Barbara E Stranger

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. pmc Genome-wide associations of gene expression variation in humans
    Barbara E Stranger
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
    PLoS Genet 1:e78. 2005
  2. pmc From DNA to RNA to disease and back: the 'central dogma' of regulatory disease variation
    Barbara E Stranger
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Hum Genomics 2:383-90. 2006
  3. pmc Population genomics of human gene expression
    Barbara E Stranger
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nat Genet 39:1217-24. 2007
  4. pmc Breaking the waves: improved detection of copy number variation from microarray-based comparative genomic hybridization
    John C Marioni
    Computational Biology Group, Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Centre for Mathematical Sciences, Wilberforce Road, Cambridge CB3 0WA, UK
    Genome Biol 8:R228. 2007
  5. ncbi Nucleotide variation at the myrosinase-encoding locus, TGG1, and quantitative myrosinase enzyme activity variation in Arabidopsis thaliana
    Barbara E Stranger
    Department of Genetics and Evolution, Max Planck Institute of Chemical Ecology, Jena, Germany
    Mol Ecol 14:295-309. 2005
  6. pmc The genetics of regulatory variation in the human genome
    Barbara E Stranger
    The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Hum Genomics 2:126-31. 2005
  7. pmc Modifier effects between regulatory and protein-coding variation
    Antigone S Dimas
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
    PLoS Genet 4:e1000244. 2008
  8. pmc Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations
    Alexandra C Nica
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS Genet 6:e1000895. 2010
  9. pmc Fast-evolving noncoding sequences in the human genome
    Christine P Bird
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK
    Genome Biol 8:R118. 2007
  10. pmc Relative impact of nucleotide and copy number variation on gene expression phenotypes
    Barbara E Stranger
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Science 315:848-53. 2007

Detail Information

Publications19

  1. pmc Genome-wide associations of gene expression variation in humans
    Barbara E Stranger
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
    PLoS Genet 1:e78. 2005
    ..In addition, we demonstrate that the HapMap cell lines themselves may serve as a useful resource for quantitative measurements at the cellular level...
  2. pmc From DNA to RNA to disease and back: the 'central dogma' of regulatory disease variation
    Barbara E Stranger
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Hum Genomics 2:383-90. 2006
    ..This paper focuses on how studies of gene expression variation might complement disease studies and provide crucial links between genotype and phenotype...
  3. pmc Population genomics of human gene expression
    Barbara E Stranger
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nat Genet 39:1217-24. 2007
    ..We also explore several methodologies that improve the current state of analysis of gene expression variation...
  4. pmc Breaking the waves: improved detection of copy number variation from microarray-based comparative genomic hybridization
    John C Marioni
    Computational Biology Group, Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Centre for Mathematical Sciences, Wilberforce Road, Cambridge CB3 0WA, UK
    Genome Biol 8:R228. 2007
    ..However, methods for analyzing the complex data produced and identifying regions of CNV are still being refined...
  5. ncbi Nucleotide variation at the myrosinase-encoding locus, TGG1, and quantitative myrosinase enzyme activity variation in Arabidopsis thaliana
    Barbara E Stranger
    Department of Genetics and Evolution, Max Planck Institute of Chemical Ecology, Jena, Germany
    Mol Ecol 14:295-309. 2005
    ....
  6. pmc The genetics of regulatory variation in the human genome
    Barbara E Stranger
    The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Hum Genomics 2:126-31. 2005
    ....
  7. pmc Modifier effects between regulatory and protein-coding variation
    Antigone S Dimas
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
    PLoS Genet 4:e1000244. 2008
    ....
  8. pmc Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations
    Alexandra C Nica
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS Genet 6:e1000895. 2010
    ..We conclude that integrating cellular phenotype associations with organismal complex traits will facilitate the biological interpretation of the genetic effects on these traits...
  9. pmc Fast-evolving noncoding sequences in the human genome
    Christine P Bird
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK
    Genome Biol 8:R118. 2007
    ..These conserved noncoding (CNC) sequences may well harbor critical regulatory variants that have driven recent human evolution...
  10. pmc Relative impact of nucleotide and copy number variation on gene expression phenotypes
    Barbara E Stranger
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Science 315:848-53. 2007
    ..Interrogation of the genome for both types of variants may be an effective way to elucidate the causes of complex phenotypes and disease in humans...
  11. pmc Genevar: a database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies
    Tsun Po Yang
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK
    Bioinformatics 26:2474-6. 2010
    ..The database and application can be installed on a standard computer in database mode and, in addition, on a server to share discoveries among affiliations or the broader community over the Internet via web services protocols...
  12. pmc Patterns of cis regulatory variation in diverse human populations
    Barbara E Stranger
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
    PLoS Genet 8:e1002639. 2012
    ....
  13. pmc Large-scale population study of human cell lines indicates that dosage compensation is virtually complete
    Colette M Johnston
    X Chromosome Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS Genet 4:e9. 2008
    ..We suggest that the potential contribution of escape from X chromosome inactivation to phenotypic differences between the sexes is more limited than previously believed...
  14. pmc Common regulatory variation impacts gene expression in a cell type-dependent manner
    Antigone S Dimas
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1HH, Cambridge, UK
    Science 325:1246-50. 2009
    ..These data suggest that the complete regulatory variant repertoire can only be uncovered in the context of cell-type specificity...
  15. ncbi Functional variation and evolution of non-coding DNA
    Christine P Bird
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SA, UK
    Curr Opin Genet Dev 16:559-64. 2006
    ..The main issues relate to the discovery, evolutionary analysis and natural variation of non-coding DNA, and the parameters that prevent us from fully understanding the properties of non-coding DNA...
  16. ncbi Genetic variation in human gene expression
    Emmanouil T Dermitzakis
    Division of Informatics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Mamm Genome 17:503-8. 2006
    ..In this review we discuss issues relating to the biological information one obtains from such studies and the biological significance and use of signals from mapping of gene expression variation...
  17. pmc Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
    Ewan Birney
    Nature 447:799-816. 2007
    ..Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function...
  18. pmc Genome-wide detection and characterization of positive selection in human populations
    Pardis C Sabeti
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA
    Nature 449:913-8. 2007
    ....
  19. pmc Multilocus analysis of variation and speciation in the closely related species Arabidopsis halleri and A. lyrata
    Sebastian E Ramos-Onsins
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain
    Genetics 166:373-88. 2004
    ....