C A Ouzounis

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. pmc Beyond 100 genomes
    Paul Janssen
    Genome Biol 4:402. 2003
  2. pmc Genome sequences and great expectations
    I Iliopoulos
    Computational Genomics Group, Research Programme, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge, CB10 1SD, UK
    Genome Biol 2:INTERACTIONS0001. 2001
  3. pmc Functional associations of proteins in entire genomes by means of exhaustive detection of gene fusions
    A J Enright
    Computational Genomics Group, European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Genome Biol 2:RESEARCH0034. 2001
  4. pmc The past, present and future of genome-wide re-annotation
    Christos A Ouzounis
    Bioinformatics Research Group, AI Center, SRI International, Menlo Park, CA 94025, USA
    Genome Biol 3:COMMENT2001. 2002
  5. pmc Myriads of protein families, and still counting
    Victor Kunin
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge, UK
    Genome Biol 4:401. 2003
  6. pmc Structural and functional properties of genes involved in human cancer
    Simon J Furney
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    BMC Genomics 7:3. 2006
  7. pmc Probabilistic annotation of protein sequences based on functional classifications
    Emmanuel D Levy
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    BMC Bioinformatics 6:302. 2005
  8. pmc Clustering the annotation space of proteins
    Victor Kunin
    Computational Genomics Group, EMBL EBI, Cambridge, CB10 1SO, UK
    BMC Bioinformatics 6:24. 2005
  9. ncbi request reprint Ancestral state reconstructions for genomes
    Christos A Ouzounis
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Curr Opin Genet Dev 15:595-600. 2005
  10. ncbi request reprint Classification schemes for protein structure and function
    Christos A Ouzounis
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Nat Rev Genet 4:508-19. 2003

Collaborators

Detail Information

Publications59

  1. pmc Beyond 100 genomes
    Paul Janssen
    Genome Biol 4:402. 2003
    ..An overview of these genomes reveals certain interesting trends and provides valuable insights into possible future developments...
  2. pmc Genome sequences and great expectations
    I Iliopoulos
    Computational Genomics Group, Research Programme, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge, CB10 1SD, UK
    Genome Biol 2:INTERACTIONS0001. 2001
    ..Despite progress in computational biology, there will always be a great need for large-scale experimental determination of protein function...
  3. pmc Functional associations of proteins in entire genomes by means of exhaustive detection of gene fusions
    A J Enright
    Computational Genomics Group, European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Genome Biol 2:RESEARCH0034. 2001
    ..CONCLUSIONS: These results provide an exhaustive set of functionally associated genes and also delineate the power of fusion analysis for the prediction of protein interactions...
  4. pmc The past, present and future of genome-wide re-annotation
    Christos A Ouzounis
    Bioinformatics Research Group, AI Center, SRI International, Menlo Park, CA 94025, USA
    Genome Biol 3:COMMENT2001. 2002
    ..We define the process of annotating a previously annotated genome sequence as 're-annotation', and examine the strengths and weaknesses of current manual and automatic genome-wide re-annotation approaches...
  5. pmc Myriads of protein families, and still counting
    Victor Kunin
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge, UK
    Genome Biol 4:401. 2003
    ..From the historical record of genome sequencing, we show that the rate of discovery of new families has remained constant over time, indicating that our knowledge of sequence space is far from complete...
  6. pmc Structural and functional properties of genes involved in human cancer
    Simon J Furney
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    BMC Genomics 7:3. 2006
    ..One of the main goals of cancer genetics is to identify the causative elements at the molecular level leading to cancer...
  7. pmc Probabilistic annotation of protein sequences based on functional classifications
    Emmanuel D Levy
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    BMC Bioinformatics 6:302. 2005
    ..Most automatic approaches developed to date rely on the identification of clusters of homologous proteins and the mapping of new proteins onto these clusters, which are expected to share functional characteristics...
  8. pmc Clustering the annotation space of proteins
    Victor Kunin
    Computational Genomics Group, EMBL EBI, Cambridge, CB10 1SO, UK
    BMC Bioinformatics 6:24. 2005
    ..Current protein clustering methods rely on either sequence or functional similarities between proteins, thereby limiting inferences to one of these areas...
  9. ncbi request reprint Ancestral state reconstructions for genomes
    Christos A Ouzounis
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Curr Opin Genet Dev 15:595-600. 2005
    ....
  10. ncbi request reprint Classification schemes for protein structure and function
    Christos A Ouzounis
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Nat Rev Genet 4:508-19. 2003
    ....
  11. ncbi request reprint Maps, books and other metaphors for systems biology
    Christos Ouzounis
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Biosystems 85:6-10. 2006
    ..Finally, we propose a metaphor for systems biology that provides an illuminating perspective for the ambitious goals of this field and delimits its current agenda...
  12. ncbi request reprint Early bioinformatics: the birth of a discipline--a personal view
    Christos A Ouzounis
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Bioinformatics 19:2176-90. 2003
    ....
  13. pmc Global properties of the metabolic map of Escherichia coli
    C A Ouzounis
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge, CB10 1SD, UK
    Genome Res 10:568-76. 2000
    ..The dimensions chosen for this analysis can be employed for comparative functional analysis of complete genomes...
  14. pmc The balance of driving forces during genome evolution in prokaryotes
    Victor Kunin
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Genome Res 13:1589-94. 2003
    ..This approach indicates that it is possible to trace genome content history and quantify the factors that shape contemporary prokaryotic genomes...
  15. pmc Strain-specific genes of Helicobacter pylori: distribution, function and dynamics
    P J Janssen
    Computational Genomics Group, Research Programme, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Nucleic Acids Res 29:4395-404. 2001
    ..If these are taken into account, a common pattern for the genome dynamics of the two Helicobacter strains emerges, suggestive of certain spatial constraints that may act as control mechanisms of gene flux...
  16. ncbi request reprint CoGenT++: an extensive and extensible data environment for computational genomics
    Leon Goldovsky
    Computational Genomics Group, The European Bioinformatics Institute EMBL, Cambridge Outstation, Cambridge CB10 1SD, UK
    Bioinformatics 21:3806-10. 2005
    ..CoGenT++ is a data environment for computational research in comparative and functional genomics, designed to address issues of consistency, reproducibility, scalability and accessibility...
  17. ncbi request reprint GeneTRACE-reconstruction of gene content of ancestral species
    Victor Kunin
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Bioinformatics 19:1412-6. 2003
    ....
  18. pmc The net of life: reconstructing the microbial phylogenetic network
    Victor Kunin
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, United Kingdom
    Genome Res 15:954-9. 2005
    ..We propose that genes might propagate extremely rapidly across microbial species through the HGT network, using certain organisms as hubs...
  19. ncbi request reprint Protein interaction maps for complete genomes based on gene fusion events
    A J Enright
    Computational Genomics Group, Research Programme, The European Bioinformatics Institute, EMBL Cambridge Outstation, UK
    Nature 402:86-90. 1999
    ..The approach is general, and can be applied even to genes of unknown function...
  20. pmc Functional versatility and molecular diversity of the metabolic map of Escherichia coli
    S Tsoka
    Computational Genomics Group, Research Programme, The European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge Outstation, Cambridge CB10 1SD, UK
    Genome Res 11:1503-10. 2001
    ..Finally, the distribution of enzyme family members across different pathways provides support for the "recruitment" hypothesis of biochemical pathway evolution...
  21. ncbi request reprint MagicMatch--cross-referencing sequence identifiers across databases
    Mike Smith
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Bioinformatics 21:3429-30. 2005
    ..At present, mapping of sequence identifiers across databases is a daunting, time-consuming and computationally expensive process, usually achieved by sequence similarity searches with strict threshold values...
  22. pmc Protein families and TRIBES in genome sequence space
    Anton J Enright
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Nucleic Acids Res 31:4632-8. 2003
    ..Finally, we analyse the functional diversity of protein families in entire genome sequences. The TRIBES protein family resource is accessible at http://www.ebi.ac.uk/research/cgg/tribes/...
  23. ncbi request reprint Evaluation of annotation strategies using an entire genome sequence
    Ioannis Iliopoulos
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Bioinformatics 19:717-26. 2003
    ..In order to quantify the accuracy and reproducibility of function assignments on a genome-wide scale, we have re-annotated the entire genome sequence of Chlamydia trachomatis (serovar D), in a collaborative manner...
  24. ncbi request reprint Genome-wide detection and family clustering of ion channels
    Rachel Harte
    Computational Genomics Group, Research Programme, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    FEBS Lett 514:129-34. 2002
    ..A total of 299 putative ion channel protein sequences were detected, with significant variations across species. The clustering of these sequences reveals complex relationships between the different ion channel families...
  25. ncbi request reprint Transcription-associated protein families are primarily taxon-specific
    R M Coulson
    Computational Genomics Group, Research Programme, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Bioinformatics 17:95-7. 2001
    ..Our results for the primary phylogenetic domains (Archaea, Bacteria and Eukaryota) show that TAP families are mostly taxon-specific and very few transcriptional regulators are common across these domains...
  26. ncbi request reprint Modeling the percolation of annotation errors in a database of protein sequences
    Walter R Gilks
    Medical Research Council Biostatistics Unit, Cambridge, UK
    Bioinformatics 18:1641-9. 2002
    ..By exploring the consequences of the model for annotation quality it is evident that this iterative approach leads to a systematic deterioration of database quality...
  27. pmc Identification of thermophilic species by the amino acid compositions deduced from their genomes
    D P Kreil
    University of Cambridge and European Bioinformatics Institute, Computational Genomics Group, Research Programme, The European Bioinformatics Institute, EMBL Outstation, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK
    Nucleic Acids Res 29:1608-15. 2001
    ..We expect this simple yet novel approach to be a useful additional tool for the study of phylogeny at the genome level...
  28. ncbi request reprint BioLayout(Java): versatile network visualisation of structural and functional relationships
    Leon Goldovsky
    Computational Genomics Group, European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge, UK
    Appl Bioinformatics 4:71-4. 2005
    ..BioLayout(Java) provides broader functionality, various analysis techniques, extensions for better visualisation and a new user interface. Examples of analysis of biological networks using BioLayout(Java) are presented...
  29. ncbi request reprint The properties of protein family space depend on experimental design
    Victor Kunin
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Bioinformatics 21:2618-22. 2005
    ..Databases of protein families often exhibit drastically different properties of the protein family space...
  30. pmc Measuring genome conservation across taxa: divided strains and united kingdoms
    Victor Kunin
    Computational Genomics Group, The European Bioinformatics Institute EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Nucleic Acids Res 33:616-21. 2005
    ..All phylogenetic reconstructions are available at the genome phylogeny server: <http://maine.ebi.ac.uk:8000/cgi-bin/gps/GPS.pl>...
  31. ncbi request reprint COmplete GENome Tracking (COGENT): a flexible data environment for computational genomics
    Paul Janssen
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Welcome Trust Genome Campus, Cambridge CB10 1SD, UK
    Bioinformatics 19:1451-2. 2003
    ..For its design we have implemented an extremely simple yet powerful schema to allow linking of genome sequence data to other resources...
  32. ncbi request reprint Detection of functional modules from protein interaction networks
    Jose B Pereira-Leal
    Computational Genomics Group, The European Bioinformatics Institute, Cambridge, United Kingdom
    Proteins 54:49-57. 2004
    ..We use an extensive statistical validation procedure to establish the biological significance of the detected modules and explore this complex, hierarchical network of modular interactions from which pathways can be inferred...
  33. ncbi request reprint Metabolic database systems for the analysis of genome-wide function
    Sophia Tsoka
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB1O 1SD, UK
    Biotechnol Bioeng 84:750-5. 2003
    ..We illustrate the design features of metabolic databases and discuss the challenges facing metabolic as well as databases of other functional type...
  34. ncbi request reprint Transcription regulation and environmental adaptation in bacteria
    Ildefonso Cases
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Wellcome Trust Genome Campus, Cambridge, CB10 1SD, UK
    Trends Microbiol 11:248-53. 2003
    ..This suggests that under complex conditions, gene expression regulation and signal integration have been strongly selected for to enable rapid adaptation to environmental conditions...
  35. pmc The phylogenetic diversity of eukaryotic transcription
    Richard M R Coulson
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Nucleic Acids Res 31:653-60. 2003
    ..This contrasts with transcriptional regulator families, that are primarily taxon-specific, indicating proteins controlling gene activation exhibit considerable sequence diversity across the eukaryotic domain...
  36. ncbi request reprint A minimal estimate for the gene content of the last universal common ancestor--exobiology from a terrestrial perspective
    Christos A Ouzounis
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Res Microbiol 157:57-68. 2006
    ....
  37. pmc Lineage-specific partitions in archaeal transcription
    Richard M R Coulson
    Microarray Group, The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Archaea 2:117-25. 2007
    ..Strikingly, the hidden Markov model profile searches revealed that archaeal chromatin and histone-modifying enzymes also display extensive taxon-restrictedness, both across and within the two phyla...
  38. pmc Denoising inferred functional association networks obtained by gene fusion analysis
    Atanas Kamburov
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    BMC Genomics 8:460. 2007
    ..The precision of this method typically improves with an ever-increasing number of reference genomes...
  39. ncbi request reprint The comparative genomics of protein interactions
    Jose M Peregrin-Alvarez
    Sick Kids Research Institute, TMDT MARS Building, 101 College St, 15th Floor, East Tower, M5G 1L7 Toronto, ON, Canada
    Genome Inform 19:131-41. 2007
    ....
  40. ncbi request reprint From genes to genomes: universal scale-invariant properties of microbial chromosome organisation
    Benjamin Audit
    Wellcome Trust Genome Campus, Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge, CB10 1SD, UK
    J Mol Biol 332:617-33. 2003
    ....
  41. pmc Automated metabolic reconstruction for Methanococcus jannaschii
    Sophia Tsoka
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Archaea 1:223-9. 2004
    ..Our results, in the form of enzymatic assignments and metabolic pathway predictions, form a database (MJCyc) that is accessible over the World Wide Web for further dissemination among members of the scientific community...
  42. pmc Metabolic innovations towards the human lineage
    Shiri Freilich
    The European Bioinformatics Institute, EMBL Cambridge Outstation, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK
    BMC Evol Biol 8:247. 2008
    ....
  43. ncbi request reprint Robustness of metabolic map reconstruction
    Dag G Ahren
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK
    J Bioinform Comput Biol 2:589-93. 2004
    ..We also discuss the implications of the results on reference genome projects as well as other large-scale sequencing data...
  44. pmc Genome-wide identification of genes likely to be involved in human genetic disease
    Nuria Lopez-Bigas
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Nucleic Acids Res 32:3108-14. 2004
    ..The probability score assignments for the human genome are accessible at http://maine.ebi. ac.uk:8000/services/dgp...
  45. ncbi request reprint Functional evolution of the yeast protein interaction network
    Victor Kunin
    Computational Genomics Group, The European Bioinformatics Institute EMBL Cambridge Outstation, Cambridge, UK
    Mol Biol Evol 21:1171-6. 2004
    ..We propose that the understanding of the mechanisms that generate the scale-free protein interaction network, and possibly other biological networks, requires consideration of protein function...
  46. ncbi request reprint Comparison of sequence masking algorithms and the detection of biased protein sequence regions
    David P Kreil
    Department of Genetics Inference Group Cavendish Laboratory, University of Cambridge, Cambridge, UK
    Bioinformatics 19:1672-81. 2003
    ..Traditionally, however, these have been neglected despite evidence of their functional relevance...
  47. pmc An efficient algorithm for large-scale detection of protein families
    A J Enright
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Nucleic Acids Res 30:1575-84. 2002
    ..The method has been used to detect and categorise protein families within the draft human genome and the resulting families have been used to annotate a large proportion of human proteins...
  48. ncbi request reprint BioLayout--an automatic graph layout algorithm for similarity visualization
    A J Enright
    Computational Genomics Group, Research Programme, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Bioinformatics 17:853-4. 2001
    ..The implementation of the algorithm is general and applicable to most types of similarity information for biological data...
  49. pmc The phylogenetic extent of metabolic enzymes and pathways
    José Manuel Peregrín-Alvarez
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Genome Res 13:422-7. 2003
    ..In addition, our analysis suggests that despite the sequence conservation and the extensive phylogenetic distribution of metabolic enzymes, their groupings into biochemical pathways are much more variable than previously thought...
  50. pmc Comparative genomics of transcriptional control in the human malaria parasite Plasmodium falciparum
    Richard M R Coulson
    Computational Genomics Group, The European Bioinformatics Institute, European Molecular Biology Laboratory Cambridge Outstation, Cambridge CB10 1SD, United Kingdom
    Genome Res 14:1548-54. 2004
    ..falciparum genome. This observation, together with the paucity of malarial transcriptional regulators identified, suggests Plasmodium protein levels are primarily determined by posttranscriptional mechanisms...
  51. ncbi request reprint An exponential core in the heart of the yeast protein interaction network
    Jose B Pereira-Leal
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Wellcome Trust Genome Campus, Cambridge, UK
    Mol Biol Evol 22:421-5. 2005
    ..Finally, we propose that this core exponential network may represent a generic scaffold around which organism-specific and taxon-specific proteins and interactions coalesce...
  52. ncbi request reprint Sensitive detection of sequence similarity using combinatorial pattern discovery: a challenging study of two distantly related protein families
    Nikos Darzentas
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge, UK
    Proteins 61:926-37. 2005
    ..Our analysis suggests that pattern discovery methods can be substantially more sensitive in detecting remote protein relationships while at the same time guaranteeing high specificity...
  53. pmc CORRIE: enzyme sequence annotation with confidence estimates
    Benjamin Audit
    Laboratoire Joliot Curie and Laboratoire de Physique, CNRS UMR5672, Ecole Normale Superieure, Lyon Cedex 07, France
    BMC Bioinformatics 8:S3. 2007
    ..The CORRIE server is available at: http://www.genomes.org/services/corrie/...
  54. ncbi request reprint Genetic variation between Helicobacter pylori strains: gene acquisition or loss?
    Santiago Garcia-Vallve
    Departament de Bioquimica i Biotecnologia, Universitat Rovira i Virgili, Pl Imperial Tarraco 1, Tarragona, Spain
    Trends Microbiol 10:445-7. 2002
    ....
  55. ncbi request reprint Highly consistent patterns for inherited human diseases at the molecular level
    Nuria Lopez-Bigas
    Genome Bioinformatics Laboratory, Center for Genomic Regulation, Universitat Pompeu Fabra, Pg Maritim de la Barceloneta 37 49, E 08003, Barcelona, Spain
    Bioinformatics 22:269-77. 2006
    ..The results further indicate that a comparative genomics approach for the analysis of genes linked to human genetic diseases will facilitate the elucidation of the underlying molecular and cellular mechanisms...
  56. pmc Expansion of the BioCyc collection of pathway/genome databases to 160 genomes
    Peter D Karp
    Bioinformatics Research Group, SRI International EK207, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Nucleic Acids Res 33:6083-9. 2005
    ..Only by harnessing the expertise of many scientists we can hope to produce biological databases, which accurately reflect the depth and breadth of knowledge that the biomedical research community is producing...
  57. pmc Genome coverage, literally speaking. The challenge of annotating 200 genomes with 4 million publications
    Paul Janssen
    Belgian Nuclear Research Centre, Belgium
    EMBO Rep 6:397-9. 2005
  58. pmc Genome evolution reveals biochemical networks and functional modules
    Christian von Mering
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Proc Natl Acad Sci U S A 100:15428-33. 2003
    ..The results indicate that modularity in protein networks is intrinsically encoded in present-day genomes...
  59. ncbi request reprint Percolation of annotation errors through hierarchically structured protein sequence databases
    Walter R Gilks
    Medical Research Council Biostatistics Unit, Institute of Public Health, University of Forvive Site, Robinson Way, Cambridge CB2 2SR, UK
    Math Biosci 193:223-34. 2005
    ..Here we apply the theory to hierarchically structured protein sequence databases, and draw conclusions about database quality at different levels of the hierarchy...