Research Topics
Genomes and Genes | Luis M VilaSummaryAffiliation: University of Puerto Rico Publications
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Publications
Early clinical manifestations, disease activity and damage of systemic lupus erythematosus among two distinct US Hispanic subpopulationsL M Vila
Department of Internal Medicine, Division of Rheumatology, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, Puerto Rico 00936 5067, USA
Rheumatology (Oxford) 43:358-63. 2004..To compare the baseline clinical manifestations, immunological features, disease activity and damage accrual in systemic lupus erythematosus (SLE) patients from two US Hispanic subgroups...- Systemic lupus erythematosus in a multiethnic US cohort LUMINA LI: anaemia as a predictor of disease activity and damage accrualA M Bertoli
Division of Rheumatology, Department of Medicine, University of Puerto Rico Medical Sciences Campus, PO Box 365067, San Juan, PR 00936 5067
Rheumatology (Oxford) 46:1471-6. 2007..To examine if anaemia (and its severity) is associated with disease activity and damage accrual in systemic lupus erythematosus (SLE)... - Chronic anemia and thrombocytosis as the initial presentation of Still's disease in an elderly patientLuis M Vila
Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
Gerontology 53:289-92. 2007..Rheumatoid factor and antinuclear antibodies were negative. She responded favorably to prednisone and methotrexate treatment. Anemia and thrombocytosis as well as Still's disease manifestations resolved... - Clinical and prognostic value of autoantibodies in puerto Ricans with systemic lupus erythematosusL M Vila
Department of Internal Medicine, Division of Rheumatology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico
Lupus 15:892-8. 2006..These findings provide valuable clinical and prognostic information for this ethnic population... - Systemic lupus erythematosus in a multiethnic US cohort, XXXVII: association of lymphopenia with clinical manifestations, serologic abnormalities, disease activity, and damage accrualLuis M Vila
Division of Rheumatology, Department of Internal Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico
Arthritis Rheum 55:799-806. 2006..To determine if lymphopenia is associated with clinical/immunologic manifestations, disease activity, and disease damage in systemic lupus erythematosus (SLE)... - Association of serum MIP-1alpha, MIP-1beta, and RANTES with clinical manifestations, disease activity, and damage accrual in systemic lupus erythematosusLuis M Vila
Department of Internal Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
Clin Rheumatol 26:718-22. 2007..MIP-1alpha is associated with discoid lupus, and MIP-1beta correlates with damage accrual in SLE. This study suggests that chemokines may have a role in the pathogenesis of SLE... - Systemic lupus erythematosus in a multiethnic cohort (LUMINA): XXIX. Elevation of erythrocyte sedimentation rate is associated with disease activity and damage accrualLuis M Vila
Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
J Rheumatol 32:2150-5. 2005..To determine if different categories of erythrocyte sedimentation rate (ESR) elevation are associated with disease activity and/or damage in systemic lupus erythematosus (SLE)... 
Systemic lupus erythematosus in a multiethnic US cohort (LUMINA): LXI. Value of C-reactive protein as a marker of disease activity and damageAna M Bertoli
Department of Medicine, Division of Rheumatology, The University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
J Rheumatol 35:2355-8. 2008..To determine whether C-reactive protein (CRP) measured by a high sensitivity (hs) assay is a surrogate marker of disease activity and damage in systemic lupus erythematosus (SLE)...- Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groupsWenfeng Tan
David Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, CA 90095 1670, USA
Arthritis Rheum 63:2755-63. 2011..This study was designed to determine whether genetic variants of PPP2AC are linked to the expression of SLE and specific clinical manifestations and account for the increased expression of PP2Ac... - Systemic lupus erythematosus in a multiethnic US cohort (LUMINA L II): relationship between vascular events and the use of hormone replacement therapy in postmenopausal womenMónica Fernández
Division of Clinical Immunology and Rheumatology, Department of Medicine, Schools of Medicine and Public Health, The University of Alabama at Birmingham, 510 20th Street South, Birmingham, AL 35294, USA
J Clin Rheumatol 13:261-5. 2007..To examine the influence of hormone replacement therapy (HRT) in the occurrence of vascular arterial and venous thrombotic events in postmenopausal women with systemic lupus erythematosus (SLE)... - Outcome and predictors of kidney disease progression in Puerto Ricans with systemic lupus erythematosus initially presenting with mild renal involvementMariely Nieves-Plaza
Department of Biostatistics and Epidemiology, Graduate School of Public Health, University of Puerto Rico Medical Sciences Campus, San Juan, PR
J Clin Rheumatol 17:179-84. 2011..The aims of this study were to determine the outcomes and predictors of renal disease progression in Puerto Ricans with systemic lupus erythematosus (SLE) initially presenting mild renal involvement... - Predictors of cardiovascular damage in patients with systemic lupus erythematosus: data from LUMINA (LXVIII), a multiethnic US cohortGuillermo J Pons-Estel
Department of Medicine, Division of Clinical Immunology and Rheumatology, Schools of Medicine and Public Health, The University of Alabama at Birmingham, Birmingham, AL, USA
Rheumatology (Oxford) 48:817-22. 2009..To determine the features predictive of atherosclerotic cardiovascular damage in patients with SLE... - Factors predictive of thrombotic events in LUMINA, a multi-ethnic cohort of SLE patients (LXXII)Paula I Burgos
Department of Medicine, Division of Clinical Immunology and Rheumatology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
Rheumatology (Oxford) 49:1720-5. 2010..Thrombosis is an important cause of morbidity and mortality in SLE. We have explored the factors associated with time to the occurrence of thrombotic events in SLE patients to expand our cohort's previous observations... - Impact of age on clinical manifestations and outcome in Puerto Ricans with rheumatoid arthritisYesenia Santiago-Casas
Division of Rheumatology, Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
Ethn Dis 20:S1-191-5. 2010..Thus, we determined the demographic characteristics, clinical manifestations, comorbidities, pharmacologic profile, and functional status among Puerto Ricans with RA of different age groups... - Association of discoid lupus erythematosus with clinical manifestations and damage accrual in a multiethnic lupus cohortYesenia Santiago-Casas
University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico 00936
Arthritis Care Res (Hoboken) 64:704-12. 2012..To determine the clinical manifestations and disease damage associated with discoid rash in a large multiethnic systemic lupus erythematosus (SLE) cohort... - Renal damage is the most important predictor of mortality within the damage index: data from LUMINA LXIV, a multiethnic US cohortMaria I Danila
Department of Medicine, Division of Clinical Immunology and Rheumatology, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA
Rheumatology (Oxford) 48:542-5. 2009..Damage accrual in SLE has been previously shown to be an independent predictor of mortality. We sought to discern which SLICC Damage Index (SDI) domains are the most important predictors of survival in SLE... - Utilization of health services and prescription patterns among lupus patients followed by primary care physicians and rheumatologists in Puerto RicoMaría J Molina
Department of Medicine, Division of Rheumatology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico, USA
Ethn Dis 18:S2-205-10. 2008..To examine the utilization of health services and prescription patterns among patients with systemic lupus erythematosus (SLE) followed by primary care physicians and rheumatologists in Puerto Rico... - The impact of increased body mass index on systemic lupus erythematosus: data from LUMINA, a multiethnic cohort (LUMINA XLVI) [corrected]Sumapa Chaiamnuay
Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA
J Clin Rheumatol 13:128-33. 2007.... - Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosusTravis Hughes
Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
Ann Rheum Dis 71:694-9. 2012..The genetic basis of sexual dimorphism in SLE is not clearly defined. A study was undertaken to examine sex-specific genetic effects among SLE susceptibility loci... - Prevalence of systemic lupus erythematosus and associated comorbidities in Puerto RicoMaría J Molina
Department of Internal Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
J Clin Rheumatol 13:202-4. 2007..To examine the prevalence of systemic lupus erythematosus (SLE) and its associated comorbidities in patients from Puerto Rico using a database from a health insurance company... 
Association of hand or knee osteoarthritis with diabetes mellitus in a population of hispanics from puerto ricoMariely Nieves-Plaza
From the Puerto Rico Clinical and Translational Research Consortium PRCTRC, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico School of Medicine, University of Pittsburgh, Pittsburgh, PA and Department of Medicine Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
J Clin Rheumatol 19:1-6. 2013..Although a higher prevalence of osteoarthritis (OA) has been reported among diabetes mellitus (DM) patients, inconsistencies and limitations of observational studies have precluded a conclusive association...- Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibilityJian Zhao
Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
PLoS Genet 7:e1002079. 2011.... - Efficacy of two cyclophosphamide regimens for the treatment of lupus nephritis in Puerto Ricans: low vs. standard doseLesliane E Castro-Santana
Division of Rheumatology, Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
Ethn Dis 20:S1-116-21. 2010..Thus, we evaluated the efficacy of two established treatment protocols for lupus nephritis (low-dose versus standard-dose cyclophosphamide) in Puerto Ricans with systemic lupus erythematosus (SLE)... - Rheumatology practice profiles in teaching and community settings in Puerto Rico: implications to subspecialty trainingAmarie M Negrón
Division of Rheumatology, Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
J Clin Rheumatol 19:67-71. 2013..University-based fellowship training programs may not always provide the required experience to manage common and less complex medical conditions usually seen at the community setting. Few studies have addressed this concern... - Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosusChaim O Jacob
The Lupus Genetic Group, Department of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
Proc Natl Acad Sci U S A 106:6256-61. 2009..This demonstration of an X chromosome gene as a disease susceptibility factor in human SLE raises the possibility that the gender difference in SLE may in part be attributed to sex chromosome genes...