Research Topics
| D K BanerjeeSummaryAffiliation: University of Puerto Rico Publications
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Publications
Requirement of protein kinase type I for cAMP-mediated up-regulation of lipid-linked oligosaccharide for asparagine-linked protein glycosylationD K Banerjee
Department of Biochemistry, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR 00936 5067, USA
Cell Mol Biol (Noisy-le-grand) 53:55-63. 2007..The turnover of LLO in MR1 and the glycoprotein profile were also at par with the wild type. Therefore, we conclude that PKA type I plays an important role in modulating the protein N-glycosylation in cAMP responsive cells...
In vitro phosphorylation by cAMP-dependent protein kinase up-regulates recombinant Saccharomyces cerevisiae mannosylphosphodolichol synthaseDipak K Banerjee
Department of Biochemistry, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico 00936 5067
J Biol Chem 280:4174-81. 2005..Thus, confirming that S. cerevisiae DPMS activity is indeed regulated by the cAMP-dependent protein phosphorylation signal, and the phosphorylation target is serine 141...
Low expression of lipid-linked oligosaccharide due to a functionally altered Dol-P-Man synthase reduces protein glycosylation in cAMP-dependent protein kinase deficient Chinese hamster ovary cellsDipak K Banerjee
Department of Biochemistry, School of Medicine, University of Puerto Rico, San Juan, PR, 00936 5067, USA
Glycoconj J 21:479-86. 2004..Exogenously added Dol-P failed to rescue the kcat for DPMS in CHO cell mutants; however, in vitro protein phosphorylation with a cAMP-dependent protein kinase restored their kinetic activity to the level of the wild type...
Expression of Glc3Man9GlcNAc2-PP-Dol is a prerequisite for capillary endothelial cell proliferationJ A Martinez
Department of Biochemistry, School of Medicine, University of Puerto Rico, San Juan 00936 5067, USA
Cell Mol Biol (Noisy-le-grand) 45:137-52. 1999....
Amphomycin inhibits mannosylphosphoryldolichol synthesis by forming a complex with dolichylmonophosphateD K Banerjee
Department of Biochemistry and Nutrition, School of Medicine, University of Puerto Rico, San Juan 00936 5067
J Biol Chem 264:2024-8. 1989..These data demonstrated that amphomycin interacted with the active site of the glycosyl-carrier lipid (Dol-P), thereby preventing its participation at the enzymatic reaction...
Angiogenesis: characterization of a cellular modelD K Banerjee
Department of Biochemistry, University of Puerto Rico, School of Medicine, San Juan 00936 5067, USA
P R Health Sci J 17:327-33. 1998..Studies completed in our laboratory also evidenced that expression of Glc3Man9GlcNAc2-PP-Dol is intricately connected with the balance between the cellular proliferation and apoptosis during angiogenesis...
Unique structural motif supports mannosylphospho dolichol synthase: an important angiogenesis regulatorKrishna Baksi
Department of Biochemistry, School of Medicine, University of Puerto Rico, Medical Sciences Campus, University of Puerto Rico, San Juan, PR 00936 5067, USA
Curr Drug Targets 9:262-71. 2008..Thus, it has been concluded that increased DPMS activity through protein phosphorylation is a driving force for angiogeneis. Its abolition, however, led to cell arrest in G1 and induction of apoptosis...
Mannosylphosphodolichol synthase activity is associated with a 32 kDa phosphoproteinD K Banerjee
Department of Biochemistry, School of Medicine, University of Puerto Rico, San Juan 00936 5067, USA
Biosci Rep 19:169-77. 1999..Instead, it was a net effect of protein phosphorylation by cAMP-dependent protein kinase. Using antibody as a probe we have now demonstrated that Dol-P-Man synthase activity is associated with a 32 kDa ER phosphoprotein...
Insulin up-regulates a Glc3Man9GlcNAc2-PP-Dol pool in capillary endothelial cells not essential for angiogenesisJosé J Tavárez-Pagán
Department of Biochemistry, School of Medicine, University of Puerto Rico, San Juan, PR
Glycoconj J 20:179-88. 2004....
Potentiation of angiogenic switch in capillary endothelial cells by cAMP: A cross-talk between up-regulated LLO biosynthesis and the HSP-70 expressionJuan A Martinez
Department of Biochemistry, School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00936 5067, USA
Glycoconj J 23:209-20. 2006..As a result capillary endothelial cell proliferation was induced...
Cloning and expression of mannosylphospho dolichol synthase from bovine adrenal medullary capillary endothelial cellsKrishna Baksi
Department of Anatomy and Cell Biology, School of Medicine, Universidad Central del Caribe, Bayamon, PR 00930 3100, USA
Glycoconj J 26:635-45. 2009..Additionally, we show here that overexpression of DPMS is indeed angiogenic. The capillary endothelial cells proliferate at a higher rate carrying the DPMS overexpression plasmid over the parental cells or the vector...
Tunicamycin inhibits capillary endothelial cell proliferation by inducing apoptosis. Targeting dolichol-pathway for generation of new anti-angiogenic therapeuticsJ A Martinez
Department of Biochemistry, School of Medicine, University of Puerto Rico, San Juan 00936 5067, USA
Adv Exp Med Biol 476:197-208. 2000....
Monoclonal antibody to amphomycin. A tool to study the topography of dolichol monophosphate in the membraneD K Banerjee
Department of Biochemistry and Nutrition, School of Medicine, University of Puerto Rico, San Juan 00936 5067
Carbohydr Res 236:301-13. 1992....
