DEREK STEMPLE

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. ncbi request reprint Structure and function of the notochord: an essential organ for chordate development
    Derek L Stemple
    Vertebrate Development and Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Development 132:2503-12. 2005
  2. ncbi request reprint TILLING--a high-throughput harvest for functional genomics
    Derek L Stemple
    Vertebrate Development and Genetics Team 31, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nat Rev Genet 5:145-50. 2004
  3. pmc Convergent extension movements and ciliary function are mediated by ofd1, a zebrafish orthologue of the human oral-facial-digital type 1 syndrome gene
    Maria I Ferrante
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK
    Hum Mol Genet 18:289-303. 2009
  4. pmc A systematic genome-wide analysis of zebrafish protein-coding gene function
    Ross N W Kettleborough
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 496:494-7. 2013
  5. pmc Zebrafish Fukutin family proteins link the unfolded protein response with dystroglycanopathies
    Yung Yao Lin
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Hum Mol Genet 20:1763-75. 2011
  6. pmc Image-based characterization of thrombus formation in time-lapse DIC microscopy
    Nicolas Brieu
    Computer Aided Medical Procedures, Technische Universität München TUM, Garching bei München 85748, Germany
    Med Image Anal 16:915-31. 2012
  7. ncbi request reprint The notochord
    Derek L Stemple
    Vertebrate Development and Genetics Team 31, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Curr Biol 14:R873-4. 2004
  8. pmc Identification of the zebrafish maternal and paternal transcriptomes
    Steven A Harvey
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Development 140:2703-10. 2013
  9. ncbi request reprint Nodal signaling and vertebrate germ layer formation
    Wei Weng
    Vertebrate Development and Genetics Team31, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
    Birth Defects Res C Embryo Today 69:325-32. 2003
  10. ncbi request reprint Zebrafish notochordal basement membrane: signaling and structure
    Annabelle Scott
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
    Curr Top Dev Biol 65:229-53. 2005

Research Grants

  1. Genetic Screens in Xenopus tropicalis
    DEREK STEMPLE; Fiscal Year: 2002
  2. Genetic Screens in Xenopus tropicalis
    DEREK STEMPLE; Fiscal Year: 2003
  3. Genetic Screens in Xenopus tropicalis
    DEREK STEMPLE; Fiscal Year: 2004
  4. A Xenopus tropicalis mutant resource
    DEREK STEMPLE; Fiscal Year: 2007
  5. A Xenopus tropicalis mutant resource
    DEREK STEMPLE; Fiscal Year: 2009
  6. Methods for Efficient Detection of Mutations in Zebrafish
    DEREK STEMPLE; Fiscal Year: 2009
  7. A Xenopus tropicalis mutant resource
    Derek L Stemple; Fiscal Year: 2010
  8. Methods for Efficient Detection of Mutations in Zebrafish
    Derek L Stemple; Fiscal Year: 2010

Collaborators

  • Francesco Muntoni
  • Edwin Cuppen
  • James C Smith
  • Yung Yao Lin
  • Leila Romio
  • Isaac J Nijman
  • A S Woolf
  • Leonor Saude
  • S W Wilson
  • Brant M Weinstein
  • Steven A Harvey
  • Michael J Parsons
  • Ross N W Kettleborough
  • Annabelle Scott
  • Fruzsina Fényes
  • Ian Sealy
  • Nicolas Brieu
  • Steven M Pollard
  • Pedro Coutinho
  • Maria I Ferrante
  • Benjamin Feldman
  • Stephen C Ekker
  • Kevin A Thomas
  • Chi Zhang
  • Wei Weng
  • Elizabeth M A Hirst
  • Richard White
  • Ross Kettleborough
  • Neha Wali
  • Colin Herd
  • Samantha Carruthers
  • Christopher M Dooley
  • Richard Gibbons
  • Selina Mehroke
  • Elisabeth M Busch-Nentwich
  • Richard J White
  • Freek van Eeden
  • Ewart de Bruijn
  • Catherine Scahill
  • Jennifer Yen
  • Amanda Hall
  • Nassir Navab
  • Martin Groher
  • Ana Cvejic
  • Willem H Ouwehand
  • Jovana Serbanovic-Canic
  • Silvia Castro
  • David A Goulding
  • John E Collins
  • Chi Bin Chien
  • Rebekah S Rasooly
  • Lorette C Javois
  • Matthew Clark
  • Makoto Kamei
  • Moon Kyoung Bae
  • Van N Pham
  • P Huw Williams
  • Peter Simpson
  • Kristin B Artinger
  • Tamara Basta
  • Laura Hernandez-Lagunas
  • Michael W Klymkowsky
  • Isabel Campos
  • Miguel L Concha
  • Richard J Adams

Detail Information

Publications18

  1. ncbi request reprint Structure and function of the notochord: an essential organ for chordate development
    Derek L Stemple
    Vertebrate Development and Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Development 132:2503-12. 2005
    ..In this review, I discuss the embryonic origin, signalling roles and ultimate fate of the notochord, with an emphasis on structural aspects of notochord biology...
  2. ncbi request reprint TILLING--a high-throughput harvest for functional genomics
    Derek L Stemple
    Vertebrate Development and Genetics Team 31, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nat Rev Genet 5:145-50. 2004
  3. pmc Convergent extension movements and ciliary function are mediated by ofd1, a zebrafish orthologue of the human oral-facial-digital type 1 syndrome gene
    Maria I Ferrante
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK
    Hum Mol Genet 18:289-303. 2009
    ..In addition, our data show that Ofd1 is important for CE during gastrulation, consistent with data linking primary cilia and non-canonical Wnt/PCP signalling...
  4. pmc A systematic genome-wide analysis of zebrafish protein-coding gene function
    Ross N W Kettleborough
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 496:494-7. 2013
    ..All mutant alleles and data are available to the community and our phenotyping scheme is adaptable to phenotypic analysis beyond embryogenesis...
  5. pmc Zebrafish Fukutin family proteins link the unfolded protein response with dystroglycanopathies
    Yung Yao Lin
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Hum Mol Genet 20:1763-75. 2011
    ..Together, our results suggest that Fukutin family proteins may play important roles in protein secretion and that the UPR may contribute to the phenotypic spectrum of some dystroglycanopathies in humans...
  6. pmc Image-based characterization of thrombus formation in time-lapse DIC microscopy
    Nicolas Brieu
    Computer Aided Medical Procedures, Technische Universität München TUM, Garching bei München 85748, Germany
    Med Image Anal 16:915-31. 2012
    ..We demonstrate the performance of our segmentation algorithm by qualitative and quantitative experiments on synthetic examples as well as on real in vivo microscopic sequences...
  7. ncbi request reprint The notochord
    Derek L Stemple
    Vertebrate Development and Genetics Team 31, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Curr Biol 14:R873-4. 2004
  8. pmc Identification of the zebrafish maternal and paternal transcriptomes
    Steven A Harvey
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Development 140:2703-10. 2013
    ....
  9. ncbi request reprint Nodal signaling and vertebrate germ layer formation
    Wei Weng
    Vertebrate Development and Genetics Team31, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
    Birth Defects Res C Embryo Today 69:325-32. 2003
    ....
  10. ncbi request reprint Zebrafish notochordal basement membrane: signaling and structure
    Annabelle Scott
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
    Curr Top Dev Biol 65:229-53. 2005
  11. ncbi request reprint Differential requirements for COPI transport during vertebrate early development
    Pedro Coutinho
    Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Dev Cell 7:547-58. 2004
    ..Moreover, we note that the mRNA encoding alpha coatomer is strikingly upregulated in notochord progenitors, and we present data suggesting that alpha coatomer transcription is tuned to activity- and cell type-specific secretory loads...
  12. ncbi request reprint Essential and overlapping roles for laminin alpha chains in notochord and blood vessel formation
    Steven M Pollard
    Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    Dev Biol 289:64-76. 2006
    ....
  13. doi request reprint Zebrafish genome project: bringing new biology to the vertebrate genome field
    Stephen C Ekker
    Department of Biochemistry and Molecular Biology, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
    Zebrafish 4:239-51. 2007
  14. ncbi request reprint Repression of nodal expression by maternal B1-type SOXs regulates germ layer formation in Xenopus and zebrafish
    Chi Zhang
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, 80309 0347, USA
    Dev Biol 273:23-37. 2004
    ..A mechanistically conserved system appears to act in a similar manner in the zebrafish...
  15. ncbi request reprint Pattern formation and developmental mechanisms: super-models of development
    Derek L Stemple
    Curr Opin Genet Dev 14:325-7. 2004
  16. ncbi request reprint Lefty antagonism of Squint is essential for normal gastrulation
    Benjamin Feldman
    Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Curr Biol 12:2129-35. 2002
    ..Furthermore, we find that Cyclops is specifically required for the maintenance of lefty1 and lefty2 transcription...
  17. ncbi request reprint Zebrafish mutants identify an essential role for laminins in notochord formation
    Michael J Parsons
    Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 129:3137-46. 2002
    ....
  18. ncbi request reprint Pioneering work in vertebrate neural development
    Derek L Stemple
    Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Dev Cell 2:687-8. 2002
    ..New work in the zebrafish lateral line shows that glia are not required for axonal pathfinding but are required for normal mature nerve organization...

Research Grants9

  1. Genetic Screens in Xenopus tropicalis
    DEREK STEMPLE; Fiscal Year: 2002
    ..tropicalis infrastructure development. Functional characterization of EST sequences will help integrate genetic and physical mapping efforts already underway. ..
  2. Genetic Screens in Xenopus tropicalis
    DEREK STEMPLE; Fiscal Year: 2003
    ..tropicalis infrastructure development. Functional characterization of EST sequences will help integrate genetic and physical mapping efforts already underway. ..
  3. Genetic Screens in Xenopus tropicalis
    DEREK STEMPLE; Fiscal Year: 2004
    ..tropicalis infrastructure development. Functional characterization of EST sequences will help integrate genetic and physical mapping efforts already underway. ..
  4. A Xenopus tropicalis mutant resource
    DEREK STEMPLE; Fiscal Year: 2007
    ....
  5. A Xenopus tropicalis mutant resource
    DEREK STEMPLE; Fiscal Year: 2009
    ....
  6. Methods for Efficient Detection of Mutations in Zebrafish
    DEREK STEMPLE; Fiscal Year: 2009
    ..These mutations will provide models of human genetic disease that may be used to identify new drugs and therapies. ..
  7. A Xenopus tropicalis mutant resource
    Derek L Stemple; Fiscal Year: 2010
    ....
  8. Methods for Efficient Detection of Mutations in Zebrafish
    Derek L Stemple; Fiscal Year: 2010
    ..These mutations will provide models of human genetic disease that may be used to identify new drugs and therapies. ..