Aswin Sai Narain Seshasayee

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. ncbi request reprint Social behavior of the yeast protein-protein interaction network
    Aswin Sai Narain Seshasayee
    EMBL EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101SD, UK
    In Silico Biol 6:127-30. 2006
  2. pmc An assessment of the role of DNA adenine methyltransferase on gene expression regulation in E coli
    Aswin Sai Narain Seshasayee
    Genomics and Regulatory Systems Group, EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
    PLoS ONE 2:e273. 2007
  3. pmc Principles of transcriptional regulation and evolution of the metabolic system in E. coli
    Aswin S N Seshasayee
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, United Kingdom
    Genome Res 19:79-91. 2009
  4. pmc Comparative genomics of cyclic-di-GMP signalling in bacteria: post-translational regulation and catalytic activity
    Aswin S N Seshasayee
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Nucleic Acids Res 38:5970-81. 2010
  5. doi request reprint Comparative genomics suggests differential deployment of linear and branched signaling across bacteria
    Aswin Sai Narain Seshasayee
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Mol Biosyst 7:3042-9. 2011
  6. pmc High-temperature unfolding of a trp-cage mini-protein: a molecular dynamics simulation study
    Aswin Sai Narain Seshasayee
    Centre for Biotechnology, Anna University, Chennai 600025, India
    Theor Biol Med Model 2:7. 2005
  7. pmc Evidence of a double-lid movement in Pseudomonas aeruginosa lipase: insights from molecular dynamics simulations
    Subbulakshmi Latha Cherukuvada
    Centre for Biotechnology, Anna University, Chennai, India
    PLoS Comput Biol 1:e28. 2005
  8. ncbi request reprint Role of hydrophobic interactions and salt-bridges in beta-hairpin folding
    Aswin Sai Narain Seshasayee
    Distributed Information Centre, Centre for Biotechnology, Anna University, 600025 Chennai, India
    J Mol Model 12:197-204. 2006
  9. ncbi request reprint Activation of Candida rugosa lipase at alkane-aqueous interfaces: a molecular dynamics study
    Jayasundar Jayant James
    Centre for Biotechnology, Anna University, Chennai 600025, India
    FEBS Lett 581:4377-83. 2007

Collaborators

  • Nicholas M Luscombe
  • M Madan Babu
  • Jayasundar Jayant James
  • Subbulakshmi Latha Cherukuvada
  • Pennathur Gautam
  • Baddireddi Subadhra Lakshmi
  • Gautam Pennathur
  • Sharmila Anishetty
  • Krishnan Raghunathan

Detail Information

Publications9

  1. ncbi request reprint Social behavior of the yeast protein-protein interaction network
    Aswin Sai Narain Seshasayee
    EMBL EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101SD, UK
    In Silico Biol 6:127-30. 2006
    ..This work, while providing an analysis of organization of genes into functional societies, can potentially be useful in assessing the accuracy of contextual gene annotation based on such interaction networks...
  2. pmc An assessment of the role of DNA adenine methyltransferase on gene expression regulation in E coli
    Aswin Sai Narain Seshasayee
    Genomics and Regulatory Systems Group, EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
    PLoS ONE 2:e273. 2007
    ..Down-regulation of Dam during stationary phase correlates with the activity of TFs whose binding sites are enriched for GATC sites...
  3. pmc Principles of transcriptional regulation and evolution of the metabolic system in E. coli
    Aswin S N Seshasayee
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, United Kingdom
    Genome Res 19:79-91. 2009
    ..Many of the observations also occur in yeast, and our findings may apply across large evolutionary distances...
  4. pmc Comparative genomics of cyclic-di-GMP signalling in bacteria: post-translational regulation and catalytic activity
    Aswin S N Seshasayee
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Nucleic Acids Res 38:5970-81. 2010
    ..Our findings will serve as a genomic framework for interpreting ongoing molecular investigations of these proteins...
  5. doi request reprint Comparative genomics suggests differential deployment of linear and branched signaling across bacteria
    Aswin Sai Narain Seshasayee
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Mol Biosyst 7:3042-9. 2011
    ..Finally, such interconnected signaling networks might be more common than anticipated, indicating the pressing need for genome-scale experimental studies of signaling networks in many understudied phylogenetic groups of organisms...
  6. pmc High-temperature unfolding of a trp-cage mini-protein: a molecular dynamics simulation study
    Aswin Sai Narain Seshasayee
    Centre for Biotechnology, Anna University, Chennai 600025, India
    Theor Biol Med Model 2:7. 2005
    ..Trp cage is a recently-constructed fast-folding miniprotein. It consists of a short helix, a 3,10 helix and a C-terminal poly-proline that packs against a Trp in the alpha helix. It is known to fold within 4 ns...
  7. pmc Evidence of a double-lid movement in Pseudomonas aeruginosa lipase: insights from molecular dynamics simulations
    Subbulakshmi Latha Cherukuvada
    Centre for Biotechnology, Anna University, Chennai, India
    PLoS Comput Biol 1:e28. 2005
    ..This work also elucidates the interplay of hydrophobic interactions in the dynamics, and hence the function, of an enzyme...
  8. ncbi request reprint Role of hydrophobic interactions and salt-bridges in beta-hairpin folding
    Aswin Sai Narain Seshasayee
    Distributed Information Centre, Centre for Biotechnology, Anna University, 600025 Chennai, India
    J Mol Model 12:197-204. 2006
    ..In the absence of hydrophobic interactions, the peptide fails to fold. However, the introduction of a salt-bridge compensates for the loss of hydrophobic interactions to a certain extent...
  9. ncbi request reprint Activation of Candida rugosa lipase at alkane-aqueous interfaces: a molecular dynamics study
    Jayasundar Jayant James
    Centre for Biotechnology, Anna University, Chennai 600025, India
    FEBS Lett 581:4377-83. 2007
    ..7 A, 10.2 A, 13.1 A at hexane-aqueous, octane-aqueous, and decane-aqueous interfaces. Further, essential dynamics analysis revealed that major anharmonic fluctuations were confined to residues 64-81, the flap of CRL...