William C Skarnes

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. pmc BayGenomics: a resource of insertional mutations in mouse embryonic stem cells
    Doug Stryke
    Department of Pharmaceutical Chemistry, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Nucleic Acids Res 31:278-81. 2003
  2. pmc A conditional knockout resource for the genome-wide study of mouse gene function
    William C Skarnes
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 474:337-42. 2011
  3. pmc Two ways to trap a gene in mice
    William C Skarnes
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    Proc Natl Acad Sci U S A 102:13001-2. 2005
  4. pmc Large-scale identification of microRNA targets in murine Dgcr8-deficient embryonic stem cell lines
    Matthew P A Davis
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
    PLoS ONE 7:e41762. 2012
  5. pmc Bi-allelic gene targeting in mouse embryonic stem cells
    Peri H Tate
    Wellcome Trust Sanger Institute, Morgan Building, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
    Methods 53:331-8. 2011
  6. pmc MiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse fibroblast cells to iPSCs
    Dong Lu
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS ONE 7:e40938. 2012
  7. pmc BioMart as an integration solution for the International Knockout Mouse Consortium
    Darren J Oakley
    The Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1HH
    Database (Oxford) 2011:bar028. 2011
  8. pmc Agouti C57BL/6N embryonic stem cells for mouse genetic resources
    Stephen J Pettitt
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Nat Methods 6:493-5. 2009
  9. pmc The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse
    Alex S Nord
    University of California San Francisco, 600 16th Street, San Francisco, CA 94143 2240, USA
    Nucleic Acids Res 34:D642-8. 2006
  10. ncbi request reprint JAM-A expression during embryonic development
    James J Parris
    Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA
    Dev Dyn 233:1517-24. 2005

Collaborators

  • Ian Dunham
  • Wei Wang
  • Elena Vigorito
  • Allan Bradley
  • Stijn van Dongen
  • Damian Smedley
  • Jessica Severin
  • Dong Lu
  • Matthew P A Davis
  • Peri H Tate
  • Anton J Enright
  • Pentao Liu
  • Cei Abreu-Goodger
  • Darren J Oakley
  • Doug Stryke
  • Stephen J Pettitt
  • Alex S Nord
  • Peter Baumeister
  • James J Parris
  • Elaine C Meng
  • Patricia C Babbitt
  • Conrad C Huang
  • Thomas E Ferrin
  • Stephen G Young
  • Courtney A Harper
  • Michiko Kawamoto
  • Susan J Johns
  • Julia Siede
  • Claudia Kutter
  • Lia S Campos
  • Nenad Bartonicek
  • Vivek Iyer
  • Haydn M Prosser
  • Xin Y Rairdan
  • Kent C Lloyd
  • Qi Liang
  • Jennifer L Moran
  • David R Beier
  • Patricia J Chang
  • Harald von Melchner
  • Songyan Liu
  • Geoffrey G Hicks
  • Bruce R Conklin
  • Janet Rossant
  • Ken Ichi Yamamura
  • William L Stanford
  • Antony V Cox
  • Philippe Soriano
  • Patricia Ruiz
  • Wolfgang Wurst
  • John H Morris
  • Shengzhan Luo
  • Melinda K Duncan
  • Guangchao Sui
  • Ulhas P Naik
  • Amy S Lee
  • Yang Shi
  • Edward Seto
  • Vesselina G Cooke
  • Leslie A King
  • Roy E Lee
  • Pao Tien Chuang
  • Alice Yee
  • Larry L'Italien

Detail Information

Publications12

  1. pmc BayGenomics: a resource of insertional mutations in mouse embryonic stem cells
    Doug Stryke
    Department of Pharmaceutical Chemistry, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Nucleic Acids Res 31:278-81. 2003
    ..They can then obtain the mutant ES cell line for the purpose of generating knockout mice...
  2. pmc A conditional knockout resource for the genome-wide study of mouse gene function
    William C Skarnes
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 474:337-42. 2011
    ....
  3. pmc Two ways to trap a gene in mice
    William C Skarnes
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    Proc Natl Acad Sci U S A 102:13001-2. 2005
  4. pmc Large-scale identification of microRNA targets in murine Dgcr8-deficient embryonic stem cell lines
    Matthew P A Davis
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
    PLoS ONE 7:e41762. 2012
    ..Additionally, our experiments have revealed a novel candidate for Dgcr8-independent microRNA genesis and highlighted the challenges currently facing miRNA annotation...
  5. pmc Bi-allelic gene targeting in mouse embryonic stem cells
    Peri H Tate
    Wellcome Trust Sanger Institute, Morgan Building, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
    Methods 53:331-8. 2011
    ..Inducible homozygous cells described here provide a precisely controlled experimental system to study gene function in a model cell...
  6. pmc MiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse fibroblast cells to iPSCs
    Dong Lu
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS ONE 7:e40938. 2012
    ..Recent studies also demonstrate that some miRNAs have important roles in reprogramming somatic cells to induced pluripotent stem cells (iPSCs)...
  7. pmc BioMart as an integration solution for the International Knockout Mouse Consortium
    Darren J Oakley
    The Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1HH
    Database (Oxford) 2011:bar028. 2011
    ..Here, we describe these datasets in more detail and illustrate the functionality of the portal using several examples...
  8. pmc Agouti C57BL/6N embryonic stem cells for mouse genetic resources
    Stephen J Pettitt
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Nat Methods 6:493-5. 2009
    ..These cells provide a robust foundation for large-scale mouse knockout programs that aim to provide a public resource of targeted mutations in the C57BL/6 genetic background...
  9. pmc The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse
    Alex S Nord
    University of California San Francisco, 600 16th Street, San Francisco, CA 94143 2240, USA
    Nucleic Acids Res 34:D642-8. 2006
    ....
  10. ncbi request reprint JAM-A expression during embryonic development
    James J Parris
    Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA
    Dev Dyn 233:1517-24. 2005
    ..Thus, JAM-A is prominently expressed in embryonic vasculature and the epithelial components of several organ systems and may have an important role in their development...
  11. pmc Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers
    Peter Baumeister
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Ave, Room 5308, MC 9176, Los Angeles, CA 90089 9176, USA
    Mol Cell Biol 25:4529-40. 2005
    ..A model for the ER stress-mediated transcription factor binding and chromatin modifications at the Grp78 promoter leading to its activation is proposed...
  12. pmc A public gene trap resource for mouse functional genomics
    William C Skarnes
    Nat Genet 36:543-4. 2004