J M Conlon

Summary

Affiliation: Faculty of Medicine and Health Sciences
Country: United Arab Emirates

Publications

  1. ncbi request reprint Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Toxicon 52:465-73. 2008
  2. ncbi request reprint Potential therapeutic applications of multifunctional host-defense peptides from frog skin as anti-cancer, anti-viral, immunomodulatory, and anti-diabetic agents
    J Michael Conlon
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, Northern Ireland BT52 1SA, UK Electronic address
    Peptides 57:67-77. 2014
  3. ncbi request reprint A family of antimicrobial and immunomodulatory peptides related to the frenatins from skin secretions of the Orinoco lime frog Sphaenorhynchus lacteus (Hylidae)
    J Michael Conlon
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates Electronic address
    Peptides 56:132-40. 2014
  4. doi request reprint Host defense peptides from Lithobates forreri, Hylarana luctuosa, and Hylarana signata (Ranidae): phylogenetic relationships inferred from primary structures of ranatuerin-2 and brevinin-2 peptides
    J Michael Conlon
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates Electronic address
    Comp Biochem Physiol Part D Genomics Proteomics 9:49-57. 2014
  5. ncbi request reprint Characterization of the host-defense peptides from skin secretions of Merlin's clawed frog Pseudhymenochirus merlini: insights into phylogenetic relationships among the Pipidae
    J Michael Conlon
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates Electronic address
    Comp Biochem Physiol Part D Genomics Proteomics 8:352-7. 2013
  6. doi request reprint Cytotoxic activities of [Ser⁴⁹]phospholipase A₂ from the venom of the saw-scaled vipers Echis ocellatus, Echis pyramidum leakeyi, Echis carinatus sochureki, and Echis coloratus
    J Michael Conlon
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, United Arab Emirates
    Toxicon 71:96-104. 2013
  7. doi request reprint Evaluation of the skin peptide defenses of the Oregon spotted frog Rana pretiosa against infection by the chytrid fungus Batrachochytrium dendrobatidis
    J Michael Conlon
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, 17666, Al Ain, United Arab Emirates
    J Chem Ecol 39:797-805. 2013
  8. doi request reprint An immunomodulatory peptide related to frenatin 2 from skin secretions of the Tyrrhenian painted frog Discoglossus sardus (Alytidae)
    J Michael Conlon
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 40:65-71. 2013
  9. doi request reprint Transformation of the naturally occurring frog skin peptide, alyteserin-2a into a potent, non-toxic anti-cancer agent
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Amino Acids 44:715-23. 2013
  10. ncbi request reprint Host-defense peptides in skin secretions of the tetraploid frog Silurana epitropicalis with potent activity against methicillin-resistant Staphylococcus aureus (MRSA)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 37:113-9. 2012

Collaborators

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Toxicon 52:465-73. 2008
    ..aureus. Cladistic analysis based upon the amino acid sequences of the brevinin-2 peptides from Asian frogs provides evidence for sister taxon relationships between O. hosii and O. livida and between H. picturata and H. güntheri...
  2. ncbi request reprint Potential therapeutic applications of multifunctional host-defense peptides from frog skin as anti-cancer, anti-viral, immunomodulatory, and anti-diabetic agents
    J Michael Conlon
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, Northern Ireland BT52 1SA, UK Electronic address
    Peptides 57:67-77. 2014
    ....
  3. ncbi request reprint A family of antimicrobial and immunomodulatory peptides related to the frenatins from skin secretions of the Orinoco lime frog Sphaenorhynchus lacteus (Hylidae)
    J Michael Conlon
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates Electronic address
    Peptides 56:132-40. 2014
    ..They may represent a template for the design of peptides with therapeutic applications as immunostimulatory agents...
  4. doi request reprint Host defense peptides from Lithobates forreri, Hylarana luctuosa, and Hylarana signata (Ranidae): phylogenetic relationships inferred from primary structures of ranatuerin-2 and brevinin-2 peptides
    J Michael Conlon
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates Electronic address
    Comp Biochem Physiol Part D Genomics Proteomics 9:49-57. 2014
    ..signata and Hylarana picturata, while showing that the species are not conspecific, with H. luctuosa more distantly related. ..
  5. ncbi request reprint Characterization of the host-defense peptides from skin secretions of Merlin's clawed frog Pseudhymenochirus merlini: insights into phylogenetic relationships among the Pipidae
    J Michael Conlon
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates Electronic address
    Comp Biochem Physiol Part D Genomics Proteomics 8:352-7. 2013
    ..The data support a close phylogenetic relationship between Hymenochirus and Pseudhymenochirus that is distinct from the Xenopodinae (Xenopus+Silurana) clade with Pipa sister-group to all other extant pipids. ..
  6. doi request reprint Cytotoxic activities of [Ser⁴⁹]phospholipase A₂ from the venom of the saw-scaled vipers Echis ocellatus, Echis pyramidum leakeyi, Echis carinatus sochureki, and Echis coloratus
    J Michael Conlon
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, United Arab Emirates
    Toxicon 71:96-104. 2013
    ..It is suggested that the [Ser⁴⁹]PLA₂ proteins play a major role in producing local tissue necrosis and hemorrhage at the site of envenomation...
  7. doi request reprint Evaluation of the skin peptide defenses of the Oregon spotted frog Rana pretiosa against infection by the chytrid fungus Batrachochytrium dendrobatidis
    J Michael Conlon
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, 17666, Al Ain, United Arab Emirates
    J Chem Ecol 39:797-805. 2013
    ..pretiosa and the high growth-inhibitory potency of certain peptides against B. dendrobatidis are important in conferring a measure of resistance to fatal chytridiomycosis...
  8. doi request reprint An immunomodulatory peptide related to frenatin 2 from skin secretions of the Tyrrhenian painted frog Discoglossus sardus (Alytidae)
    J Michael Conlon
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 40:65-71. 2013
    ..The biological role of frenatin 2D is unknown but it is speculated that the peptide acts on skin macrophages to produce a cytokine-mediated stimulation of the adaptive immune system in response to invasion by microorganisms...
  9. doi request reprint Transformation of the naturally occurring frog skin peptide, alyteserin-2a into a potent, non-toxic anti-cancer agent
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Amino Acids 44:715-23. 2013
    ....
  10. ncbi request reprint Host-defense peptides in skin secretions of the tetraploid frog Silurana epitropicalis with potent activity against methicillin-resistant Staphylococcus aureus (MRSA)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 37:113-9. 2012
    ....
  11. ncbi request reprint Host-defense peptides in skin secretions of African clawed frogs (Xenopodinae, Pipidae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Gen Comp Endocrinol 176:513-8. 2012
    ..CPF-AM1 and PGLa-AM1 from X. amieti show potential for development into anti-infective agents for use against antibiotic-resistant gram-negative bacteria...
  12. doi request reprint Analogues of the frog skin peptide alyteserin-2a with enhanced antimicrobial activities against Gram-negative bacteria
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    J Pept Sci 18:270-5. 2012
    ..The analogue shows potential for treatment of nosocomial pulmonary infections caused by bacteria that have developed resistance to commonly used antibiotics...
  13. doi request reprint Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    Toxicon 53:699-705. 2009
    ..coli (MIC=50microM) and S. aureus (MIC=50microM). In contrast to brevinin-1BLc, ranatuerin-2Ya showed appreciably greater cytolytic activity against HepG2 cells (LC(50)=20microM) than against erythrocytes (LC(50)>100microM)...
  14. doi request reprint Antimicrobial peptides from the skins of North American frogs
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Biochim Biophys Acta 1788:1556-63. 2009
    ..Cladistic analysis based upon the amino acid sequences of the brevinin-1 peptides provides strong support for this assignment...
  15. ncbi request reprint Effect of aminoisobutyric acid (Aib) substitutions on the antimicrobial and cytolytic activities of the frog skin peptide, temporin-1DRa
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 28:2075-80. 2007
    ....
  16. ncbi request reprint Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Toxicon 50:746-56. 2007
    ..okinavana and R. tsushimensis. These conclusions are consistent with previous analyses based upon allozyme variations and comparisons of the nucleotide sequences of mitochondrial genes...
  17. ncbi request reprint Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Toxicon 50:498-506. 2007
    ....
  18. ncbi request reprint Strategies for transformation of naturally-occurring amphibian antimicrobial peptides into therapeutically valuable anti-infective agents
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Methods 42:349-57. 2007
    ..The data suggest a strategy of selective increases in cationicity concomitant with decreases in helicity and hydrophobicity in the transformation of naturally-occurring antimicrobial peptides into non-toxic therapeutic agents...
  19. ncbi request reprint Liberation of urotensin II from the teleost urophysis: an historical overview
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 29:651-7. 2008
    ....
  20. ncbi request reprint Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 28:1268-74. 2007
    ..aurora form a clade that is distinct from one containing R. draytonii, R. boylii, and R. luteiventris. This conclusion is consistent with previous analyses based upon comparisons of the nucleotide sequences of mitochondrial genes...
  21. ncbi request reprint Purification of naturally occurring peptides by reversed-phase HPLC
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
    Nat Protoc 2:191-7. 2007
    ..The limiting factor in the time taken to isolate a peptide is usually the speed at which assays to detect the peptide can be performed, but purifications can generally be accomplished within 1 or 2 weeks...
  22. ncbi request reprint Peptidomic analysis of skin secretions from Rana heckscheri and Rana okaloosae provides insight into phylogenetic relationships among frogs of the Aquarana species group
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Regul Pept 138:87-93. 2007
    ..heckscheri and R. grylio and a close, but less well defined, phylogenetic relationship between R. okaloosae and R. clamitans...
  23. ncbi request reprint A family of antimicrobial peptides related to japonicin-2 isolated from the skin of the chaochiao brown frog Rana chaochiaoensis
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Comp Biochem Physiol C Toxicol Pharmacol 144:101-5. 2006
    ..The data indicate a close phylogenetic relationship between R. chaochiaoensis and R. japonica but demonstrate that the species are not conspecific...
  24. ncbi request reprint Purification and properties of laticeptin, an antimicrobial peptide from skin secretions of the South American frog Leptodactylus laticeps
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Protein Pept Lett 13:411-5. 2006
    ....
  25. doi request reprint Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Comp Biochem Physiol C Toxicol Pharmacol 150:150-4. 2009
    ..This component contains an Ala-Met bond that constitutes the scissile bond in the selective elastase inhibitor, elafin but the peptide did not inhibit pancreatic elastase at concentrations up to 100 microM...
  26. doi request reprint A glycine-leucine-rich peptide structurally related to the plasticins from skin secretions of the frog Leptodactylus laticeps (Leptodactylidae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    Peptides 30:888-92. 2009
    ..Ocellatin-L2 was devoid of antimicrobial and hemolytic activity but also showed significant activity in stimulating insulin release from BRIN-BD11 cells (181% of basal rate at 3 microM)...
  27. doi request reprint Host defense peptides in skin secretions of the Oregon spotted frog Rana pretiosa: implications for species resistance to chytridiomycosis
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Dev Comp Immunol 35:644-9. 2011
    ..pretiosa may be pivotal in defending the species against environmental pathogens such as B. dendrobatidis...
  28. doi request reprint Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 32:664-9. 2011
    ..Cladistic analysis based upon the primary structures of brevinin-1 peptides indicates a close phylogenetic relationship between L. chiricahuensis, L. onca, and L. yavapaiensis...
  29. doi request reprint Purification and properties of antimicrobial peptides from skin secretions of the Eritrea clawed frog Xenopus clivii (Pipidae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Comp Biochem Physiol C Toxicol Pharmacol 153:350-4. 2011
    ....
  30. doi request reprint The contribution of skin antimicrobial peptides to the system of innate immunity in anurans
    J Michael Conlon
    Faculty of Medicine and Health Sciences, Department of Biochemistry, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Cell Tissue Res 343:201-12. 2011
    ....
  31. ncbi request reprint Potent and rapid bactericidal action of alyteserin-1c and its [E4K] analog against multidrug-resistant strains of Acinetobacter baumannii
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 31:1806-10. 2010
    ....
  32. ncbi request reprint Orthologs of magainin, PGLa, procaerulein-derived, and proxenopsin-derived peptides from skin secretions of the octoploid frog Xenopus amieti (Pipidae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 31:989-94. 2010
    ..amieti lineage. However, the very low antimicrobial activity of the magainin-AM1 and PGLa-AM2 paralogs suggests the possibility that certain peptides may have evolved toward a new, as yet undetermined, function (neofunctionalization)...
  33. doi request reprint Granin-derived peptides as diagnostic and prognostic markers for endocrine tumors
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Regul Pept 165:5-11. 2010
    ..These examples point to a limited although potentially valuable role for granin-derived peptides as tumor markers...
  34. doi request reprint Evidence from the primary structures of dermal antimicrobial peptides that Rana tagoi okiensis and Rana tagoi tagoi (Ranidae) are not conspecific subspecies
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Toxicon 55:430-5. 2010
    ..t. okiensis but not R. t. tagoi. The data provide evidence to support the proposal that R. t. tagoi and R. t. okiensis should be regarded as separate species (R. tagoi and R. okiensis) rather than conspecific subspecies...
  35. ncbi request reprint Antimicrobial properties of brevinin-2-related peptide and its analogs: Efficacy against multidrug-resistant Acinetobacter baumannii
    J Michael Conlon
    Department of Biochemistry, United Arab Emirates University, Al Ain, UAE
    Chem Biol Drug Des 74:488-93. 2009
    ....
  36. doi request reprint Antimicrobial peptides from the skin secretions of the New World frogs Lithobates capito and Lithobates warszewitschii (Ranidae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 30:1775-81. 2009
    ..L. warszewitschii is most closely related to the Central American species Lithobates tarahumarae and Lithobates vaillanti...
  37. doi request reprint The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 30:1069-73. 2009
    ..The data demonstrate that the frogs belonging to the family Alytidae are among those producing dermal antimicrobial peptides that may represent a component of the animal's system of innate immunity...
  38. doi request reprint Dermal cytolytic peptides and the system of innate immunity in anurans
    J Michael Conlon
    Weill Cornell Medical College in Qatar, Qatar Foundation Education City, Doha, Qatar
    Ann N Y Acad Sci 1163:75-82. 2009
    ..While the production of dermal cytolytic peptides may offer definite evolutionary advantage to anurans, their precise biological function, for example during metamorphosis, may need to be re-evaluated...
  39. ncbi request reprint Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 27:2111-7. 2006
    ..grahami antimicrobial peptides suggest a close relationship of this species with the Japanese pond frogs R. nigromaculata and R. porosa brevipoda...
  40. ncbi request reprint Antimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Comp Biochem Physiol C Toxicol Pharmacol 143:42-9. 2006
    ..The peptide therefore represents a candidate for drug development...
  41. ncbi request reprint The evolution of neuroendocrine peptides
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Gen Comp Endocrinol 142:53-9. 2005
    ....
  42. ncbi request reprint Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Regul Pept 131:38-45. 2005
    ..Our data support the placement of R. virgatipes in the Aquarana and indicate a closer phylogenetic relationship of R. virgatipes with R. septentrionalis than with R. catesbeiana, R. clamitans and R. grylio...
  43. ncbi request reprint Bradykinin-related peptides and tryptophyllins in the skin secretions of the most primitive extant frog, Ascaphus truei
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Gen Comp Endocrinol 143:193-9. 2005
    ..The data show that the synthesis of dermal peptides that may play a role in defense against predators arose early in the evolution of anurans...
  44. ncbi request reprint Antimicrobial and cytolytic properties of the frog skin peptide, kassinatuerin-1 and its L- and D-lysine-substituted derivatives
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, P O Box 17666, Al Ain, United Arab Emirates
    Peptides 26:2104-10. 2005
    ..However, the reduction in alpha-helicity produced by the D-amino acid substitutions resulted in analogs with reduced potencies against Gram-positive bacteria and against C. albicans...
  45. ncbi request reprint Antimicrobial peptides from ranid frogs: taxonomic and phylogenetic markers and a potential source of new therapeutic agents
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666 Al Ain, United Arab Emirates
    Biochim Biophys Acta 1696:1-14. 2004
    ....
  46. ncbi request reprint A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Regul Pept 118:135-41. 2004
    ..NH(2)) and temporin-1PRb (ILPILGNLLNSLL.NH(2)) that atypically lacked basic amino acid residues and showed only very weak antimicrobial and hemolytic activity...
  47. ncbi request reprint An atypical member of the brevinin-1 family of antimicrobial peptides isolated from the skin of the European frog Rana dalmatina
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666 Al Ain, United Arab Emirates
    Comp Biochem Physiol C Toxicol Pharmacol 137:191-6. 2004
    ..The minimum inhibitory concentration of the peptide, termed brevinin-1 Da, against the Gram-positive bacterium Staphylococcus aureus was 7 microM and against the Gram-negative bacterium Escherichia coli was 30 microM...
  48. ncbi request reprint The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Biochem Biophys Res Commun 320:170-5. 2004
    ..The data indicate that the host defence strategy of using antimicrobial peptides in skin secretions arose early in the evolution of anurans...
  49. ncbi request reprint Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666, Al Ain, United Arab Emirates
    Dev Comp Immunol 29:83-90. 2005
    ..Its biological function remains to be established. The primary structures of the antimicrobial peptides are consistent with a close phylogenetic relationship between R. aurora, Rana boylii and Rana luteiventris...
  50. ncbi request reprint Isolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii
    J M Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, UAE
    J Pept Res 62:207-13. 2003
    ..Two members of the ranatuerin-2 family and one member of the temporin family were also isolated from the secretions but showed relatively low potency against the three microorganisms tested...
  51. ncbi request reprint A family of acyclic brevinin-1 peptides from the skin of the Ryukyu brown frog Rana okinavana
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 26:185-90. 2005
    ....
  52. ncbi request reprint Comparative peptidomics of the endocrine pancreas: islet hormones from the clawed frog Xenopus laevis and the red-bellied newt Cynops pyrrhogaster
    J M Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666 Al Ain, United Arab Emirates
    J Endocrinol 175:769-77. 2002
    ..This study has illustrated the power of electrospray mass spectrometry for the rapid and reliable identification of peptides in chromatographic fractions without the need to use radioimmunoassay, radioreceptor assay or bioassay...
  53. ncbi request reprint Evidence from peptidomic analysis of skin secretions that the red-legged frogs, Rana aurora draytonii and Rana aurora aurora, are distinct species
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 27:1305-12. 2006
    ..The data emphasize that amino acid sequences of antimicrobial peptides in skin secretions may be used to infer taxonomic and phylogenetic relationships between species of ranid frogs...
  54. doi request reprint Structural diversity and species distribution of host-defense peptides in frog skin secretions
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666, Al Ain, United Arab Emirates
    Cell Mol Life Sci 68:2303-15. 2011
    ....
  55. ncbi request reprint A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, United Arab Emirates
    Biochem Biophys Res Commun 306:496-500. 2003
    ..However, at non-cytotoxic concentrations (<or=8 microM), MRP did not protect HeLa cells from cell death produced by human rhinovirus type 2 infection...
  56. doi request reprint Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, UAE
    Chem Biol Drug Des 72:58-64. 2008
    ....
  57. doi request reprint Primary structures of skin antimicrobial peptides indicate a close, but not conspecific, phylogenetic relationship between the leopard frogs Lithobates onca and Lithobates yavapaiensis (Ranidae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Comp Biochem Physiol C Toxicol Pharmacol 151:313-7. 2010
    ..The data indicate a close phylogenetic relationship between L. onca and L. yavapaiensis but suggest that they are not conspecific species...
  58. ncbi request reprint Antimicrobial peptides in frog skin secretions
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
    Methods Mol Biol 618:3-14. 2010
    ..Individual peptides with activity are purified to near homogeneity by further chromatography on butylsilyl-(C(4)) and diphenylmethylsilyl-silica columns and characterized structurally by automated Edman degradation and mass spectrometry...
  59. ncbi request reprint Design of potent, non-toxic antimicrobial agents based upon the structure of the frog skin peptide, pseudin-2
    Tibor Pal
    Department of Medical Microbiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666 Al Ain, United Arab Emirates
    Regul Pept 129:85-91. 2005
    ....
  60. ncbi request reprint Antimicrobial properties of the frog skin peptide, ranatuerin-1 and its [Lys-8]-substituted analog
    Agnes Sonnevend
    Department of Medical Microbiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666, Al Ain, United Arab Emirates
    Peptides 25:29-36. 2004
    ..01) against all strains. The data demonstrate that [Lys-8] ranatuerin-1 shows potential as a candidate for drug development...
  61. doi request reprint Tigerinin-1R: a potent, non-toxic insulin-releasing peptide isolated from the skin of the Asian frog, Hoplobatrachus rugulosus
    O O Ojo
    School of Biomedical Sciences, University of Ulster, Coleraine, UK
    Diabetes Obes Metab 13:1114-22. 2011
    ..Characterization of peptides in the skin of the Vietnamese common lowland frog Hoplobatrachus rugulosus with the ability to stimulate insulin release in vitro and improve glucose tolerance in vivo...
  62. ncbi request reprint N-terminal glycation of cholecystokinin-8 abolishes its insulinotropic action on clonal pancreatic B-cells
    Y H Abdel-Wahab
    School of Biomedical Sciences, University of Ulster, Coleraine, UK
    Biochim Biophys Acta 1452:60-7. 1999
    ..These data indicate that structural modification by glycation at the amino-terminal Asp(1) residue effectively abolishes and/or antagonises the insulinotropic activity of CCK-8...
  63. ncbi request reprint Activities of the frog skin peptide, ascaphin-8 and its lysine-substituted analogs against clinical isolates of extended-spectrum beta-lactamase (ESBL) producing bacteria
    Adrian Eley
    Department of Medical Microbiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 29:25-30. 2008
    ..5-25 microM) and its Lys4-substituted analog (MIC= 6 microM), although non-ESBL isolates of this organism were resistant to these peptides (MIC> 100 microM)...
  64. doi request reprint Antimicrobial peptides from the skin secretions of the South-East Asian frog Hylarana erythraea (Ranidae)
    Nadia Al-Ghaferi
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 31:548-54. 2010
    ..Phylogenetic analysis based upon the amino acid sequences of 47 brevinin-2 peptides from 17 Asian species belonging to the family Ranidae provides support for the placement of H. erythraea in the genus Hylarana...
  65. doi request reprint Identification and analysis of bioactive peptides in amphibian skin secretions
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
    Methods Mol Biol 615:145-57. 2010
    ..The use of mixtures of synthetic peptides of appropriate molecular mass as calibration standards enables mass determination to a high degree of precision...
  66. doi request reprint A potent, non-toxic insulin-releasing peptide isolated from an extract of the skin of the Asian frog, Hylarana guntheri (Anura:Ranidae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Regul Pept 151:153-9. 2008
    ..05) improved glucose tolerance following a intraperitoneal injection of glucose, thereby demonstrating that the peptide shows potential for development into a therapeutically valuable agent for the treatment of Type 2 diabetes...
  67. ncbi request reprint Major contributions of comparative endocrinology to the development and exploitation of the incretin concept
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    J Exp Zool A Comp Exp Biol 305:781-6. 2006
    ....
  68. doi request reprint Investigation of the pyrolysis products of methionine-enkephalin-Arg-Gly-Leu using liquid chromatography-tandem mass spectrometry
    Mohammed A Meetani
    Department of Chemistry, Faculty of Science, United Arab Emirates University, P O Box 17551, Al Ain, United Arab Emirates
    J Mass Spectrom 45:1320-31. 2010
    ....
  69. ncbi request reprint Brevinin-1BYa: a naturally occurring peptide from frog skin with broad-spectrum antibacterial and antifungal properties
    Tibor Pal
    Department of Medical Microbiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Int J Antimicrob Agents 27:525-9. 2006
    ..It is suggested that brevinin-1BYa represents a candidate for drug development, particularly for topical applications against antibiotic-resistant microorganisms...
  70. ncbi request reprint Antimicrobial peptides with therapeutic potential from skin secretions of the Marsabit clawed frog Xenopus borealis (Pipidae)
    Milena Mechkarska
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Comp Biochem Physiol C Toxicol Pharmacol 152:467-72. 2010
    ..CPF-B1 was active against clinical isolates of the nosocomial pathogens, methicillin-resistant S. aureus (MRSA) and multidrug-resistant Acinetobacter baumannii (MDRAB) with MIC values in the range 4-8 microM...
  71. ncbi request reprint Insulin releasing properties of the temporin family of antimicrobial peptides
    Yasser H A Abdel-Wahab
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, UAE
    Protein Pept Lett 14:702-7. 2007
    ..Temporin-1DRa was without effect. The temporins at 10(-7) M had no effect on intracellular calcium concentrations suggesting that they stimulate insulin release via a K(ATP) channel- independent pathway...
  72. doi request reprint Reflections on a systematic nomenclature for antimicrobial peptides from the skins of frogs of the family Ranidae
    J Michael Conlon
    Weill Cornell Medical College in Qatar, Qatar Foundation Education City, Doha, Qatar
    Peptides 29:1815-9. 2008
    ..Species names and assignments to genera may be obtained from Amphibian Species of the World Electronic Database, accessible at http://research.amnh.org/herpetology/amphibia/index.php. American Museum of Natural History, New York, USA...
  73. ncbi request reprint Structure, antihyperglycemic activity and cellular actions of a novel diglycated human insulin
    F P O'Harte
    School of Biomedical Sciences, University of Ulster, BT52 1SA, Northern, Coleraine, Ireland
    Peptides 21:1519-26. 2000
    ..001) than native insulin in stimulating glucose uptake, glucose oxidation and glycogen production in isolated mouse abdominal muscle...
  74. ncbi request reprint A proposed nomenclature for antimicrobial peptides from frogs of the genus Leptodactylus
    J Michael Conlon
    Weill Cornell Medical College in Qatar, Qatar Foundation Education City, P O Box 24144, Doha, Qatar
    Peptides 29:1631-2. 2008
    ..Fallaxin is replaced by ocellatin-F1, pentadactylin by ocellatin-P1, laticeptin by ocellatin-L1, syphaxin by ocellatin-S1, and the paralogs from L. validus are termed ocellatin-V1, -V2, and -V3...
  75. ncbi request reprint Expression of the oxytocin gene, but not the vasopressin gene, in the rat uterus during pregnancy: influence of oestradiol and progesterone
    T Bossmar
    Department of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
    J Endocrinol 193:121-6. 2007
    ..No evidence was found for the presence of VP in the uterus so that, if the hormone is involved in a stimulatory action on this tissue, it probably acts via an endocrine mechanism...
  76. pmc Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declines
    Louise A Rollins-Smith
    Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Antimicrob Agents Chemother 47:1157-60. 2003
    ..Differences in potency due to amino acid substitution suggest that ability to penetrate membranes and form an alpha-helical structure is important for their effectiveness against this pathogen...
  77. pmc Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells
    Scott E VanCompernolle
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, 21st Ave South, Medical Center North, Room AA5206, Nashville, TN 37232 2363, USA
    J Virol 79:11598-606. 2005
    ..Thus, amphibian-derived antimicrobial peptides show promise as topical inhibitors of mucosal HIV transmission and provide novel tools to understand the complex biology of HIV capture by DCs...
  78. ncbi request reprint Antimicrobial peptide defenses of the mountain yellow-legged frog (Rana muscosa)
    Louise A Rollins-Smith
    Department of Microbiology and Immunology, Vanderbilt University, A 5301 Medical Center North, Nashville, TN 37232, USA
    Dev Comp Immunol 30:831-42. 2006
    ..dendrobatidis in nature. Possible differences in the antimicrobial peptide repertoires and life history traits of the two species that may account for differences in susceptibility are discussed...
  79. ncbi request reprint Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata
    Mohamed F Ali
    Department of Biomedical Sciences, Creighton University Medical School, Omaha, NE 68178, USA
    Biochim Biophys Acta 1601:55-63. 2002
    ..The data suggest that protease inhibitors in skin secretions may play a role complementary to cationic, amphipathic alpha-helical peptides in protecting anurans from invasions by microorganisms...
  80. ncbi request reprint Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii
    Hiroe Suzuki
    Department of Biology, Faculty of Science, Toho University, 2 2 1 Miyama Funabashi, Chiba 274 8510, Japan
    Peptides 28:505-14. 2007
    ..sakuraii dermal peptides with those of Tago's brown frog Rana tagoi provides evidence for a close phylogenetic relationship between these species...
  81. pmc Cloning, structural characterization and functional expression of a zebrafish bradykinin B2-related receptor
    Torun Dunér
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, P O Box 593, SE 751 24 Uppsala, Sweden
    Biochem J 364:817-24. 2002
    ..The B1-selective analogue [Arg0,Trp5,Leu8,des-Arg9]-BK was inactive at nanomolar concentrations. Taken together, these results strongly support the gene's identity as a piscine orthologue of the mammalian B2 receptor...
  82. ncbi request reprint Purification, characterization, and biological activity of insulins from the spotted dogfish, Scyliorhinus canicula, and the hammerhead shark, Sphyrna lewini
    W Gary Anderson
    Gatty Marine Laboratory, School of Biology, St Andrews KY16 8LB, United Kingdom
    Gen Comp Endocrinol 126:113-22. 2002
    ..The data indicate that the metabolic actions of an endogenous elasmobranch insulin in an elasmobranch are similar to those previously described for mammalian insulin...
  83. ncbi request reprint Activity of antimicrobial skin peptides from ranid frogs against Batrachochytrium dendrobatidis, the chytrid fungus associated with global amphibian declines
    Louise A Rollins-Smith
    Departments of Microbiology and Immunology and Pediatrics, Vanderbilt University, Medical Center North, A 5301, Nashville, TN 37232, USA
    Dev Comp Immunol 26:471-9. 2002
    ..This may provide some natural resistance to infection, but if environmental factors inhibit the synthesis and release of the skin peptides, the pathogen could gain the advantage...
  84. ncbi request reprint Antimicrobial peptides with atypical structural features from the skin of the Japanese brown frog Rana japonica
    Todd Isaacson
    Regulatory Peptide Center, Department of Biomedical Sciences, Creighton University Medical School, Omaha, NE 68178, USA
    Peptides 23:419-25. 2002
    ..coli were japonicin-1, 30 microM; japonicin-2, 12 microM; and temporin-1Ja > 100 microM. The MICs against S. aureus were japonicin-1, > 100 microM; japonicin-2, 20 microM; and temporin-1Ja, > 100 microM...
  85. ncbi request reprint The origin and evolution of peptide YY (PYY) and pancreatic polypeptide (PP)
    J Michael Conlon
    Regulatory Peptide Center, Department of Biomedical Sciences, Creighton University Medical School, Omaha, NE 68178 0405, USA
    Peptides 23:269-78. 2002
    ..conserved in mammals, with the exception of the rodents, the extreme variability in the sequences of amphibian and reptilian PPs means that the peptide is a useful molecular marker to study the branching order in early tetrapod evolution..
  86. ncbi request reprint Molecular cloning and sequence analyses of preprotemporin mRNAs containing premature stop codons from extradermal tissues of Rana tagoi
    Shawichi Iwamuro
    Department of Biology, Faculty of Science, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Peptides 27:2124-8. 2006
    ..5 microM) and producing hemolysis of human erythrocytes (LD50 = 50 microM)...
  87. ncbi request reprint Peptidomic analysis of the skin secretions of the pickerel frog Rana palustris identifies six novel families of structurally-related peptides
    Yousef J Basir
    Department of Biomedical Sciences, Creighton University Medical School, Omaha, NE 68178, USA
    Peptides 24:379-83. 2003
    ..The peptides did not inhibit the growth of Escherichia coli or Staphylococcus aureus and were inactive on hamster vascular or gastric smooth muscle preparations so that their biological functions, if any, remain to be established...
  88. ncbi request reprint Antimicrobial peptides from the skin of the Japanese mountain brown frog Rana ornativentris: evidence for polymorphism among preprotemporin mRNAs
    Aya Ohnuma
    Department of Biology, Faculty of Science, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Peptides 28:524-32. 2007
    ....
  89. ncbi request reprint Activities of four frog skin-derived antimicrobial peptides (temporin-1DRa, temporin-1Va and the melittin-related peptides AR-23 and RV-23) against anaerobic bacteria
    Edit Urban
    Department of Clinical Microbiology, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Int J Antimicrob Agents 29:317-21. 2007
    ....
  90. ncbi request reprint Processing of multiple forms of preprosodefrin in the abdominal gland of the red-bellied newt Cynops pyrrhogaster: regional and individual differences in preprosodefrin gene expression
    Takeo Iwata
    Department of Biology, School of Education, Waseda University, Nishiwaseda 1 6 1, Shinjuku ku, Tokyo 169 8050, Japan
    Peptides 25:1537-43. 2004
    ..However, genes encoding sodefrin were found to be expressed in all the specimens sampled...
  91. doi request reprint Conformational analysis of the broad-spectrum antibacterial peptide, ranatuerin-2CSa: identification of a full length helix-turn-helix motif
    Anusha P Subasinghage
    UCD School of Biomolecular and Biomedical Science, UCD Centre for Synthesis and Chemical Biology, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Biochim Biophys Acta 1784:924-9. 2008
    ..This structural information will facilitate the design of novel therapeutic agents based upon the ranatuerin-2CSa structure with improved antimicrobial potencies but decreased cytolytic activities against mammalian cells...
  92. doi request reprint Insulin-releasing properties of the frog skin peptide pseudin-2 and its [Lys18]-substituted analogue
    Yasser H A Abdel-Wahab
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, UK
    Biol Chem 389:143-8. 2008
    ....
  93. ncbi request reprint An antimicrobial peptide from the skin secretions of the mountain chicken frog Leptodactylus fallax (Anura:Leptodactylidae)
    Louise A Rollins-Smith
    Departments of Microbiology and Immunology and of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Regul Pept 124:173-8. 2005
    ..The hemolytic activity of fallaxin was very low (HC50>200 microM). A second peptide, comprising residues (1-22) of fallaxin, was also isolated from the skin secretions but this component was inactive against the microorganisms tested...
  94. ncbi request reprint Evidence that the genes encoding the melittin-related peptides in the skins of the Japanese frogs Rana sakuraii and Rana tagoi are not orthologous to bee venom melittin genes: developmental- and tissue-dependent gene expression
    Hiroe Suzuki
    Department of Biology, Faculty of Science, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Peptides 28:2061-8. 2007
    ..In R. tagoi, preproMRP mRNA was not detected in skin prior to the onset of metamorphosis, but its level increased markedly during metamorphosis reaching a maximum at the stages of metamorphic climax...
  95. pmc Pharmacological characterization of ligand-receptor interactions at the zebrafish bradykinin receptor
    Torun Bromée
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Box 593, SE 75124 Uppsala, Sweden
    Br J Pharmacol 144:11-6. 2005
    ..These results increase our understanding of the evolution of BK receptors and the functions of the kallikrein-kinin system...
  96. ncbi request reprint Characterization of a peptide from skin secretions of male specimens of the frog, Leptodactylus fallax that stimulates aggression in male frogs
    Jay D King
    Department of Biology, University of Missouri St Louis, St Louis, MO 63121, USA
    Peptides 26:597-601. 2005
    ..It is suggested that this peptide may play an important role in initiating the competitive male-male interactions that are associated with the onset of reproductive behavior in L. fallax...
  97. ncbi request reprint Production of transgenic tilapia with Brockmann bodies secreting [desThrB30] human insulin
    Bill Pohajdak
    Department of Biology, Dalhousie University, Nova Scotia, Canada
    Transgenic Res 13:313-23. 2004
    ..When transplanted into diabetic nude mice, tilapia islets provide long-term normoglycemia and mammalian-like glucose tolerance profiles...
  98. ncbi request reprint Developmental and triiodothyronine-induced expression of genes encoding preprotemporins in the skin of Tago's brown frog Rana tagoi
    Aya Ohnuma
    Department of Biology, Faculty of Science, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Gen Comp Endocrinol 146:242-50. 2006
    ....
  99. ncbi request reprint A protein with antimicrobial activity in the skin of Schlegel's green tree frog Rhacophorus schlegelii (Rhacophoridae) identified as histone H2B
    Hiroaki Kawasaki
    Department of Biology, Faculty of Science, Toho University, Funabashi, 274 8510, Chiba, Japan
    Biochem Biophys Res Commun 312:1082-6. 2003
    ..The data provide further evidence that histones play a role in the defense against microorganisms...
  100. ncbi request reprint Isolation, characterization and bioactivity of a region-specific pheromone, [Val8]sodefrin from the newt Cynops pyrrhogaster
    Tomoaki Nakada
    Department of Biology, School of Education, Waseda University, Nishiwaseda 1 6 1, Shinjuku ku, Tokyo 169 8050, Japan
    Peptides 28:774-80. 2007
    ..It is speculated that the coevolution of a novel pheromone and its complementary receptor in the Nara newts may lead to reproductive isolation and eventual differentiation into a separate species...
  101. ncbi request reprint Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex
    Mohamed F Ali
    Department of Biomedical Sciences, Creighton University Medical School, Omaha, NE 68178, USA
    Peptides 24:955-61. 2003
    ..It is proposed that the distribution and amino acid sequences of skin antimicrobial peptides may be useful markers for taxonomic classification of particular sub-populations and for an understanding of phylogenetic interrelationships...