Pedro A Ferchmin

Summary

Affiliation: University of Puerto Rico

Publications

  1. ncbi request reprint Spermine is neuroprotective against anoxia and N-methyl-D-aspartate in hippocampal slices
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Department of Biochemistry, Universidad Central del Caribe School of Medicine, Bayamon, USA
    Brain Res 859:273-9. 2000
  2. ncbi request reprint Tobacco cembranoids block behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptor function
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Universidad Central del Caribe, Bayamon, 00960 6032, Puerto Rico
    J Neurosci Res 64:18-25. 2001
  3. ncbi request reprint Nicotinic receptors differentially regulate N-methyl-D-aspartate damage in acute hippocampal slices
    P A Ferchmin
    Department of Biochemistry, Universidad Central del Caribe, P O Box 60 327, Bayamon, Puerto Rico 00960 6032
    J Pharmacol Exp Ther 305:1071-8. 2003
  4. ncbi request reprint Tobacco cembranoids protect the function of acute hippocampal slices against NMDA by a mechanism mediated by alpha4beta2 nicotinic receptors
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Universidad Central del Caribe, Bayamon, Puerto Rico
    J Neurosci Res 82:631-41. 2005
  5. pmc Protective activity of (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol analogues against diisopropylfluorophosphate neurotoxicity: preliminary structure-activity relationship and pharmacophore modeling
    Vesna A Eterovic
    Department of Biochemistry, School of Medicine, Universidad Central del Caribe, Bayamon, PR 00960, USA
    Bioorg Med Chem 21:4678-86. 2013
  6. pmc Actions of octocoral and tobacco cembranoids on nicotinic receptors
    P A Ferchmin
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR, USA
    Toxicon 54:1174-82. 2009
  7. ncbi request reprint Gene expression is differentially regulated by neurotransmitters in embryonic neuronal cortical culture
    Cristina A Ghiani
    Mental Retardation Research Center, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7332, USA
    J Neurochem 97:35-43. 2006
  8. ncbi request reprint Genetic program of neuronal differentiation and growth induced by specific activation of NMDA receptors
    Cristina A Ghiani
    Mental Retardation Research Center, Jane and Terry Semel Institute for Neuroscience and Human Behaviour, Department of Neurobiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Neurochem Res 32:363-76. 2007

Collaborators

  • A D Rodriguez
  • Henning Ulrich
  • RONALD LUKAS
  • Cristina A Ghiani
  • Vesna A Eterovic
  • Daniel M Sforza
  • Desmond J Smith
  • Jean de Vellis
  • Luis Beltran-Parrazal
  • Mohammad A Khanfar
  • Khalid A El Sayed
  • Dinely Perez
  • Angelie Del Valle-Rodriguez
  • Marimée Carrasco
  • Andrew Charles
  • Ruth Cole
  • Akop Seksenyan
  • Jemily S Malvar
  • Andrew C Charles
  • Jemily Malvar
  • Vincent Lelievre

Detail Information

Publications8

  1. ncbi request reprint Spermine is neuroprotective against anoxia and N-methyl-D-aspartate in hippocampal slices
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Department of Biochemistry, Universidad Central del Caribe School of Medicine, Bayamon, USA
    Brain Res 859:273-9. 2000
    ..In addition, several noxious stimuli trigger the release of intracellular spermine and could raise local levels of spermine. Therefore, it is possible that spermine has a neuroprotective role in vivo...
  2. ncbi request reprint Tobacco cembranoids block behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptor function
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Universidad Central del Caribe, Bayamon, 00960 6032, Puerto Rico
    J Neurosci Res 64:18-25. 2001
    ..IC(50) values were in the submicromolar to low-micromolar range, with 4R displaying an order of magnitude higher potency than its diastereoisomer, 4S...
  3. ncbi request reprint Nicotinic receptors differentially regulate N-methyl-D-aspartate damage in acute hippocampal slices
    P A Ferchmin
    Department of Biochemistry, Universidad Central del Caribe, P O Box 60 327, Bayamon, Puerto Rico 00960 6032
    J Pharmacol Exp Ther 305:1071-8. 2003
    ....
  4. ncbi request reprint Tobacco cembranoids protect the function of acute hippocampal slices against NMDA by a mechanism mediated by alpha4beta2 nicotinic receptors
    P A Ferchmin
    Center for Molecular and Behavioral Neuroscience, Universidad Central del Caribe, Bayamon, Puerto Rico
    J Neurosci Res 82:631-41. 2005
    ..In conclusion, these findings demonstrate that there are two different nicotinic neuroprotective mechanisms mediated by alpha4beta2...
  5. pmc Protective activity of (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol analogues against diisopropylfluorophosphate neurotoxicity: preliminary structure-activity relationship and pharmacophore modeling
    Vesna A Eterovic
    Department of Biochemistry, School of Medicine, Universidad Central del Caribe, Bayamon, PR 00960, USA
    Bioorg Med Chem 21:4678-86. 2013
    ..A pharmacophore model consisting of 1 hydrogen bond acceptor (HBA), 2 Hbic, and 10 exclusion spheres was established using HipHop-REFINE and supported the above mentioned pharmacophoric hypothesis...
  6. pmc Actions of octocoral and tobacco cembranoids on nicotinic receptors
    P A Ferchmin
    Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR, USA
    Toxicon 54:1174-82. 2009
    ..In addition, cembranoids are known to act as anti-tumor compounds. In conclusion, cembranoids provide a promising source of lead drugs for many clinical areas, including neuroprotection, smoking-cessation, and anti-cancer therapies...
  7. ncbi request reprint Gene expression is differentially regulated by neurotransmitters in embryonic neuronal cortical culture
    Cristina A Ghiani
    Mental Retardation Research Center, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7332, USA
    J Neurochem 97:35-43. 2006
    ..Nicotine effects on immature cortical neurons perhaps do not require gene regulation but may be still acting on signalling pathways...
  8. ncbi request reprint Genetic program of neuronal differentiation and growth induced by specific activation of NMDA receptors
    Cristina A Ghiani
    Mental Retardation Research Center, Jane and Terry Semel Institute for Neuroscience and Human Behaviour, Department of Neurobiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Neurochem Res 32:363-76. 2007
    ....