Leopold Parts

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. pmc Joint genetic analysis of gene expression data with inferred cellular phenotypes
    Leopold Parts
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS Genet 7:e1001276. 2011
  2. pmc Revealing the genetic structure of a trait by sequencing a population under selection
    Leopold Parts
    The Wellcome Trust Sanger Institute, Hinxton, United Kingdom
    Genome Res 21:1131-8. 2011
  3. pmc Mapping cis- and trans-regulatory effects across multiple tissues in twins
    Elin Grundberg
    Wellcome Trust Sanger Institute, Hinxton, UK
    Nat Genet 44:1084-9. 2012
  4. pmc Inferring genome-wide recombination landscapes from advanced intercross lines: application to yeast crosses
    Christopher J R Illingworth
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS ONE 8:e62266. 2013
  5. pmc A map of human genome variation from population-scale sequencing
    Richard M Durbin
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK
    Nature 467:1061-73. 2010
  6. pmc Patterns of cis regulatory variation in diverse human populations
    Barbara E Stranger
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
    PLoS Genet 8:e1002639. 2012
  7. pmc Extent, causes, and consequences of small RNA expression variation in human adipose tissue
    Leopold Parts
    Wellcome Trust Sanger Institute, Hinxton, United Kingdom
    PLoS Genet 8:e1002704. 2012
  8. pmc Quantifying selection acting on a complex trait using allele frequency time series data
    Christopher J R Illingworth
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    Mol Biol Evol 29:1187-97. 2012
  9. pmc The architecture of gene regulatory variation across multiple human tissues: the MuTHER study
    Alexandra C Nica
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
    PLoS Genet 7:e1002003. 2011
  10. pmc Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants
    Gemma C Langridge
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
    Genome Res 19:2308-16. 2009

Detail Information

Publications10

  1. pmc Joint genetic analysis of gene expression data with inferred cellular phenotypes
    Leopold Parts
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS Genet 7:e1001276. 2011
    ..For the first time, we consider and find interactions between genotype and intermediate phenotypes inferred from gene expression levels, complementing and extending established results...
  2. pmc Revealing the genetic structure of a trait by sequencing a population under selection
    Leopold Parts
    The Wellcome Trust Sanger Institute, Hinxton, United Kingdom
    Genome Res 21:1131-8. 2011
    ....
  3. pmc Mapping cis- and trans-regulatory effects across multiple tissues in twins
    Elin Grundberg
    Wellcome Trust Sanger Institute, Hinxton, UK
    Nat Genet 44:1084-9. 2012
    ....
  4. pmc Inferring genome-wide recombination landscapes from advanced intercross lines: application to yeast crosses
    Christopher J R Illingworth
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS ONE 8:e62266. 2013
    ..Our method has general applicability to other crossing experiments, including a variety of experimental designs...
  5. pmc A map of human genome variation from population-scale sequencing
    Richard M Durbin
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK
    Nature 467:1061-73. 2010
    ..These methods and public data will support the next phase of human genetic research...
  6. pmc Patterns of cis regulatory variation in diverse human populations
    Barbara E Stranger
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
    PLoS Genet 8:e1002639. 2012
    ....
  7. pmc Extent, causes, and consequences of small RNA expression variation in human adipose tissue
    Leopold Parts
    Wellcome Trust Sanger Institute, Hinxton, United Kingdom
    PLoS Genet 8:e1002704. 2012
    ..This study highlights the similar genetic complexity and shared genetic control of small RNA and mRNA transcripts, and gives a quantitative picture of small RNA expression variation in the human population...
  8. pmc Quantifying selection acting on a complex trait using allele frequency time series data
    Christopher J R Illingworth
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    Mol Biol Evol 29:1187-97. 2012
    ..Our approach is applicable to study adaptation in a range of systems under different evolutionary pressures...
  9. pmc The architecture of gene regulatory variation across multiple human tissues: the MuTHER study
    Alexandra C Nica
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
    PLoS Genet 7:e1002003. 2011
    ..Our results underline the need to account for the complexity of eQTL tissue-specificity in an effort to assess consequences of such variants for complex traits...
  10. pmc Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants
    Gemma C Langridge
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
    Genome Res 19:2308-16. 2009
    ..Typhi in the gall bladder. This screen validated our hypothesis that we can simultaneously assay every gene in the genome to identify niche-specific essential genes...