Julia Tischler

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. pmc Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference
    Ben Lehner
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Genome Biol 7:R4. 2006
  2. doi request reprint Evolutionary plasticity of genetic interaction networks
    Julia Tischler
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Nat Genet 40:390-1. 2008
  3. pmc Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution
    Julia Tischler
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
    Genome Biol 7:R69. 2006
  4. ncbi request reprint Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways
    Ben Lehner
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Nat Genet 38:896-903. 2006
  5. ncbi request reprint RNAi screens in Caenorhabditis elegans in a 96-well liquid format and their application to the systematic identification of genetic interactions
    Ben Lehner
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Nat Protoc 1:1617-20. 2006
  6. pmc Systems biology: where it's at in 2005
    Ben Lehner
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Genome Biol 6:338. 2005
  7. pmc Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression
    Gerda Lagger
    Institute of Medical Biochemistry, Division of Molecular Biology, University of Vienna, Vienna Biocenter, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
    EMBO J 21:2672-81. 2002

Collaborators

Detail Information

Publications7

  1. pmc Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference
    Ben Lehner
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Genome Biol 7:R4. 2006
    ..The effectiveness of RNAi varies from gene to gene, however, and neuronally expressed genes are largely refractive to RNAi in wild-type worms...
  2. doi request reprint Evolutionary plasticity of genetic interaction networks
    Julia Tischler
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Nat Genet 40:390-1. 2008
    ..Genetic interactions are therefore unlikely to represent simple redundancy between genes or pathways, and genetic interactions from yeast do not directly predict genetic interactions in higher eukaryotes, including humans...
  3. pmc Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution
    Julia Tischler
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
    Genome Biol 7:R69. 2006
    ..Developing tools for the systematic mapping of genetic interactions is thus a key step in exploring the relationship between genotype and phenotype...
  4. ncbi request reprint Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways
    Ben Lehner
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Nat Genet 38:896-903. 2006
    ..We propose that these genes function as general buffers of genetic variation and that these hub genes may act as modifier genes in multiple, mechanistically unrelated genetic diseases in humans...
  5. ncbi request reprint RNAi screens in Caenorhabditis elegans in a 96-well liquid format and their application to the systematic identification of genetic interactions
    Ben Lehner
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Nat Protoc 1:1617-20. 2006
    ..We also describe how the protocol can be adapted to target two genes simultaneously by combinatorial RNAi...
  6. pmc Systems biology: where it's at in 2005
    Ben Lehner
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Genome Biol 6:338. 2005
    ..A report on the joint Keystone Symposia on Systems and Biology and Proteomics and Bioinformatics, Keystone, USA, 8-13 April 2005...
  7. pmc Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression
    Gerda Lagger
    Institute of Medical Biochemistry, Division of Molecular Biology, University of Vienna, Vienna Biocenter, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
    EMBO J 21:2672-81. 2002
    ..Our study provides the first evidence that a histone deacetylase is essential for unrestricted cell proliferation by repressing the expression of selective cell cycle inhibitors...