Irving E Vega

Summary

Affiliation: University of Puerto Rico

Publications

  1. ncbi The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells
    Irving E Vega
    Department of Cell Biology and Neuroscience, Rutgers, Nelson Biological Laboratories, State University of New Jersey, Piscataway 08854, USA
    Neuroreport 14:31-7. 2003
  2. ncbi Phosphorylated p38MAPK specific antibodies cross-react with sarkosyl-insoluble hyperphosphorylated tau proteins
    Naruhiko Sahara
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA
    J Neurochem 90:829-38. 2004
  3. ncbi Recent advances in experimental modeling of the assembly of tau filaments
    Li wen Ko
    Department of Neuroscience, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Biochim Biophys Acta 1739:125-39. 2005
  4. pmc Increase in tau tyrosine phosphorylation correlates with the formation of tau aggregates
    Irving E Vega
    Department of Neuroscience, Mayo Clinic College of Medicine, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Brain Res Mol Brain Res 138:135-44. 2005
  5. pmc A novel calcium-binding protein is associated with tau proteins in tauopathy
    Irving E Vega
    Department of Biology, University of Puerto Rico Rio Piedras Campus, San Juan, Puerto Rico
    J Neurochem 106:96-106. 2008
  6. pmc Taxol and tau overexpression induced calpain-dependent degradation of the microtubule-destabilizing protein SCG10
    Irving E Vega
    Department of Neuroscience, Mayo Clinic College of Medicine, Mayo Clinic Jacksonville, Birdsall Medical Research Bldg, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Exp Neurol 202:152-60. 2006
  7. pmc Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1
    Clarivel Lasalde
    Department of Biology, University of Puerto Rico Rio Piedras Campus, San Juan, PR, Department of Reproductive Medicine, University of California, San Diego, CA, Department of Biochemistry, University of Puerto Rico Medical Sciences Campus, San Juan, PR and Molecular Sciences Research Building, San Juan, PR
    Nucleic Acids Res 42:1916-29. 2014
  8. pmc EFhd2 is a novel amyloid protein associated with pathological tau in Alzheimer's disease
    Yancy Ferrer-Acosta
    Department of Biology, College of Natural Sciences, University of Puerto Rico, San Juan, Puerto Rico
    J Neurochem 125:921-31. 2013
  9. pmc Amphiphysin-1 protein level changes associated with tau-mediated neurodegeneration
    Héctor J De Jesús-Cortés
    Department of Biology, College of Natural Sciences, University of Puerto Rico, San Juan, Puerto Rico
    Neuroreport 23:942-6. 2012
  10. pmc Functional and structural analysis of the conserved EFhd2 protein
    Yancy Ferrer-Acosta
    Department of Biology, University of Puerto Rico Rio Piedras Campus, San Juan, PR 00931, USA
    Protein Pept Lett 20:573-83. 2013

Research Grants

Collaborators

Detail Information

Publications11

  1. ncbi The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells
    Irving E Vega
    Department of Cell Biology and Neuroscience, Rutgers, Nelson Biological Laboratories, State University of New Jersey, Piscataway 08854, USA
    Neuroreport 14:31-7. 2003
    ..Taken together, these findings suggest that Nedd5 may be required for polarized neurite outgrowth, perhaps, by facilitating the exocyst complex function during neuronal differentiation...
  2. ncbi Phosphorylated p38MAPK specific antibodies cross-react with sarkosyl-insoluble hyperphosphorylated tau proteins
    Naruhiko Sahara
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA
    J Neurochem 90:829-38. 2004
    ..Together, the results indicate that the cross-reactivity of antiactive-p38MAPK antibody with phosphorylated tau is responsible for the immunolabeling of tau-positive inclusion...
  3. ncbi Recent advances in experimental modeling of the assembly of tau filaments
    Li wen Ko
    Department of Neuroscience, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Biochim Biophys Acta 1739:125-39. 2005
    ..This review highlights the latest developments in new models and how their utility improves our understanding of the sequence of events leading to human tauopathy...
  4. pmc Increase in tau tyrosine phosphorylation correlates with the formation of tau aggregates
    Irving E Vega
    Department of Neuroscience, Mayo Clinic College of Medicine, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Brain Res Mol Brain Res 138:135-44. 2005
    ..The results suggest that tyrosine phosphorylation is as important as phosphorylation of other residues in tauopathy...
  5. pmc A novel calcium-binding protein is associated with tau proteins in tauopathy
    Irving E Vega
    Department of Biology, University of Puerto Rico Rio Piedras Campus, San Juan, Puerto Rico
    J Neurochem 106:96-106. 2008
    ....
  6. pmc Taxol and tau overexpression induced calpain-dependent degradation of the microtubule-destabilizing protein SCG10
    Irving E Vega
    Department of Neuroscience, Mayo Clinic College of Medicine, Mayo Clinic Jacksonville, Birdsall Medical Research Bldg, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Exp Neurol 202:152-60. 2006
    ..The results provide evidence for the existence of an intracellular mechanism involved in the regulation of SCG10 upon microtubule stabilization...
  7. pmc Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1
    Clarivel Lasalde
    Department of Biology, University of Puerto Rico Rio Piedras Campus, San Juan, PR, Department of Reproductive Medicine, University of California, San Diego, CA, Department of Biochemistry, University of Puerto Rico Medical Sciences Campus, San Juan, PR and Molecular Sciences Research Building, San Juan, PR
    Nucleic Acids Res 42:1916-29. 2014
    ..We provide evidence that two tyrosines within this phospho-motif (Y-738 and Y-742) act redundantly to promote ATP hydrolysis, NMD efficiency and translation termination fidelity. ..
  8. pmc EFhd2 is a novel amyloid protein associated with pathological tau in Alzheimer's disease
    Yancy Ferrer-Acosta
    Department of Biology, College of Natural Sciences, University of Puerto Rico, San Juan, Puerto Rico
    J Neurochem 125:921-31. 2013
    ..Hence, EFhd2 may play an important role in the pathobiology of tau-mediated neurodegeneration...
  9. pmc Amphiphysin-1 protein level changes associated with tau-mediated neurodegeneration
    Héctor J De Jesús-Cortés
    Department of Biology, College of Natural Sciences, University of Puerto Rico, San Juan, Puerto Rico
    Neuroreport 23:942-6. 2012
    ..Taken together, the results suggest that the reduction of the AMPH1 protein level is a molecular event associated with the progression of tau-mediated neurodegeneration...
  10. pmc Functional and structural analysis of the conserved EFhd2 protein
    Yancy Ferrer-Acosta
    Department of Biology, University of Puerto Rico Rio Piedras Campus, San Juan, PR 00931, USA
    Protein Pept Lett 20:573-83. 2013
    ..Overall, these studies contribute to our understanding on EFhd2 functional and structural properties, and introduce it into the family of canonical EF-hand domain containing proteins...
  11. pmc Geographical differences in the occurrence of Alzheimer's disease mortality: United States versus Puerto Rico
    Raul Figueroa
    Department of Biology, University of Puerto Rico Rio Piedras Campus, San Juan, Puerto Rico
    Am J Alzheimers Dis Other Demen 23:462-9. 2008
    ..These results highlight the need for comprehensive studies on factors that may influence diagnosis, death certificate coding practices, and development of Alzheimer's disease pathology in different geographical regions...

Research Grants1

  1. Proteome analysis in mice expressing P301L tau
    Irving Vega; Fiscal Year: 2005
    ..These approaches may contribute to the identification of important biological markers involved at early stages of the development of tauopathy and may bring insights into the molecular mechanism underline tau aggregation ..