Michael Stratton

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. doi request reprint Genome resequencing and genetic variation
    Michael Stratton
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Nat Biotechnol 26:65-6. 2008
  2. pmc Deciphering signatures of mutational processes operative in human cancer
    Ludmil B Alexandrov
    Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
    Cell Rep 3:246-59. 2013
  3. pmc Mutational processes molding the genomes of 21 breast cancers
    Serena Nik-Zainal
    Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
    Cell 149:979-93. 2012
  4. pmc Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer
    Elizabeth P Murchison
    Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK
    Cell 148:780-91. 2012
  5. pmc Somatic structural rearrangements in genetically engineered mouse mammary tumors
    Ignacio Varela
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB101SA, UK
    Genome Biol 11:R100. 2010
  6. pmc RNA editing of human microRNAs
    Matthew J Blow
    Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Genome Biol 7:R27. 2006
  7. pmc The cancer genome
    Michael R Stratton
    Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Nature 458:719-24. 2009
  8. doi request reprint Exploring the genomes of cancer cells: progress and promise
    Michael R Stratton
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Science 331:1553-8. 2011
  9. pmc Mutation analysis of 24 known cancer genes in the NCI-60 cell line set
    Ogechi N Ikediobi
    Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    Mol Cancer Ther 5:2606-12. 2006
  10. ncbi request reprint Distinct genomic profiles in hereditary breast tumors identified by array-based comparative genomic hybridization
    Goran Jonsson
    Department of Oncology, University Hospital, Lund, Sweden
    Cancer Res 65:7612-21. 2005

Collaborators

  • P Andrew Futreal
  • Stijn van Dongen
  • Anton J Enright
  • David Richardson
  • Peter J Campbell
  • John N Weinstein
  • David Jones
  • Tara L Naylor
  • Markus Ringner
  • Richard Wooster
  • Thomas Santarius
  • Ludmil B Alexandrov
  • David C Wedge
  • Serena Nik-Zainal
  • Ignacio Varela
  • Keiran Raine
  • Goran Jonsson
  • Elizabeth P Murchison
  • David J McBride
  • Graham R Bignell
  • John Marshall
  • Laura J Mudie
  • Russell J Grocock
  • Andrew Menzies
  • Jonathan Hinton
  • Ake Borg
  • Matthew J Blow
  • Ogechi N Ikediobi
  • Ed Dicks
  • Elli Papaemmanuil
  • Gilles Thomas
  • Christopher D Greenman
  • Zemin Ning
  • Aquila Fatima
  • David R Bentley
  • Catherine Leroy
  • Mark Maddison
  • Anne Vincent Salomon
  • Judy E Garber
  • Alexandre Kreiss
  • Adam P Butler
  • Gary Schroth
  • Daniel Silver
  • Matthew Hims
  • Adam Shlien
  • King Wai Lau
  • Fengtang Yang
  • Shujun Luo
  • Irina Khrebtukova
  • Samuel A J R Aparicio
  • Lina Chen
  • Sancha Martin
  • Andrew Tutt
  • Kenric Leung
  • Anne Lise Børresen-Dale
  • Gregory M Woods
  • Albert J Vilella
  • Stuart McLaren
  • Zoya Kingsbury
  • Philip Tedder
  • Sandrine Boyault
  • Sergii Ivakhno
  • Jon W Teague
  • Stephen M J Searle
  • Anita Langerød
  • Jennifer Becq
  • Markus J Bauer
  • Zhihao Ding
  • Caitlin Stewart
  • Nigel P Carter
  • Anthony T Papenfuss
  • Yong Gu
  • Susanna L Cooke
  • Patrick S Tarpey
  • Philip J Stephens
  • Richard Shaw
  • R Keira Cheetham
  • Manasa Ramakrishna
  • Bronwen Aken
  • Dirk J Evers
  • Michael S Neuberger
  • Bee Ling Ng
  • Niall Gormley
  • Isabelle Rasolonjatovo
  • Sean Humphray
  • Ian Whitmore
  • William Cheng
  • Beiyuan Fu
  • Simon White
  • John Gamble

Detail Information

Publications10

  1. doi request reprint Genome resequencing and genetic variation
    Michael Stratton
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Nat Biotechnol 26:65-6. 2008
  2. pmc Deciphering signatures of mutational processes operative in human cancer
    Ludmil B Alexandrov
    Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
    Cell Rep 3:246-59. 2013
    ..Our approach provides a basis for characterizing mutational signatures from cancer-derived somatic mutational catalogs, paving the way to insights into the pathogenetic mechanism underlying all cancers...
  3. pmc Mutational processes molding the genomes of 21 breast cancers
    Serena Nik-Zainal
    Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
    Cell 149:979-93. 2012
    ..The mechanisms underlying most of these mutational signatures are unknown. However, a role for the APOBEC family of cytidine deaminases is proposed...
  4. pmc Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer
    Elizabeth P Murchison
    Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK
    Cell 148:780-91. 2012
    ....
  5. pmc Somatic structural rearrangements in genetically engineered mouse mammary tumors
    Ignacio Varela
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB101SA, UK
    Genome Biol 11:R100. 2010
    ..These were models of Trp53-mutated breast cancer, Brca1- and Brca2-associated hereditary breast cancer, and E-cadherin (Cdh1) mutated lobular breast cancer...
  6. pmc RNA editing of human microRNAs
    Matthew J Blow
    Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Genome Biol 7:R27. 2006
    ..MicroRNAs (miRNAs) are short RNAs of around 22 nucleotides that regulate gene expression. The primary transcripts of miRNAs contain double-stranded RNA and are therefore potential substrates for adenosine to inosine (A-to-I) RNA editing...
  7. pmc The cancer genome
    Michael R Stratton
    Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Nature 458:719-24. 2009
    ..These studies will provide us with a detailed and comprehensive perspective on how individual cancers have developed...
  8. doi request reprint Exploring the genomes of cancer cells: progress and promise
    Michael R Stratton
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Science 331:1553-8. 2011
    ..Here, I provide an overview of what these efforts have revealed to date about the origin and behavioral features of cancer cells and how this genomic information is being exploited to improve diagnosis and therapy of the disease...
  9. pmc Mutation analysis of 24 known cancer genes in the NCI-60 cell line set
    Ogechi N Ikediobi
    Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    Mol Cancer Ther 5:2606-12. 2006
    ....
  10. ncbi request reprint Distinct genomic profiles in hereditary breast tumors identified by array-based comparative genomic hybridization
    Goran Jonsson
    Department of Oncology, University Hospital, Lund, Sweden
    Cancer Res 65:7612-21. 2005
    ..00005, respectively). Further validation may prove this tumor classifier to be useful for selecting familial breast cancer cases for further mutation screening, particularly, as these data can be obtained using archival tissue...