Luis Ulloa

Summary

Publications

  1. ncbi The vagus nerve and the nicotinic anti-inflammatory pathway
    Luis Ulloa
    Center of Immunology and Inflammation, Institute for Medical Research, North Shore University Hospital, 350 Community Drive, New York 11030, USA
    Nat Rev Drug Discov 4:673-84. 2005
  2. ncbi High-mobility group box 1 (HMGB1) protein: friend and foe
    Luis Ulloa
    Center of Immunology and Inflammation, North Shore University Hospital, 350 Community Drive, Manhasset, NY 11030, USA
    Cytokine Growth Factor Rev 17:189-201. 2006
  3. ncbi Structural basis for the proinflammatory cytokine activity of high mobility group box 1
    Jianhua Li
    Laboratory of Biomedical Science, North Shore-Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Mol Med 9:37-45. 2003
  4. ncbi Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms
    Guoqian Chen
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA
    J Leukoc Biol 76:994-1001. 2004
  5. ncbi Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis
    Guoqian Chen
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, Manhasset, NY 11030, USA
    J Lipid Res 46:623-7. 2005
  6. ncbi Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
    Hong Wang
    The Center for Immunology and Inflammation, North Shore-LIJ Research Institute, North Shore University Hospital, 350 Community Drive, Manhasset, New York 11030, USA
    Nat Med 10:1216-21. 2004
  7. ncbi Reversing established sepsis with antagonists of endogenous high-mobility group box 1
    Huan Yang
    Laboratory of Biomedical Science, North Shore-Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 101:296-301. 2004
  8. ncbi Recombinant HMGB1 with cytokine-stimulating activity
    Jianhua Li
    Laboratories of Biomedical Science, North Shore-Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    J Immunol Methods 289:211-23. 2004
  9. ncbi Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    J Exp Med 203:1623-8. 2006
  10. ncbi Alpha-chemokine receptor blockade reduces high mobility group box 1 protein-induced lung inflammation and injury and improves survival in sepsis
    Xinchun Lin
    Department of Surgery, North Shore University Hospital, Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Am J Physiol Lung Cell Mol Physiol 289:L583-90. 2005

Collaborators

Detail Information

Publications23

  1. ncbi The vagus nerve and the nicotinic anti-inflammatory pathway
    Luis Ulloa
    Center of Immunology and Inflammation, Institute for Medical Research, North Shore University Hospital, 350 Community Drive, New York 11030, USA
    Nat Rev Drug Discov 4:673-84. 2005
    ..Similar to the development of alpha- and beta-agonists for adrenoceptors, selective agonists for alpha7nAChR could represent a promising pharmacological strategy against infectious and inflammatory diseases...
  2. ncbi High-mobility group box 1 (HMGB1) protein: friend and foe
    Luis Ulloa
    Center of Immunology and Inflammation, North Shore University Hospital, 350 Community Drive, Manhasset, NY 11030, USA
    Cytokine Growth Factor Rev 17:189-201. 2006
    ..This article focus on the immuno-regulatory role of HMGB1 and its contribution to infectious and inflammatory disorders...
  3. ncbi Structural basis for the proinflammatory cytokine activity of high mobility group box 1
    Jianhua Li
    Laboratory of Biomedical Science, North Shore-Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Mol Med 9:37-45. 2003
    ..These results indicate that a proinflammatory domain of HMGB1 maps to the highly conserved DNA-binding B box, making this primary sequence a suitable target in the design of therapeutics...
  4. ncbi Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms
    Guoqian Chen
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA
    J Leukoc Biol 76:994-1001. 2004
    ..g., 10 ng/ml). Taken together, these data suggest that LPS stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms...
  5. ncbi Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis
    Guoqian Chen
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, Manhasset, NY 11030, USA
    J Lipid Res 46:623-7. 2005
    ..Thus, stearoyl LPC confers protection against lethal experimental sepsis partly by facilitating the elimination of the invading pathogens and partly by inhibiting endotoxin-induced release of a late proinflammatory cytokine, HMGB1...
  6. ncbi Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
    Hong Wang
    The Center for Immunology and Inflammation, North Shore-LIJ Research Institute, North Shore University Hospital, 350 Community Drive, Manhasset, New York 11030, USA
    Nat Med 10:1216-21. 2004
    ....
  7. ncbi Reversing established sepsis with antagonists of endogenous high-mobility group box 1
    Huan Yang
    Laboratory of Biomedical Science, North Shore-Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 101:296-301. 2004
    ..These observations demonstrate that specific inhibition of endogenous HMGB1 therapeutically reverses lethality of established sepsis indicating that HMGB1 inhibitors can be administered in a clinically relevant time frame...
  8. ncbi Recombinant HMGB1 with cytokine-stimulating activity
    Jianhua Li
    Laboratories of Biomedical Science, North Shore-Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    J Immunol Methods 289:211-23. 2004
    ..This strategy provides an important advance in methodology to facilitate future HMGB1 studies...
  9. ncbi Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    J Exp Med 203:1623-8. 2006
    ....
  10. ncbi Alpha-chemokine receptor blockade reduces high mobility group box 1 protein-induced lung inflammation and injury and improves survival in sepsis
    Xinchun Lin
    Department of Surgery, North Shore University Hospital, Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Am J Physiol Lung Cell Mol Physiol 289:L583-90. 2005
    ..These data demonstrate that alpha-chemokine receptor inhibition can reduce HMGB1-induced lung injury and lethality in established sepsis and may provide a novel treatment in this devastating disease...
  11. ncbi High-mobility group box-1 isoforms as potential therapeutic targets in sepsis
    William Parrish
    North Shore University Hospital, Manhasset, NY, USA
    Methods Mol Biol 361:145-62. 2007
    ..This article reviews the recent studies on HMGB1 regulation and their impact on the inflammatory activity and pathological contribution of HMGB 1 to infectious and inflammatory disorders...
  12. ncbi Adrenomedullin and its binding protein attenuate the proinflammatory response after hemorrhage
    Xiaoxuan Cui
    Division of Surgical Research, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    Crit Care Med 33:391-8. 2005
    ....
  13. ncbi Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation
    Hong Wang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, New York 11030, USA
    Nature 421:384-8. 2003
    ..Thus, the nicotinic acetylcholine receptor alpha7 subunit is essential for inhibiting cytokine synthesis by the cholinergic anti-inflammatory pathway...
  14. ncbi The neuronal strategy for inflammation
    Luis Ulloa
    Feinstein Institute of Biomedical Research, Department of Surgery, North Shore University Hospital, 350 Community Drive, Manhasset, NY 11030, USA
    Novartis Found Symp 280:223-33; discussion 233-7. 2007
    ..Similar to the development of selective agonists for adrenergic receptors, selective nicotinic agonists for the alpha7nAChR may represent a promising pharmacological strategy against infectious and inflammatory diseases...
  15. ncbi The "cytokine profile": a code for sepsis
    Luis Ulloa
    Center of Immunology and Inflammation, North Shore LIJ Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Trends Mol Med 11:56-63. 2005
    ..Future clinical trials might define patient populations and therapeutic strategies according to the profile of expression of cytokines...
  16. ncbi Neuroimmune perspectives in sepsis
    Luis Ulloa
    Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Avenue, PO Box 1709, Newark, NJ 07103, USA
    Crit Care 13:133. 2009
    ..Since the nervous system is the principal regulator of the immune system, physiologic studies understanding the neuroimmune connections can provide major advantages to design novel therapeutic strategies for sepsis...
  17. ncbi Scientific and clinical challenges in sepsis
    Luis Ulloa
    Laboratory of Anti inflammatory Signaling and Surgical Immunology, Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Curr Pharm Des 15:1918-35. 2009
    ..This article reviews novel inflammatory molecular aspects and the experimental anti-inflammatory strategies for sepsis, as they may represent particular pathological processes in specific subsets of patients...
  18. ncbi Alpha7 nicotinic acetylcholine receptor: a link between inflammation and neurodegeneration
    Concepcion Conejero-Goldberg
    The Litwin Zucker Research Center for the Study of Alzheimer s Disease, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Neurosci Biobehav Rev 32:693-706. 2008
    ..Among them, alpha7nAChR may represent a pharmacological target to control these two mechanisms during the pathogenesis of neurodegenerative and behavioral disorders...
  19. ncbi Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation
    Luis Ulloa
    Laboratory of Biomedical Science, North Shore-LIJ Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 99:12351-6. 2002
    ..EP now warrants further evaluation as an experimental "rescue" therapeutic for sepsis and other potentially fatal systemic inflammatory disorders...
  20. ncbi Pharmacological stimulation of the cholinergic antiinflammatory pathway
    Thomas R Bernik
    Laboratory of Biomedical Science, North Shore-LIJ Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    J Exp Med 195:781-8. 2002
    ..Together, these results indicate that stimulation of the cholinergic antiinflammatory pathway by either pharmacological or electrical methods can attenuate the systemic inflammatory response to endotoxin-induced shock...
  21. ncbi Hmgb-1 as a therapeutic target for infectious and inflammatory disorders
    Lin L Mantell
    St. John's University College of Pharmacy, Jamaica, NY 11439, USA
    Shock 25:4-11. 2006
    ..This article analyzes the value of HMGB-1 as a therapeutic target for the treatment of diverse infectious and inflammatory disorders and its interest for human clinical trials...
  22. ncbi High mobility group box chromosomal protein 1 as a nuclear protein, cytokine, and potential therapeutic target in arthritis
    Luis Ulloa
    Arthritis Rheum 48:876-81. 2003
  23. ncbi The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice
    David J van Westerloo
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Gastroenterology 130:1822-30. 2006
    ..This anti-inflammatory effect is mediated by an interaction of acetylcholine, the principal neurotransmitter of the vagus nerve, with macrophage cholinergic nicotinic receptors expressing the alpha7 subunit...