Samir Attoub

Summary

Affiliation: Faculty of Medicine and Health Sciences
Country: United Arab Emirates

Publications

  1. doi request reprint Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo
    Samir Attoub
    Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
    Fundam Clin Pharmacol 27:557-69. 2013
  2. pmc Frondoside a suppressive effects on lung cancer survival, tumor growth, angiogenesis, invasion, and metastasis
    Samir Attoub
    Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, U A E University, Al Ain, United Arab Emirates
    PLoS ONE 8:e53087. 2013
  3. doi request reprint The transforming functions of PI3-kinase-gamma are linked to disruption of intercellular adhesion and promotion of cancer cell invasion
    Samir Attoub
    INSERM U 673, Molecular and Clinical Oncology of Solid Tumors, University Pierre et Marie Curie Paris VI, Hospital Saint Antoine, Paris, France
    Ann N Y Acad Sci 1138:204-13. 2008
  4. doi request reprint Captopril as a potential inhibitor of lung tumor growth and metastasis
    Samir Attoub
    Department of Pharmacology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Ann N Y Acad Sci 1138:65-72. 2008
  5. doi request reprint Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells
    Samir Attoub
    Department of Pharmacology and Therapeutics, United Arab Emirates University, Al Ain, United Arab Emirates
    Eur J Pharmacol 651:18-25. 2011
  6. doi request reprint Frondoside A inhibits human breast cancer cell survival, migration, invasion and the growth of breast tumor xenografts
    Nadia Al Marzouqi
    Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, UAE University, Al Ain, PO Box 17666, United Arab Emirates
    Eur J Pharmacol 668:25-34. 2011
  7. pmc Anti-metastatic and anti-tumor growth effects of Origanum majorana on highly metastatic human breast cancer cells: inhibition of NFκB signaling and reduction of nitric oxide production
    Yusra Al Dhaheri
    Department of Biology, College of Science, United Arab Emirates University, Alabama, Ain, United Arab Emirates
    PLoS ONE 8:e68808. 2013
  8. doi request reprint Salinomycin induces apoptosis and senescence in breast cancer: upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation
    Yusra Al Dhaheri
    Department of Biology, College of Science, UAE University, P O Box 17551, United Arab Emirates University, Al Ain, P O Box 15551, United Arab Emirates
    Biochim Biophys Acta 1830:3121-35. 2013
  9. doi request reprint Esculentin-2CHa: a host-defense peptide with differential cytotoxicity against bacteria, erythrocytes and tumor cells
    Samir Attoub
    Department of Pharmacology, College of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 39:95-102. 2013
  10. doi request reprint Transformation of the naturally occurring frog skin peptide, alyteserin-2a into a potent, non-toxic anti-cancer agent
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Amino Acids 44:715-23. 2013

Collaborators

Detail Information

Publications30

  1. doi request reprint Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo
    Samir Attoub
    Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
    Fundam Clin Pharmacol 27:557-69. 2013
    ..In view of the available experimental findings, we contend that thymoquinone and/or its analogues may have clinical potential as an anticancer agent alone or in combination with chemotherapeutic drugs such as cisplatin...
  2. pmc Frondoside a suppressive effects on lung cancer survival, tumor growth, angiogenesis, invasion, and metastasis
    Samir Attoub
    Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, U A E University, Al Ain, United Arab Emirates
    PLoS ONE 8:e53087. 2013
    ..Moreover, Frondoside A enhanced the inhibition of lung tumor growth induced by the chemotherapeutic agent cisplatin. These findings identify Frondoside A as a promising novel therapeutic agent for lung cancer...
  3. doi request reprint The transforming functions of PI3-kinase-gamma are linked to disruption of intercellular adhesion and promotion of cancer cell invasion
    Samir Attoub
    INSERM U 673, Molecular and Clinical Oncology of Solid Tumors, University Pierre et Marie Curie Paris VI, Hospital Saint Antoine, Paris, France
    Ann N Y Acad Sci 1138:204-13. 2008
    ....
  4. doi request reprint Captopril as a potential inhibitor of lung tumor growth and metastasis
    Samir Attoub
    Department of Pharmacology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Ann N Y Acad Sci 1138:65-72. 2008
    ..In view of these experimental findings, we conclude that captopril could be a promising option for the treatment of lung cancer...
  5. doi request reprint Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells
    Samir Attoub
    Department of Pharmacology and Therapeutics, United Arab Emirates University, Al Ain, United Arab Emirates
    Eur J Pharmacol 651:18-25. 2011
    ....
  6. doi request reprint Frondoside A inhibits human breast cancer cell survival, migration, invasion and the growth of breast tumor xenografts
    Nadia Al Marzouqi
    Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, UAE University, Al Ain, PO Box 17666, United Arab Emirates
    Eur J Pharmacol 668:25-34. 2011
    ..Moreover, we found that Frondoside A could enhance the killing of breast cancer cells induced by the chemotherapeutic agent paclitaxel. These findings identify Frondoside A as a promising novel therapeutic agent for breast cancer...
  7. pmc Anti-metastatic and anti-tumor growth effects of Origanum majorana on highly metastatic human breast cancer cells: inhibition of NFκB signaling and reduction of nitric oxide production
    Yusra Al Dhaheri
    Department of Biology, College of Science, United Arab Emirates University, Alabama, Ain, United Arab Emirates
    PLoS ONE 8:e68808. 2013
    ..Here, we extended our study by investigating the effect of O. majorana on the migration, invasion and tumor growth of these cells...
  8. doi request reprint Salinomycin induces apoptosis and senescence in breast cancer: upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation
    Yusra Al Dhaheri
    Department of Biology, College of Science, UAE University, P O Box 17551, United Arab Emirates University, Al Ain, P O Box 15551, United Arab Emirates
    Biochim Biophys Acta 1830:3121-35. 2013
    ..In the present study, we investigated the effect of Salinomycin on the survival of three human breast cancer cell lines MCF-7, T47D and MDA-MB-231 grown in adherent culture conditions...
  9. doi request reprint Esculentin-2CHa: a host-defense peptide with differential cytotoxicity against bacteria, erythrocytes and tumor cells
    Samir Attoub
    Department of Pharmacology, College of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 39:95-102. 2013
    ..The more cationic [D20K, D27K] analog showed a modest increase in potency against all microorganisms (up to 4-fold) but a marked increase in cytotoxicity against erythrocytes (LC(50)=11 μM) and A549 cells (LC(50)=3 μM)...
  10. doi request reprint Transformation of the naturally occurring frog skin peptide, alyteserin-2a into a potent, non-toxic anti-cancer agent
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Amino Acids 44:715-23. 2013
    ....
  11. doi request reprint Cytotoxic activities of [Ser⁴⁹]phospholipase A₂ from the venom of the saw-scaled vipers Echis ocellatus, Echis pyramidum leakeyi, Echis carinatus sochureki, and Echis coloratus
    J Michael Conlon
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, United Arab Emirates
    Toxicon 71:96-104. 2013
    ..It is suggested that the [Ser⁴⁹]PLA₂ proteins play a major role in producing local tissue necrosis and hemorrhage at the site of envenomation...
  12. ncbi request reprint Implication of STAT3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3) -- and vascular endothelial growth factor-mediated cellular invasion and tumor growth
    Christine Rivat
    Institut National de la Sante et de la Recherche Medicale U482, Hopital Saint Antoine, Paris, France
    Cancer Res 65:195-202. 2005
    ..We also validate new therapeutic strategies targeting STAT3 signaling by pharmacologic inhibitors and RNA interference for the treatment of colorectal cancer patients...
  13. ncbi request reprint Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts
    Quang De Nguyen
    Institut National de la Sante et de la Recherche Medicale U673, Universite Pierre et Marie Curie Paris 6, Molecular and Clinical Oncology of Solid Tumors, Hopital Saint Antoine, 75571 Paris Cedex 12, France
    Mol Cancer Ther 5:2070-7. 2006
    ....
  14. ncbi request reprint Short-term effects of oral administration of Pistacia lentiscus oil on tissue-specific toxicity and drug metabolizing enzymes in mice
    Samir Attoub
    Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    Cell Physiol Biochem 33:1400-10. 2014
    ..The aim of this study was to assess whether Pistacia lentiscus oil has any short term toxic effects in vivo and in vitro...
  15. pmc Amorphous silica nanoparticles impair vascular homeostasis and induce systemic inflammation
    Abderrahim Nemmar
    Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    Int J Nanomedicine 9:2779-89. 2014
    ..Overall, the effects observed with 50 nm SiNPs were more pronounced than those with 500 nm SiNPs. These findings provide new insight into the deleterious effect of amorphous SiNPs on vascular homeostasis. ..
  16. doi request reprint Anti-tumor activities of the host-defense peptide hymenochirin-1B
    Samir Attoub
    Department of Pharmacology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    Regul Pept 187:51-6. 2013
    ..1-21 μM) but show reduced hemolytic activity (LC50>300 μM). The data suggest that hymenochirin-1B has therapeutic potential as a template to generate potent, non-toxic anti-cancer agents...
  17. pmc Mitotic arrest and apoptosis in breast cancer cells induced by Origanum majorana extract: upregulation of TNF-α and downregulation of survivin and mutant p53
    Yusra Al Dhaheri
    Department of Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates
    PLoS ONE 8:e56649. 2013
    ..In the present study, we investigated the effect of Origanum majorana ethanolic extract on the survival of the highly proliferative and invasive triple-negative p53 mutant breast cancer cell line MDA-MB-231...
  18. doi request reprint Acute respiratory and systemic toxicity of pulmonary exposure to rutile Fe-doped TiO(2) nanorods
    Abderrahim Nemmar
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666, Al Ain, United Arab Emirates
    Toxicology 279:167-75. 2011
    ..It affects the liver, enhances thrombotic potential, heart rate and systolic blood pressure. Moreover, the rutile Fe-TiO₂ elicited direct toxicity on NCI-H460-Luc2 and HepG2 cells...
  19. ncbi request reprint Gamma-synuclein and the progression of cancer
    Mushfika Ahmad
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates, Al Ain, PO Box 17666, United Arab Emirates
    FASEB J 21:3419-30. 2007
    ..This review will discuss the involvement of gamma-syn in cancer progression, metastasis and its potential as a marker...
  20. doi request reprint Analogues of the frog skin peptide alyteserin-2a with enhanced antimicrobial activities against Gram-negative bacteria
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    J Pept Sci 18:270-5. 2012
    ..The analogue shows potential for treatment of nosocomial pulmonary infections caused by bacteria that have developed resistance to commonly used antibiotics...
  21. doi request reprint Attenuated bacteria as effectors in cancer immunotherapy
    Basel K al-Ramadi
    Department of Microbiology and Immunology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Ann N Y Acad Sci 1138:351-7. 2008
    ..This supports the notion of using cytokine-expressing attenuated Salmonella organisms in cancer therapy...
  22. ncbi request reprint Anticancer activity of BIM-46174, a new inhibitor of the heterotrimeric Galpha/Gbetagamma protein complex
    Gregoire P Prevost
    Ipsen Institut Henri Beaufour, Les Ulis, France
    Cancer Res 66:9227-34. 2006
    ..Our data validate the feasibility of targeting heterotrimeric G-protein functions downstream the GPCRs to improve anticancer chemotherapy...
  23. ncbi request reprint The c-kit tyrosine kinase inhibitor STI571 for colorectal cancer therapy
    Samir Attoub
    INSERM U482, Signal Transduction and Cellular Functions in Diabetes and Digestive Cancers, Hopital Saint Antoine, 75571 Paris Cedex 12, France
    Cancer Res 62:4879-83. 2002
    ....
  24. ncbi request reprint Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell-cell adhesion complexes
    Christine Rivat
    INSERM U 482, Signal Transduction and Cellular Functions in Diabetes and Digestive Cancers, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France
    Oncogene 23:3317-27. 2004
    ..Disruption of this cascade by Y705F reveals the proinvasive potential of altered forms of STAT3 as a persistent signaling adaptor in cytokine/transforming growth factor receptor scaffolds and oncogenic pathways...
  25. ncbi request reprint Trefoil factor family (TFF) peptides and cancer progression
    Shahin Emami
    INSERM U482, Signal Transduction and Cellular Functions in Diabetes and Digestive Cancers, Hopital Saint Antoine, 75571 Paris Cedex 12, France
    Peptides 25:885-98. 2004
    ..As a consequence, the TFF signaling pathways may serve as potential targets in the control of chronic inflammation and progression of human solid tumors...
  26. ncbi request reprint Selective abrogation of the proinvasive activity of the trefoil peptides pS2 and spasmolytic polypeptide by disruption of the EGF receptor signaling pathways in kidney and colonic cancer cells
    Sylvie Rodrigues
    INSERM U482, Signal Transduction and Cellular Functions in Diabetes and Digestive Cancers, Hopital Saint Antoine, 75571 Paris, France
    Oncogene 22:4488-97. 2003
    ..It is concluded that although pS2, SP and ITF belong to the same family of inflammation- and cancer-associated regulatory peptides, they do not control identical signaling networks...
  27. ncbi request reprint Expression of neurotensin and NT1 receptor in human breast cancer: a potential role in tumor progression
    Frédérique Souazé
    Institut National de la Sante et de la Recherche Medicale U673 and UPMC, Hopital Saint Antoine, France
    Cancer Res 66:6243-9. 2006
    ..These strategies would increase the range of therapeutic approaches and be beneficial for specific patients...
  28. ncbi request reprint Trefoil peptides as proangiogenic factors in vivo and in vitro: implication of cyclooxygenase-2 and EGF receptor signaling
    Sylvie Rodrigues
    INSERM U482, Signal Transduction and Cellular Functions in Diabetes and Digestive Cancers, Hopital Saint Antoine, 75571 Paris Cedex 12, France
    FASEB J 17:7-16. 2003
    ....
  29. ncbi request reprint Synergistic cooperation between the AP-1 and LEF-1 transcription factors in activation of the matrilysin promoter by the src oncogene: implications in cellular invasion
    Christine Rivat
    INSERM U 482, Hopital Saint Antoine, 75571, Paris Cedex 12, France
    FASEB J 17:1721-3. 2003
    ..This mechanism may thereby contribute to cellular invasion during the early-stage adenoma/adenocarcinoma conversion and the metastatic process of digestive tumors...