Derya Unutmaz

Summary

Publications

  1. pmc Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression
    Rui Wang
    Department of Microbiology, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 3:e2705. 2008
  2. doi request reprint RORC2: the master of human Th17 cell programming
    Derya Unutmaz
    Department of Microbiology, Department of Pathology, NYU School of Medicine, NY, USA
    Eur J Immunol 39:1452-5. 2009
  3. pmc CCR5 is a receptor for Staphylococcus aureus leukotoxin ED
    Francis Alonzo
    Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
    Nature 493:51-5. 2013
  4. pmc Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells
    Rui Wang
    Department of Microbiology, NYU Cancer Institute and New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 106:13439-44. 2009
  5. pmc Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection
    Aimee El Hed
    Departments of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    J Infect Dis 201:843-54. 2010
  6. ncbi request reprint Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells
    Shekhar Srivastava
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell 24:665-75. 2006
  7. pmc A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
    Nicolas Manel
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 467:214-7. 2010
  8. pmc GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo
    Angela X Zhou
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 190:5057-64. 2013
  9. pmc Staphylococcus aureus leukotoxin ED targets the chemokine receptors CXCR1 and CXCR2 to kill leukocytes and promote infection
    Tamara Reyes-Robles
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Cell Host Microbe 14:453-9. 2013
  10. pmc Revisiting immune exhaustion during HIV infection
    Alka Khaitan
    Department of Pediatrics, New York University School of Medicine, NY 10016, USA
    Curr HIV/AIDS Rep 8:4-11. 2011

Collaborators

Detail Information

Publications22

  1. pmc Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression
    Rui Wang
    Department of Microbiology, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 3:e2705. 2008
    ..These findings reveal a novel cell surface molecule-mediated regulatory mechanism, with implications for modulating aberrant immune responses...
  2. doi request reprint RORC2: the master of human Th17 cell programming
    Derya Unutmaz
    Department of Microbiology, Department of Pathology, NYU School of Medicine, NY, USA
    Eur J Immunol 39:1452-5. 2009
    ..These findings support the notion that RORC2 is a master switch that initiates a wide range of phenotypic and functional programming during Th17 cell differentiation...
  3. pmc CCR5 is a receptor for Staphylococcus aureus leukotoxin ED
    Francis Alonzo
    Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
    Nature 493:51-5. 2013
    ..aureus infection, highlighting the importance of CCR5 targeting in S. aureus pathogenesis. Thus, depletion of CCR5(+) leukocytes by LukED suggests a new immune evasion mechanism of S. aureus that can be therapeutically targeted...
  4. pmc Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells
    Rui Wang
    Department of Microbiology, NYU Cancer Institute and New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 106:13439-44. 2009
    ..Our findings highlight the significance of GARP both in dissecting duality of Treg/Th17 cell differentiation and as a marker to identify bona fide Tregs during diseases with chronic immune activation...
  5. pmc Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection
    Aimee El Hed
    Departments of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    J Infect Dis 201:843-54. 2010
    ..Identification of the Th17 T cell subset as important mediators of host defense and pathology prompted us to determine their susceptibility to human immunodeficiency virus (HIV) infection...
  6. ncbi request reprint Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells
    Shekhar Srivastava
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell 24:665-75. 2006
    ..The critical role for NDPK-B in the reactivation of CD4 T cells indicates that understanding NDPK-B regulation should uncover novel pathways required for T cell activation...
  7. pmc A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
    Nicolas Manel
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 467:214-7. 2010
    ..The virulence of HIV-1 may be related to evasion of this response, the manipulation of which may be necessary to generate an effective HIV-1 vaccine...
  8. pmc GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo
    Angela X Zhou
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 190:5057-64. 2013
    ..These findings suggest a role for GARP in natural and induced Treg development through activation of bound latent TGF-β and signaling, which negatively regulates GARP expression on Tregs...
  9. pmc Staphylococcus aureus leukotoxin ED targets the chemokine receptors CXCR1 and CXCR2 to kill leukocytes and promote infection
    Tamara Reyes-Robles
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Cell Host Microbe 14:453-9. 2013
    ..Thus, LukED is a versatile toxin that endows S. aureus with the ability to simultaneously disarm both innate and adaptive compartments of the host immune response. ..
  10. pmc Revisiting immune exhaustion during HIV infection
    Alka Khaitan
    Department of Pediatrics, New York University School of Medicine, NY 10016, USA
    Curr HIV/AIDS Rep 8:4-11. 2011
    ..In this review we discuss the evolution of our understanding of immune exhaustion during HIV infection, highlighting novel markers and potential therapeutic targets...
  11. pmc Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+ human memory T cells
    Qi Wan
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 208:1875-87. 2011
    ..Furthermore, these findings suggest that ex vivo analysis of IL-17 expression may greatly underestimate the frequency and pathogenic potential of the human Th17 compartment...
  12. pmc Probing the effector and suppressive functions of human T cell subsets using antigen-specific engineered T cell receptors
    Qi Wan
    Department of Microbiology, New York University School of Medicine, New York, New York, USA
    PLoS ONE 8:e56302. 2013
    ....
  13. pmc Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response
    Mark S Sundrud
    Department of Pathology, Harvard Medical School and Immune Disease Institute, Boston, MA 02115, USA
    Science 324:1334-8. 2009
    ..These results indicate that the AAR pathway is a potent and selective regulator of inflammatory T cell differentiation in vivo...
  14. pmc The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
    Nicolas Manel
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 9:641-9. 2008
    ..Our studies identify RORgammat as having a central function in the differentiation of human T(H)-17 cells from naive CD4+ T cells and suggest that similar cytokine pathways are involved in this process in mice and humans...
  15. pmc The metalloprotease ADAM12 regulates the effector function of human Th17 cells
    Angela X Zhou
    Department of Microbiology, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 8:e81146. 2013
    ..Together, our findings reveal a novel regulatory role for ADAM12 in Th17 cell differentiation or function and may have implications in regulating their aberrant responses during immune pathologies. ..
  16. pmc Th17 cells and HIV infection
    Aimee Elhed
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Curr Opin HIV AIDS 5:146-50. 2010
    ..We discuss the recent findings on Th17 deficiency in HIV/simian immunodeficiency virus (SIV) infection and how this deficiency may impact the mucosal host defenses, potentially contributing to chronic immune activation...
  17. pmc Expression and function of TNF and IL-1 receptors on human regulatory T cells
    Frances Mercer
    Department of Microbiology, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 5:e8639. 2010
    ..In conclusion, our findings that human Tregs preferentially express receptors for TNF and IL-1 suggest a potential function in sensing and dampening local inflammation...
  18. pmc Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis
    Ashley L Dumont
    Departments of Microbiology Medicine Division of Infectious Diseases Pathology, New York University School of Medicine, New York, NY 10016, USA
    Mol Microbiol 79:814-25. 2011
    ..Collectively, these results extend our understanding of how S. aureus avoids phagocyte-mediated clearance, and underscore LukAB as an important factor that contributes to staphylococcal pathogenesis...
  19. pmc Perturbation of the P-body component Mov10 inhibits HIV-1 infectivity
    Vyacheslav Furtak
    Department of Microbiology, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 5:e9081. 2010
    ..Because Mov10 is implicated as part of the P-body complex, these findings point to the potential role of cytoplasmic RNA processing machinery in infectious retroviral production...
  20. pmc Topical TLR7 agonist imiquimod can induce immune-mediated rejection of skin metastases in patients with breast cancer
    Sylvia Adams
    Departments of Medicine, New York University School of Medicine, New York, New York 10016, USA
    Clin Cancer Res 18:6748-57. 2012
    ..Here we tested the hypothesis that topical imiquimod stimulates local antitumor immunity and induces the regression of breast cancer skin metastases...
  21. pmc The biology of FoxP3: a key player in immune suppression during infections, autoimmune diseases and cancer
    Frances Mercer
    Department of Microbiology, New York University School of Medicine, Smilow Research Center, 522 First Avenue, Smilow Building Rm 1011, New York, New York 10016, USA
    Adv Exp Med Biol 665:47-59. 2009
    ..Understanding the biological properties of FoxP3 has a wide range of implications for immune tolerance, autoimmune disorders, inflammation and immune response to infectious diseases and cancer...
  22. pmc Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells
    Shekhar Srivastava
    Department of Pharmacology, The Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell Biol 26:5595-602. 2006
    ....