Oleg A Krishtal

Summary

Affiliation: National Academy of Sciences of Ukraine
Country: Ukraine

Publications

  1. ncbi request reprint New channel blocker BIIA388CL blocks delayed rectifier, but not A-type potassium current in central neurons
    O Krishtal
    Bogomoletz Institute of Physiology, Department of Cellular Membranology, Bogomoletz str, 4, Kyiv, Ukraine, 01024
    Neuropharmacology 40:233-41. 2001
  2. ncbi request reprint Modulation of ion channels in rat neurons by the constituents of Hypericum perforatum
    O Krishtal
    Bogomoletz Institute of Physiology, Kiev, Ukraine
    Pharmacopsychiatry 34:S74-82. 2001
  3. ncbi request reprint Inhibition of hippocampal LTP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors
    Elena L Kondratskaya
    Department of Cellular Membranology, A A Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Bogomoletz St 4, 01024, Kiev, Ukraine
    Neurochem Int 44:171-7. 2004
  4. ncbi request reprint The ASICs: signaling molecules? Modulators?
    Oleg Krishtal
    Bogomoletz Institute of Physiology, Bogomoletz str 4, 01024, Kiev, Ukraine
    Trends Neurosci 26:477-83. 2003
  5. ncbi request reprint Ginkgolide B preferentially blocks chloride channels formed by heteromeric glycine receptors in hippocampal pyramidal neurons of rat
    Elena L Kondratskaya
    Department of Cellular Membranology, A A Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Bogomoletz St 4, Kiev 01024, Ukraine
    Brain Res Bull 63:309-14. 2004
  6. ncbi request reprint Role for P2X receptors in long-term potentiation
    Yuri V Pankratov
    Department of Cellular Membranology, Bogomoletz Institute of Physiology, 01024 Kiev, Ukraine
    J Neurosci 22:8363-9. 2002
  7. ncbi request reprint BN52021, a platelet activating factor antagonist, is a selective blocker of glycine-gated chloride channel
    Elena L Kondratskaya
    Department of Cellular Membranology, A A Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Bogomoletz St 4, Kiev 01024, Ukraine
    Neurochem Int 40:647-53. 2002
  8. ncbi request reprint Post-synaptic N-methyl-d-aspartate signalling in hippocampal neurons of rat: spillover increases the impact of each spike in a short burst discharge
    Sergei E Grebenyuk
    Bogomoletz Institute of Physiology, 4, Bogomoletz St, 01024 Kiev, Ukraine
    Neurosci Lett 361:60-3. 2004
  9. pmc Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape 'superslow' afterburst EPSC in rat hippocampus
    Natasha A Lozovaya
    Department of Cellular Membranology, Bogomoletz Institute of Physiology, 01024 Kiev, Ukraine
    J Physiol 558:451-63. 2004
  10. ncbi request reprint P2X3 receptor gating near normal body temperature
    V Khmyz
    Bogomoletz Institute of Physiology, Bogomoletz Street 4, Kyiv 24, Ukraine
    Pflugers Arch 456:339-47. 2008

Collaborators

  • Yuri V Pankratov
  • Alexej Verkhratsky
  • Bodo Laube
  • Elena L Kondratskaya
  • I Chizhmakov
  • Yevgen K Yudin
  • Natasha A Lozovaya
  • Sergei E Grebenyuk
  • Shyam S Chatterjee
  • V Khmyz
  • N Mamenko
  • Zinayida A Tamarova
  • O Ostrovskaya
  • I Khasabova
  • D A Simone
  • T Volkova
  • O Maximyuk
  • V Teslenko
  • Z Tamarova
  • I Prudnikov
  • Y Yudin
  • Heinrich Betz
  • Olga I Ostrovskaya
  • Timur S Tsintsadze
  • Ulyana V Lalo
  • Daniel T Monaghan
  • Bihua Feng
  • Alexander I Fisyunov
  • L Moroz
  • Leonid L Moroz
  • Timur Sh Tsintsadze
  • Polina V Lishko

Detail Information

Publications18

  1. ncbi request reprint New channel blocker BIIA388CL blocks delayed rectifier, but not A-type potassium current in central neurons
    O Krishtal
    Bogomoletz Institute of Physiology, Department of Cellular Membranology, Bogomoletz str, 4, Kyiv, Ukraine, 01024
    Neuropharmacology 40:233-41. 2001
    ..This current is the main pathway for the loss of intracellular potassium by depolarized neurons. Selective obstruction of this pathway could be useful for neuroprotection...
  2. ncbi request reprint Modulation of ion channels in rat neurons by the constituents of Hypericum perforatum
    O Krishtal
    Bogomoletz Institute of Physiology, Kiev, Ukraine
    Pharmacopsychiatry 34:S74-82. 2001
    ..The results presented here indicate that multiple mechanisms and extract constituents may be involved in the antidepressant action of Hypericum extracts, and that they could also possess neuroprotective and analgesic effects...
  3. ncbi request reprint Inhibition of hippocampal LTP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors
    Elena L Kondratskaya
    Department of Cellular Membranology, A A Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Bogomoletz St 4, 01024, Kiev, Ukraine
    Neurochem Int 44:171-7. 2004
    ..Both ginkgolides and strychnine significantly facilitated short-term potentiation (STP). Our data support a hypothesis according to which ginkgolides affect LTP by inhibiting PAFRs...
  4. ncbi request reprint The ASICs: signaling molecules? Modulators?
    Oleg Krishtal
    Bogomoletz Institute of Physiology, Bogomoletz str 4, 01024, Kiev, Ukraine
    Trends Neurosci 26:477-83. 2003
    ..The question of whether tissue pH is subject to quick fluctuations of a magnitude sufficient to activate ASICs is a crucial point that will determine the functional significance of these channels...
  5. ncbi request reprint Ginkgolide B preferentially blocks chloride channels formed by heteromeric glycine receptors in hippocampal pyramidal neurons of rat
    Elena L Kondratskaya
    Department of Cellular Membranology, A A Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Bogomoletz St 4, Kiev 01024, Ukraine
    Brain Res Bull 63:309-14. 2004
    ..Taken together, these findings indicate that ginkgolide B has higher affinity to heteromeric Gly receptor-gated channels than to the homomeric ones...
  6. ncbi request reprint Role for P2X receptors in long-term potentiation
    Yuri V Pankratov
    Department of Cellular Membranology, Bogomoletz Institute of Physiology, 01024 Kiev, Ukraine
    J Neurosci 22:8363-9. 2002
    ..We suggest that, by controlling the background calcium and thus the activity of NMDA receptors at low firing frequencies, P2X receptors act as a dynamic low-frequency filter so that weak stimuli do not induce LTP...
  7. ncbi request reprint BN52021, a platelet activating factor antagonist, is a selective blocker of glycine-gated chloride channel
    Elena L Kondratskaya
    Department of Cellular Membranology, A A Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Bogomoletz St 4, Kiev 01024, Ukraine
    Neurochem Int 40:647-53. 2002
    ..This substance fails to affect AMPA and NMDA responses. It may be concluded that BN52021 inhibits glycine-gated Cl- channels by interacting with the pore region and does not compete for the strychnine-binding centre...
  8. ncbi request reprint Post-synaptic N-methyl-d-aspartate signalling in hippocampal neurons of rat: spillover increases the impact of each spike in a short burst discharge
    Sergei E Grebenyuk
    Bogomoletz Institute of Physiology, 4, Bogomoletz St, 01024 Kiev, Ukraine
    Neurosci Lett 361:60-3. 2004
    ..The phenomenon is most probably due to the spillover-mediated recruitment of extrasynaptic NMDA receptors. In terms of post-synaptic signalling it dramatically increases the impact of each spike in a short burst discharge...
  9. pmc Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape 'superslow' afterburst EPSC in rat hippocampus
    Natasha A Lozovaya
    Department of Cellular Membranology, Bogomoletz Institute of Physiology, 01024 Kiev, Ukraine
    J Physiol 558:451-63. 2004
    ..Long-term potentiation (LTP) induced by successive rounds of burst stimulation is accompanied by a long-term increase in the contribution of extrasynaptic receptors in the afterburst EPSC(NMDA.)..
  10. ncbi request reprint P2X3 receptor gating near normal body temperature
    V Khmyz
    Bogomoletz Institute of Physiology, Bogomoletz Street 4, Kyiv 24, Ukraine
    Pflugers Arch 456:339-47. 2008
    ..Unusual combination of temperature sensitivity/insensitivity of P2X3 receptors may be related to their pivotal role in the processing of thermal sensitivity as revealed by recent knockout experiments...
  11. pmc Distinct quantal features of AMPA and NMDA synaptic currents in hippocampal neurons: implication of glutamate spillover and receptor saturation
    Yuri V Pankratov
    Bogomoletz Institute of Physiology, Kiev, Ukraine
    Biophys J 85:3375-87. 2003
    ....
  12. ncbi request reprint Peripherally applied neuropeptide SF is equally algogenic in wild type and ASIC3-/- mice
    Yevgen K Yudin
    Bogomoletz Institute of Physiology, Bogomoletz str 4, 01024 Kiev, Ukraine
    Neurosci Res 55:421-5. 2006
    ..Thus peripheral algogenic effects of NPSF cannot be explained only in terms of their action on the ASIC3 channels and involves some other, still unidentified mechanism...
  13. ncbi request reprint Opioids inhibit purinergic nociceptors in the sensory neurons and fibres of rat via a G protein-dependent mechanism
    I Chizhmakov
    Department of Cellular Membranology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Neuropharmacology 48:639-47. 2005
    ..Intracellular GDP eliminated the effects of opioids, while pertussis toxin (PTX) abolished only the inhibition phase. Thus, P2X receptors in the sensory neurons are affected by opioids via multiple G protein-dependent pathways...
  14. doi request reprint P2X receptors in sensory neurons co-cultured with cancer cells exhibit a decrease in opioid sensitivity
    I Chizhmakov
    Bogomoletz Institute of Physiology, Ukraine Bogomoletz Institute of Physiology, Kiev, Ukraine
    Eur J Neurosci 29:76-86. 2009
    ..These phenomena may increase neuronal excitability initiated by peripheral ATP release and thereby contribute to the decreased sensitivity of cancer pain to opioids...
  15. ncbi request reprint Modulatory action of RFamide-related peptides on acid-sensing ionic channels is pH dependent: the role of arginine
    O Ostrovskaya
    Department Cellular Membranology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    J Neurochem 91:252-5. 2004
    ..We suggest that the pH dependence of the modulatory action of RFa-related peptides can be associated with the interaction of a positively charged arginine with histidine residues in the molecule of ASIC...
  16. ncbi request reprint The agonists for nociceptors are ubiquitous, but the modulators are specific: P2X receptors in the sensory neurons are modulated by cannabinoids
    O Krishtal
    Department of Cellular Membranology, Bogomoletz Institute of Physiology, Bogomoletz Street 4, Kiev, 01024, Ukraine
    Pflugers Arch 453:353-60. 2006
    ..These data indicate that cannabinoids may inhibit nociceptive responses produced by P2X receptors...
  17. ncbi request reprint RFa-related peptides are algogenic: evidence in vitro and in vivo
    Yevgen K Yudin
    Bogomoletz Institute of Physiology, 01024, Kiev, Ukraine
    Eur J Neurosci 20:1419-23. 2004
    ..The peptides do not activate any conductance in the somatic membrane of dorsal root ganglion neurons of rats and probably affect still unidentified molecular target(s) responsible for nociceptive signalling...
  18. ncbi request reprint The beta subunit increases the ginkgolide B sensitivity of inhibitory glycine receptors
    Elena L Kondratskaya
    Department of Neurochemistry, Max Planck Institute for Brain Research, Deutschordenstrasse 46, 60528 Frankfurt, Germany
    Neuropharmacology 49:945-51. 2005
    ..As hetero-oligomeric GlyRs are known to be synaptically localized, GB represents a channel blocker that may be employed to separate extrasynaptic from synaptic glycine currents...