W C De Mello

Summary

Affiliation: University of Puerto Rico

Publications

  1. request reprint
    De Mello W, Ferrario C, Jessup J. Beneficial versus harmful effects of Angiotensin (1-7) on impulse propagation and cardiac arrhythmias in the failing heart. J Renin Angiotensin Aldosterone Syst. 2007;8:74-80 pubmed
    ....
  2. request reprint
    De Mello W, Monterrubio J. Intracellular and extracellular angiotensin II enhance the L-type calcium current in the failing heart. Hypertension. 2004;44:360-4 pubmed
    ..Moreover, intracellular enalaprilat by itself reduced the peak I(Ca) density. These observations might indicate that endogenous Ang II is contributing to I(Ca) modulation in the failing heart. ..
  3. request reprint
    De Mello W. Effect of extracellular and intracellular angiotensins on heart cell function; on the cardiac renin-angiotensin system. Regul Pept. 2003;114:87-90 pubmed
    ..Moreover, I discussed the most relevant information about the origin of cardiac renin, the presence of a cardiac renin-angiotensin aldosterone system and its possible relevance for heart cell physiology and pathology. ..
  4. request reprint
    De Mello W. Further studies on the effect of intracellular angiotensins on heart cell communication: on the role of endogenous angiotensin II. Regul Pept. 2003;115:31-6 pubmed
    ....
  5. request reprint
    De Mello W. Angiotensin (1-7) re-establishes impulse conduction in cardiac muscle during ischaemia-reperfusion. The role of the sodium pump. J Renin Angiotensin Aldosterone Syst. 2004;5:203-8 pubmed
    ..These effects of Ang (1-7), and the increment of cardiac refractoriness, provide an explanation for the reduced incidence of arrhythmias during ischaemia/reperfusion in the presence of Ang (1-7). ..

Detail Information

Publications5

  1. request reprint
    De Mello W, Ferrario C, Jessup J. Beneficial versus harmful effects of Angiotensin (1-7) on impulse propagation and cardiac arrhythmias in the failing heart. J Renin Angiotensin Aldosterone Syst. 2007;8:74-80 pubmed
    ....
  2. request reprint
    De Mello W, Monterrubio J. Intracellular and extracellular angiotensin II enhance the L-type calcium current in the failing heart. Hypertension. 2004;44:360-4 pubmed
    ..Moreover, intracellular enalaprilat by itself reduced the peak I(Ca) density. These observations might indicate that endogenous Ang II is contributing to I(Ca) modulation in the failing heart. ..
  3. request reprint
    De Mello W. Effect of extracellular and intracellular angiotensins on heart cell function; on the cardiac renin-angiotensin system. Regul Pept. 2003;114:87-90 pubmed
    ..Moreover, I discussed the most relevant information about the origin of cardiac renin, the presence of a cardiac renin-angiotensin aldosterone system and its possible relevance for heart cell physiology and pathology. ..
  4. request reprint
    De Mello W. Further studies on the effect of intracellular angiotensins on heart cell communication: on the role of endogenous angiotensin II. Regul Pept. 2003;115:31-6 pubmed
    ....
  5. request reprint
    De Mello W. Angiotensin (1-7) re-establishes impulse conduction in cardiac muscle during ischaemia-reperfusion. The role of the sodium pump. J Renin Angiotensin Aldosterone Syst. 2004;5:203-8 pubmed
    ..These effects of Ang (1-7), and the increment of cardiac refractoriness, provide an explanation for the reduced incidence of arrhythmias during ischaemia/reperfusion in the presence of Ang (1-7). ..