Abderrahim Nemmar

Summary

Affiliation: Faculty of Medicine and Health Sciences
Country: United Arab Emirates

Publications

  1. doi request reprint Short-term systemic effects of nose-only cigarette smoke exposure in mice: role of oxidative stress
    Abderrahim Nemmar
    Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
    Cell Physiol Biochem 31:15-24. 2013
  2. doi request reprint Evaluation of the pulmonary effects of short-term nose-only cigarette smoke exposure in mice
    Abderrahim Nemmar
    Department of Physiology, United Arab Emirates University, PO Box 17666, Al Ain, UAE
    Exp Biol Med (Maywood) 237:1449-56. 2012
  3. pmc Protective effect of curcumin on pulmonary and cardiovascular effects induced by repeated exposure to diesel exhaust particles in mice
    Abderrahim Nemmar
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    PLoS ONE 7:e39554. 2012
  4. ncbi request reprint Diesel exhaust particles in blood trigger systemic and pulmonary morphological alterations
    Abderrahim Nemmar
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666, Al Ain, United Arab Emirates
    Toxicol Lett 176:20-30. 2008
  5. doi request reprint The acute proinflammatory and prothrombotic effects of pulmonary exposure to rutile TiO2 nanorods in rats
    Abderrahim Nemmar
    Faculty of Medicine and Health Sciences, Department of Physiology, United Arab Emirates University, PO Box 17666, Al Ain, UAE
    Exp Biol Med (Maywood) 233:610-9. 2008
  6. ncbi request reprint Evaluation of the direct systemic and cardiopulmonary effects of diesel particles in spontaneously hypertensive rats
    Abderrahim Nemmar
    Department of Physiology, United Arab Emirates University, Al Ain, United Arab Emirates
    Toxicology 262:50-6. 2009
  7. pmc Contrasting actions of diesel exhaust particles on the pulmonary and cardiovascular systems and the effects of thymoquinone
    Abderrahim Nemmar
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
    Br J Pharmacol 164:1871-82. 2011
  8. doi request reprint Pulmonary exposure to diesel exhaust particles promotes cerebral microvessel thrombosis: protective effect of a cysteine prodrug l-2-oxothiazolidine-4-carboxylic acid
    Abderrahim Nemmar
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666, Al Ain, United Arab Emirates
    Toxicology 263:84-92. 2009
  9. doi request reprint Diesel exhaust particles in the lung aggravate experimental acute renal failure
    Abderrahim Nemmar
    Department of Physiology, United Arab Emirates University, Al Ain, United Arab Emirates
    Toxicol Sci 113:267-77. 2010
  10. doi request reprint Time-course effects of systemically administered diesel exhaust particles in rats
    Abderrahim Nemmar
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates
    Toxicol Lett 194:58-65. 2010

Collaborators

Detail Information

Publications38

  1. doi request reprint Short-term systemic effects of nose-only cigarette smoke exposure in mice: role of oxidative stress
    Abderrahim Nemmar
    Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
    Cell Physiol Biochem 31:15-24. 2013
    ..However, data on the systemic effects of short-term CS exposure (STCSE) are scarce. Presently, using a nose-only exposure system, we evaluated the systemic effects of STCSE in mice...
  2. doi request reprint Evaluation of the pulmonary effects of short-term nose-only cigarette smoke exposure in mice
    Abderrahim Nemmar
    Department of Physiology, United Arab Emirates University, PO Box 17666, Al Ain, UAE
    Exp Biol Med (Maywood) 237:1449-56. 2012
    ..In conclusion, our data indicate that short-term nose-only exposure to CS causes lung inflammation and increase of airway resistance mediated at least partly through the oxidative stress...
  3. pmc Protective effect of curcumin on pulmonary and cardiovascular effects induced by repeated exposure to diesel exhaust particles in mice
    Abderrahim Nemmar
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    PLoS ONE 7:e39554. 2012
    ..Our findings indicate that curcumin is a potent anti-inflammatory agent that prevents the release of TNFα and protects against the pulmonary and cardiovascular effects of DEP...
  4. ncbi request reprint Diesel exhaust particles in blood trigger systemic and pulmonary morphological alterations
    Abderrahim Nemmar
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666, Al Ain, United Arab Emirates
    Toxicol Lett 176:20-30. 2008
    ..We conclude that 48h after their systemic administration, DEP cause systemic and pulmonary morphological alterations...
  5. doi request reprint The acute proinflammatory and prothrombotic effects of pulmonary exposure to rutile TiO2 nanorods in rats
    Abderrahim Nemmar
    Faculty of Medicine and Health Sciences, Department of Physiology, United Arab Emirates University, PO Box 17666, Al Ain, UAE
    Exp Biol Med (Maywood) 233:610-9. 2008
    ..Rutile TiO2 nanorods also triggered platelet aggregation in vivo and in vitro...
  6. ncbi request reprint Evaluation of the direct systemic and cardiopulmonary effects of diesel particles in spontaneously hypertensive rats
    Abderrahim Nemmar
    Department of Physiology, United Arab Emirates University, Al Ain, United Arab Emirates
    Toxicology 262:50-6. 2009
    ..We conclude that, in SHR, the presence of DEP in the systemic circulation leads not only to cardiac and systemic changes, but also triggers pulmonary inflammatory reaction involving IL-6, LTB4 and oxidative stress...
  7. pmc Contrasting actions of diesel exhaust particles on the pulmonary and cardiovascular systems and the effects of thymoquinone
    Abderrahim Nemmar
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
    Br J Pharmacol 164:1871-82. 2011
    ..Thymoquinone also prevented the decrease in platelet numbers and the prothrombotic events but not platelet aggregation in vitro...
  8. doi request reprint Pulmonary exposure to diesel exhaust particles promotes cerebral microvessel thrombosis: protective effect of a cysteine prodrug l-2-oxothiazolidine-4-carboxylic acid
    Abderrahim Nemmar
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666, Al Ain, United Arab Emirates
    Toxicology 263:84-92. 2009
    ..OTC pretreatment abrogated these effects through its ability to balance oxidant-antioxidant status...
  9. doi request reprint Diesel exhaust particles in the lung aggravate experimental acute renal failure
    Abderrahim Nemmar
    Department of Physiology, United Arab Emirates University, Al Ain, United Arab Emirates
    Toxicol Sci 113:267-77. 2010
    ..These included marked interstitial cell infiltration and congestion. We conclude that the presence of DEP in the lung aggravated the renal, pulmonary, and systemic effects of CP-induced ARF...
  10. doi request reprint Time-course effects of systemically administered diesel exhaust particles in rats
    Abderrahim Nemmar
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates
    Toxicol Lett 194:58-65. 2010
    ....
  11. doi request reprint Exacerbation of thrombotic events by diesel exhaust particle in mouse model of hypertension
    Abderrahim Nemmar
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
    Toxicology 285:39-45. 2011
    ..Our findings, therefore, provide a possible plausible explanation for the cardiovascular morbidity and mortality accompanying urban air pollution...
  12. doi request reprint Airway resistance, inflammation and oxidative stress following exposure to diesel exhaust particle in angiotensin II-induced hypertension in mice
    Abderrahim Nemmar
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666, Al Ain, United Arab Emirates
    Toxicology 292:162-8. 2012
    ..On the contrary, at the dose of DEP and time point investigated, airway resistance, inflammation and oxidative stress are increased in normotensive compared to hypertensive mice...
  13. doi request reprint Acute respiratory and systemic toxicity of pulmonary exposure to rutile Fe-doped TiO(2) nanorods
    Abderrahim Nemmar
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666, Al Ain, United Arab Emirates
    Toxicology 279:167-75. 2011
    ..It affects the liver, enhances thrombotic potential, heart rate and systolic blood pressure. Moreover, the rutile Fe-TiO₂ elicited direct toxicity on NCI-H460-Luc2 and HepG2 cells...
  14. doi request reprint Short-term effects of nose-only cigarette smoke exposure on glutathione redox homeostasis, cytochrome P450 1A1/2 and respiratory enzyme activities in mice tissues
    Haider Raza
    Department of Biochemistry College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Cell Physiol Biochem 31:683-92. 2013
    ..Recently, we have also shown increased oxidative stress and associated inflammatory responses in various tissues after exposure to cigarette smoke...
  15. ncbi request reprint Cardiovascular and lung inflammatory effects induced by systemically administered diesel exhaust particles in rats
    Abderrahim Nemmar
    Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Sultanate of Oman
    Am J Physiol Lung Cell Mol Physiol 292:L664-70. 2007
    ..We conclude that the presence of DEP in the systemic circulation leads not only to cardiovascular and haemostatic changes but it also triggers pulmonary inflammation...
  16. doi request reprint Influence of experimental type 1 diabetes on the pulmonary effects of diesel exhaust particles in mice
    Abderrahim Nemmar
    Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666, Al Ain, United Arab Emirates
    Toxicol Lett 217:170-6. 2013
    ....
  17. doi request reprint Cardiovascular effects of nose-only water-pipe smoking exposure in mice
    Abderrahim Nemmar
    Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    Am J Physiol Heart Circ Physiol 305:H740-6. 2013
    ..We conclude that 1-mo nose-only exposure to WPS increased SBP and caused cardiac inflammation, oxidative stress, and prothrombotic events. Our findings provide plausible elucidation that WPS is injurious to the cardiovascular system. ..
  18. doi request reprint Interaction of diesel exhaust particles with human, rat and mouse erythrocytes in vitro
    Abderrahim Nemmar
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
    Cell Physiol Biochem 29:163-70. 2012
    ..Human erythrocytes showed the highest resistance to the observed effects. These species difference should be noted when using rats and mice blood as models for humans...
  19. doi request reprint Nose-only water-pipe smoking effects on airway resistance, inflammation, and oxidative stress in mice
    Abderrahim Nemmar
    Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    J Appl Physiol (1985) 115:1316-23. 2013
    ..Our results provide a mechanistic explanation for the limited clinical studies that reported the detrimental respiratory effects of WPS. ..
  20. ncbi request reprint Pancreatic effects of diesel exhaust particles in mice with type 1 diabetes mellitus
    Abderrahim Nemmar
    Department of Physiology, United Arab Emirates University, College of Medicine and Health Sciences, Al Ain, United Arab Emirates
    Cell Physiol Biochem 33:413-22. 2014
    ..We recently demonstrated an increased cardiovascular and respiratory susceptibility to diesel exhaust particles (DEP) in mice with type 1 diabetes. However, the pancreatic effects of DEP in healthy and diabetic mice are unknown...
  21. ncbi request reprint Amorphous silica nanoparticles impair vascular homeostasis and induce systemic inflammation
    Abderrahim Nemmar
    Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    Int J Nanomedicine 9:2779-89. 2014
    ..Overall, the effects observed with 50 nm SiNPs were more pronounced than those with 500 nm SiNPs. These findings provide new insight into the deleterious effect of amorphous SiNPs on vascular homeostasis. ..
  22. ncbi request reprint Short-term effects of oral administration of Pistacia lentiscus oil on tissue-specific toxicity and drug metabolizing enzymes in mice
    Samir Attoub
    Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    Cell Physiol Biochem 33:1400-10. 2014
    ..The aim of this study was to assess whether Pistacia lentiscus oil has any short term toxic effects in vivo and in vitro...
  23. doi request reprint Frondoside A inhibits human breast cancer cell survival, migration, invasion and the growth of breast tumor xenografts
    Nadia Al Marzouqi
    Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, UAE University, Al Ain, PO Box 17666, United Arab Emirates
    Eur J Pharmacol 668:25-34. 2011
    ..Moreover, we found that Frondoside A could enhance the killing of breast cancer cells induced by the chemotherapeutic agent paclitaxel. These findings identify Frondoside A as a promising novel therapeutic agent for breast cancer...
  24. pmc Recent advances in particulate matter and nanoparticle toxicology: a review of the in vivo and in vitro studies
    Abderrahim Nemmar
    Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, UAE
    Biomed Res Int 2013:279371. 2013
    ..In the present review, we discuss the current advances on the toxicology of particulate matter and nanoparticles based on these techniques. ..
  25. pmc Vitamin E ameliorates the decremental effect of paraquat on cardiomyocyte contractility in rats
    Mohamed Abdelmonem Fahim
    Department of Physiology, Faculty of Medicine, United Arab Emirates University, Al Ain, United Arab Emirates
    PLoS ONE 8:e57651. 2013
    ..The mechanisms of PAR induced myocardial dysfunction and the impact of antioxidant protection was investigated in rat ventricular myocytes...
  26. ncbi request reprint Ultrafine particles affect experimental thrombosis in an in vivo hamster model
    Abderrahim Nemmar
    Laboratory of Pneumology, Unit of Lung Toxicology, K U Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Am J Respir Crit Care Med 166:998-1004. 2002
    ..The observed in vivo prothrombotic tendency results, at least in part, from platelet activation by positively charged amine-polystyrene particles...
  27. ncbi request reprint Pharmacological stabilization of mast cells abrogates late thrombotic events induced by diesel exhaust particles in hamsters
    Abderrahim Nemmar
    Laboratory of Pneumology, Lung Toxicology Unit, Katholieke Universiteit Leuven, Leuven, Belgium
    Circulation 110:1670-7. 2004
    ..Particulate air pollution is associated with cardiovascular diseases and myocardial infarction (MI)...
  28. ncbi request reprint Possible mechanisms of the cardiovascular effects of inhaled particles: systemic translocation and prothrombotic effects
    Abderrahim Nemmar
    Laboratory of Pneumology, Unit of Lung Toxicology, K U Leuven, Herestraat, 49, Leuven 3000, Belgium
    Toxicol Lett 149:243-53. 2004
    ..These effects persisted up to 24 h after instillation. Our results provide plausible mechanistic explanations for the epidemiologically established link between air pollution and acute cardiovascular effects...
  29. ncbi request reprint Diesel exhaust particles in lung acutely enhance experimental peripheral thrombosis
    Abderrahim Nemmar
    Laboratory of Pneumology, Unit of Lung Toxicology, Kapholieke Universiteit Leuven, Leuven, Belgium
    Circulation 107:1202-8. 2003
    ..Pollution by particulates has consistently been associated with increased cardiovascular morbidity and mortality, but a plausible biological basis for this association is lacking...
  30. ncbi request reprint Quantification of extrapulmonary translocation of intratracheal-instilled particles in vivo in rats: effect of lipopolysaccharide
    Jianmin Chen
    Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
    Toxicology 222:195-201. 2006
    ..Thus, pulmonary inflammation seems to play a major role in enhancing the extrapulmonary translocation of particles...
  31. ncbi request reprint Effects of particulate air pollution on hemostasis
    Abderrahim Nemmar
    K U Leuven, Laboratory of Pneumology Unit of Lung Toxicology, Herestraat 49, B 3000, Leuven, Belgium
    Clin Occup Environ Med 5:865-81. 2006
    ..Despite recent advances, additional studies are needed to investigate the pathophysiologic mechanisms linking particulate air pollution and hemostasis...
  32. ncbi request reprint Size effect of intratracheally instilled particles on pulmonary inflammation and vascular thrombosis
    Abderrahim Nemmar
    Laboratory of Pneumology Lung Toxicology, KULeuven, B 3000 Leuven, Belgium
    Toxicol Appl Pharmacol 186:38-45. 2003
    ..Positive UFPs, but not the 400-nm particles enhance thrombosis. Hence, particle-induced lung inflammation and thrombogenesis can be partially uncoupled...
  33. ncbi request reprint Pulmonary inflammation and thrombogenicity caused by diesel particles in hamsters: role of histamine
    Abderrahim Nemmar
    Laboratory of Pneumology Lung Toxicity and Center for Molecular and Vascular Biology, K U Leuven, Leuven, Belgium
    Am J Respir Crit Care Med 168:1366-72. 2003
    ....
  34. ncbi request reprint Health impact of nanomaterials?
    Peter H M Hoet
    Nat Biotechnol 22:19. 2004
  35. pmc Translocation of ultrafine particles
    Abderrahim Nemmar
    Environ Health Perspect 114:A211-2; author reply A212-3. 2006
  36. ncbi request reprint Silica particles enhance peripheral thrombosis: key role of lung macrophage-neutrophil cross-talk
    Abderrahim Nemmar
    K U Leuven, Laboratory of Pneumology, Unit of Lung Toxicology, Herestraat 49, B 3000 Leuven, Belgium
    Am J Respir Crit Care Med 171:872-9. 2005
    ..In addition, the consequences of pulmonary macrophage and circulating monocyte and neutrophil depletion on the thrombogenicity were investigated...
  37. ncbi request reprint Evaluation of particle translocation across the alveolo-capillary barrier in isolated perfused rabbit lung model
    Abderrahim Nemmar
    K U Leuven, Laboratory of Pneumology Lung Toxicology, Herestraat 49, B 3000 Leuven, Belgium
    Toxicology 208:105-13. 2005
    ..The relevance of these ex vivo findings for the in vivo translocation of inhaled ultrafine particles remains to be established...