Jacqueline K White

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. pmc Optimising experimental design for high-throughput phenotyping in mice: a case study
    Natasha A Karp
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Mamm Genome 21:467-76. 2010
  2. pmc High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice
    Christine Podrini
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK
    Mamm Genome 24:240-51. 2013
  3. pmc Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes
    Jacqueline K White
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Cell 154:452-64. 2013
  4. pmc Experimental and husbandry procedures as potential modifiers of the results of phenotyping tests
    Anna Karin Gerdin
    Mouse Genetics Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Physiol Behav 106:602-11. 2012
  5. doi request reprint The fallacy of ratio correction to address confounding factors
    Natasha A Karp
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Lab Anim 46:245-52. 2012
  6. pmc Mcph1-deficient mice reveal a role for MCPH1 in otitis media
    Jing Chen
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
    PLoS ONE 8:e58156. 2013
  7. pmc Omi, a recessive mutation on chromosome 10, is a novel allele of Ostm1
    Erika A Bosman
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Mamm Genome 24:44-53. 2013
  8. pmc Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene
    Simon Maguire
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom
    PLoS ONE 9:e91807. 2014
  9. pmc Generation of the Sotos syndrome deletion in mice
    Anna M Migdalska
    Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1HH, UK
    Mamm Genome 23:749-57. 2012
  10. pmc Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome
    Rebecca E McIntyre
    Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
    PLoS Genet 8:e1003022. 2012

Collaborators

Detail Information

Publications11

  1. pmc Optimising experimental design for high-throughput phenotyping in mice: a case study
    Natasha A Karp
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Mamm Genome 21:467-76. 2010
    ..Consequently, in confirmatory studies, a power analysis along with the 3Rs can provide justification to increase the number of mice used...
  2. pmc High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice
    Christine Podrini
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK
    Mamm Genome 24:240-51. 2013
    ..Our results suggest that the B6N mouse strain is a versatile background for studying diet-induced metabolic syndrome and may also represent a model for early nonalcoholic fatty liver disease...
  3. pmc Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes
    Jacqueline K White
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Cell 154:452-64. 2013
    ..Phenotypic data and more than 900 mutants are openly available for further analysis. PAPERCLIP: ..
  4. pmc Experimental and husbandry procedures as potential modifiers of the results of phenotyping tests
    Anna Karin Gerdin
    Mouse Genetics Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Physiol Behav 106:602-11. 2012
    ..These results have important implications for the design and implementation of multiple component experiments where the lasting effects of stress from previous tests may modify the outcomes of subsequent ones...
  5. doi request reprint The fallacy of ratio correction to address confounding factors
    Natasha A Karp
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Lab Anim 46:245-52. 2012
    ..This study is therefore a clear example of why assumption testing is an important component of a study and thus why it is included in the Animal Research: Reporting of In Vivo Experiment (ARRIVE) guidelines...
  6. pmc Mcph1-deficient mice reveal a role for MCPH1 in otitis media
    Jing Chen
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
    PLoS ONE 8:e58156. 2013
    ....
  7. pmc Omi, a recessive mutation on chromosome 10, is a novel allele of Ostm1
    Erika A Bosman
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Mamm Genome 24:44-53. 2013
    ..To date we have not been able to identify the causative mutation. We propose that omi is a novel hypomorphic mutation affecting Ostm1 expression, potentially in a regulatory element...
  8. pmc Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene
    Simon Maguire
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom
    PLoS ONE 9:e91807. 2014
    ..We explore the ramifications associated with this particular targeted mutation and emphasise the need to interpret phenotypes taking into consideration all potential underlying genetic mechanisms...
  9. pmc Generation of the Sotos syndrome deletion in mice
    Anna M Migdalska
    Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1HH, UK
    Mamm Genome 23:749-57. 2012
    ..Thus, haploinsufficiency of genes within the mouse 4732471D19Rik-B4galt7 deletion interval play important roles in growth, memory retention, and the development of the renal pelvicalyceal system...
  10. pmc Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome
    Rebecca E McIntyre
    Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
    PLoS Genet 8:e1003022. 2012
    ..Increased cell death due to mitotic failure during embryonic development is likely to contribute to the proportionate dwarfism that is associated with CENPJ-Seckel syndrome...
  11. doi request reprint Large-scale mouse knockouts and phenotypes
    Ramiro Ramirez-Solis
    Mouse Pipelines, Wellcome Trust Sanger Institute, Hinxton, UK
    Wiley Interdiscip Rev Syst Biol Med 4:547-63. 2012
    ..It is a challenging and exciting time to work in mouse genetics...