Jack W Winter
- Cost-effectiveness of thiopurine methyltransferase genotype screening in patients about to commence azathioprine therapy for treatment of inflammatory bowel diseaseJ Winter
Gastroenterology Unit, Gartnavel General Hospital, Glasgow, Scotland
Aliment Pharmacol Ther 20:593-9. 2004..Its use is limited by its side-effect profile. Marrow toxicity occurs in approximately 3.2% of patients and is known to be associated with diminished thiopurine methyltransferase enzyme activity resulting from genetic polymorphisms...
- Assessment of thiopurine methyltransferase enzyme activity is superior to genotype in predicting myelosuppression following azathioprine therapy in patients with inflammatory bowel diseaseJ W Winter
Gastroenterology Unit, Gartnavel General Hospital, Glasgow, UK
Aliment Pharmacol Ther 25:1069-77. 2007..It has been proposed that pretreatment assessment of TPMT status reduces the incidence of toxicity and is cost-effective...
- N-nitrosamine generation from ingested nitrate via nitric oxide in subjects with and without gastroesophageal refluxJack W Winter
Division of Medicine, Western Infirmary, Glasgow, United Kingdom
Gastroenterology 133:164-74. 2007..We aimed to ascertain if luminal nitric oxide exerts nitrosative stress in the human upper gastrointestinal tract, and to assess the influence of acid reflux on this phenomenon...
- The nonerosive reflux disease-gastroesophageal reflux disease controversyJack W Winter
Glasgow Royal Infirmary, Glasgow, UK
Curr Opin Gastroenterol 24:509-15. 2008..To analyse the concept of nonerosive reflux disease (NERD), examining its evolving definition and its relationship to reflux disease and functional gastrointestinal disorders...