Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation inductionEnrico Papaleo
IVF Unit, Gynaecological Obstetric Department, IRCCS San Raffaele Hospital, Vita Salute University, Milan, Italy
Gynecol Endocrinol 23:700-3. 2007
..We hypothesized that the administration of an isoform of inositol (myo-inositol), belonging to the vitamin B complex, would improve the insulin-receptor activity, restoring normal ovulatory function...
- High dose of phytoestrogens can reverse the antiestrogenic effects of clomiphene citrate on the endometrium in patients undergoing intrauterine insemination: a randomized trial
Vittorio Unfer
A G UN CO Obstetrics and Gynecology Centre, University La Sapienza, Via G Cassini 15, 00155 Rome, Italy
J Soc Gynecol Investig 11:323-8. 2004
..To compare the effectiveness of clomiphene citrate (CC) alone or combined with phytoestrogens (PE) in ovulation induction in patients who had intrauterine insemination in a randomized, double-blind study...
- Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study
Vittorio Unfer
AGUNCO, Obstetrics and Gynecology Centre, Rome, Italy
Fertil Steril 82:145-8, quiz 265. 2004
..To determine the effects of 5 years of treatment with soy phytoestrogens on histological characteristics of endometrium in postmenopausal women...
- 17 alpha-hydroxyprogesterone caproate versus intravaginal progesterone in IVF-embryo transfer cycles: a prospective randomized study
Vittorio Unfer
A G UN CO, Obstetrics and Gynecology Centre, via G Cassiani, 15 00155 Rome, Italy
Reprod Biomed Online 9:17-21. 2004
..The data showed that 17-HPC administered every 3 days appears to be more effective in providing luteal support in comparison to intra-vaginal progesterone...
- Phytoestrogens may improve the pregnancy rate in in vitro fertilization-embryo transfer cycles: a prospective, controlled, randomized trial
Vittorio Unfer
Gynecology Association Unfer Costabile A G UN CO, Obstetrics and Gynecology Center, Rome, Italy
Fertil Steril 82:1509-13. 2004
..To compare the effectiveness of i.m. P and i.m. P plus oral phytoestrogens for luteal phase support in patients undergoing IVF-ET cycles...
- Different routes of progesterone administration and polycystic ovary syndrome: a review of the literature
Vittorio Unfer
AGUNCO Obstetrics and Gynecology Centre, via G Cassiani, Rome 15 00155, Italy
Gynecol Endocrinol 21:119-27. 2005
..We discuss the pharmacologic characteristics of the different routes of progesterone administration with reference to these diverse indications, the therapeutic objectives and patient compliance...
- Psychological assessment of the effects of treatment with phytoestrogens on postmenopausal women: a randomized, double-blind, crossover, placebo-controlled study
Maria Luisa Casini
Department of Human Physiology and Pharmacology Vittorio Erspamer, University La Sapienza, Rome, Italy
Fertil Steril 85:972-8. 2006
..To investigate the effects of soy isoflavones on mood and cognitive function in postmenopausal women...
Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort studyVittorio Unfer
AGUNCO Obstetrics and Gynecology Centre, via G Cassiani, Rome, 15 00155, Italy
Gynecol Endocrinol 27:857-61. 2011
..Recently, a number of studies have shown that the presence of several compounds in the follicular fluid positively correlates with oocyte quality and maturation (i.e., myo-inositol and melatonin)...
- Effects of the position of fibroids on fertility
Maria Luisa Casini
Department of Human Physiology and Pharmacology 'Vittorio Erspamer, University of Rome 'La Sapienza, Rome, Italy
Gynecol Endocrinol 22:106-9. 2006
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- An infertile couple suffering from oligospermia by partial sperm maturation arrest: can phytoestrogens play a therapeutic role? A case report study
Maria Luisa Casini
Department of Human Physiology and Pharmacology Vittorio Erspamer, University La Sapienza, Rome, Italy
Gynecol Endocrinol 22:399-401. 2006
..However, it is evident that a validation stage and randomized, controlled studies are essential in order to confirm this observation and verify that phytoestrogens can play an important role in male infertility...
- Efficacy and safety of 17alpha-hydroxyprogesterone caproate in hormone replacement therapy
Riccardo Agostini
First Institute of Obstetrics and Gynecology, University La Sapienza, Rome, Italy
Gynecol Endocrinol 21:265-7. 2005
..No biopsies had to be performed at the end of the 12th month of treatment. No serious adverse effect where recorded during the study period. In conclusion, our data show the efficacy and safety of 17alpha-HPC in HRT...
- Myo-inositol soft gel capsules may prevent the risk of coffee-induced neural tube defects
Sara De Grazia
A G UN CO, Obstetrics and Gynecology Center, Gennaro Cassiani 15, 00155 Rome, Italy
Expert Opin Drug Deliv 9:1033-9. 2012
..In the present study, we tested the hypothesis that, beside affecting the inositol signaling pathway, coffee also interferes with inositol absorption...
- The effect of a combination therapy with myo-inositol and a combined oral contraceptive pill versus a combined oral contraceptive pill alone on metabolic, endocrine, and clinical parameters in polycystic ovary syndrome
Massimo Minozzi
University La Sapienza, Institute of Gynecology and Obstetrics, Rome, Italy
Gynecol Endocrinol 27:920-4. 2011
..Compare the effects of a combined contraceptive pill (OCP) in combination with myo-inositol (MI) on endocrine, metabolic, and clinical parameters in patients with polycystic ovary syndrome (PCOS)...
- Myo-inositol in a new pharmaceutical form: a step forward to a broader clinical use
Gianfranco Carlomagno
Obstetrics and Gynecology Center, viaG Cassiani, Rome, Italy
Expert Opin Drug Deliv 9:267-71. 2012
..Aiming to search for a pharmaceutical form able to be better absorbed, the pharmacokinetic (PK) profile of the new manufactured MI soft gelatin capsule form was evaluated and compared with the commercially available MI powder...
- The D-chiro-inositol paradox in the ovary
Gianfranco Carlomagno
Associazione Ginecologi Unfer Costabile AGUNCO Obstetrics and Gynecology Center, Rome, Italy
Fertil Steril 95:2515-6. 2011
..We hypothesize that in the ovaries of polycystic ovary syndrome patients, epimerase activity is enhanced, leading to a local myo-inositol deficiency which in turn is responsible for the poor oocyte quality...
- Ovulation induction with urinary FSH or recombinant FSH in polycystic ovary syndrome patients: a prospective randomized analysis of cost-effectiveness
Sandro Gerli
Centre of Reproductive and Perinatal Medicine, Department of Gynecological, Obstetrical and Pediatric Sciences, University of Perugia, Italy
Reprod Biomed Online 9:494-9. 2004
..37 in the rFSH group. In conclusion, uFSH and rFSH demonstrated the same effectiveness in ovarian stimulation in IUI cycles in PCOS patients. The urinary preparation is more cost-effective due to the difference of its cost per IU...
- Diclofenac pyrrolidine versus Ketoprofen for the relief of pain from episiotomy: a randomized controlled trial
Fabio Facchinetti
Mother Infant Department, Unit of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Modena, Italy
Acta Obstet Gynecol Scand 84:951-5. 2005
..We performed a randomized double-blind controlled trial to compare the effectiveness and side-effects of two analgesics in the management of postpartum perineal pain. Patient preference toward the two medications was also analyzed...
- Recombinant versus urinary follicle-stimulating hormone in intrauterine insemination cycles: a prospective, randomized analysis of cost effectiveness
Sandro Gerli
Centre of Reproductive and Perinatal Medicine, Department of Gynecological, Obstetrical and Pediatric Sciences, University of Perugia, Policlinico Monteluce, Perugia 06122, Italy
Fertil Steril 82:573-8. 2004
..To compare the clinical results and the cost effectiveness of urinary FSH and recombinant FSH in ovarian stimulation for IUI cycles...
- Laparoscopy and methylene blue intrauterine injection immediately after undiagnosed conception: effect on pregnancy and neonatal outcome
Sandro Gerli
Department of Gynecological, Obstetrical and Pediatric Sciences, Centre of Reproductive and Perinatal Medicine, University of Perugia, Policlinico Monteluce, 06122 Perugia, Italy
Eur J Obstet Gynecol Reprod Biol 112:102-3. 2004
..A 39-year-old woman with infertility and chronic pelvic pain underwent a diagnostic laparoscopy with dye-test performed approximately 7 days after conception. No effects were reported on pregnancy and neonatal outcome...
