Affiliation: Wellcome Trust Genome Campus
- Genome resequencing and genetic variationMichael Stratton
Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Nat Biotechnol 26:65-6. 2008
- Genome sequencing and analysis of the Tasmanian devil and its transmissible cancerElizabeth P Murchison
Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK
Cell 148:780-91. 2012....
- Somatic structural rearrangements in genetically engineered mouse mammary tumorsIgnacio Varela
Wellcome Trust Sanger Institute, Hinxton, Cambridge CB101SA, UK
Genome Biol 11:R100. 2010..These were models of Trp53-mutated breast cancer, Brca1- and Brca2-associated hereditary breast cancer, and E-cadherin (Cdh1) mutated lobular breast cancer...
- RNA editing of human microRNAsMatthew J Blow
Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
Genome Biol 7:R27. 2006..These miRNAs may have been annotated to the wrong genomic strand. CONCLUSION: Our results indicate that RNA editing increases the diversity of miRNAs and their targets, and hence may modulate miRNA function...
- Mutation analysis of 24 known cancer genes in the NCI-60 cell line setOgechi N Ikediobi
Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
Mol Cancer Ther 5:2606-12. 2006....
- The cancer genomeMichael R Stratton
Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Nature 458:719-24. 2009..These studies will provide us with a detailed and comprehensive perspective on how individual cancers have developed...
- Exploring the genomes of cancer cells: progress and promiseMichael R Stratton
Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
Science 331:1553-8. 2011..Here, I provide an overview of what these efforts have revealed to date about the origin and behavioral features of cancer cells and how this genomic information is being exploited to improve diagnosis and therapy of the disease...
- Distinct genomic profiles in hereditary breast tumors identified by array-based comparative genomic hybridizationGoran Jonsson
Department of Oncology, University Hospital, Lund, Sweden
Cancer Res 65:7612-21. 2005..00005, respectively). Further validation may prove this tumor classifier to be useful for selecting familial breast cancer cases for further mutation screening, particularly, as these data can be obtained using archival tissue...