H Raza

Summary

Affiliation: Faculty of Medicine and Health Sciences
Country: United Arab Emirates

Publications

  1. doi request reprint Short-term effects of nose-only cigarette smoke exposure on glutathione redox homeostasis, cytochrome P450 1A1/2 and respiratory enzyme activities in mice tissues
    Haider Raza
    Department of Biochemistry College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Cell Physiol Biochem 31:683-92. 2013
  2. pmc Alterations in glutathione redox metabolism, oxidative stress, and mitochondrial function in the left ventricle of elderly zucker diabetic Fatty rat heart
    Haider Raza
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, P O Box 17666, UAE
    Int J Mol Sci 13:16241-54. 2012
  3. pmc Implications of altered glutathione metabolism in aspirin-induced oxidative stress and mitochondrial dysfunction in HepG2 cells
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates UAE University, Al Ain, United Arab Emirates
    PLoS ONE 7:e36325. 2012
  4. ncbi request reprint Green tea polyphenol epigallocatechin-3-gallate differentially modulates oxidative stress in PC12 cell compartments
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
    Toxicol Appl Pharmacol 207:212-20. 2005
  5. ncbi request reprint 4-hydroxynonenal induces mitochondrial oxidative stress, apoptosis and expression of glutathione S-transferase A4-4 and cytochrome P450 2E1 in PC12 cells
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, PO Box 17666, UAE University, Al Ain, United Arab Emirates
    Toxicol Appl Pharmacol 216:309-18. 2006
  6. ncbi request reprint In vitro protection of reactive oxygen species-induced degradation of lipids, proteins and 2-deoxyribose by tea catechins
    H Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, P O Box 17666, UAE University, Al Ain, United Arab Emirates
    Food Chem Toxicol 45:1814-20. 2007
  7. ncbi request reprint Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, POBox 17666, Al Ain, United Arab Emirates
    Toxicol Appl Pharmacol 226:161-8. 2008
  8. doi request reprint Acetylsalicylic acid-induced oxidative stress, cell cycle arrest, apoptosis and mitochondrial dysfunction in human hepatoma HepG2 cells
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, POBox 17666, Al Ain, United Arab Emirates
    Eur J Pharmacol 668:15-24. 2011
  9. pmc Dual localization of glutathione S-transferase in the cytosol and mitochondria: implications in oxidative stress, toxicity and disease
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, Al Ain, UAE
    FEBS J 278:4243-51. 2011
  10. ncbi request reprint Flavin-containing monooxygenase activity in camel tissues: comparison with rat and human liver enzymes
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, P O Box 17666, UAE University, Al Ain, United Arab Emirates
    Comp Biochem Physiol C Toxicol Pharmacol 139:289-93. 2004

Collaborators

Detail Information

Publications31

  1. doi request reprint Short-term effects of nose-only cigarette smoke exposure on glutathione redox homeostasis, cytochrome P450 1A1/2 and respiratory enzyme activities in mice tissues
    Haider Raza
    Department of Biochemistry College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Cell Physiol Biochem 31:683-92. 2013
    ..Recently, we have also shown increased oxidative stress and associated inflammatory responses in various tissues after exposure to cigarette smoke...
  2. pmc Alterations in glutathione redox metabolism, oxidative stress, and mitochondrial function in the left ventricle of elderly zucker diabetic Fatty rat heart
    Haider Raza
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, P O Box 17666, UAE
    Int J Mol Sci 13:16241-54. 2012
    ..These results might have implications in the elucidation of the mechanism of disease progression and designing strategies for diabetes prevention...
  3. pmc Implications of altered glutathione metabolism in aspirin-induced oxidative stress and mitochondrial dysfunction in HepG2 cells
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates UAE University, Al Ain, United Arab Emirates
    PLoS ONE 7:e36325. 2012
    ..Our results strongly suggest that GSH dependent redox homeostasis in HepG2 cells is critical in preserving mitochondrial functions and preventing oxidative stress associated complications caused by aspirin treatment...
  4. ncbi request reprint Green tea polyphenol epigallocatechin-3-gallate differentially modulates oxidative stress in PC12 cell compartments
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
    Toxicol Appl Pharmacol 207:212-20. 2005
    ..These results may have implications in determining the chemopreventive therapeutic use of tea polyphenols in vivo...
  5. ncbi request reprint 4-hydroxynonenal induces mitochondrial oxidative stress, apoptosis and expression of glutathione S-transferase A4-4 and cytochrome P450 2E1 in PC12 cells
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, PO Box 17666, UAE University, Al Ain, United Arab Emirates
    Toxicol Appl Pharmacol 216:309-18. 2006
    ..These results suggest that HNE-induced oxidative stress and apoptosis might be associated with altered mitochondrial functions and a compromised GSH metabolism and ROS clearance...
  6. ncbi request reprint In vitro protection of reactive oxygen species-induced degradation of lipids, proteins and 2-deoxyribose by tea catechins
    H Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, P O Box 17666, UAE University, Al Ain, United Arab Emirates
    Food Chem Toxicol 45:1814-20. 2007
    ..These results may have implications in determining the chemotherapeutic use of tea catechins in oxidative stress related diseases...
  7. ncbi request reprint Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, POBox 17666, Al Ain, United Arab Emirates
    Toxicol Appl Pharmacol 226:161-8. 2008
    ..The alterations in mitochondrial energy metabolism and redox functions may therefore be critical in determining the difference between cell death and survival...
  8. doi request reprint Acetylsalicylic acid-induced oxidative stress, cell cycle arrest, apoptosis and mitochondrial dysfunction in human hepatoma HepG2 cells
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, POBox 17666, Al Ain, United Arab Emirates
    Eur J Pharmacol 668:15-24. 2011
    ..These findings strongly suggest that ASA-induced toxicity in human hepatoma HepG2 cells is mediated by increased metabolic and oxidative stress, accompanied by mitochondrial dysfunction which result in apoptosis...
  9. pmc Dual localization of glutathione S-transferase in the cytosol and mitochondria: implications in oxidative stress, toxicity and disease
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, Al Ain, UAE
    FEBS J 278:4243-51. 2011
    ..Both physiological and pathophysiological implications of GST translocation to mitochondria are discussed in the review...
  10. ncbi request reprint Flavin-containing monooxygenase activity in camel tissues: comparison with rat and human liver enzymes
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, P O Box 17666, UAE University, Al Ain, United Arab Emirates
    Comp Biochem Physiol C Toxicol Pharmacol 139:289-93. 2004
    ..These results may help in better understanding the effects of pharmacologically and toxicologically active compounds administered to camels...
  11. ncbi request reprint Glutathione metabolism and oxidative stress in neonatal rat tissues from streptozotocin-induced diabetic mothers
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, UAE
    Diabetes Metab Res Rev 20:72-8. 2004
    ..Diabetes in pregnancy has been reported to cause congenital malformations in the offspring. Hyperglycemia-induced teratogenicity is related to the increased oxidative stress and depletion of glutathione (GSH) in fetal tissues...
  12. ncbi request reprint Tissue specific expression and immunohistochemical localization of glutathione S-transferase in streptozotocin induced diabetic rats: modulation by Momordica charantia (karela) extract
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, P O Box 17666, Al Ain, United Arab Emirates
    Life Sci 74:1503-11. 2004
    ..These results suggest that glutathione metabolism and GST distribution in the tissues of diabetic rats may play an important role in the etiology, pathology and prevention of diabetes...
  13. ncbi request reprint Modulation of xenobiotic metabolism and oxidative stress in chronic streptozotocin-induced diabetic rats fed with Momordica charantia fruit extract
    H Raza
    Department of Biochemistry Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    J Biochem Mol Toxicol 14:131-9. 2000
    ..The findings may have significant implications in elucidating the therapeutic use of antidiabetic drugs and management of Type 1 diabetes in chronic diabetic patients...
  14. ncbi request reprint Differential modulation of growth and glutathione metabolism in cultured rat astrocytes by 4-hydroxynonenal and green tea polyphenol, epigallocatechin-3-gallate
    I Ahmed
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Neurotoxicology 23:289-300. 2002
    ..However, HNE seems to be a stronger apoptotic and cytotoxic agent than EGCG. These results suggest that HNE and EGCG differentially modulate oxidative stress and regulate the growth and survival of astrocytes...
  15. doi request reprint Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, UAE
    Chem Biol Drug Des 72:58-64. 2008
    ....
  16. ncbi request reprint Effect of bitter melon (Momordica charantia) fruit juice on the hepatic cytochrome P450-dependent monooxygenases and glutathione S-transferases in streptozotocin-induced diabetic rats
    H Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Biochem Pharmacol 52:1639-42. 1996
    ..In addition, we have also observed that karela does not always reverse the effects on drug-metabolizing enzymes in STZ-induced diabetes...
  17. ncbi request reprint Hypotriglyceridemic and hypocholesterolemic effects of anti-diabetic Momordica charantia (karela) fruit extract in streptozotocin-induced diabetic rats
    I Ahmed
    Departments of Anatomy and Biochemistry, Faculty of Medicine and Health Sciences, UAE University, P.O. Box 17666, Al Ain, United Arab Emirates
    Diabetes Res Clin Pract 51:155-61. 2001
    ..These results suggest that M. charantia fruit extract exhibits hypolipidemic as well as hypoglycemic effects in the STZ-induced diabetic rat...
  18. doi request reprint In vitro effects of tea polyphenols on redox metabolism, oxidative stress, and apoptosis in PC12 cells
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Ann N Y Acad Sci 1138:358-65. 2008
    ..These results may have implications in determining the chemopreventive and therapeutic use of tea catechins in vivo...
  19. ncbi request reprint Multiplicity and tissue specific expression of camel cytochrome P450(s)
    H Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 121:205-11. 1998
    ..These observations may be important in understanding the differential susceptibility of camel tissues to the toxic/therapeutic effects of xenobiotics/drugs and environmental pollution...
  20. doi request reprint Increased mitochondrial stress and modulation of mitochondrial respiratory enzyme activities in acetaminophen-induced toxicity in mouse macrophage cells
    Thekra Al-Belooshi
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, United Arab Emirates
    Food Chem Toxicol 48:2624-32. 2010
    ..The study may have long term implications to better understand the role of macrophages in the toxicology and pharmacology of APAP...
  21. doi request reprint Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Comp Biochem Physiol C Toxicol Pharmacol 150:150-4. 2009
    ..This component contains an Ala-Met bond that constitutes the scissile bond in the selective elastase inhibitor, elafin but the peptide did not inhibit pancreatic elastase at concentrations up to 100 microM...
  22. ncbi request reprint Effect of aminoisobutyric acid (Aib) substitutions on the antimicrobial and cytolytic activities of the frog skin peptide, temporin-1DRa
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 28:2075-80. 2007
    ....
  23. ncbi request reprint Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Toxicon 50:498-506. 2007
    ....
  24. ncbi request reprint Cloning, characterisation and bacterial expression of full length cDNA for the mouse liver microsomal glutathione S-transferase
    H Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Oncol Rep 7:645-9. 2000
    ..These results should facilitate studies on the role of MGST in the regulation of chemical carcinogenesis and in the prevention of oxidative stress caused by endogenous and exogenous chemicals...
  25. doi request reprint Contractility of ventricular myocytes is well preserved despite altered mechanisms of Ca2+ transport and a changing pattern of mRNA in aged type 2 Zucker diabetic fatty rat heart
    F C Howarth
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
    Mol Cell Biochem 361:267-80. 2012
    ....
  26. ncbi request reprint Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: tissue-specific variations and roles in oxidative stress
    Haider Raza
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Diabetes 53:185-94. 2004
    ..These results indicate, for the first time, a marked increase in mitochondrial oxidative stress in target tissues of STZ-treated rats and implicate a direct role for mitochondrial CYP2E1 in the generation of intramitochondrial ROS...
  27. ncbi request reprint Protein kinase A-mediated phosphorylation modulates cytochrome c oxidase function and augments hypoxia and myocardial ischemia-related injury
    Subbuswamy K Prabu
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    J Biol Chem 281:2061-70. 2006
    ..Our results pointed to an exciting possibility of using CcO activity modulators for controlling myocardial injury associated with ischemia and oxidative stress conditions...
  28. pmc Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress
    Haider Raza
    Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6047, U S A
    Biochem J 366:45-55. 2002
    ..Our results suggest that mitochondrial GSTs may play an important role in defence against chemical and oxidative stress...
  29. ncbi request reprint Phosphorylation enhances mitochondrial targeting of GSTA4-4 through increased affinity for binding to cytoplasmic Hsp70
    Marie Anne Robin
    Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:18960-70. 2003
    ..We demonstrate for the first time that PKA and PKC modulate the cytoplasmic and mitochondrial pools of GSTA4-4...
  30. ncbi request reprint Bioinformatic and enzymatic characterization of the MAPEG superfamily
    Anders Bresell
    IFM Bioinformatics, Linkoping University, Sweden
    FEBS J 272:1688-703. 2005
    ....
  31. pmc Site specific phosphorylation of cytochrome c oxidase subunits I, IVi1 and Vb in rabbit hearts subjected to ischemia/reperfusion
    Ji Kang Fang
    Laboratory of Biochemistry, The Department of Animal Biology, School of Veterinary Medicine, 3800 Spruce Street, University of Pennsylvania, Philadelphia, PA 19104, United States
    FEBS Lett 581:1302-10. 2007
    ..These sites are highly conserved in mammalian species. Molecular modeling suggests that phosphorylation sites of subunit I face the inter membrane space while those of subunits IVi1 and Vb face the matrix side...