Research Topics
| Derek PickardSummaryAffiliation: Wellcome Trust Genome Campus Country: UK Publications
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Detail Information
Publications
A conserved acetyl esterase domain targets diverse bacteriophages to the Vi capsular receptor of Salmonella enterica serovar TyphiDerek Pickard
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Sulston Building, Hinxton, Cambridge CB10 1SA, United Kingdom
J Bacteriol 192:5746-54. 2010..Thus, we provide a simple explanation and paradigm of how a diverse group of phages target a single key virulence antigen associated with this important human-restricted pathogen...- Molecular characterization of the Salmonella enterica serovar Typhi Vi-typing bacteriophage E1Derek Pickard
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
J Bacteriol 190:2580-7. 2008..The genome of the Vi phage E1 is significantly related to other bacteriophages belonging to the same serovar Typhi phage-typing set, and we demonstrate a role for phage DNA modification in determining host specificity... - Characterization of a ViI-like phage specific to Escherichia coli O157:H7Elizabeth M Kutter
The Evergreen State College, Olympia, WA, USA
Virol J 8:430. 2011.... - Characterization of the genomes of a diverse collection of Salmonella enterica serovar Typhimurium definitive phage type 104Fiona J Cooke
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
J Bacteriol 190:8155-62. 2008..Thus, here the nature of variation in different Salmonella serovar Typhimurium DT104 isolates is further defined at the gene and whole-genome levels, illustrating how this phage type evolves over time... - Characterisation of a live Salmonella vaccine stably expressing the Mycobacterium tuberculosis Ag85B-ESAT6 fusion proteinLindsay J Hall
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
Vaccine 27:6894-904. 2009..Thus, live oral priming with the recombinant Salmonella/Ag85B-ESAT6 and boosting with Ag85B-ESAT6 plus the adjuvant LTK63 represents an effective mucosal vaccination regimen... - Structure, diversity, and mobility of the Salmonella pathogenicity island 7 family of integrative and conjugative elements within EnterobacteriaceaeHelena M B Seth-Smith
Pathogen Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK
J Bacteriol 194:1494-504. 2012..We present a growing family of SPI-7-related ICEs whose mobility, abundance, and cargo variability indicate that these elements may have had a large impact on the evolution of the Enterobacteriaceae... - Mobilization of the incQ plasmid R300B with a chromosomal conjugation system in Salmonella enterica serovar typhiStephen Baker
The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
J Bacteriol 190:4084-7. 2008..Evidence suggests that SPI-7 is susceptible to spontaneous circularization, loss, and transposition. Here, we demonstrate that a region within SPI-7 has the ability to mobilize the small incQ plasmid R300B... - Citrobacter rodentium is an unstable pathogen showing evidence of significant genomic fluxNicola K Petty
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
PLoS Pathog 7:e1002018. 2011..We draw parallels with the evolution of other bacterial pathogens and conclude that C. rodentium is a recently evolved pathogen that may have emerged alongside the development of inbred mice as a model for human disease... - Analysis of the hypervariable region of the Salmonella enterica genome associated with tRNA(leuX)Anne L Bishop
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
J Bacteriol 187:2469-82. 2005..coli, suggesting that these mobile genetic elements have played a major role in driving the variability of this region... - Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathwaysNicholas R Thomson
The Pathogen Sequencing Unit, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
Genome Res 18:1624-37. 2008..Enteritidis-harboring mutations in functional homologs of the pseudogenes present in S. Gallinarum could provide an experimentally tractable route toward unraveling the genetic basis of host adaptation in S. enterica... 
The role of prophage-like elements in the diversity of Salmonella enterica serovarsNicholas Thomson
The Pathogen Sequencing Unit, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
J Mol Biol 339:279-300. 2004..Lysogenic bacteriophages therefore play a crucial role in the generation of genetic diversity within S.enterica...- Candidate live, attenuated Salmonella enterica serotype Typhimurium vaccines with reduced fecal shedding are immunogenic and effective oral vaccinesMoataz Abd El Ghany
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
Infect Immun 75:1835-42. 2007..Further, immunization with serotype Typhimurium aroA candidate vaccines harboring shdA and misL afforded complete protection against challenge with a virulent strain of serotype Typhimurium...