Liudmyla Tsyba

Summary

Affiliation: Institute of Molecular Biology and Genetics
Country: Ukraine

Publications

  1. doi request reprint Alternative splicing affecting the SH3A domain controls the binding properties of intersectin 1 in neurons
    Liudmyla Tsyba
    Institute of Molecular Biology and Genetics, 150 Zabolotnogo Street, Kyiv 03143, Ukraine
    Biochem Biophys Res Commun 372:929-34. 2008
  2. doi request reprint Identification and characterization of a novel mammalian isoform of the endocytic adaptor ITSN1
    Mykola Dergai
    Department of Functional Genomics, Institute of Molecular Biology and Genetics, 150 Zabolotnogo Street, Kyiv 03680, Ukraine
    Gene 485:120-9. 2011
  3. pmc Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins
    Olga Novokhatska
    Department of Functional Genomics, Institute of Molecular Biology and Genetics, Kyiv, Ukraine
    PLoS ONE 8:e70546. 2013
  4. doi request reprint Intersectin multidomain adaptor proteins: regulation of functional diversity
    Liudmyla Tsyba
    Department of Functional Genomics, Institute of Molecular Biology and Genetics, NASU, 150 Zabolotnogo Street, Kyiv, Ukraine
    Gene 473:67-75. 2011
  5. doi request reprint Structural diversity and differential expression of novel human intersectin 1 isoforms
    Sergii Kropyvko
    Institute of Molecular Biology and Genetics, 150 Zabolotnogo Street, 03680 Kyiv, Ukraine
    Mol Biol Rep 37:2789-96. 2010
  6. doi request reprint Endocytic adaptor protein intersectin 1 forms a complex with microtubule stabilizer STOP in neurons
    Dmytro Morderer
    State Key Laboratory on Molecular and Cellular Biology, Institute of Molecular Biology and Genetics, 150 Zabolotnogo Street, Kyiv 03680, Ukraine
    Gene 505:360-4. 2012
  7. doi request reprint Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits
    Oleksandr Dergai
    Department of Functional Genomics, Institute of Molecular Biology and Genetics, NASU, 150 Zabolotnogo Street, 03680 Kyiv, Ukraine
    Biochem Biophys Res Commun 402:408-13. 2010
  8. doi request reprint The LMP2A protein of Epstein-Barr virus regulates phosphorylation of ITSN1 and Shb adaptors by tyrosine kinases
    Oleksandr Dergai
    State Key Laboratory of Molecular and Cellular Biology, Institute of Molecular Biology and Genetics, 150 Zabolotnogo Street, Kyiv 03680, Ukraine
    Cell Signal 25:33-40. 2013
  9. ncbi request reprint Intersectin 1 forms a complex with adaptor protein Ruk/CIN85 in vivo independently of epidermal growth factor stimulation
    Oleksii Nikolaienko
    Institute of Molecular Biology and Genetics, 150 Zabolotnogo Street, Kyiv 03680, Ukraine
    Cell Signal 21:753-9. 2009
  10. doi request reprint Intersectin 2 nucleotide exchange factor regulates Cdc42 activity during Xenopus early development
    Olga Novokhatska
    Department of Functional Genomics, Institute of Molecular Biology and Genetics, National Academy of Sciences Ukraine, 150 Zabolotnogo Street, Kyiv, Ukraine
    Biochem Biophys Res Commun 408:663-8. 2011

Collaborators

  • Olga Novokhatska
  • Pavel Belan
  • Lyudmyla Drobot
  • Oleksandr Dergai
  • Inessa Skrypkina
  • Alla Rynditch
  • Mykola Dergai
  • Oleksii Nikolaienko
  • Dmytro Morderer
  • Sergii Kropyvko
  • Daria Gudkova
  • Liudmila Matskova
  • Volodymyr Cherkas
  • Valeriy Filonenko
  • Jacques Moreau
  • Dmytro Gerasymchuk
  • Vladimir Buchman
  • Yaroslav Fedyshyn
  • Susana De La Luna

Detail Information

Publications10

  1. doi request reprint Alternative splicing affecting the SH3A domain controls the binding properties of intersectin 1 in neurons
    Liudmyla Tsyba
    Institute of Molecular Biology and Genetics, 150 Zabolotnogo Street, Kyiv 03143, Ukraine
    Biochem Biophys Res Commun 372:929-34. 2008
    ..These results demonstrate that alternative splicing leads to the formation of two pools of ITSN1 with potentially different properties in neurons, affecting ITSN1 function as adaptor protein...
  2. doi request reprint Identification and characterization of a novel mammalian isoform of the endocytic adaptor ITSN1
    Mykola Dergai
    Department of Functional Genomics, Institute of Molecular Biology and Genetics, 150 Zabolotnogo Street, Kyiv 03680, Ukraine
    Gene 485:120-9. 2011
    ..Thus, this novel mammalian ITSN1 isoform possesses a significantly altered domain structure and performs specific protein-protein interactions...
  3. pmc Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins
    Olga Novokhatska
    Department of Functional Genomics, Institute of Molecular Biology and Genetics, Kyiv, Ukraine
    PLoS ONE 8:e70546. 2013
    ..These proteins are closely related but have implications in distinct pathologies. To determine how these proteins could be separated in certain cell pathways we performed a comparative study of ITSNs...
  4. doi request reprint Intersectin multidomain adaptor proteins: regulation of functional diversity
    Liudmyla Tsyba
    Department of Functional Genomics, Institute of Molecular Biology and Genetics, NASU, 150 Zabolotnogo Street, Kyiv, Ukraine
    Gene 473:67-75. 2011
    ..The diversity of mechanisms in the regulation of ITSN expression and specificity in different cells emphasizes the important role of ITSN proteins in vesicle trafficking and signalling...
  5. doi request reprint Structural diversity and differential expression of novel human intersectin 1 isoforms
    Sergii Kropyvko
    Institute of Molecular Biology and Genetics, 150 Zabolotnogo Street, 03680 Kyiv, Ukraine
    Mol Biol Rep 37:2789-96. 2010
    ..The isoforms identified differ in domain organization and expression level in different tissues and more likely contribute to the modulation of many complex protein interactions in which ITSN1 participates...
  6. doi request reprint Endocytic adaptor protein intersectin 1 forms a complex with microtubule stabilizer STOP in neurons
    Dmytro Morderer
    State Key Laboratory on Molecular and Cellular Biology, Institute of Molecular Biology and Genetics, 150 Zabolotnogo Street, Kyiv 03680, Ukraine
    Gene 505:360-4. 2012
    ..As STOP is a microtubule-stabilizing protein that is required for several forms of synaptic plasticity in the hippocampus, identification of this interaction raises the possibility of ITSN1 participation in this process...
  7. doi request reprint Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits
    Oleksandr Dergai
    Department of Functional Genomics, Institute of Molecular Biology and Genetics, NASU, 150 Zabolotnogo Street, 03680 Kyiv, Ukraine
    Biochem Biophys Res Commun 402:408-13. 2010
    ..These findings expand the role of ITSN1 as a scaffolding molecule bringing together components of endocytic complexes...
  8. doi request reprint The LMP2A protein of Epstein-Barr virus regulates phosphorylation of ITSN1 and Shb adaptors by tyrosine kinases
    Oleksandr Dergai
    State Key Laboratory of Molecular and Cellular Biology, Institute of Molecular Biology and Genetics, 150 Zabolotnogo Street, Kyiv 03680, Ukraine
    Cell Signal 25:33-40. 2013
    ..Considering that Shb and ITSN1 are implicated in various receptor tyrosine kinase signaling, our results indicate that LMP2A can affect a number of signaling pathways by regulating the phosphorylation of the ITSN1 and Shb adaptors...
  9. ncbi request reprint Intersectin 1 forms a complex with adaptor protein Ruk/CIN85 in vivo independently of epidermal growth factor stimulation
    Oleksii Nikolaienko
    Institute of Molecular Biology and Genetics, 150 Zabolotnogo Street, Kyiv 03680, Ukraine
    Cell Signal 21:753-9. 2009
    ..Moreover, both proteins colocalize in MCF-7 cells with their common binding partner, the ubiquitin ligase c-Cbl. The possible biological role of the interaction between ITSN1 and Ruk/CIN85 is discussed...
  10. doi request reprint Intersectin 2 nucleotide exchange factor regulates Cdc42 activity during Xenopus early development
    Olga Novokhatska
    Department of Functional Genomics, Institute of Molecular Biology and Genetics, National Academy of Sciences Ukraine, 150 Zabolotnogo Street, Kyiv, Ukraine
    Biochem Biophys Res Commun 408:663-8. 2011
    ..Thus, our data indicate that the ITSN2 exchange factor regulates the activity of Cdc42 during embryo development affecting actin cytoskeleton in Xenopus embryos...