Motoko Unoki

Summary

Affiliation: Kyushu University
Location: Fukuoka, Japan
URL: http://network.nature.com/profile/motokounoki

Publications

  1. ncbi request reprint Association studies of 33 single nucleotide polymorphisms (SNPs) in 29 candidate genes for bronchial asthma: positive association a T924C polymorphism in the thromboxane A2 receptor gene
    M Unoki
    Laboratory of Molecular Medicine, Institute of Medical Science, University of Tokyo, Japan
    Hum Genet 106:440-6. 2000
  2. pmc A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis
    Motoko Unoki
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Dr, Bldg 37, Rm 3068, Bethesda, MD 20892, USA
    FEBS Lett 582:3868-74. 2008
  3. pmc Reviewing the current classification of inhibitor of growth family proteins
    Motoko Unoki
    Laboratory for Biomarker, The Institute of Physical and Chemical Research, RIKEN, Tokyo, Japan
    Cancer Sci 100:1173-9. 2009
  4. pmc ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression
    Kensuke Kumamoto
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4258, USA
    Int J Cancer 125:1306-15. 2009
  5. pmc ING proteins as potential anticancer drug targets
    M Unoki
    Laboratory for Biomarker, The Institute of Physical and Chemical Research, RIKEN, Tokyo 108 8639, Japan
    Curr Drug Targets 10:442-54. 2009
  6. pmc UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer
    M Unoki
    Laboratory for Biomarker Development, The Institute of Physical and Chemical Research, RIKEN, Tokyo, Japan
    Br J Cancer 101:98-105. 2009
  7. doi request reprint Drug discovery targeting epigenetic codes: the great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis
    Motoko Unoki
    Laboratory for Biomarker Development, The Institute of Physical and Chemical Research, Center for Genomic Medicine, RIKEN, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biochem Pharmacol 78:1279-88. 2009
  8. pmc Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway
    Shinya Hayami
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Mol Cancer 9:59. 2010
  9. doi request reprint Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers
    Shinya Hayami
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo, Japan
    Int J Cancer 128:574-86. 2011
  10. doi request reprint Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers
    Masanori Yoshimatsu
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo, Japan
    Int J Cancer 128:562-73. 2011

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Association studies of 33 single nucleotide polymorphisms (SNPs) in 29 candidate genes for bronchial asthma: positive association a T924C polymorphism in the thromboxane A2 receptor gene
    M Unoki
    Laboratory of Molecular Medicine, Institute of Medical Science, University of Tokyo, Japan
    Hum Genet 106:440-6. 2000
    ..71, P=0.030), especially with respect to adult patients (chi2=6.20, P=0.013). Our results suggest that variants of the TBXA2R gene or some nearby gene(s) may play an important role in the pathogenesis of adult BA...
  2. pmc A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis
    Motoko Unoki
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Dr, Bldg 37, Rm 3068, Bethesda, MD 20892, USA
    FEBS Lett 582:3868-74. 2008
    ..ING2a and ING2b have compensatory roles that protect cells from cell cycle arrest and apoptosis and may be involved in development of chemotherapeutic resistance...
  3. pmc Reviewing the current classification of inhibitor of growth family proteins
    Motoko Unoki
    Laboratory for Biomarker, The Institute of Physical and Chemical Research, RIKEN, Tokyo, Japan
    Cancer Sci 100:1173-9. 2009
    ..In the present article, we briefly review ING history and propose a possible interpretation of discrepancies between past and recent data...
  4. pmc ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression
    Kensuke Kumamoto
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4258, USA
    Int J Cancer 125:1306-15. 2009
    ..Taken together, upregulation of ING2 was associated with colon cancer and MMP13-dependent cellular invasion, indicating that ING2 expression might be involved with cancer invasion and metastasis...
  5. pmc ING proteins as potential anticancer drug targets
    M Unoki
    Laboratory for Biomarker, The Institute of Physical and Chemical Research, RIKEN, Tokyo 108 8639, Japan
    Curr Drug Targets 10:442-54. 2009
    ..In this brief review, we discuss possible clinical applications of ING2 with the latest knowledge of molecular targeted therapies...
  6. pmc UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer
    M Unoki
    Laboratory for Biomarker Development, The Institute of Physical and Chemical Research, RIKEN, Tokyo, Japan
    Br J Cancer 101:98-105. 2009
    ..Previous reports have shown that UHRF1 (ubiquitin-like with PHD and ring-finger domains 1) is essential for cellular proliferation. In this study, we examined whether UHRF1 can be a novel molecular marker of bladder cancer...
  7. doi request reprint Drug discovery targeting epigenetic codes: the great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis
    Motoko Unoki
    Laboratory for Biomarker Development, The Institute of Physical and Chemical Research, Center for Genomic Medicine, RIKEN, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biochem Pharmacol 78:1279-88. 2009
    ..In this review, we discuss several possible methods that can inhibit the multiple unique functions of UHRF1, which can be utilized for treating cancers and toxoplasmosis...
  8. pmc Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway
    Shinya Hayami
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Mol Cancer 9:59. 2010
    ..Cell cycle-dependent characteristics of KDM5B were identified by immunofluorescence and FACS...
  9. doi request reprint Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers
    Shinya Hayami
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo, Japan
    Int J Cancer 128:574-86. 2011
    ....
  10. doi request reprint Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers
    Masanori Yoshimatsu
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo, Japan
    Int J Cancer 128:562-73. 2011
    ..In summary, our results suggest that dysregulation of PRMT1 and PRMT6 can be involved in human carcinogenesis and that these Type I arginine methyltransferases are good therapeutic targets for various types of cancer...
  11. pmc UHRF1 is a novel diagnostic marker of lung cancer
    M Unoki
    Laboratory for Biomarker, The Institute of Physical and Chemical Research, Center for Genomic Medicine, RIKEN, Tokyo 108 8639, Japan
    Br J Cancer 103:217-22. 2010
    ....
  12. ncbi request reprint Current and potential anticancer drugs targeting members of the UHRF1 complex including epigenetic modifiers
    Motoko Unoki
    Laboratory for Biomarker Development, The Institute of Physical and Chemical Research, Center for Genomic Medicine, RIKEN, Tokyo 108 8639, Japan
    Recent Pat Anticancer Drug Discov 6:116-30. 2011
    ..In this article, the relevant patents on the strategies to develop safer anticancer drugs targeting epigenetic modulators, focusing on members and modifiers of the UHRF1 complex, are discussed...
  13. doi request reprint A concern regarding the current confusion with the human homolog of mouse Np95, ICBP90/UHRF1
    Motoko Unoki
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4258, USA
    Radiat Res 169:240-4. 2008
    ..Here we show the revised ICBP90 gene structure and 366 polymorphisms in this gene. Our conclusion is that the human homolog of Np95 is ICBP90, whose gene symbol is UHRF1...
  14. ncbi request reprint Toxoplasma gondii exploits UHRF1 and induces host cell cycle arrest at G2 to enable its proliferation
    Julie Brunet
    Institut de Parasitologie et de Pathologie Tropicale de Strasbourg, UPRES E A 3950 Interactions Cellulaires et Moléculaires Hôte Parasite, Faculte de Medecine, Universite Louis Pasteur, 67000 Strasbourg, France
    Cell Microbiol 10:908-20. 2008
    ..gondii growth...
  15. pmc Association between a single-nucleotide polymorphism in the promoter of the human interleukin-3 gene and rheumatoid arthritis in Japanese patients, and maximum-likelihood estimation of combinatorial effect that two genetic loci have on susceptibility to t
    R Yamada
    Laboratory of Rheumatic Diseases, SNP Research Center, Institute of Physical and Chemical Research, Tokyo, Japan
    Am J Hum Genet 68:674-85. 2001
    ..The utility of combining the genotype data in this way to identify possible contributions of various genes to this disease is discussed...
  16. ncbi request reprint Amino-acid substitutions in the IKAP gene product significantly increase risk for bronchial asthma in children
    S Takeoka
    Laboratory of Molecular Medicine, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Shirokanedai, Japan
    J Hum Genet 46:57-63. 2001
    ..83; 95% CI, 8.35-11.31). These results indicated that specific variants of the IKAP gene, or a variant in linkage disequilibrium with the TGAAAT haplotype, might be associated with mechanisms responsible for early-onset BA...
  17. ncbi request reprint Identification and allelic frequencies of novel single-nucleotide polymorphisms in the DUSP1 and BTG1 genes
    C Suzuki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Japan
    J Hum Genet 46:155-7. 2001
    ..These polymorphic sites will be useful for detecting losses of heterozygosity (LOH) in tumors and for examining latent associations between specific alleles and disease susceptibility...
  18. ncbi request reprint Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous PTEN
    M Matsushima-Nishiu
    Laboratories of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
    Cancer Res 61:3741-9. 2001
    ..Analysis of expression profiles with microarrays appears to be a powerful approach for identifying anticancer genes and/or disease-specific targets for cancer therapy...
  19. ncbi request reprint Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway
    M Unoki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Oncogene 20:4457-65. 2001
    ..Anti-sense oligonucleotides for BPOZ or EGR2 effectively inhibited their expression, and cell growth was accelerated. Therefore both genes appear to be novel candidates as mediators of the PTEN growth-suppressive signaling pathway...
  20. ncbi request reprint EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK
    Motoko Unoki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japam
    Oncogene 22:2172-85. 2003
    ..Our results helped to clarify the molecular mechanism of the apoptotic pathway induced by PTEN-EGR2, and suggested that EGR2 may be an excellent target molecule for gene therapy to treat a variety of cancers...
  21. ncbi request reprint Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia
    Motoko Unoki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Int J Oncol 22:1217-23. 2003
    ..Our results suggest that ZFP91 is likely to play an important role in cell proliferation and/or anti-apoptosis, and may serve as a molecular marker for AML...
  22. ncbi request reprint Methylation at CpG islands in intron 1 of EGR2 confers enhancer-like activity
    Motoko Unoki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    FEBS Lett 554:67-72. 2003
    ..Moreover, reporter gene experiments revealed that methylated intron 1 had somehow conferred enhancer-like activity. The data imply the existence of a previously unsuspected mechanism of gene expression regulation...
  23. ncbi request reprint ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain
    Motoko Unoki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shiorokanedai, Minato ku, Tokyo 108 8639, Japan
    Oncogene 23:7601-10. 2004
    ..The data reported here suggest that ICBP90 is involved in cell proliferation by way of methylation-mediated regulation of certain genes...
  24. ncbi request reprint Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility
    Motoko Unoki
    Laboratory of Human Carcinogenesis, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:34677-86. 2006
    ..Understanding the functions of the four splice variants may aid in defining their roles in human carcinogenesis...
  25. pmc Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1
    Jiang Cheng Shen
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4258, USA
    Cancer Res 67:2552-8. 2007
    ..In addition to its nuclear functions, cytoplasmic ING4 interacts with liprin alpha1 to regulate cell migration and, with its known antiangiogenic function, may prevent invasion and metastasis...
  26. doi request reprint Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells
    Hyun Soo Cho
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo, Japan
    Cancer Res 71:655-60. 2011
    ..Taken together, our results comprise a novel cell cycle regulatory mechanism mediated by methylation/demethylation dynamics, and they reveal the significance of LSD1 overexpression in human carcinogenesis...