K R Chapman

Summary

Affiliation: University of Toronto

Publications

  1. ncbi request reprint Seretide for obstructive lung disease
    Kenneth R Chapman
    Asthma Centre and Pulmonary Rehabilitation Program, Toronto Western Hospital, University Health Network, Suite 4 011 ECW, 399 Bathurst Street, Toronto, Ontario, M5T 2S8, Canada
    Expert Opin Pharmacother 3:341-50. 2002
  2. pmc Single maintenance and reliever therapy (SMART) of asthma: a critical appraisal
    Kenneth R Chapman
    Asthma and Airway Centre, University Health Network, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada
    Thorax 65:747-52. 2010
  3. pmc Comparative efficacy of indacaterol in chronic obstructive pulmonary disease
    Marcos Ribeiro
    Asthma and Airway Centre, University Health Network, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
    Int J Chron Obstruct Pulmon Dis 7:145-52. 2012
  4. doi request reprint A blinded evaluation of the efficacy and safety of glycopyrronium, a once-daily long-acting muscarinic antagonist, versus tiotropium, in patients with COPD: the GLOW5 study
    Kenneth R Chapman
    Asthma and Airway Centre, University Health Network, Toronto Western Hospital, Rm 7 451 East Wing, 399 Bathurst Street, Toronto, ON, Canada
    BMC Pulm Med 14:4. 2014
  5. doi request reprint Do we know the minimal clinically important difference (MCID) for COPD exacerbations?
    Kenneth R Chapman
    Asthma and Airway Centre, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
    COPD 10:243-9. 2013
  6. pmc Pharmacokinetic comparability of Prolastin®-C to Prolastin® in alpha₁-antitrypsin deficiency: a randomized study
    James M Stocks
    Department of Medicine, University of Texas Health Science Center at Tyler, 75708 3154, USA
    BMC Clin Pharmacol 10:13. 2010
  7. ncbi request reprint Suboptimal asthma control: prevalence, detection and consequences in general practice
    K R Chapman
    University of Toronto, Canada
    Eur Respir J 31:320-5. 2008
  8. ncbi request reprint Impact of 'mild' asthma on health outcomes: findings of a systematic search of the literature
    K R Chapman
    Asthma and Airway Centre, Toronto Western Hospital, University Health Network, Toronto, Ont, Canada M5T 2S8
    Respir Med 99:1350-62. 2005
  9. ncbi request reprint The burden of COPD in Canada: results from the Confronting COPD survey
    K R Chapman
    University of Toronto, Ontario, Canada
    Respir Med 97:S23-31. 2003
  10. doi request reprint Long-term safety and efficacy of indacaterol, a long-acting β₂-agonist, in subjects with COPD: a randomized, placebo-controlled study
    Kenneth R Chapman
    Asthma and Airway Centre, University Health Network, Toronto Western Hospital, Toronto, ON, Canada
    Chest 140:68-75. 2011

Detail Information

Publications61

  1. ncbi request reprint Seretide for obstructive lung disease
    Kenneth R Chapman
    Asthma Centre and Pulmonary Rehabilitation Program, Toronto Western Hospital, University Health Network, Suite 4 011 ECW, 399 Bathurst Street, Toronto, Ontario, M5T 2S8, Canada
    Expert Opin Pharmacother 3:341-50. 2002
    ..At a time when the prevalence of both asthma and COPD is increasing, Seretide is a valuable step in the management of these common obstructive lung diseases...
  2. pmc Single maintenance and reliever therapy (SMART) of asthma: a critical appraisal
    Kenneth R Chapman
    Asthma and Airway Centre, University Health Network, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada
    Thorax 65:747-52. 2010
    ..At present, there is no evidence that better asthma treatment outcomes can be obtained by moment-to-moment symptom-driven use of ICS/LABA therapy than conventional physician-monitored and adjusted ICS/LABA therapy...
  3. pmc Comparative efficacy of indacaterol in chronic obstructive pulmonary disease
    Marcos Ribeiro
    Asthma and Airway Centre, University Health Network, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
    Int J Chron Obstruct Pulmon Dis 7:145-52. 2012
    ..It is likely that once-daily dosing of a bronchodilator would be a significant convenience and probably a compliance-enhancing advantage, leading to improved overall clinical outcomes in patients with COPD...
  4. doi request reprint A blinded evaluation of the efficacy and safety of glycopyrronium, a once-daily long-acting muscarinic antagonist, versus tiotropium, in patients with COPD: the GLOW5 study
    Kenneth R Chapman
    Asthma and Airway Centre, University Health Network, Toronto Western Hospital, Rm 7 451 East Wing, 399 Bathurst Street, Toronto, ON, Canada
    BMC Pulm Med 14:4. 2014
    ..Previous studies have compared glycopyrronium with open-label tiotropium. In the GLOW5 study, we compare glycopyrronium with blinded tiotropium...
  5. doi request reprint Do we know the minimal clinically important difference (MCID) for COPD exacerbations?
    Kenneth R Chapman
    Asthma and Airway Centre, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
    COPD 10:243-9. 2013
    ..We find no evidence of an established MCID but suggest that interventions reducing exacerbations by as little as 11% appear to be regarded widely as clinically important...
  6. pmc Pharmacokinetic comparability of Prolastin®-C to Prolastin® in alpha₁-antitrypsin deficiency: a randomized study
    James M Stocks
    Department of Medicine, University of Texas Health Science Center at Tyler, 75708 3154, USA
    BMC Clin Pharmacol 10:13. 2010
    ..The pharmacokinetic comparability of Prolastin-C to Prolastin was assessed in subjects with AAT deficiency...
  7. ncbi request reprint Suboptimal asthma control: prevalence, detection and consequences in general practice
    K R Chapman
    University of Toronto, Canada
    Eur Respir J 31:320-5. 2008
    ..Lack of control can be recognised by physicians who are likely to consider appropriate changes to therapy. A lack of short-term symptom control of asthma is associated with excess healthcare utilisation...
  8. ncbi request reprint Impact of 'mild' asthma on health outcomes: findings of a systematic search of the literature
    K R Chapman
    Asthma and Airway Centre, Toronto Western Hospital, University Health Network, Toronto, Ont, Canada M5T 2S8
    Respir Med 99:1350-62. 2005
    ..By contrast, the strategy of treating to achieve disease control has been validated and offers the advantage of simplicity in its application...
  9. ncbi request reprint The burden of COPD in Canada: results from the Confronting COPD survey
    K R Chapman
    University of Toronto, Ontario, Canada
    Respir Med 97:S23-31. 2003
    ..Early diagnosis and the application of available but underused interventions (e.g. smoking cessation, inhaled drug therapies and pulmonary rehabilitation) could reduce the morbidity and costs of COPD in this country...
  10. doi request reprint Long-term safety and efficacy of indacaterol, a long-acting β₂-agonist, in subjects with COPD: a randomized, placebo-controlled study
    Kenneth R Chapman
    Asthma and Airway Centre, University Health Network, Toronto Western Hospital, Toronto, ON, Canada
    Chest 140:68-75. 2011
    ..Indacaterol is an inhaled, long-acting β(2)-agonist providing 24-h bronchodilation with once-daily dosing in patients with COPD...
  11. pmc Delivery characteristics and patients' handling of two single-dose dry-powder inhalers used in COPD
    Kenneth R Chapman
    Asthma and Airway Centre, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
    Int J Chron Obstruct Pulmon Dis 6:353-63. 2011
    ..These are important factors for optimum dose delivery and successful COPD management...
  12. ncbi request reprint The impact of budesonide and other inhaled corticosteroid therapies in the management of asthma in children and adults
    Kenneth R Chapman
    Asthma Centre and Pulmonary Rehabilitation Program, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Clin Ther 25:C2-C14. 2003
    ..International treatment guidelines currently recommend early intervention with ICS therapy to improve lung function and disease control...
  13. ncbi request reprint Augmentation therapy for alpha1 antitrypsin deficiency: a meta-analysis
    Kenneth R Chapman
    Asthma and Airway Centre, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
    COPD 6:177-84. 2009
    ..Augmentation with exogenous alpha1-antitrypsin (alpha1-AT) is the only specific therapy for alpha1-AT deficiency. Uncertainty persists concerning its effectiveness...
  14. ncbi request reprint Chronic obstructive pulmonary disease: are women more susceptible than men?
    Kenneth R Chapman
    Department of Medicine, University of Toronto, Canada
    Clin Chest Med 25:331-41. 2004
    ..There are documented differences in health care use between men and women who have COPD, but too few studies have been done to allow conclusions to be drawn about the impact of sex and gender on the prognosis of the disease...
  15. ncbi request reprint Epidemiology and costs of chronic obstructive pulmonary disease
    K R Chapman
    Asthma and Airway Centre, Toronto University Health Network, Toronto Western Hospital, Room 7 451 New East Wing, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
    Eur Respir J 27:188-207. 2006
  16. pmc Asthma in Canada: missing the treatment targets
    Kenneth R Chapman
    Asthma and Airway Centre, University Health Network, Toronto Western Hospital, and the University of Toronto, Toronto, Ont
    CMAJ 178:1027-8. 2008
  17. doi request reprint Safer inhaled corticosteroid therapy for asthma
    Kenneth R Chapman
    Asthma and Airway Centre, University Health Network, Toronto Western Hospital, Room 7 451 East Wing, 399 Bathurst St, Toronto, Ontario, Canada M5T 2S8
    Pediatrics 121:179-80. 2008
  18. pmc The role of omalizumab in the treatment of severe allergic asthma
    Kenneth R Chapman
    University of Toronto, Toronto, Ontario, Canada
    Can Respir J 13:1B-9B. 2006
    ..A novel anti-immunoglobulin E (anti-IgE) therapy for asthma, omalizumab, has been approved for use in Canada...
  19. ncbi request reprint The addition of salmeterol 50 microg bid to anticholinergic treatment in patients with COPD: a randomized, placebo controlled trial. Chronic obstructive pulmonary disease
    Kenneth R Chapman
    Toronto Western Hospital, Ontario
    Can Respir J 9:178-85. 2002
    ..In the past, the role of long-acting beta(2-) agonists in chronic obstructive pulmonary disease (COPD) relative to other agents has been unclear...
  20. ncbi request reprint Salmeterol and fluticasone propionate (50/250 microg) administered via combination Diskus inhaler: as effective as when given via separate Diskus inhalers
    K R Chapman
    Toronto Hospital, Western Division, Toronto, Canada
    Can Respir J 6:45-51. 1999
    ..To compare the efficacy and safety of a new combination Diskus inhaler containing both salmeterol 50 mg and fluticasone propionate 250 mg (Seretide) with the two drugs delivered via separate Diskus inhalers...
  21. ncbi request reprint The patient level cost of asthma in adults in south central Ontario. Pharmacy Medication Monitoring Program Advisory Board
    W J Ungar
    Department of Health Administration and Division of Respirology, University of Toronto, Toronto, Canada
    Can Respir J 5:463-71. 1998
    ..To assess the annual cost of asthma per adult patient from the perspectives of society, the Ontario Ministry of Health and the patient...
  22. ncbi request reprint Exhaled nitric oxide in chronic obstructive pulmonary disease: relationship to pulmonary function
    K Ansarin
    Asthma Centre of the University Health Network, Toronto, Ontario, Canada
    Eur Respir J 17:934-8. 2001
    ..Exhaled nitric oxide is increased in patients with chronic obstructive pulmonary disease, an increase that is influenced by structural abnormalities of tobacco-induced lung damage...
  23. ncbi request reprint Maintenance of asthma control by once-daily inhaled ciclesonide in adults with persistent asthma
    K R Chapman
    Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Allergy 60:330-7. 2005
    ..This 12-week, double-blind, randomized, parallel-group, placebo-controlled study evaluated the efficacy and safety of ciclesonide in adults with persistent asthma...
  24. ncbi request reprint Defining the asthma phenotype for the purpose of genetic analysis
    S Kesten
    University of Toronto, Canada
    J Asthma 34:483-91. 1997
    ....
  25. ncbi request reprint Effectiveness and safety of salmeterol in nonspecialist practice settings
    K R Chapman
    University of Toronto, Toronto, Ontario, Canada
    Chest 119:714-9. 2001
    ..028). CONCLUSIONS: Salmeterol treatment is effective in subjects typically cared for in the primary-care setting and does not increase the frequency of severe exacerbations...
  26. ncbi request reprint Respiratory rate during acute asthma
    S Kesten
    Division of Respiratory Medicine, Toronto Western Hospital, Canada
    Chest 97:58-62. 1990
    ..In the former setting, the respiratory rate is correlated with spirometric measures of airflow obstruction, but the weakness of the correlation does not allow the respiratory rate to be used as a substitute for spirometry...
  27. ncbi request reprint Inhaled beclomethasone dipropionate improves acoustic measures of voice in patients with asthma
    M S Balter
    Asthma Education Clinic, Mt Sinai Hospital, University of Toronto, Toronto, Canada
    Chest 120:1829-34. 2001
    ..Inhaled corticosteroids have the potential to produce upper-airway side effects such as hoarseness. As new compounds and delivery devices are developed and compared, it is difficult to quantify their adverse upper-airway effects...
  28. ncbi request reprint Exhaled nitric oxide and hydrogen peroxide in patients with chronic obstructive pulmonary disease: effects of inhaled beclomethasone
    I M Ferreira
    Asthma Centre, University of Toronto, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 164:1012-5. 2001
    ..50). We conclude that inhaled beclomethasone reduces ENO levels in stable nonsmoking patients with COPD, a finding compatible with an antiinflammatory mechanism of action...
  29. ncbi request reprint Gender bias in the diagnosis of COPD
    K R Chapman
    Division of Respiratory Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Chest 119:1691-5. 2001
    ..There may also be underdiagnosis and misdiagnosis of COPD in both sexes because objective measures of lung function are underused...
  30. ncbi request reprint Control of asthma in Canada: failure to achieve guideline targets
    K R Chapman
    University of Toronto, Toronto, Canada
    Can Respir J 8:35A-40A. 2001
    ..To assess the degree of asthma control achieved by patients with asthma in Canada and to describe the impact of poor asthma control...
  31. doi request reprint The clinical impact of single inhaler therapy in asthma
    K Czarnecka
    Asthma and Airway Centre, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
    Clin Exp Allergy 42:1006-13. 2012
    ....
  32. ncbi request reprint The impact of a nationally coordinated pharmacy-based asthma education intervention
    S A Diamond
    Pedipharm Consultants, Toronto, Ontario
    Can Respir J 8:261-5. 2001
    ..To assess the impact of a nationally coordinated pharmacy-based educational intervention on self-management behaviour and markers of asthma control in self-referred patients with asthma...
  33. ncbi request reprint Changes in pulmonary function and cross-sectional area of trachea and bronchi in asthmatics following inhalation of procaterol hydrochloride and ipratropium bromide
    V Hoffstein
    Department of Medicine, St Michael s Hospital, Toronto, Canada
    Am J Respir Crit Care Med 149:81-5. 1994
    ..abstract truncated at 250 words)..
  34. ncbi request reprint Inhaler education for hospital-based pharmacists: how much is required?
    C A Jackevicius
    The Toronto Hospital and Faculty of Pharmacy, University of Toronto, Toronto, Canada
    Can Respir J 6:237-44. 1999
    ..To compare the effectiveness of a more intensive educational intervention with a less intensive intervention on the ability of hospital pharmacists to be prepared to educate patients regarding inhaled device technique...
  35. doi request reprint Seretide: a pharmacoeconomic analysis
    Leandro Fritscher
    Asthma and Airway Centre, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
    J Med Econ 11:555-70. 2008
    ..The fixed-dose combination of fluticasone and salmeterol has been a safe and effective therapy for these diseases...
  36. doi request reprint The effect of montelukast on exhaled nitric oxide of alveolar and bronchial origin in inhaled corticosteroid-treated asthma
    Leandro G Fritscher
    Asthma and Airway Centre, University Health Network, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Respir Med 103:296-300. 2009
    ..Systemic therapy with an oral anti-leukotriene agent may suppress NO production in distal airways and alveoli not reached by inhaled therapy...
  37. ncbi request reprint Effect of montelukast on exhaled nitric oxide and nonvolatile markers of inflammation in mild asthma
    Alessandra Sandrini
    Asthma and Airway Centre of the Toronto Western Hospital, Division of Respiratory Medicine, University Health Network, University of Toronto, Toronto, ON, Canada
    Chest 124:1334-40. 2003
    ....
  38. ncbi request reprint Corticosteroid therapy for patients with acute exacerbations of chronic obstructive pulmonary disease: a systematic review
    J M Singh
    Division of Internal Medicine, Room 4 154, St Michael s Hospital, 30 Bond St, Toronto, Ontario, Canada M5B 1W8
    Arch Intern Med 162:2527-36. 2002
    ..To determine whether systemic corticosteroids are of benefit to patients with acute exacerbations of chronic obstructive pulmonary disease (COPD)...
  39. ncbi request reprint Difficult asthma: consider all of the possibilities
    L C Cicutto
    Toronto Western Hospital, Toronto, Canada
    Can Respir J 7:415-8. 2000
    ..This led to a surgical resection of a mucoepidermoid carcinoma. This case highlights the need to consider all possibilities during the evaluation of patients with difficult asthma...
  40. ncbi request reprint Evaluation of a questionnaire to assess compliance with anti-asthma medications
    Katherine M Walewski
    The Division of Respiratory Medicine, Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Asthma 41:77-83. 2004
    ....
  41. ncbi request reprint Assessment of a medication-based asthma index for population research
    Wendy J Ungar
    Division of Population Health Sciences, Hospital for Sick Children Research Institute, University of Toronto, Ontario, Canada
    Am J Respir Crit Care Med 165:190-4. 2002
    ..We conclude that a medication use index may be useful in population-based research where clinical asthma severity data are lacking. Such an index is distinct from but is related to disease control...
  42. ncbi request reprint Patient handling of a dry-powder inhaler in clinical practice
    S Epstein
    Asthma Centre, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Chest 120:1480-4. 2001
    ..The most common handling flaw, suboptimal breath-holding, is not specific to this device and is of uncertain clinical significance...
  43. doi request reprint Variations and gaps in management of acute asthma in Ontario emergency departments
    M Diane Lougheed
    Division of Respirology, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Chest 135:724-36. 2009
    ..We investigated ED management of asthma and differences in practice patterns for pediatric (< 20 years old) and adult (> or = 20 years old) patients in Ontario EDs...
  44. ncbi request reprint Effect of nasal triamcinolone acetonide on lower airway inflammatory markers in patients with allergic rhinitis
    Alessandra Sandrini
    Asthma and Airway Centre of the Toronto Western Hospital, University Health Network, Division of Respiratory Medicine, University of Toronto, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
    J Allergy Clin Immunol 111:313-20. 2003
    ..AR, even in the absence of asthma, is associated with increased levels of exhaled nitric oxide (ENO) and hydrogen peroxide (H(2)O(2)) in exhaled breath condensate, 2 noninvasive markers of lower airway inflammation...
  45. ncbi request reprint Women and asthma: lessons from a gender analysis of the asthma in Canada survey
    Anna Day
    Division of Respiratory Medicine, University of Toronto, Toronto, Canada
    J Asthma 43:169-73. 2006
    ..To compare the degree of asthma control achieved by men and women with asthma in Canada and to explore differences in patient perspectives, treatments used, and health care resources used between men and women with asthma...
  46. ncbi request reprint Induced sputum: comparison of postinfectious cough with allergic asthma in children
    B Zimmerman
    Gage Occupational and Environmental Health Unit, St Michael s Hospital, and the Asthma Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    J Allergy Clin Immunol 105:495-9. 2000
    ..Cough persisting after a respiratory infection is common in children and is often managed as asthma. However, little is known about the pathophysiologic mechanisms of such cough and how it compares with asthma...
  47. pmc A 21-year-old man with systemic-onset juvenile rheumatoid arthritis, cough and progressive dyspnea
    A Leber
    Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Can Respir J 17:e42-4. 2010
    ..Multiple treatment regimens were attempted; however, definitive management was only achieved through double-lung transplantation...
  48. ncbi request reprint Economic issues in the use of office spirometry for lung health assessment
    Murray Krahn
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Can Respir J 10:320-6. 2003
    ..Such analyses should play a role in future clinical policy making. Even modest quit rates attributable to screening spirometry may result in highly favourable cost effectiveness ratios...
  49. ncbi request reprint Parent-reported symptoms may not be adequate to define asthma control in children
    Sharon D Dell
    Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Pulmonol 42:1117-24. 2007
    ..In adults, symptom-based asthma control parameters have been shown to predict exacerbations and health care services use (HSU). We hypothesize that defining asthma control using parent-reported symptoms alone is not adequate in children...
  50. pmc Predicting the need for supplemental oxygen during airline flight in patients with chronic pulmonary disease: a comparison of predictive equations and altitude simulation
    Ana C Bradi
    University Health Network, Toronto Western Hospital, Toronto, Ontario
    Can Respir J 16:119-24. 2009
    ..Screening guidelines, predictive equations based on ground level measurements and altitude simulation laboratory procedures have been recommended for determining risk but have not been rigorously evaluated and compared...
  51. ncbi request reprint Diffuse panbronchiolitis in a Caucasian man in Canada
    Alessandra Sandrini
    Division of Respiratory Medicine, Department of Medicine, University of Toronto, Ontario, Canada
    Can Respir J 10:449-51. 2003
    ..Physicians should be aware that DPB may occur in Western countries, and that DPB should be considered in the differential diagnosis of patients with persistent air flow obstruction and nodular shadows on chest radiograms...
  52. ncbi request reprint Multicentre evaluation of an emergency department asthma care pathway for adults
    M Diane Lougheed
    Clinical Research Centre, Kingston General Hospital, Kingston, Ontario, Canada
    CJEM 11:215-29. 2009
    ..We sought to determine whether a standardized emergency department (ED) asthma care pathway (ACP) for adults would be accepted by ED staff, improve adherence to Canadian ED asthma management guidelines and improve patient outcomes...
  53. ncbi request reprint The Ontario Asthma Regional Variation Study: emergency department visit rates and the relation to hospitalization rates
    M Diane Lougheed
    Division of Respirology, Department of Medicine, Queen s University, Kingston, ON, Canada
    Chest 129:909-17. 2006
    ..Hospitalization rates for asthma vary more than threefold across regions of Ontario. It is not known whether this variation is primarily due to regional differences in the rate of emergency department (ED) visits or hospital admissions...
  54. pmc Hot tub lung mimicking classic acute and chronic hypersensitivity pneumonitis: two case reports
    Geetika Verma
    Department of Medicine, Division of Respirology, University Health Network, University of Toronto, Toronto, Ontario
    Can Respir J 14:354-6. 2007
    ..Both cases exhibited clinical, radiological and pathological findings closely mimicking classic subacute and chronic hypersensitivity pneumonitis...
  55. pmc Asthma control in Canada: no improvement since we last looked in 1999
    R Andrew McIvor
    McMaster University and Firestone Institute for Respiratory Health, St Joseph s Healthcare, 50 Charlton Ave E, Hamilton, ON L8N 4A6
    Can Fam Physician 53:672-7. 2007
    ..To determine whether asthma control in Canada had improved since the last major survey in 1999 by exploring how well patients' asthma was controlled, how much they knew about asthma control, and how they used health care resources...
  56. ncbi request reprint The value of early diagnosis for effective management of chronic obstructive pulmonary disease
    Dennis E Doherty
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Kentucky, Veterans Administration Medical Center, Lexington, KY, USA
    J Fam Pract 56:S1-24. 2007
  57. ncbi request reprint Safety and effectiveness of long-acting inhaled beta-agonist bronchodilators when taken with inhaled corticosteroids
    Pierre Ernst
    McGill University, Montreal, Quebec, Canada
    Ann Intern Med 145:692-4. 2006
    ....
  58. pmc Asthma control in Canada remains suboptimal: the Reality of Asthma Control (TRAC) study
    J Mark FitzGerald
    Centre for Clinical Epidemiology and Evaluation, University of British Columbia, Vancouver
    Can Respir J 13:253-9. 2006
    ..Two Canadian studies showed that 55% of patients with asthma had daily symptoms (in 1996) and that 57% of patients suffered from poorly controlled asthma (in 1999)...
  59. ncbi request reprint Enhanced synergy between fluticasone propionate and salmeterol inhaled from a single inhaler versus separate inhalers
    Harold S Nelson
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 112:29-36. 2003
    ..The coadministration of long-acting inhaled beta(2)-agonists and inhaled corticosteroids is the most effective treatment for persistent asthma...
  60. doi request reprint The coming of age of asthma guidelines
    R Andrew McIvor
    Firestone Institute for Respiratory Health, McMaster University, St Joseph s Healthcare, Hamilton, ON, Canada
    Lancet 372:1021-2. 2008
  61. ncbi request reprint Tiotropium and simplified detection of dynamic hyperinflation
    Arthur F Gelb
    Department of Pharmacy Services, Lakewood Regional Medical Center, Lakewood, CA 90712, USA
    Chest 131:690-5. 2007
    ..To detect dynamic hyperinflation (DH) by evaluating reduction in inspiratory capacity (IC) during metronome-paced hyperventilation (MPH) in patients with moderate-to-severe COPD, studied before and after treatment with tiotropium...