M Saeed Arayne

Summary

Affiliation: University of Karachi

Publications

  1. ncbi Interactions between ciprofloxacin and antacids--dissolution and adsorption studies
    M Saeed Arayne
    Department of Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan
    Drug Metabol Drug Interact 21:117-29. 2005
  2. ncbi In vitro availability of ofloxacin in presence of metals essential to human body
    Najma Sultana
    Research Institute of Pharmaceutical Sciences, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:42-7. 2007
  3. ncbi In vitro interactions of captopril with H2-receptor antagonists
    Najma Sultana
    Department of Pharmaceutical Chemistry, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:132-9. 2007
  4. ncbi In vitro availability studies of enoxacin in presence of H2 receptor antagonists
    M Saeed Arayne
    Department of Chemistry, University of Karachi Karachi 75270, Pakistan
    Pak J Pharm Sci 20:235-43. 2007
  5. doi Spectrophotometric determination of gabapentin in pharmaceutical formulations using ninhydrin and pi-acceptors
    Farhan Ahmed Siddiqui
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Eur J Med Chem 45:2761-7. 2010
  6. ncbi Fosinopril H(2)-receptor antagonists interaction studies by derivative spectroscopy
    Najma Sultana
    Research Institute of Pharmaceutical Sciences, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:19-25. 2007
  7. ncbi Interactions between sparfloxacin and antacids - dissolution and adsorption studies
    Fida Hussain
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 19:16-21. 2006
  8. ncbi Simultaneous determination of metformin, cimetidine, famotidine, and ranitidine in human serum and dosage formulations using HPLC with UV detection
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    J Chromatogr Sci 48:721-5. 2010
  9. ncbi Simultaneous determination of piracetam and its four impurities by RP-HPLC with UV detection
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    J Chromatogr Sci 48:589-94. 2010
  10. ncbi In vitro hypoglycemic activity of methanolic extract of some indigenous plants
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:268-73. 2007

Collaborators

  • Fida Hussain
  • M Afzal
  • Najma Sultana
  • Farhan Ahmed Siddiqui
  • Agha Zeeshan Mirza
  • Nighat Shafi
  • Faiza Qureshi
  • Asia Naz
  • M Kamran Zaman
  • Bushra Khan
  • Abid Iftikhar
  • M Ahmed Mesaik
  • Saeeda Nadir Ali
  • Azhar Hussain
  • Saima Sher Bahadur
  • Hina Shamshad
  • M Hashim Zuberi
  • Nadia Rehman
  • Nawab Sher Afridi
  • S Shahid Ali
  • Shahnawaz Sajid
  • Nuvaira Yasmeen
  • Reeshanul Quraish
  • Aisha Sana
  • Noman Ahmed
  • Afghan Farooq
  • Aizaz Fatima
  • Reeshan Ul Quraishi
  • Naveen Mukhtar
  • Shaista Naz
  • Rizwana Sabri
  • Hina Furqan

Detail Information

Publications56

  1. ncbi Interactions between ciprofloxacin and antacids--dissolution and adsorption studies
    M Saeed Arayne
    Department of Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan
    Drug Metabol Drug Interact 21:117-29. 2005
    ..Magaldrate and calcium carbonate in simulated gastric juice exhibited relatively higher adsorption capacities, as did magnesium trisilicate and calcium hydroxide in simulated intestinal juice...
  2. ncbi In vitro availability of ofloxacin in presence of metals essential to human body
    Najma Sultana
    Research Institute of Pharmaceutical Sciences, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:42-7. 2007
    ..4 and 9. The result showed that availability of ofloxacin slightly changed in presence of all metals in all these dissolution mediums...
  3. ncbi In vitro interactions of captopril with H2-receptor antagonists
    Najma Sultana
    Department of Pharmaceutical Chemistry, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:132-9. 2007
    ..As a result, the availability of captopril was affected by the concurrent administration of H2-receptor antagonists. Accordingly coadministration of both the drugs should be avoided...
  4. ncbi In vitro availability studies of enoxacin in presence of H2 receptor antagonists
    M Saeed Arayne
    Department of Chemistry, University of Karachi Karachi 75270, Pakistan
    Pak J Pharm Sci 20:235-43. 2007
    ....
  5. doi Spectrophotometric determination of gabapentin in pharmaceutical formulations using ninhydrin and pi-acceptors
    Farhan Ahmed Siddiqui
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Eur J Med Chem 45:2761-7. 2010
    ..3 to 100.7 The association constants and free energy changes using Benesi-Hildebrand plots are also studied...
  6. ncbi Fosinopril H(2)-receptor antagonists interaction studies by derivative spectroscopy
    Najma Sultana
    Research Institute of Pharmaceutical Sciences, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:19-25. 2007
    ....
  7. ncbi Interactions between sparfloxacin and antacids - dissolution and adsorption studies
    Fida Hussain
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 19:16-21. 2006
    ....
  8. ncbi Simultaneous determination of metformin, cimetidine, famotidine, and ranitidine in human serum and dosage formulations using HPLC with UV detection
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    J Chromatogr Sci 48:721-5. 2010
    ..217, 0.352, 0.405, and 0.368 μg/mL for Metf, Cimt, Famt, and Rant, respectively. The applicability of the method was demonstrated by determining the drug content in pharmaceutical formulations, where it exhibited good performance...
  9. ncbi Simultaneous determination of piracetam and its four impurities by RP-HPLC with UV detection
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    J Chromatogr Sci 48:589-94. 2010
    ..The proposed method shows high efficiency, allowing the separation of the main component piracetam from other impurities...
  10. ncbi In vitro hypoglycemic activity of methanolic extract of some indigenous plants
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:268-73. 2007
    ..The results in three different media revealed that, hypoglycemic activity is more prominent in neutral and basic media as compared to acidic medium...
  11. ncbi Cephradine antacids interaction studies
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:179-84. 2007
    ..Moreover, these studies indicated that cephradine was strongly adsorbed on antacids; magnesium trisilicate and simeco tablets (powdered) exhibited relatively higher adsorption capacities...
  12. ncbi In vitro monitoring of ciprofloxacin antacids interactions by UV & HPLC
    Najma Sultana
    Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 18:23-31. 2005
    ..These studies were carried out in simulated gastric and intestinal juices for three hours at 37 degrees C. The availability of ciprofloxacin was found to be markedly retarded in presence of all the antacids studied...
  13. ncbi Spectrophotometric methods for the simultaneous analysis of meclezine hydrochloride and pyridoxine hydrochloride in bulk drug and pharmaceutical formulations
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:149-56. 2007
    ..The suggested procedures were successfully applied to the determination of these compounds in synthetic mixtures and in pharmaceutical preparations, with high percentage of recovery, good accuracy and precision...
  14. ncbi Simultaneous determination of gliquidone, fexofenadine, buclizine, and levocetirizine in dosage formulation and human serum by RP-HPLC
    M Saeed Arayne
    Lab 9, Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    J Chromatogr Sci 48:382-5. 2010
    ..Thus, the proposed method is suitable for the simultaneous analysis of active ingredients in tablet dosage forms and human serum...
  15. ncbi Development and validation of RP-HPLC method for the analysis of metformin
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 19:231-5. 2006
    ..The proposed method is rapid, accurate, economical and selective and it may be used for the quantitative analysis of metformin in Neodipar tablets because of its sensitivity and reproducibility...
  16. ncbi Development and validation of new assay method for the simultaneous analysis of diltiazem, metformin, pioglitazone and rosiglitazone by RP-HPLC and its applications in pharmaceuticals and human serum
    Najma Sultana
    Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Pakistan
    J Chromatogr Sci 49:774-9. 2011
    ..The validation results, together with statistical treatment of the data, demonstrated the reliability of this method...
  17. ncbi In vitro activity of cefadroxil, cephalexin, cefatrizine and cefpirome in presence of essential and trace elements
    Najma Sultana
    Department of Pharmaceutical Chemistry, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:305-10. 2007
    ....
  18. ncbi Synthesis and characterization of glibenclamide complexes of magnesium, chromium, cobalt, nickel, zinc and cadmium salts
    M Kamran Zaman
    Department of Chemistry, University of Karachi, Karachi 75270
    Pak J Pharm Sci 19:114-8. 2006
    ..These complexes were characterized by their physical characteristics, 1H-NMR, IR and Atomic absorption studies...
  19. ncbi Optimization of levofloxacin analysis by RP-HPLC using multivariate calibration technique
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:100-6. 2007
    ..2 %. Validation parameters as specificity, accuracy and robustness were also determined. The method can conveniently be used for analysis of levofloxacin pharmacokinetic levels in human serum and pharmaceutical formulations...
  20. ncbi RP-LC method for the simultaneous determination of gliquidone, pioglitazone hydrochloride, and atorvastatin in formulations and human serum
    Agha Zeeshan Mirza
    University of Karachi, Department of Chemistry, Lab 9, Karachi, 75270, Pakistan Intertek Pakistan Pvt Ltd, Analytical Lab, Karachi, 75270, Pakistan
    J AOAC Int 96:56-9. 2013
    ..The proposed method was successfully applied to the determination of these drugs in commercial tablets and human serum. The established method was validated with respect to specificity, linearity, precision, accuracy, and ruggedness...
  21. ncbi Spectrophotometric method for quantitative determination of gliquidone in bulk drug, pharmaceutical formulations and human serum
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 19:185-9. 2006
    ....
  22. ncbi In vitro availability of metformin in presence of h(2) receptor antagonists
    Najma Sultana
    Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 19:28-34. 2006
    ..On the other hand, increase in metformin concentration may result in hypoglycemic effects...
  23. ncbi A validated method for the analysis of diltiazem in raw materials and pharmaceutical formulations by rp-HPLC
    Najma Sultana
    Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:284-90. 2007
    ..0184 microg/ml and the quantitation limit was about 0.056 microg/ml and therefore could be employed as a more convenient and efficient option for the analysis of diltiazem and its related compounds in drug substance and formulations...
  24. ncbi Development and validation of an HPLC-UV method for the determination of gatifloxacin in bulk material, pharmaceutical formulations, human plasma and metal complexes
    Najma Sultana
    Research Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi
    Pak J Pharm Sci 19:275-81. 2006
    ..73 ng/ml in human plasma while quantification limit in human serum was 5.77 ng/ml. The proposed method is applicable to routine analysis of GTX in pharmaceutical formulations as well as in human plasma samples...
  25. ncbi Erythromycin synergism with essential and trace elements
    Najma Sultana
    Department of Pharmaceutical Chemistry, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 18:35-9. 2005
    ..e., antimicrobial activity of complexes of erythromycin increases with respect to parent erythromycin drug and MIC of drug metal complexes decreased...
  26. ncbi Degradation studies of azithromycin and its spectrophotometric determination in pharmaceutical dosage forms
    Najma Sultana
    Department of Pharmaceutical Chemistry, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 19:98-103. 2006
    ....
  27. ncbi Simultaneous determination of cefazolin or ceftizoxime in presence of ascorbic acid from pharmaceutical formulation and human serum by RP-HPLC
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:56-61. 2007
    ..0-100.0% with an inter and intra day CV <3%. The method does not require more than 8 minutes for analysis with good peak resolution and low LOD 0.1 microg/ml and LOQ 0.3 microg/ml...
  28. doi Synthesis, characterization and biological activity of a series of carboxamide derivatives of ofloxacin
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Arch Pharm Res 33:1901-9. 2010
    ..The synthesized compounds showed diverse antimicrobial profiles. Among them, a few compounds possessed a comparable or better activity in comparison to the reference drug...
  29. ncbi Multivariate calibrations in UV spectrophotometric analysis
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:163-74. 2007
    ..Calibration techniques (used in the calibration step) differ in determining coefficient values for the preceding or similar equations...
  30. ncbi Cleaning validation of ofloxacin on pharmaceutical manufacturing equipment and validation of desired HPLC method
    M Saeed Arayne
    Department of Chemistry, University of Karachi 75270, Pakistan
    PDA J Pharm Sci Technol 62:353-61. 2008
    ..This confirms that the desired level of cleanliness is achieved using the current cleaning procedures, which were consequently validated...
  31. ncbi In vitro availability of atorvastatin in presence of losartan
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 19:134-41. 2006
    ..4 and 9. This high availability of one drug in presence of other is attributed to the formation of a charge-transfer complex, which was stable at elevated temperatures, except at 60 degrees C in pH 1...
  32. ncbi Simultaneous determination of gliquidone, pioglitazone hydrochloride, and verapamil in formulation and human serum by RP-HPLC
    M Saeed Arayne
    Lab 9, Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    J Chromatogr Sci 49:114-7. 2011
    ..There were no interfering peaks due to the excipients present in the pharmaceutical tablets. Thus, the proposed method is simple and suitable for the simultaneous analysis of active ingredients in dosage forms and human serum...
  33. ncbi Development and validation of stability-indicating HPLC method for the simultaneous determination of paracetamol, tizanidine, and diclofenac in pharmaceuticals and human serum
    Farhan Ahmed Siddiqui
    University of Karachi, Department of Chemistry, Karachi 75270, Pakistan
    J AOAC Int 94:150-8. 2011
    ..The developed method, after being validated in terms of precision, robustness, recovery, LOD, and LOQ, was successively applied to the analysis of pharmaceutical formulations and human serum...
  34. ncbi In vitro interaction studies of diltiazem with NSAID's using UV spectrophotometry and RP-HPLC techniques
    Najma Sultana
    Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi 75270
    Pak J Pharm Sci 20:202-13. 2007
    ..Present study clearly indicated that most of the NSAID's studied bind to DTZ forming charge transfer complexes, evident from the high availability of DTZ. Hence, concurrent administration of NSAID's with DTZ is not recommended...
  35. ncbi Fabrication of solid nanoparticles for drug delivery
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:251-9. 2007
    ..The former two techniques are mostly used to fabricate porous nanoparticles. Present paper reviews these techniques so as to give an idea to those planning to start with the fabrication of nanoparticles in a particular area of interest...
  36. ncbi Validated RP-HPLC method for determination of permethrin in bulk and topical preparations using UV-vis detector
    M Saeed Arayne
    Room 09, Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    J Chromatogr Sci 49:287-91. 2011
    ..The method was validated as per ICH guidelines and USP requirements and found advantageous for the routine analysis of the drug in pharmaceutical formulations and in pharmaceutical investigations involving permethrin...
  37. ncbi The berberis story: Berberis vulgaris in therapeutics
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:83-92. 2007
    ..It is the most widely used drug in Homeopathic system of medicine for kidney pain and for removal of kidney stones. In this article, we present countless blessings of nature encountered through this herb which are worthy of recording...
  38. ncbi A new RP-HPLC method for analysis of mebeverine hydrochloride in raw materials and tablets
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 18:11-4. 2005
    ..It was possible to determine all of them in the concentration range of 5-30 nano grams. The detection limit of mebeverine hydrochloride was 0.4-nano gram...
  39. ncbi In vitro interactions of captopril with NSAID's
    Najma Sultana
    Department of Pharmaceutical Chemistry, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 19:202-7. 2006
    ..Accordingly coadministration of both the drugs should be avoided...
  40. ncbi Review: nanoparticles in drug delivery for the treatment of cancer
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 19:258-68. 2006
    ..Among the newly developed nanomedicine and nanodevices such as quantum dots, nanowires, nanotubes, nanocantilevers, and nanopores, nanoshells and nanoparticles are the most promising applications for various cancer treatments...
  41. ncbi Interaction studies of omeprazole with mefloquine, pyrimethamine and sulfadoxine
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 19:314-21. 2006
    ..The effect of dissolution mediums, simulating various body environments with respect to pH and the influence of temperature on these interactions has been examined in order to elucidate the mechanism of these interactions...
  42. ncbi Quantitation of buclizine hydrochloride in pharmaceutical formulations and human serum by RP-HPLC
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 19:326-9. 2006
    ..07 to 100.34. The proposed method was validated for selectivity, linearity, accuracy, and precision. The method was found to be suitable for the quality control of buclizine hydrochloride in bulk drug as well as in human serum...
  43. ncbi A rp-HPLC method for the assay of cefpirome and its application in drug-metal interaction studies
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 19:39-44. 2006
    ..The order of complexation was ferric>chromium>copper>nickel>cadmium>zinc>magnesium>manganese>calcium>cobalt...
  44. ncbi Liquid chromatographic method for the simultaneous determination of captopril, piroxicam, and amlodipine in bulk drug, pharmaceutical formulation, and human serum by programming the detector
    Najma Sultana
    Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan
    J Sep Sci 36:3176-83. 2013
    ..This method is applicable for the analysis of drugs in bulk drug, tablets, serum, and in clinical samples without interference of excipients or endogenous serum components. ..
  45. ncbi A new RP-HPLC method for analysis of meloxicam in tablets
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 18:58-62. 2005
    ..27 % to 100.06 %. Piroxicam was used as an internal standard. The proposed method is rapid, accurate and selective; it may be used for the quantitative analysis of meloxicam from raw materials, in bulk drugs and other dosage formulations...
  46. ncbi Review: nanoparticles in delivery of cardiovascular drugs
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:340-8. 2007
    ..Also how nanocarriers are improving molecular imaging to help improve diagnosis and treatment of cardiovascular disease is focused in this article...
  47. ncbi Simultaneous determination of olmesartan medoxomil and irbesartan and hydrochlorothiazide in pharmaceutical formulations and human serum using high performance liquid chromatography
    Najma Sultana
    Department of Pharmaceutical Chemistry, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
    Se Pu 26:544-9. 2008
    ....
  48. ncbi In vitro release of tetracyclines in presence of H2-receptor antagonists
    Abid Iftikhar
    Faculty of Pharmacy, Hamdard University, Karachi
    Pak J Pharm Sci 18:55-60. 2005
    ..An attempt was made to elucidate the mechanism of this effect...
  49. ncbi In vitro availability of lomefloxacin hydrochloride in presence of essential and trace elements
    Najma Sultana
    Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 18:59-65. 2005
    ..e., Staphylococcus aureus, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Bacillus fragilis and Streptococcus pneumonia by disc diffusion method to measure the inhibitory zone and MIC were determined by tube dilution method...
  50. pmc Identification of anti-inflammatory and other biological activities of 3-carboxamide, 3-carbohydrazide and ester derivatives of gatifloxacin
    Najma Sultana
    Department of Chemistry, University of Karachi, Karachi, Pakistan
    Chem Cent J 7:6. 2013
    ..The methodology allows the introduction of a variety of substituents such as amines, alcohol, phenol, amides and alkyl halides into the core structure of gatifloxacin...
  51. ncbi Porous nanoparticles in drug delivery systems
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 19:158-69. 2006
    ..This article will highlight rational approaches in design and surface engineering of nanoscale vehicles and entities for site-specific drug delivery. Potential pitfalls or side effects associated with nanoparticles are also discussed...
  52. ncbi Synthesis and antibacterial activity of cephradine metal complexes : part II complexes with cobalt, copper, zinc and cadmium
    Najma Sultana
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Pakistan
    Pak J Pharm Sci 18:36-42. 2005
    ..Our investigations reveal that formation of complexes results in decrease in antibacterial activity of cephradine and MIC values are increased...
  53. ncbi Synthesis and characterization of gliclazide complexes of magnesium, calcium, chromium, manganese, iron, nickel, copper, zinc and cadmium salts
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 18:35-40. 2005
    ..These complexes were characterized through physical characteristics, IR, H(1)-NMR, and atomic absorption spectroscopic studies...
  54. ncbi In vitro availability of trimethylphloroglucinol and its degradation product from dosage formulations by RP-HPLC
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 18:7-12. 2005
    ..It was possible to determine both phloroglucinol and trimethylphloroglucinol in the concentration range of 5 nano gram to 30 nano grams. The detection limit of both phloroglucinol and trimethylphloroglucinol were 0.4 nano gram...
  55. ncbi Grape fruit juice-drug interactions
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270
    Pak J Pharm Sci 18:45-57. 2005
    ..A recent investigation indicated that neither of these substances made a major contribution to grapefruit juice-drug interactions in humans (Guo et al., 2000)...
  56. ncbi Hypogylcemic activity of aqueous extract of some indigenous plants
    Bushra Khan
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 18:62-4. 2005
    ..The results in three different media revealed that, hypoglycemic activity is more prominent in neutral and basic media as compared to acidic medium...