 44:231-51. 2007
    ..Despite overlapping substrate specificities and subcellular localizations, the two types of peroxidases can obviously not substitute for each other which suggests distinct cell-physiological roles...
  9. doi Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification
    Florencia Irigoín
    Departmento de Histología y Embriología, Facultad de Medicina, Universidad de la Republica, Uruguay
    Free Radic Biol Med 45:733-42. 2008
    ..Together, the evidence suggests a central role of the trypanothione-dependent antioxidant systems in the infection process...