Dietrich E Lorke

Summary

Affiliation: Faculty of Medicine and Health Sciences
Country: United Arab Emirates

Publications

  1. pmc Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients
    Dietrich E Lorke
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Box 17666, Al Ain, United Arab Emirates
    BMC Neurosci 7:36. 2006
  2. doi Increased number of microglia in the brain of severe combined immunodeficient (SCID) mice
    Dietrich E Lorke
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Box 17666, Al Ain, United Arab Emirates
    Histochem Cell Biol 130:693-7. 2008
  3. ncbi Entry of oximes into the brain: a review
    D E Lorke
    Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, POBox 17666, Al Ain, UAE
    Curr Med Chem 15:743-53. 2008
  4. ncbi TUNEL and growth factor expression in the prefrontal cortex of Alzheimer patients over 80 years old
    D E Lorke
    Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    Int J Immunopathol Pharmacol 23:13-23. 2010
  5. ncbi Methylene blue inhibits the function of α7-nicotinic acetylcholine receptors
    Abdulla S Al Mansouri
    Functional Lipidomics Branch, Department of Pharmacology, Faculty of Medicine and Health Sciences, UAE University, Abu Dhabi, Al Ain, 17666, UAE
    CNS Neurol Disord Drug Targets 11:791-800. 2012
  6. doi Pretreatment for acute exposure to diisopropylfluorophosphate: in vivo efficacy of various acetylcholinesterase inhibitors
    Dietrich E Lorke
    Department of Anatomy, FMHS, UAE University, Al Ain, UAE Department of Cellular Biology and Pharmacology, Florida International University, Miami, FL, USA
    J Appl Toxicol 31:515-23. 2011
  7. doi Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6
    D E Lorke
    Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
    Toxicol Mech Methods 19:327-33. 2009
  8. doi Minireview: does in-vitro testing of oximes help predict their in-vivo action after paraoxon exposure?
    D E Lorke
    Department of Anatomy, FMHS, UAE University, Al Ain, UAE
    J Appl Toxicol 29:459-69. 2009
  9. doi Efficacy of eight experimental bispyridinium oximes against paraoxon-induced mortality: comparison with the conventional oximes pralidoxime and obidoxime
    S M Nurulain
    Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17 666, Al Ain, United Arab Emirates
    Neurotox Res 16:60-7. 2009
  10. ncbi The organophosphate paraoxon has no demonstrable effect on the murine immune system following subchronic low dose exposure
    M J Fernandez-Cabezudo
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Int J Immunopathol Pharmacol 21:891-901. 2008

Collaborators

Detail Information

Publications21

  1. pmc Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients
    Dietrich E Lorke
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Box 17666, Al Ain, United Arab Emirates
    BMC Neurosci 7:36. 2006
    ..Cellular expressions of the two serotonergic receptors 5-HT2A and 5-HT6 have therefore been determined by immunohistochemistry in the prefrontal cortex of patients with AD (n=6) and normal age-matched controls (n = 7)...
  2. doi Increased number of microglia in the brain of severe combined immunodeficient (SCID) mice
    Dietrich E Lorke
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Box 17666, Al Ain, United Arab Emirates
    Histochem Cell Biol 130:693-7. 2008
    ..9-58.7%), followed by the fimbria hippocampi and the molecular layer of hippocampal CA1/CA3 region. These data need to be taken into account when using SCID mice as a model for microglial reaction in immunodeficient mice...
  3. ncbi Entry of oximes into the brain: a review
    D E Lorke
    Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, POBox 17666, Al Ain, UAE
    Curr Med Chem 15:743-53. 2008
    ..The clinical relevance of this effect is hotly debated. Possible strategies to improve brain penetration of oximes are discussed...
  4. ncbi TUNEL and growth factor expression in the prefrontal cortex of Alzheimer patients over 80 years old
    D E Lorke
    Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    Int J Immunopathol Pharmacol 23:13-23. 2010
    ..The distinct differences between younger and older AD patients suggest a faster progression of AD in older patients...
  5. ncbi Methylene blue inhibits the function of α7-nicotinic acetylcholine receptors
    Abdulla S Al Mansouri
    Functional Lipidomics Branch, Department of Pharmacology, Faculty of Medicine and Health Sciences, UAE University, Abu Dhabi, Al Ain, 17666, UAE
    CNS Neurol Disord Drug Targets 11:791-800. 2012
    ..These results demonstrate that MB inhibits the function of human α7 nAChRs expressed in Xenopus oocytes and of α7 nAChR-mediated responses in rat hippocampal neurons...
  6. doi Pretreatment for acute exposure to diisopropylfluorophosphate: in vivo efficacy of various acetylcholinesterase inhibitors
    Dietrich E Lorke
    Department of Anatomy, FMHS, UAE University, Al Ain, UAE Department of Cellular Biology and Pharmacology, Florida International University, Miami, FL, USA
    J Appl Toxicol 31:515-23. 2011
    ..K-27 may be a more efficacious alternative to pyridostigmine, when passage into the brain precludes administration of physostigmine or tacrine...
  7. doi Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6
    D E Lorke
    Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
    Toxicol Mech Methods 19:327-33. 2009
    ..05). Conclusion. Our data provide further evidence that K-27 is a very promising candidate for the treatment of intoxication with a broad spectrum of OPCs...
  8. doi Minireview: does in-vitro testing of oximes help predict their in-vivo action after paraoxon exposure?
    D E Lorke
    Department of Anatomy, FMHS, UAE University, Al Ain, UAE
    J Appl Toxicol 29:459-69. 2009
    ..These data highlight the good predictive value of in vitro IC(50) testing for in vivo toxicity and the limited practical significance of in vitro assessment of protective potency...
  9. doi Efficacy of eight experimental bispyridinium oximes against paraoxon-induced mortality: comparison with the conventional oximes pralidoxime and obidoxime
    S M Nurulain
    Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17 666, Al Ain, United Arab Emirates
    Neurotox Res 16:60-7. 2009
    ..Further studies in other species exposed to a broader spectrum of OPCs are, however, necessary before considering their use in humans...
  10. ncbi The organophosphate paraoxon has no demonstrable effect on the murine immune system following subchronic low dose exposure
    M J Fernandez-Cabezudo
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Int J Immunopathol Pharmacol 21:891-901. 2008
    ..These data suggest that although subchronic exposure to paraoxon induced a transient inhibition in AChE activity, it had no demonstrable effect on the host immune system...
  11. ncbi Pyridinium oxime reactivators of cholinesterase inhibited by diisopropyl-fluorophosphate (DFP): predictive value of in-vitro testing for in-vivo efficacy
    G A Petroianu
    Faculty of Medicine and Health Sciences, United Arab Emirates University, Department of Pharmacology and Therapeutics, P O Box 17 666, Al Ain UAE
    Mini Rev Med Chem 8:1328-42. 2008
    ..In vitro reactivation capacity of human red blood cell (RBC)-AChE has no predictive value for in vivo (rat) efficacy, at least in the case of DFP exposure...
  12. doi Eight new bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: in vivo efficacy to protect from diisopropylfluorophosphate toxicity
    D E Lorke
    Department of Anatomy, FMHS, UAE University, Al Ain, United Arab Emirates
    J Appl Toxicol 28:920-8. 2008
    ..Dosage calculations based on in vitro IC50 measurements may therefore in future replace in vivo LD50 determinations, thereby reducing the number of animals required...
  13. doi Effect of intrathecal pralidoxime administration upon survival of rats exposed to the organophosphate paraoxon
    D E Lorke
    Department of Anatomy, FMHS, UAE University, Al Ain, United Arab Emirates
    Neurotoxicology 29:663-70. 2008
    ..Supplementary injection of pentobarbital, presumably by its anticonvulsive action, has a superior efficacy compared to 2-PAM i.p. alone, irrespective of additional intrathecal 2-PAM administration...
  14. doi In vitro oxime protection of human red blood cell acetylcholinesterase inhibited by diisopropyl-fluorophosphate
    D E Lorke
    UAE University, Faculty of Medicine and Health Sciences, Al Ain, United Arab Emirates
    J Appl Toxicol 28:422-9. 2008
    ..8), obidoxime (1.5), HI-6 (0.8), trimedoxime (2.9) and methoxime (5.9), with K-107 (17), K-108 (20), and K-113 (16) being the outstanding compounds...
  15. ncbi Entry of two new asymmetric bispyridinium oximes (K-27 and K-48) into the rat brain: comparison with obidoxime
    D E Lorke
    Department of Anatomy, FMHS, UAE University, Al Ain, United Arab Emirates
    J Appl Toxicol 27:482-90. 2007
    ..As already observed for pralidoxime, injection of POX before oxime administration had no influence upon penetration across the blood-brain barrier...
  16. ncbi Paraoxon has only a minimal effect on pralidoxime brain concentration in rats
    G A Petroianu
    Department of Pharmacology and Therapeutics, FMHS, United Arab Emirates University, Al Ain, United Arab Emirates
    J Appl Toxicol 27:350-7. 2007
    ..Brain perfusion does not significantly alter 2-PAM measurements and is therefore considered unnecessary...
  17. ncbi On the interaction of β-amyloid peptides and α7-nicotinic acetylcholine receptors in Alzheimer's disease
    Murat Oz
    Department of Pharmacology, Laboratory of Functional Lipidomics, Faculty of Medicine and Health Sciences, UAE, Abu Dhabi, Al Ain, UAE
    Curr Alzheimer Res 10:618-30. 2013
    ....
  18. doi N3,N7-diaminophenothiazinium derivatives as antagonists of α7-nicotinic acetylcholine receptors expressed in Xenopus oocytes
    Bassem Sadek
    Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, P O Box 17666, United Arab Emirates
    Pharmacol Res 66:213-8. 2012
    ..These results emphasize the importance of amine and/or alkylamine moieties for the inhibitory effect of PTZ derivatives and provide further insights for the development of novel antagonists targeting α7-nAChRs...
  19. pmc Cholinergic stimulation of the immune system protects against lethal infection by Salmonella enterica serovar Typhimurium
    Maria J Fernandez-Cabezudo
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Immunology 130:388-98. 2010
    ..Hence, in a model of Gram-negative bacterial infection, cholinergic stimulation is shown to enhance the anti-microbial immune response leading to effective control of bacterial proliferation and enhanced animal survival...
  20. pmc Methylene blue inhibits function of the 5-HT transporter
    Murat Oz
    Department of Pharmacology, UAE University, Al Ain, UAE
    Br J Pharmacol 166:168-76. 2012
    ..Given the role of the 5-HT transporter (SERT) in the regulation of extracellular 5-HT concentrations, the present study aimed to characterize the effect of MB on SERT...
  21. ncbi Caspase-3 immunoreactivity in different cortical areas of young and aging macaque (Macaca mulatta) monkeys
    Aiqun Zhang
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China
    Neurosignals 15:64-73. 2006
    ..This clustering of caspase-3 indicates increased vulnerability of a subset of pyramidal cells in the aging brain...