Neil D Rawlings

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. ncbi request reprint Managing peptidases in the genomic era
    Alan J Barrett
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxon, Cambridgeshire CB10 1SA, UK
    Biol Chem 384:873-82. 2003
  2. pmc Pepsin homologues in bacteria
    Neil D Rawlings
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
    BMC Genomics 10:437. 2009
  3. pmc Evolution of the thermopsin peptidase family (A5)
    Neil D Rawlings
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridgeshire, United Kingdom
    PLoS ONE 8:e78998. 2013
  4. pmc MEROPS: the database of proteolytic enzymes, their substrates and inhibitors
    Neil D Rawlings
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Nucleic Acids Res 40:D343-50. 2012
  5. pmc Asparagine peptide lyases: a seventh catalytic type of proteolytic enzymes
    Neil David Rawlings
    Wellcome Trust Genome Campus, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
    J Biol Chem 286:38321-8. 2011
  6. doi request reprint Peptidase inhibitors in the MEROPS database
    Neil D Rawlings
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Biochimie 92:1463-83. 2010
  7. pmc MEROPS: the peptidase database
    Neil D Rawlings
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Nucleic Acids Res 38:D227-33. 2010
  8. pmc MEROPS: the peptidase database
    Neil D Rawlings
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
    Nucleic Acids Res 36:D320-5. 2008
  9. ncbi request reprint The MEROPS batch BLAST: a tool to detect peptidases and their non-peptidase homologues in a genome
    Neil D Rawlings
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Biochimie 90:243-59. 2008
  10. pmc MEROPS: the peptidase database
    Neil D Rawlings
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nucleic Acids Res 32:D160-4. 2004

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Managing peptidases in the genomic era
    Alan J Barrett
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxon, Cambridgeshire CB10 1SA, UK
    Biol Chem 384:873-82. 2003
    ..The peptidase classification has now been adopted for use by many other databases, and provides the structure around which the MEROPS protease database (http://merops.sanger.ac.uk) is built...
  2. pmc Pepsin homologues in bacteria
    Neil D Rawlings
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
    BMC Genomics 10:437. 2009
    ..The presence of a pepsin homologue in a prokaryote might give insights into the evolution of the pepsin family...
  3. pmc Evolution of the thermopsin peptidase family (A5)
    Neil D Rawlings
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridgeshire, United Kingdom
    PLoS ONE 8:e78998. 2013
    ..Putative catalytic residues have been predicted here by examination of aligned sequences. ..
  4. pmc MEROPS: the database of proteolytic enzymes, their substrates and inhibitors
    Neil D Rawlings
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Nucleic Acids Res 40:D343-50. 2012
    ....
  5. pmc Asparagine peptide lyases: a seventh catalytic type of proteolytic enzymes
    Neil David Rawlings
    Wellcome Trust Genome Campus, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
    J Biol Chem 286:38321-8. 2011
    ..We have assembled ten families based on sequence similarity in which cleavage is thought to be catalyzed by an asparagine...
  6. doi request reprint Peptidase inhibitors in the MEROPS database
    Neil D Rawlings
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Biochimie 92:1463-83. 2010
    ..Small molecule inhibitors are now included in MEROPS and over 160 summaries have been written...
  7. pmc MEROPS: the peptidase database
    Neil D Rawlings
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Nucleic Acids Res 38:D227-33. 2010
    ..This has allowed us to add an analysis tool to the relevant species pages to show significant gains and losses of peptidase genes relative to related species...
  8. pmc MEROPS: the peptidase database
    Neil D Rawlings
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
    Nucleic Acids Res 36:D320-5. 2008
    ..New ways to compare peptidase and inhibitor complements between any two organisms whose genomes have been completely sequenced, or between different strains or subspecies of the same organism, have been devised...
  9. ncbi request reprint The MEROPS batch BLAST: a tool to detect peptidases and their non-peptidase homologues in a genome
    Neil D Rawlings
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Biochimie 90:243-59. 2008
    ..A non-peptidase homologue can be distinguished by the absence or unacceptable replacement of any of these residues. An analysis of peptidase homologues in the genome of the bacterium Erythrobacter litoralis is presented as an example...
  10. pmc MEROPS: the peptidase database
    Neil D Rawlings
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nucleic Acids Res 32:D160-4. 2004
    ..A new way of making hyperlinks to the database has been devised and a BlastP search of our library of peptidase and inhibitor sequences has been added...
  11. pmc Evolutionary families of peptidase inhibitors
    Neil D Rawlings
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Biochem J 378:705-16. 2004
    ..The system of families and clans of inhibitors described has been implemented in the MEROPS peptidase database (http://merops.sanger.ac.uk/), and this will provide a mechanism for updating it as new information becomes available...
  12. pmc MEROPS: the peptidase database
    Neil D Rawlings
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Nucleic Acids Res 34:D270-2. 2006
    ..A new way to display information at taxonomic levels higher than species has been devised. In the Literature pages, references have been flagged to draw attention to particularly 'hot' topics...
  13. ncbi request reprint MEROPS: the database of proteolytic enzymes, their substrates and inhibitors
    Neil D Rawlings
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK and Proteins and Protein Families, EMBO European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK
    Nucleic Acids Res 42:D503-9. 2014
    ....
  14. pmc New mini- zincin structures provide a minimal scaffold for members of this metallopeptidase superfamily
    Christine B Trame
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, UK
    BMC Bioinformatics 15:1. 2014
    ..The Acel_2062 protein was chosen by the Joint Center for Structural Genomics for crystal structure determination to explore novel protein sequence space and structure-based function annotation...
  15. pmc A comparison of Pfam and MEROPS: two databases, one comprehensive, and one specialised
    David J Studholme
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    BMC Bioinformatics 4:17. 2003
    ..An additional reason for carrying out this study was to explore the extent of consensus in the definition of a protein family...
  16. ncbi request reprint 'Species' of peptidases
    Alan J Barrett
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
    Biol Chem 388:1151-7. 2007
    ..We suggest that new forms of analysis of the sequences of the unassigned peptidases may give early indications of how they will cluster into the new species of the future...
  17. ncbi request reprint The PepSY domain: a regulator of peptidase activity in the microbial environment?
    Corin Yeats
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Trends Biochem Sci 29:169-72. 2004
  18. pmc Identification and prioritization of novel uncharacterized peptidases for biochemical characterization
    Neil D Rawlings
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Database (Oxford) 2013:bat022. 2013
    ..The 42 most widely distributed of these putative peptidases have been identified and discussed here and are prioritized as ideal candidates for biochemical characterization. Database URL: http://merops.sanger.ac.uk...
  19. ncbi request reprint Genome of the host-cell transforming parasite Theileria annulata compared with T. parva
    Arnab Pain
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Science 309:131-3. 2005
    ....
  20. ncbi request reprint The CHAP domain: a large family of amidases including GSP amidase and peptidoglycan hydrolases
    Alex Bateman
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK CB10 1SA
    Trends Biochem Sci 28:234-7. 2003
    ..The large number of multifunctional hydrolases suggests that they might act in a cooperative manner to cleave specialized substrates...
  21. pmc Unusual phyletic distribution of peptidases as a tool for identifying potential drug targets
    Neil D Rawlings
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
    Biochem J 401:e5-7. 2007
    ..To understand how unusual this phyletic distribution is among the 183 families of peptidases, several other examples of horizontal transfers are presented, as well as some unusual losses of peptidase genes...
  22. pmc MEROPS: the protease database
    Neil D Rawlings
    MRC Molecular Enzymology Laboratory, The Babraham Institute, Babraham, Cambridgeshire CB2 4AT, UK
    Nucleic Acids Res 30:343-6. 2002
    ....
  23. ncbi request reprint Fxna, a novel gene differentially expressed in the rat ovary at the time of folliculogenesis, is required for normal ovarian histogenesis
    Cecilia Garcia-Rudaz
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA
    Development 134:945-57. 2007
    ..As an endoplasmic reticulum-bound peptidase, Fxna may facilitate follicular organization by processing precursor proteins required for intraovarian cell-to-cell communication...