Paul Welsh

Summary

Country: UK

Publications

  1. doi request reprint The value of N-terminal pro-B-type natriuretic peptide in determining antihypertensive benefit: observations from the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)
    Paul Welsh
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Pl, Glasgow G12 8TA, United Kingdom or
    Hypertension 63:507-13. 2014
  2. doi request reprint Circulating 25OHD, dietary vitamin D, PTH, and calcium associations with incident cardiovascular disease and mortality: the MIDSPAN Family Study
    Paul Welsh
    Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom
    J Clin Endocrinol Metab 97:4578-87. 2012
  3. doi request reprint B-type natriuretic peptide and glycaemia: an emerging cardiometabolic pathway?
    P Welsh
    BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA Scotland, UK
    Diabetologia 55:1240-3. 2012
  4. doi request reprint Circulating interleukin-10 and risk of cardiovascular events: a prospective study in the elderly at risk
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Scotland
    Arterioscler Thromb Vasc Biol 31:2338-44. 2011
  5. doi request reprint Adipocytokines and risk of stroke in older people: a nested case-control study
    David J Stott
    Division of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Scotland, UK
    Int J Epidemiol 38:253-61. 2009
  6. pmc Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population
    Paul Welsh
    Faculty of Medicine, University of Glasgow, Scotland, UK
    Diabetes Care 32:308-10. 2009
  7. pmc N-terminal pro-B-type natriuretic peptide and the prediction of primary cardiovascular events: results from 15-year follow-up of WOSCOPS
    Paul Welsh
    College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
    Eur Heart J 34:443-50. 2013
  8. doi request reprint Obesity is associated with fatal coronary heart disease independently of traditional risk factors and deprivation
    Jennifer Logue
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Heart 97:564-8. 2011
  9. doi request reprint Associations of inflammatory and haemostatic biomarkers with poor outcome in acute ischaemic stroke
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Cerebrovasc Dis 27:247-53. 2009
  10. doi request reprint Does interleukin-18 or tumour necrosis factor-alpha have an independent association with the risk of coronary heart disease? Results from a prospective study in New Zealand
    Paul Welsh
    University of Glasgow, Scotland, UK
    Cytokine 50:94-8. 2010

Detail Information

Publications31

  1. doi request reprint The value of N-terminal pro-B-type natriuretic peptide in determining antihypertensive benefit: observations from the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)
    Paul Welsh
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Pl, Glasgow G12 8TA, United Kingdom or
    Hypertension 63:507-13. 2014
    ..If confirmed, these novel results suggest that NT-proBNP, as well as aiding cardiovascular disease risk assessment, may also help assess the efficacy of specific antihypertensive regimens. Further relevant studies seem warranted. ..
  2. doi request reprint Circulating 25OHD, dietary vitamin D, PTH, and calcium associations with incident cardiovascular disease and mortality: the MIDSPAN Family Study
    Paul Welsh
    Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom
    J Clin Endocrinol Metab 97:4578-87. 2012
    ..Observational studies relating circulating 25-hydroxyvitamin D (25OHD) and dietary vitamin D intake to cardiovascular disease (CVD) have reported conflicting results...
  3. doi request reprint B-type natriuretic peptide and glycaemia: an emerging cardiometabolic pathway?
    P Welsh
    BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA Scotland, UK
    Diabetologia 55:1240-3. 2012
    ..Further investigation of the links between natriuretic peptide and glycaemia would seem important given the potential to reveal novel mechanisms to treat diabetes...
  4. doi request reprint Circulating interleukin-10 and risk of cardiovascular events: a prospective study in the elderly at risk
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Scotland
    Arterioscler Thromb Vasc Biol 31:2338-44. 2011
    ..The goal of this study was to examine the association of the antiinflammatory interleukin-10 (IL-10) with risk of cardiovascular disease (CVD)...
  5. doi request reprint Adipocytokines and risk of stroke in older people: a nested case-control study
    David J Stott
    Division of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Scotland, UK
    Int J Epidemiol 38:253-61. 2009
    ..Inflammation may play an important role in atherothrombosis and in promoting cerebral damage after stroke. We hypothesized that plasma adipocytokine concentrations would be associated with risk of stroke in older people...
  6. pmc Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population
    Paul Welsh
    Faculty of Medicine, University of Glasgow, Scotland, UK
    Diabetes Care 32:308-10. 2009
    ..To clarify the association of circulating levels of leptin with risk for cardiovascular disease (CVD) events and new-onset diabetes in men and women...
  7. pmc N-terminal pro-B-type natriuretic peptide and the prediction of primary cardiovascular events: results from 15-year follow-up of WOSCOPS
    Paul Welsh
    College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
    Eur Heart J 34:443-50. 2013
    ..To test whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) was independently associated with, and improved the prediction of, cardiovascular disease (CVD) in a primary prevention cohort...
  8. doi request reprint Obesity is associated with fatal coronary heart disease independently of traditional risk factors and deprivation
    Jennifer Logue
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Heart 97:564-8. 2011
    ..However, there is now evidence of a differential effect of risk factors on fatal and non-fatal CHD events, with markers of inflammation more strongly associated with fatal than non-fatal events...
  9. doi request reprint Associations of inflammatory and haemostatic biomarkers with poor outcome in acute ischaemic stroke
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Cerebrovasc Dis 27:247-53. 2009
    ..Many inflammatory and haemostatic biomarkers show associations with acute ischaemic stroke outcome, but few studies compare a large range of markers...
  10. doi request reprint Does interleukin-18 or tumour necrosis factor-alpha have an independent association with the risk of coronary heart disease? Results from a prospective study in New Zealand
    Paul Welsh
    University of Glasgow, Scotland, UK
    Cytokine 50:94-8. 2010
    ..We aimed to extend data on their relationships to the risk of CHD in generally healthy populations...
  11. pmc Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Clin Endocrinol Metab 95:93-9. 2010
    ..Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven...
  12. doi request reprint Associations of circulating TNFalpha and IL-18 with myocardial infarction and cardiovascular risk markers: the Glasgow Myocardial Infarction Study
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, UK
    Cytokine 47:143-7. 2009
    ..There are a lack of data on the associations of circulating levels of TNFalpha and IL-18 with myocardial infarction (MI), and on the extent of confounding by classical and inflammatory risk markers...
  13. pmc Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events?
    Naveed Sattar
    Division of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, Scotland, UK
    PLoS Med 6:e1000099. 2009
    ..We tested whether interleukin (IL)-6, C-reactive protein (CRP), and fibrinogen more strongly associate with fatal compared to nonfatal myocardial infarction (MI) and stroke...
  14. doi request reprint Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials
    Naveed Sattar
    British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Lancet 375:735-42. 2010
    ..We aimed to establish by a meta-analysis of published and unpublished data whether any relation exists between statin use and development of diabetes...
  15. pmc Soluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes?
    Ashley M Miller
    Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS ONE 7:e47830. 2012
    ..Further mechanistic studies determining how sST2 is linked to diabetes pathways may offer new insights into the inflammatory paradigm for type 2 diabetes...
  16. pmc Which circulating antioxidant vitamins are confounded by socioeconomic deprivation? The MIDSPAN family study
    Dinesh Talwar
    Department of Clinical Biochemistry, Glasgow Royal Infirmary, Glasgow, United Kingdom
    PLoS ONE 5:e11312. 2010
    ..We aimed to compare to what extent a range of antioxidant vitamins and carotenoids are associated with adulthood and childhood markers of socioeconomic deprivation and to adverse lifestyle factors...
  17. doi request reprint Fasting plasma glucose in non-diabetic participants and the risk for incident cardiovascular events, diabetes, and mortality: results from WOSCOPS 15-year follow-up
    David Preiss
    Faculty of Medicine, University of Glasgow, Glasgow, UK
    Eur Heart J 31:1230-6. 2010
    ..The evidence base for fasting plasma glucose (FPG) in the non-diabetic range as a risk factor for cardiovascular disease (CVD) is inconclusive. We investigated this question in the West of Scotland Coronary Prevention Study (WOSCOPS)...
  18. doi request reprint Associations of proinflammatory cytokines with the risk of recurrent stroke
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK
    Stroke 39:2226-30. 2008
    ..We studied the association of interleukin (IL)-6, IL-18, and tumor necrosis factor-alpha (TNF-alpha) with recurrent stroke in a nested case-control study derived from the Perindopril Protection Against Recurrent Stroke Study (PROGRESS)...
  19. doi request reprint NT-proBNP is associated with coronary heart disease risk in healthy older women but fails to enhance prediction beyond established risk factors: results from the British Women's Heart and Health Study
    Naveed Sattar
    Division of Cardiovascular and Medical Sciences, BHF Cardiovascular Research Building, Faculty of Medicine, University of Glasgow, 126 University Place, Scotland, UK
    Atherosclerosis 209:295-9. 2010
    ..Limited evidence suggests NT-proBNP improves prediction of coronary heart disease (CHD) events but further data are needed, especially in people without pre-existing CHD and in women...
  20. pmc Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension
    Sandosh Padmanabhan
    Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS Genet 6:e1001177. 2010
    ..The newly discovered UMOD locus for hypertension has the potential to give new insights into the role of uromodulin in BP regulation and to identify novel drugable targets for reducing cardiovascular risk...
  21. doi request reprint Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial
    David Preiss
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK Electronic address
    Lancet Diabetes Endocrinol 2:116-24. 2014
    ..Metformin reduces cardiovascular risk in patients with type 2 diabetes seemingly independent of lowering blood glucose concentration. We assessed the cardiovascular effects of metformin in individuals without type 2 diabetes...
  22. doi request reprint Lipid-modifying therapies and risk of pancreatitis: a meta-analysis
    David Preiss
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Pl, Glasgow G12 8TA, United Kingdom
    JAMA 308:804-11. 2012
    ..Although lipid guidelines recommend fibrate therapy to reduce pancreatitis risk in persons with hypertriglyceridemia, fibrates may lead to the development of gallstones, a risk factor for pancreatitis...
  23. doi request reprint Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis
    David Preiss
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Pl, Glasgow G12 8TA, Scotland, United Kingdom
    JAMA 305:2556-64. 2011
    ..A recent meta-analysis demonstrated that statin therapy is associated with excess risk of developing diabetes mellitus...
  24. doi request reprint Novel antecedent plasma biomarkers of cardiovascular disease: improved evaluation methods and comparator benchmarks raise the bar
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Scotland, UK
    Curr Opin Lipidol 19:563-71. 2008
    ..To assess recent advances in cardiovascular disease biomarkers, focusing on past failings, current promise, and areas for future work...
  25. doi request reprint Validation of uromodulin as a candidate gene for human essential hypertension
    Lesley A Graham
    Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, United Kingdom
    Hypertension 63:551-8. 2014
    ....
  26. doi request reprint Plasmacytoid dendritic cells play a key role in promoting atherosclerosis in apolipoprotein E-deficient mice
    Neil Macritchie
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, 120 University Place, Glasgow G12 8TA, United Kingdom
    Arterioscler Thromb Vasc Biol 32:2569-79. 2012
    ..Results from animal models are controversial, with pDCs seen to inhibit or promote lesion development depending on the experimental settings. Here, we investigated the role of pDCs in atherosclerosis in apolipoprotein E-deficient mice...
  27. doi request reprint Simultaneous activation of the liver X receptors (LXRα and LXRβ) drives murine collagen-induced arthritis disease pathology
    Darren L Asquith
    Glasgow Biomedical Research Centre, Institute of Immunity, Infection and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK
    Ann Rheum Dis 70:2225-8. 2011
    ..It has previously been shown that dual activation of the Liver X Receptors (LXRα and LXRβ) by the agonist, GW3965, enhances pathology in a murine model of collagen-induced arthritis...
  28. doi request reprint Serial changes in adiponectin and BNP in ACS patients: paradoxical associations with each other and with prognosis
    Donald S C Ang
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, Scotland, UK
    Clin Sci (Lond) 117:41-8. 2009
    ..The results of the present study allude to a potential direct or indirect relationship between adiponectin and BNP post-ACS which requires further investigation...
  29. doi request reprint A single-centre evaluation of two new anti-Mullerian hormone assays and comparison with the current clinical standard assay
    Paul Welsh
    Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Hum Reprod 29:1035-41. 2014
    ..Are the new Ansh Labs Ultra-Sensitive anti-Müllerian hormone (AMH) and picoAMH ELISA assays suitable for clinical use and is the Ultra-Sensitive assay comparable to the Beckman Coulter AMH Gen II assay?..
  30. pmc Clinical and subclinical macrovascular disease as predictors of cognitive decline in older patients with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    Insa Feinkohl
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Diabetes Care 36:2779-86. 2013
    ..We aimed to determine associations of measures of macrovascular disease with cognitive change in a cognitively healthy older population with type 2 diabetes...
  31. doi request reprint Associations of plasma pro-inflammatory cytokines, fibrinogen, viscosity and C-reactive protein with cardiovascular risk factors and social deprivation: the fourth Glasgow MONICA study
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Br J Haematol 141:852-61. 2008
    ....