Brian J Willett

Summary

Country: UK

Publications

  1. pmc The virus-receptor interaction in the replication of feline immunodeficiency virus (FIV)
    Brian J Willett
    MRC University of Glasgow Centre for Virus Research, Glasgow, United Kingdom Electronic address
    Curr Opin Virol 3:670-5. 2013
  2. doi Feline leukaemia virus: half a century since its discovery
    Brian J Willett
    Medical Research Council University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Bearsden Road, Glasgow G61 1QH, Scotland, United Kingdom
    Vet J 195:16-23. 2013
  3. pmc Modulation of the virus-receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody
    Brian J Willett
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow, UK
    Retrovirology 7:38. 2010
  4. pmc A single site for N-linked glycosylation in the envelope glycoprotein of feline immunodeficiency virus modulates the virus-receptor interaction
    Brian J Willett
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK
    Retrovirology 5:77. 2008
  5. doi Feline immunodeficiency virus env gene evolution in experimentally infected cats
    Martin Kraase
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom
    Vet Immunol Immunopathol 134:96-106. 2010
  6. pmc Identification of novel subgroup A variants with enhanced receptor binding and replicative capacity in primary isolates of anaemogenic strains of feline leukaemia virus
    Hazel Stewart
    Medical Research Council University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, 464 Bearsden Road, Glasgow, UK
    Retrovirology 9:48. 2012
  7. pmc Enforced covalent trimerisation of soluble feline CD134 (OX40)-ligand generates a functional antagonist of feline immunodeficiency virus
    Brian J Willett
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom
    Mol Immunol 46:1020-30. 2009
  8. pmc Mapping the domains of CD134 as a functional receptor for feline immunodeficiency virus
    Brian J Willett
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom
    J Virol 80:7744-7. 2006
  9. pmc Genetically divergent strains of feline immunodeficiency virus from the domestic cat (Felis catus) and the African lion (Panthera leo) share usage of CD134 and CXCR4 as entry receptors
    William A McEwan
    Faculty of Veterinary Medicine, Retrovirus Research Laboratory, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow, United Kingdom
    J Virol 82:10953-8. 2008
  10. pmc Selective expansion of viral variants following experimental transmission of a reconstituted feline immunodeficiency virus quasispecies
    Brian J Willett
    MRC University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom
    PLoS ONE 8:e54871. 2013

Collaborators

Detail Information

Publications26

  1. pmc The virus-receptor interaction in the replication of feline immunodeficiency virus (FIV)
    Brian J Willett
    MRC University of Glasgow Centre for Virus Research, Glasgow, United Kingdom Electronic address
    Curr Opin Virol 3:670-5. 2013
    ..This review examines the contribution of the virus-receptor interaction to replication in vivo as well as the significance of these findings to the development of vaccines and therapeutics. ..
  2. doi Feline leukaemia virus: half a century since its discovery
    Brian J Willett
    Medical Research Council University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Bearsden Road, Glasgow G61 1QH, Scotland, United Kingdom
    Vet J 195:16-23. 2013
    ....
  3. pmc Modulation of the virus-receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody
    Brian J Willett
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow, UK
    Retrovirology 7:38. 2010
    ..These differences in receptor recognition manifest as variations in sensitivity to receptor antagonists. In this study, we ask whether the nature of the virus-receptor interaction evolves in vivo...
  4. pmc A single site for N-linked glycosylation in the envelope glycoprotein of feline immunodeficiency virus modulates the virus-receptor interaction
    Brian J Willett
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK
    Retrovirology 5:77. 2008
    ....
  5. doi Feline immunodeficiency virus env gene evolution in experimentally infected cats
    Martin Kraase
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom
    Vet Immunol Immunopathol 134:96-106. 2010
    ..Therefore these results indicate that the FIV env gene evolves during the course of infection, giving rise to variants that resist neutralization and likely lead to disease progression...
  6. pmc Identification of novel subgroup A variants with enhanced receptor binding and replicative capacity in primary isolates of anaemogenic strains of feline leukaemia virus
    Hazel Stewart
    Medical Research Council University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, 464 Bearsden Road, Glasgow, UK
    Retrovirology 9:48. 2012
    ..In order to understand further the emergence of FeLV-C in the infected cat, we examined primary isolates of FeLV-C for evidence of FeLV-A variants that bore mutations consistent with a gradual evolution from FeLV-A to FeLV-C...
  7. pmc Enforced covalent trimerisation of soluble feline CD134 (OX40)-ligand generates a functional antagonist of feline immunodeficiency virus
    Brian J Willett
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom
    Mol Immunol 46:1020-30. 2009
    ....
  8. pmc Mapping the domains of CD134 as a functional receptor for feline immunodeficiency virus
    Brian J Willett
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom
    J Virol 80:7744-7. 2006
    ....
  9. pmc Genetically divergent strains of feline immunodeficiency virus from the domestic cat (Felis catus) and the African lion (Panthera leo) share usage of CD134 and CXCR4 as entry receptors
    William A McEwan
    Faculty of Veterinary Medicine, Retrovirus Research Laboratory, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow, United Kingdom
    J Virol 82:10953-8. 2008
    ..The shared usage of CD134 and CXCR4 by FIV(Fca) and FIV(Ple)-E may have implications for in vivo cell tropism and the pathogenicity of the E subtype among free-ranging lion populations...
  10. pmc Selective expansion of viral variants following experimental transmission of a reconstituted feline immunodeficiency virus quasispecies
    Brian J Willett
    MRC University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom
    PLoS ONE 8:e54871. 2013
    ..The data suggest that viral variants with GL8-like characteristics have an early, replicative advantage and should provide the focus for future vaccine development...
  11. pmc Feline tetherin efficiently restricts release of feline immunodeficiency virus but not spreading of infection
    Isabelle Dietrich
    MRC University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom
    J Virol 85:5840-52. 2011
    ..Accordingly, tetherin expression in vivo may promote the selective expansion of viral variants capable of more efficient cell-to-cell spread...
  12. pmc Vaccination with an inactivated virulent feline immunodeficiency virus engineered to express high levels of Env
    Margaret J Hosie
    Retrovirus Research Laboratory, Institute of Comparative Medicine, University of Glasgow, Bearsden Rd, Glasgow G61 1QH, United Kingdom
    J Virol 79:1954-7. 2005
    ..Evidence of protection following challenge demonstrated the potential of this approach to lentiviral vaccination...
  13. pmc Restriction of the felid lentiviruses by a synthetic feline TRIM5-CypA fusion
    Isabelle Dietrich
    Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom
    Vet Immunol Immunopathol 143:235-42. 2011
    ..Feline TRIMCyp and FIV infection of the cat offers a unique opportunity to evaluate TRIMCyp-based approaches to genetic therapy for HIV infection and the treatment of AIDS...
  14. pmc Potent lentiviral restriction by a synthetic feline TRIM5 cyclophilin A fusion
    Isabelle Dietrich
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom
    J Virol 84:8980-5. 2010
    ..FeTRIMCyp and FIV infections of the cat offer a unique opportunity to evaluate TRIMCyp-based approaches to genetic therapy for HIV infection and the treatment of AIDS...
  15. pmc Chemokine receptors and co-stimulatory molecules: unravelling feline immunodeficiency virus infection
    Brian J Willett
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsen Road, Glasgow G61 1QH, United Kingdom
    Vet Immunol Immunopathol 123:56-64. 2008
    ..It is these early viruses that may be transmitted and should be considered as candidates for the development of vaccine regimes and novel therapeutic agents...
  16. pmc Probing the interaction between feline immunodeficiency virus and CD134 by using the novel monoclonal antibody 7D6 and the CD134 (Ox40) ligand
    Brian J Willett
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow, United Kingdom
    J Virol 81:9665-79. 2007
    ..In contrast, GL8, CPG, and NCSU were relatively refractory to inhibition by both 7D6 and CD134L and, accordingly, may have a higher-affinity interaction with CD134, permitting infection of cells where CD134 levels are limiting...
  17. pmc An investigation of the breadth of neutralizing antibody response in cats naturally infected with feline immunodeficiency virus
    Paweł M Bęczkowski
    MRC University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, UK Small Animal Hospital, University of Glasgow, Glasgow, UK
    J Gen Virol 96:671-80. 2015
    ..Similarly, no correlation was observed between the development of autologous NAbs and the duration of infection. Furthermore, cross-neutralizing antibodies were evident in only a small proportion (13 %) of cats...
  18. pmc The role of BST2/tetherin in feline retrovirus infection
    Isabelle Dietrich
    Retrovirus Research Laboratory, MRC University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Glasgow G611QH, United Kingdom
    Vet Immunol Immunopathol 143:255-64. 2011
    ....
  19. pmc Upregulation of surface feline CXCR4 expression following ectopic expression of CCR5: implications for studies of the cell tropism of feline immunodeficiency virus
    Brian J Willett
    Retrovirus Research Laboratory, Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow G61 1QH, United Kingdom
    J Virol 76:9242-52. 2002
    ..The data suggest that beta-chemokine receptors may influence FIV infection by modulating the expression of CXCR4...
  20. pmc Rapid evolution of the env gene leader sequence in cats naturally infected with feline immunodeficiency virus
    Paweł M Bęczkowski
    MRC University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, UK Small Animal Hospital, University of Glasgow, Glasgow, UK
    J Gen Virol 96:893-903. 2015
    ....
  21. pmc Recent developments in human immunodeficiency virus-1 latency research
    Chi Ngai Chan
    MRC University of Glasgow Centre for Virus Research, Bearsden Road, Glasgow G61 1QH, UK
    J Gen Virol 94:917-32. 2013
    ..In this review, the latest developments in HIV-persistence and latency research are presented...
  22. pmc Prostratin exhibits both replication enhancing and inhibiting effects on FIV infection of feline CD4+ T-cells
    Chi Ngai Chan
    MRC University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
    Virus Res 171:121-8. 2013
    ..Co-application of the protein kinase C (PKC) inhibitor Gö6850 with Prostratin reversed both the inhibitory and stimulatory effects, suggesting that PKC is crucial for FIV replication...
  23. pmc Differential utilization of CD134 as a functional receptor by diverse strains of feline immunodeficiency virus
    Brian J Willett
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom
    J Virol 80:3386-94. 2006
    ....
  24. pmc Contrasting clinical outcomes in two cohorts of cats naturally infected with feline immunodeficiency virus (FIV)
    Paweł M Bęczkowski
    MRC Centre for Virus Research, University of Glasgow, Glasgow, UK Small Animal Hospital, University of Glasgow, Glasgow, UK Electronic address
    Vet Microbiol 176:50-60. 2015
    ..In conclusion, the results of this study suggest that management and housing conditions impact on disease progression and survival times of FIV-positive cats. ..
  25. pmc Neutralising antibody response in domestic cats immunised with a commercial feline immunodeficiency virus (FIV) vaccine
    Paweł M Bęczkowski
    Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom Small Animal Hospital, University of Glasgow, Glasgow, United Kingdom Electronic address
    Vaccine 33:977-84. 2015
    ..Cats vaccinated against FIV did not display broadly neutralising antibodies, suggesting that protection may not extend to some virulent recombinant strains of FIV circulating in Australia. ..
  26. pmc Evolution of replication efficiency following infection with a molecularly cloned feline immunodeficiency virus of low virulence
    Margaret J Hosie
    Department of Veterinary Pathology, University of Glasgow, Glasgow G61 1QH, United Kingdom
    J Virol 76:6062-72. 2002
    ....