Wei Wang

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. pmc A recessive genetic screen for host factors required for retroviral infection in a library of insertionally mutated Blm-deficient embryonic stem cells
    Wei Wang
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing, PR China
    Genome Biol 8:R48. 2007
  2. ncbi request reprint Highly infectious SARS-CoV pseudotyped virus reveals the cell tropism and its correlation with receptor expression
    Yuchun Nie
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, PR China
    Biochem Biophys Res Commun 321:994-1000. 2004
  3. ncbi request reprint Neutralizing antibodies in patients with severe acute respiratory syndrome-associated coronavirus infection
    Yuchun Nie
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China
    J Infect Dis 190:1119-26. 2004
  4. pmc Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells
    Ling Yi
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, Peoples Republic of China
    J Virol 78:11334-9. 2004
  5. ncbi request reprint A novel variant lattice corneal dystrophy caused by association of mutation (V625D) in TGFBI gene
    Xin Tian
    Department of Ophthalmology, Third Hospital, Peking University, Beijing, China
    Am J Ophthalmol 144:473-5. 2007
  6. ncbi request reprint New triterpenoids from Kadsura heteroclita and their cytotoxic activity
    Wei Wang
    School of Pharmaceutical Sciences, Peking University, Beijing, People s Republic of China
    Planta Med 72:450-7. 2006
  7. doi request reprint Simultaneous quantification of 18 bioactive constituents in Tripterygium wilfordii using liquid chromatography-electrospray ionization-mass spectrometry
    Feng Zeng
    The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
    Planta Med 79:797-805. 2013
  8. pmc Enhanced stability of thylakoid membrane proteins and antioxidant competence contribute to drought stress resistance in the tasg1 wheat stay-green mutant
    Fengxia Tian
    State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai an, Shandong 271018, PR China
    J Exp Bot 64:1509-20. 2013
  9. doi request reprint Drought tolerance through over-expression of the expansin gene TaEXPB23 in transgenic tobacco
    Feng Li
    State Key Laboratory of Crop Biology, Shandong Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai an, Shandong 271018, PR China
    J Plant Physiol 168:960-6. 2011
  10. doi request reprint Two prenylated and C-methylated flavonoids from Tripterygium wilfordii
    Feng Zeng
    School of Pharmaceutical Sciences, Peking University, Beijing, People s Republic of China
    Planta Med 76:1596-9. 2010

Collaborators

  • Xiaolei Yin
  • Bin Gao
  • wen he
  • Huamin Han
  • Jian Chen
  • Zhihong Li
  • Lei Wang
  • Feng Li
  • Jin Zhang
  • Hong Zhang
  • Youxin Wang
  • Yuchun Nie
  • Qi Niu
  • Feng Zeng
  • Chao Wang
  • Yinhua Lei
  • De An Guo
  • Mingxiao Ding
  • Hongkui Deng
  • Xuanling Shi
  • Feifei Zhao
  • Shuang Shao
  • Xin Tian
  • Manshu Song
  • Ikhlas A Khan
  • Min Yang
  • Xiuxia Qu
  • Guangwen Wang
  • Ming Zhao
  • Taisheng Li
  • Hongjun Gao
  • Xinwei Yu
  • Chengda Zhang
  • Fengxia Tian
  • Ge Zhang
  • Bhargavi M Boruah
  • Changzhen Liu
  • Xiaoqin Lu
  • Juan Du
  • Lijuan Wu
  • Qi Lv
  • Yanrui Ju
  • Huihui Yuan
  • Li Yan Zhao
  • Fan Gao
  • Ting Ma
  • Yi Wei
  • Sheng xian Yu
  • Yong Li
  • Zewen Wei
  • Ling Yi
  • Min Luo
  • Ke Ke Cheng
  • Kehu Yuan
  • Peigang Wang
  • Xi Yang
  • Jing Wang
  • Wengang Wu
  • Shuang Qiu
  • Min Ye
  • Yong Hong Liang
  • Hongzhe Zhou
  • Jun Cheng
  • Jinghua Zhao
  • Jie Lan
  • Yang Han
  • Baojun Wei
  • Xuxia Liu
  • Qifang Guo
  • Shiqi Peng
  • Lingbao Kong
  • Atsushi Kanai
  • Akira Murakami
  • Keiko Fujiki
  • Lujun Zhang
  • Min Fang
  • Jianhe Hu
  • Tingting Qing
  • Lei Tan
  • Xijun Song
  • Pengfei Jiang
  • Zai Wang
  • Aihua Zheng
  • Yuanyuan Qiao
  • Hongzhi He
  • Zhaoxu Zheng
  • Lanping Zhou
  • Fang Liu
  • Yousheng Mao
  • Xiaohang Zhao

Detail Information

Publications58

  1. pmc A recessive genetic screen for host factors required for retroviral infection in a library of insertionally mutated Blm-deficient embryonic stem cells
    Wei Wang
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing, PR China
    Genome Biol 8:R48. 2007
    ..In order to identify the host factors involved in retroviral infection, we designed and implemented a scheme for identifying ES cells that are resistant to retroviral infection and subsequent cloning of the mutated gene...
  2. ncbi request reprint Highly infectious SARS-CoV pseudotyped virus reveals the cell tropism and its correlation with receptor expression
    Yuchun Nie
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, PR China
    Biochem Biophys Res Commun 321:994-1000. 2004
    ..In addition, we also demonstrated angiotensin 1 converting enzyme (ACE)-the homologue of ACE2 could not function as a receptor for SARS-CoV...
  3. ncbi request reprint Neutralizing antibodies in patients with severe acute respiratory syndrome-associated coronavirus infection
    Yuchun Nie
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China
    J Infect Dis 190:1119-26. 2004
    ..We analyzed serum samples obtained from 623 patients with SARS in Beijing, to determine whether infection with SARS-CoV can elicit neutralizing antibodies (NAbs)...
  4. pmc Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells
    Ling Yi
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, Peoples Republic of China
    J Virol 78:11334-9. 2004
    ....
  5. ncbi request reprint A novel variant lattice corneal dystrophy caused by association of mutation (V625D) in TGFBI gene
    Xin Tian
    Department of Ophthalmology, Third Hospital, Peking University, Beijing, China
    Am J Ophthalmol 144:473-5. 2007
    ..To characterize the molecular defect in the TGFBI gene in a Chinese family affected with an atypical lattice corneal dystrophy...
  6. ncbi request reprint New triterpenoids from Kadsura heteroclita and their cytotoxic activity
    Wei Wang
    School of Pharmaceutical Sciences, Peking University, Beijing, People s Republic of China
    Planta Med 72:450-7. 2006
    ..Among the compounds tested, heteroclitalactone D (4) showed the strongest cytotoxic activity against the HL-60 cells with an IC50 of 6.76 microM...
  7. doi request reprint Simultaneous quantification of 18 bioactive constituents in Tripterygium wilfordii using liquid chromatography-electrospray ionization-mass spectrometry
    Feng Zeng
    The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
    Planta Med 79:797-805. 2013
    ..9990) within the test range. The established method showed good precision and accuracy with intraday and interday variations of 2-5 % and 1-4 %, respectively, and recoveries of 95.5-104.5 %...
  8. pmc Enhanced stability of thylakoid membrane proteins and antioxidant competence contribute to drought stress resistance in the tasg1 wheat stay-green mutant
    Fengxia Tian
    State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai an, Shandong 271018, PR China
    J Exp Bot 64:1509-20. 2013
    ..These results suggest greater functional stability of thylakoid membrane proteins in tasg1 compared with the WT, and the higher antioxidant competence of tasg1 may play an important role in the enhanced drought tolerance of tasg1...
  9. doi request reprint Drought tolerance through over-expression of the expansin gene TaEXPB23 in transgenic tobacco
    Feng Li
    State Key Laboratory of Crop Biology, Shandong Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai an, Shandong 271018, PR China
    J Plant Physiol 168:960-6. 2011
    ....
  10. doi request reprint Two prenylated and C-methylated flavonoids from Tripterygium wilfordii
    Feng Zeng
    School of Pharmaceutical Sciences, Peking University, Beijing, People s Republic of China
    Planta Med 76:1596-9. 2010
    ..0 ± 0.7  µM. Both compounds showed moderate antiproliferative activity against the tumor cell lines HT-29 and ZR-75-1...
  11. doi request reprint Expression of wheat expansin driven by the RD29 promoter in tobacco confers water-stress tolerance without impacting growth and development
    Feng Li
    State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai an, Shandong, 271018, PR China
    J Biotechnol 163:281-91. 2013
    ..Therefore, the use of stress-inducible promoters, such as RD29A, may minimize the negative effects of constitutive transgene expression and improve the water-stress tolerance of plants...
  12. pmc Retargeting T Cells for HER2-Positive Tumor Killing by a Bispecific Fv-Fc Antibody
    Lei Wang
    Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology CASPMI, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China
    PLoS ONE 8:e75589. 2013
    ..Furthermore, FcabCD3 was effective in eliminating the Colo205 tumor established on BALB/c nu/nu mice. ..
  13. pmc Identification of an antigenic determinant on the S2 domain of the severe acute respiratory syndrome coronavirus spike glycoprotein capable of inducing neutralizing antibodies
    Hong Zhang
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China
    J Virol 78:6938-45. 2004
    ..Identification of a conserved antigenic determinant on the S2 domain of the SARS-CoV S protein, which has the potential for inducing neutralizing antibodies, has implications in the development of effective vaccines against SARS-CoV...
  14. pmc Single domain antibody multimers confer protection against rabies infection
    Bhargavi M Boruah
    CAS Key Laboratory for Pathogenic Microbiology and Immunology CASPMI, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China
    PLoS ONE 8:e71383. 2013
    ..The results demonstrate that the combodies could be valuable tools in understanding viral mechanisms, diagnosis and possible anti-viral candidate for RABV infection. ..
  15. doi request reprint Retargeting NK-92 for anti-melanoma activity by a TCR-like single-domain antibody
    Ge Zhang
    1 The Centre for Molecular Immunology and China Japan Joint Laboratory of Molecular Immunology and Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China 2 University of Chinese Academy of Sciences, Beijing, China
    Immunol Cell Biol 91:615-24. 2013
    ....
  16. ncbi request reprint Suppression of SARS-CoV entry by peptides corresponding to heptad regions on spike glycoprotein
    Kehu Yuan
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, PR China
    Biochem Biophys Res Commun 319:746-52. 2004
    ..HR1-1 and HR2-18 can serve as functional probes for dissecting the fusion mechanism of SARS-CoV and also provide the potential of further identifying potent inhibitors for SARS-CoV entry...
  17. pmc Molecular basis of live-attenuated influenza virus
    Wen He
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China
    PLoS ONE 8:e60413. 2013
    ..The information of these mutation loci could be used for elucidation of mechanism of temperature-sensitive attenuation and as a new strategy for influenza vaccine development...
  18. doi request reprint Amperometric hydrogen peroxide biosensor based on the immobilization of heme proteins on gold nanoparticles-bacteria cellulose nanofibers nanocomposite
    Wei Wang
    Beijing National Laboratory for Molecular Sciences BNLMS, Key Laboratory of Biochemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing 100871, PR China
    Talanta 84:71-7. 2011
    ..3 μM to 1.00 mM, and a low detection limit of 0.1 μM based on S/N=3. The high performance of the biosensor made Au-BC nanocomposite superior to other materials as immobilization matrix...
  19. doi request reprint Mechanosensitivity of STREX-lacking BKCa channels in the colonic smooth muscle of the mouse
    Wei Wang
    Dept of Physiology, Capital Medical Univ, Beijing, PR China
    Am J Physiol Gastrointest Liver Physiol 299:G1231-40. 2010
    ..We suggest that in addition to the STREX domain, there are other additional structures in the channel responsible for mechanically coupling with the cell membrane...
  20. doi request reprint A laminar flow electroporation system for efficient DNA and siRNA delivery
    Zewen Wei
    National Key Laboratory of Science and Technology on Micro Nano Fabrication, Institute of Microelectronics, Peking University, Beijing, People s Republic of China
    Anal Chem 83:5881-7. 2011
    ..Furthermore, successful electrotransfection of plasmid DNA and, more importantly, synthetic siRNA, was demonstrated in several hard-to-transfect cell types using this system...
  21. pmc Low molecular weight heparin ablates lung cancer cisplatin-resistance by inducing proteasome-mediated ABCG2 protein degradation
    Qi Niu
    Department of Medical Oncology, No 309 PLA Hospital, Beijing, PR China
    PLoS ONE 7:e41035. 2012
    ..This study provides an experimental basis for using a combination of LMWH, which targets lung SP cells, with chemotherapy to improve lung cancer survival...
  22. doi request reprint Construction of armored RNA containing long-size chimeric RNA by increasing the number and affinity of the pac site in exogenous rna and sequence coding coat protein of the MS2 bacteriophage
    Baojun Wei
    Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, National Center for Clinical Laboratory, Beijing Hospital, Beijing, PR China
    Intervirology 51:144-50. 2008
    ..To construct a one-plasmid expression system of the armored RNA containing long chimeric RNA by increasing the number and affinity of the pac site...
  23. pmc The expected number of background disease events during mass immunization in China
    Youxin Wang
    School of Public Health, Capital Medical University, Beijing, China Municipal Key Laboratory of Clinical Epidemiology, Beijing, China School of Medical Sciences, Edith Cowan University, Perth, Australia
    PLoS ONE 8:e71818. 2013
    ..These findings may encourage health authorities to screen the safety of vaccines against unpredictable pathogens. ..
  24. doi request reprint A microfluidics cytometer for mice anemia detection
    Yanrui Ju
    National Key Laboratory of Science and Technology on Nano Micro Fabrication Technology, Institute of Microelectronics, Peking University, Beijing, 100871, China
    Lab Chip 12:4355-62. 2012
    ....
  25. doi request reprint Bioactive polar compounds from stem bark of Magnolia officinalis
    Sheng xian Yu
    Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, PR China
    Fitoterapia 83:356-61. 2012
    ..All of the compounds, except compound 8 showed potent antioxidant capacity in the ORAC assay, while compounds 1-5 and 11 exhibited potent antioxidant activity in the DPPH assay...
  26. doi request reprint Measuring the distance between two mercapto groups with an optical molecular ruler on the nanometer scale
    Fan Gao
    Beijing National Laboratory for Molecular Sciences BNLMS, College of Chemistry, Peking University, Beijing, 100871, China
    Phys Chem Chem Phys 14:15321-7. 2012
    ..With this simple method, we can estimate the distance between two mercapto groups on the scale of 0.4-1 nm. This method can also be used to monitor conformation transition, which is demonstrated by a silver ion titration experiment...
  27. doi request reprint A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei
    Yong Hong Liang
    School of Pharmaceutical Sciences, Peking University, Beijing, PR China
    Fitoterapia 81:988-91. 2010
    ..Primary bioassays showed that compound 1 had significant cytotoxic activity against Hela, PC3 and HepG2 cells, with IC(50) of 2.92 μM, 1.08 μM and 2.45 μM, respectively...
  28. doi request reprint N-[2-chloro-9H-purin-6-yl]-N-cyclopropylglycylamino acids and derivatives: synthesis, evaluation as a class of novel analgesics, and 3D QSAR analysis
    Jinghua Zhao
    College of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China
    Bioorg Med Chem 17:6305-10. 2009
    ..923, and 0.852, respectively. Using this equation pain threshold variations of 9 compounds were predicted and the errors ranged from 1.71 to 8.92...
  29. doi request reprint Studies on Parylene C-caulked PDMS (pcPDMS) for low permeability required microfluidics applications
    Yinhua Lei
    National Key Laboratory of Science and Technology on Micro Nano Fabrication, Institute of Microelectronics, Peking University, Beijing, PR China
    Lab Chip 11:1385-8. 2011
    ..The bonding issue enrolled in the pcPDMS fabrication was solved based on careful surface analyses of the Parylene C caulked status in the PDMS matrix...
  30. ncbi request reprint Inhibition of HCV RNA-dependent RNA polymerase activity by aqueous extract from Fructus Ligustri Lucidi
    Lingbao Kong
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei Province 430072, PR China
    Virus Res 128:9-17. 2007
    ..Taken together, these results indicated that Fructus Ligustri Lucidi might offer a promising source of antiviral drugs against HCV NS5B. Purification of the active compound(s) and antiviral effect are clearly required in the future...
  31. doi request reprint Pseudo-homogeneous immunoextraction of epitestosterone from human urine samples based on gold-coated magnetic nanoparticles
    Shuang Qiu
    Beijing National Laboratory for Molecular Sciences BNLMS, Key Laboratory of Biochemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry, Peking University, Beijing, China
    Talanta 81:819-23. 2010
    ..Compared with the conventional technique using immunoaffinity column, the method described here for sample pretreatment was fast, highly specific, and easy to operate...
  32. ncbi request reprint Characterization of phenolic compounds in the crude extract of Hedysarum multijugum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry
    Min Yang
    The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China
    Rapid Commun Mass Spectrom 21:3833-41. 2007
    ..The method established in this study could be applied to the comprehensive quality control of the herb and its formulations. It could also be applied to the biological and pharmacological research of traditional Chinese medicines...
  33. doi request reprint The effect of Acorus gramineus on the bioavailabilities and brain concentrations of ginsenosides Rg1, Re and Rb1 after oral administration of Kai-Xin-San preparations in rats
    Wei Wang
    Institute of Medicinal Plant Development IMPLAD, Chinese Academy of Medical Sciences and Peking Union Medical College, Haidian District, Beijing, PR China
    J Ethnopharmacol 131:313-20. 2010
    ....
  34. pmc Generation of monoclonal antibodies against highly conserved antigens
    Hongzhe Zhou
    Center of Infection and Immunity, National Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, PR China
    PLoS ONE 4:e6087. 2009
    ..However, due to immune tolerance, some proteins that are highly conserved between mice and humans are not very immunogenic in mice, making it difficult to generate antibodies using a conventional approach...
  35. doi request reprint Identification of tumor antigens that elicit a humoral immune response in the sera of Chinese esophageal squamous cell carcinoma patients by modified serological proteome analysis
    Hongjun Gao
    Clinical Laboratory of China Meitan General Hospital, Beijing, PR China
    Cancer Lett 344:54-61. 2014
    ..The preliminary results suggest the potential utility of screening autoantibodies in sera for use as biomarkers for cancer diagnosis...
  36. doi request reprint The interaction of CD4 T-cell count and nevirapine hepatotoxicity in China: a change in national treatment guidelines may be warranted
    Chengda Zhang
    Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, PR China
    J Acquir Immune Defic Syndr 62:540-5. 2013
    ..These studies have informed Chinese national treatment guidelines. We evaluate whether current Chinese guidelines for NVP use are appropriate...
  37. pmc The ecology of medical care in Beijing
    Shuang Shao
    General Practice and Continue Education School, Capital Medical University, Beijing, China Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China School of Yan Jing Medical Sciences, Capital Medical University, Beijing, China
    PLoS ONE 8:e82446. 2013
    ....
  38. doi request reprint Cellulose synthesized by Enterobacter sp. FY-07 under aerobic and anaerobic conditions
    Ting Ma
    Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, PR China
    Bioresour Technol 126:18-23. 2012
    ..4%) were superior to those reported for BC produced by the aerobic bacteria G. xylinum BCRC12335 and Acetobacter sp. V6. These results will facilitate static submerged fermentation for the production of BC...
  39. doi request reprint Microcosmic mechanisms for protein incomplete release and stability of various amphiphilic mPEG-PLA microspheres
    Yi Wei
    National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, PR China
    Langmuir 28:13984-92. 2012
    ....
  40. doi request reprint DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer
    Qi Lv
    Molecular Immunology and Cancer Pharmacology Groups, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
    Cancer Res 72:3238-50. 2012
    ..DEDD expression therefore may represent a prognostic marker and potential therapeutic target for the prevention and treatment of cancer metastasis...
  41. ncbi request reprint Synthesis and cytotoxic activities of beta-carboline amino acid ester conjugates
    Ming Zhao
    College of Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing, 100054, PR China
    Bioorg Med Chem 14:6998-7010. 2006
    ....
  42. ncbi request reprint [Significance of phosphoinositide 3 kinase/AKT pathway alterations in endometrial carcinoma]
    Xi Yang
    Department of Gynecology and Obstetrics, First Hospital, Peking University, Beijing, China
    Zhonghua Bing Li Xue Za Zhi 40:799-804. 2011
    ..To investigate the clinicopathologic and prognostic implications of phosphoinositide 3 kinase (PI3K)/AKT pathway alterations in endometrial cancers of Chinese women...
  43. pmc Prevalence and factors associated with hepatitis B immunization and infection among men who have sex with men in Beijing, China
    Chao Wang
    School of Public Health and Family Medicine, Capital Medical University, Beijing, China
    PLoS ONE 7:e48219. 2012
    ..Men who have sex with men (MSM) are at increased risk for HBV infection; however, the prevalence of HBV immunization and infection among Chinese MSM remains undetermined...
  44. ncbi request reprint Therapeutic role of a vaccine targeting RANKL and TNF-α on collagen-induced arthritis
    Huihui Yuan
    Department of Immunology, Institute of Basic Medical Sciences, Beijing, PR China
    Biomaterials 33:8177-85. 2012
    ..Our results showed the RTFP-2 vaccine of dual targets ameliorated the symptoms of CIA mice, suggesting the potential possibility to treat inflammatory bone diseases such as RA...
  45. pmc The role of dorsal anterior cingulate cortex in the regulation of craving by reappraisal in smokers
    Li Yan Zhao
    National Institute on Drug Dependence, Peking University, Beijing, China
    PLoS ONE 7:e43598. 2012
    ..In present study, we sought to determine whether such cognitive regulation engages the dACC and improves inhibition of craving in smokers...
  46. ncbi request reprint Bacterial expression and purification of biologically active human TFF3
    Min Fang
    Department of Biochemistry and Molecular Biology, National Laboratory of Protein Engineering, College of Life Science, Peking University, Beijing, PR China
    Peptides 25:785-92. 2004
    ..Oral administration of recombinant hTFF3 has a dose dependent protective effect against ethanol-induced or pylorus ligation-induced gastric mucosa injury in rat, which indicates that our recombinant hTFF3 is biologically active...
  47. ncbi request reprint Expression cloning of functional receptor used by SARS coronavirus
    Peigang Wang
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, PR China
    Biochem Biophys Res Commun 315:439-44. 2004
    ..When human ACE2 cDNA was transduced into NIH3T3 cells, the ACE2 expressing NIH3T3 cells could be infected with HIV/SARS pseudovirus. These data clearly demonstrated that ACE2 was the functional receptor for SARS-CoV...
  48. ncbi request reprint Four new lignans from the stems of Kadsura heteroclita
    Wei Wang
    The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, PR China
    Planta Med 72:284-8. 2006
    ..The structures of these compounds were characterized by extensive 1D and 2D NMR spectral data analysis...
  49. ncbi request reprint Kinetic difference of baicalin in rat blood and cerebral nuclei after intravenous administration of Scutellariae Radix extract
    Lujun Zhang
    Laboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, PR China
    J Ethnopharmacol 103:120-5. 2006
    ....
  50. doi request reprint Drought tolerance through overexpression of monoubiquitin in transgenic tobacco
    Qifang Guo
    State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Shandong, PR China
    J Plant Physiol 165:1745-55. 2008
    ..Our results indicate that Ub may be involved in the response of plants to drought stress and that overexpression of monoubiquitin might be an effective strategy for enhancing drought tolerance...
  51. ncbi request reprint Novel mutation (V505D) of the TGFBI gene found in a Chinese family with lattice corneal dystrophy, type I
    Xin Tian
    Department of Ophthalmology, Third Hospital, Peking University, Beijing, China
    Jpn J Ophthalmol 49:84-8. 2005
    ..To report a novel V505D mutation of the human transforming growth factor beta-induced (TGFBI) gene found in a Chinese family with lattice corneal dystrophy, type I (LCDI)...
  52. ncbi request reprint Stretch-activated potassium channels in hypotonically induced blebs of atrial myocytes
    Xuxia Liu
    Department of Physiology, Capital Medical University, Beijing, PR China
    J Membr Biol 226:17-25. 2008
    ..The mechanosensitivity of SAKCs appears to be the result of interaction with membrane lipids and not of direct involvement of the cytoskeleton...
  53. pmc The impact of demographic and risk factor changes on coronary heart disease deaths in Beijing, 1999-2010
    Jun Cheng
    Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital affiliated to the Capital Medical University, Beijing, PR China
    BMC Public Health 9:30. 2009
    ..Our study aimed to assess the potential impact of subsequent changes in risk factors and population ageing on CHD deaths in Beijing between 1999 and 2010...
  54. doi request reprint Association between dopaminergic genes (SLC6A3 and DRD2) and stuttering among Han Chinese
    Jie Lan
    Department of Genetics, College of Life Sciences, Graduate University of Chinese Academy of Sciences, Beijing, PR China
    J Hum Genet 54:457-60. 2009
    ..The results show that the presence of C allele at rs6277 in DRD2 gene is associated with increased susceptibility to the disorder, whereas T allele is protective. Haplotype 939T/957T is also a protective factor...
  55. doi request reprint Suspended nanoparticle crystal (S-NPC): A nanofluidics-based, electrical read-out biosensor
    Yinhua Lei
    Institute of Microelectronics, Peking University, Beijing, PR China
    Lab Chip 10:2338-40. 2010
    ..Being easy to get established, low-cost, and having large electrical read-out signal, the present S-NPC is believed to be a promising biosensing scheme in the micro total analysis system...
  56. doi request reprint Cord blood-derived cytokine-induced killer cells biotherapy combined with second-line chemotherapy in the treatment of advanced solid malignancies
    Qi Niu
    Beijing GreatWall International Cancer Center, No 309 PLA Hospital, Beijing, PR China
    Int Immunopharmacol 11:449-56. 2011
    ....
  57. pmc Inhibitory effect of aqueous Dandelion extract on HIV-1 replication and reverse transcriptase activity
    Huamin Han
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China
    BMC Complement Altern Med 11:112. 2011
    ..In this study, we aimed to investigate the anti-HIV-1 activity of aqueous dandelion extract...
  58. doi request reprint Statistical optimization of sulfite pretreatment of corncob residues for high concentration ethanol production
    Ke Ke Cheng
    Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing, PR China
    Bioresour Technol 102:3014-9. 2011
    ..In the subsequent simultaneous saccharification and fermentation (SSF) experiments using 15% glucan substrates pretreated under this kind of conditions, 60.8 g ethanol l(-1) with 72.2% theoretical yield was obtained...