Sandra Orchard

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. ncbi Debunking minimum information myths: one hat need not fit all
    Sandra Orchard
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK
    N Biotechnol 25:171-2. 2009
  2. ncbi Molecular interaction databases
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 12:1656-62. 2012
  3. ncbi Protein interaction data curation: the International Molecular Exchange (IMEx) consortium
    Sandra Orchard
    European Molecular Biology Laboratory European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK
    Nat Methods 9:345-50. 2012
  4. ncbi The HUPO pre-congress Proteomics Standards Initiative workshop. HUPO 5th annual World Congress. Long Beach, CA, USA 28 October-1 November 2006
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK
    Proteomics 7:1006-8. 2007
  5. ncbi Publication Committee meeting. HUPO 5th annual World Congress. Long Beach, CA, USA 30 October 2006
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK
    Proteomics 7:1009-11. 2007
  6. ncbi The minimum information required for reporting a molecular interaction experiment (MIMIx)
    Sandra Orchard
    European Molecular Biology Laboratory EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Nat Biotechnol 25:894-8. 2007
  7. ncbi Submit your interaction data the IMEx way: a step by step guide to trouble-free deposition
    Sandra Orchard
    European Bioinformatics Institute, Hinxton, Cambridge, UK
    Proteomics 7:28-34. 2007
  8. ncbi Five years of progress in the Standardization of Proteomics Data 4th Annual Spring Workshop of the HUPO-Proteomics Standards Initiative April 23-25, 2007 Ecole Nationale Supérieure (ENS), Lyon, France
    Sandra Orchard
    EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 7:3436-40. 2007
  9. ncbi Annual spring meeting of the Proteomics Standards Initiative 23-25 April 2008, Toledo, Spain
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Proteomics 8:4168-72. 2008
  10. ncbi The HUPO proteomics standards initiative--easing communication and minimizing data loss in a changing world
    Sandra Orchard
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Brief Bioinform 9:166-73. 2008

Detail Information

Publications59

  1. ncbi Debunking minimum information myths: one hat need not fit all
    Sandra Orchard
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK
    N Biotechnol 25:171-2. 2009
    ..This response is an attempt to set the record straight and ensure that other groups are not discouraged from using these standards or from joining in their further development in either existing or novel areas of research...
  2. ncbi Molecular interaction databases
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 12:1656-62. 2012
    ....
  3. ncbi Protein interaction data curation: the International Molecular Exchange (IMEx) consortium
    Sandra Orchard
    European Molecular Biology Laboratory European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK
    Nat Methods 9:345-50. 2012
    ..We discuss the advantages of such a service to the user, our quality-control measures and our data-distribution practices...
  4. ncbi The HUPO pre-congress Proteomics Standards Initiative workshop. HUPO 5th annual World Congress. Long Beach, CA, USA 28 October-1 November 2006
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK
    Proteomics 7:1006-8. 2007
    ..This should be achieved by early in 2007...
  5. ncbi Publication Committee meeting. HUPO 5th annual World Congress. Long Beach, CA, USA 30 October 2006
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK
    Proteomics 7:1009-11. 2007
    ..Discussions centred on how best to structure interactions between journals, databases and researchers to improve accessibility to data, and facilitate comparisons between datasets...
  6. ncbi The minimum information required for reporting a molecular interaction experiment (MIMIx)
    Sandra Orchard
    European Molecular Biology Laboratory EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Nat Biotechnol 25:894-8. 2007
    ....
  7. ncbi Submit your interaction data the IMEx way: a step by step guide to trouble-free deposition
    Sandra Orchard
    European Bioinformatics Institute, Hinxton, Cambridge, UK
    Proteomics 7:28-34. 2007
    ..This article walks the potential submitter through the various routes by which data may be deposited with the databases and describes the tools which have been developed to assist in this process...
  8. ncbi Five years of progress in the Standardization of Proteomics Data 4th Annual Spring Workshop of the HUPO-Proteomics Standards Initiative April 23-25, 2007 Ecole Nationale Supérieure (ENS), Lyon, France
    Sandra Orchard
    EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 7:3436-40. 2007
    ..Finally the Molecular Interaction group discussed the development of a molecular interaction scoring system with accompanying gold standard data test sets...
  9. ncbi Annual spring meeting of the Proteomics Standards Initiative 23-25 April 2008, Toledo, Spain
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Proteomics 8:4168-72. 2008
    ..The accompanying controlled vocabularies are continuing to evolve and a number of standards papers are now being finalised prior to publication...
  10. ncbi The HUPO proteomics standards initiative--easing communication and minimizing data loss in a changing world
    Sandra Orchard
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Brief Bioinform 9:166-73. 2008
    ..This article will provide an update on the work of this group, the creation and implementation of these standards and the standards-compliant data repositories being established as result of their efforts...
  11. ncbi Proteomics: from technology development to biomarker applications
    Sandra Orchard
    EMBL - European Bioinformatics Institute, Wellcome Trust, Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
    Expert Rev Proteomics 4:709-10. 2007
  12. ncbi 6th HUPO Annual World Congress - Proteomics Standards Initiative Workshop 6-10 October 2007, Seoul, Korea
    Sandra Orchard
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 8:1331-3. 2008
    ..The session ended with a lively debate on the practical implications these advances will have on daily laboratory work, on submission procedures and the tools which are being developed to assist in these activities...
  13. ncbi Managing the data explosion. A report on the HUPO-PSI Workshop. August 2008, Amsterdam, The Netherlands
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 9:499-501. 2009
    ..Community input on this initiative was requested. Finally, the impact these new data standards are having on the data submission process, which increasingly is an integral part of the publication process, was reviewed and discussed...
  14. ncbi HUPO World Congress Publication Committee meeting. August 2008, Amsterdam, The Netherlands
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 9:502-3. 2009
    ..Delegates from industry, academia and the publishing houses discussed how best to bring these bodies closer to together and facilitate the publication process for the bench scientist...
  15. ncbi Second Joint HUPO publication and Proteomics Standards Initiative workshop
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Proteomics 9:4426-8. 2009
    ..Most of the specialist journals publishing in this field were represented at the event as well as data providers, databases and the authors of the HUPO-PSI standards documents...
  16. ncbi Annual spring meeting of the Proteomics Standards Initiative
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Proteomics 9:4429-32. 2009
    ....
  17. ncbi Minimum information about a bioactive entity (MIABE)
    Sandra Orchard
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK
    Nat Rev Drug Discov 10:661-9. 2011
    ....
  18. ncbi Entering the implementation era: a report on the HUPO-PSI Fall workshop 25-27 September 2006, Washington DC, USA
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 7:337-9. 2007
    ..In parallel with this, minimum reporting requirement have been developed and are now maturing to the point where they have been submitted for journal publication after prolonged exposure to community-input via the PSI website...
  19. ncbi Kinases as targets: prospects for chronic therapy
    Sandra Orchard
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
    Curr Opin Drug Discov Devel 5:713-7. 2002
    ....
  20. ncbi Common interchange standards for proteomics data: Public availability of tools and schema
    Sandra Orchard
    EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 4:490-1. 2004
    ..A draft XML interchange format for mass spectrometry data has been written and is currently undergoing evaluation whilst work is ongoing to develop a proteomics data integration model, MIAPE...
  21. ncbi Further steps towards data standardisation: the Proteomic Standards Initiative HUPO 3(rd) annual congress, Beijing 25-27(th) October, 2004
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 5:337-9. 2005
    ..Parallel sessions allowed the three work groups to present their progress to interested parties and to collect feedback from groups already implementing the available formats...
  22. ncbi Current status of proteomic standards development
    Sandra Orchard
    EMBL Outstation, European Bioinformatics Institute, Wellcome Trust, Genome Campus, Hinxton, Cambridge, UK
    Expert Rev Proteomics 1:179-83. 2004
    ..The eXtensible Mark-up Language-MI data interchange format, which allows exchange of molecular interaction data, has already been published and major databases within this field are supplying data downloads in this format...
  23. ncbi Human Proteome Organisation Proteomics Standards Initiative. Pre-Congress Initiative
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Proteomics 5:4651-2. 2005
    ..The General Proteomics Standards group is now working closely with the Functional Genomics Experiment efforts to define a general standard in which to encode data that will enable a systems biology approach to data analysis...
  24. ncbi Second proteomics standards initiative spring workshop
    Sandra Orchard
    EMBL Outstation - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Expert Rev Proteomics 2:287-9. 2005
  25. ncbi Further steps in standardisation. Report of the second annual Proteomics Standards Initiative Spring Workshop (Siena, Italy 17-20th April 2005)
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 5:3552-5. 2005
    ....
  26. ncbi Further advances in the development of a data interchange standard for proteomics data
    Sandra Orchard
    EMBL Outstation, European Bioinformatics Institute, Hinxton, Cambridge, UK
    Proteomics 3:2065-6. 2003
    ..In collaboration with the American Society for Tests and Measurements, the PSI propose to publish this first draft at the forthcoming HUPO 2nd World Congress in Montreal, 8-11 October 2003...
  27. ncbi Autumn 2005 Workshop of the Human Proteome Organisation Proteomics Standards Initiative (HUPO-PSI) Geneva, September, 4-6, 2005
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 6:738-41. 2006
    ..Common to all these efforts is the field of protein modifications, and work has been initiated to establish an ontology in this field that can be used by both workers in the field of proteomics and the wider scientific community...
  28. ncbi HUPO Publications Committee Meeting: 21 April 2006, San Francisco, CA, USA
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK
    Proteomics 6:4436-8. 2006
    ..The current status of data formats and reporting requirements was reviewed and the attendees agreed that the use of data standards was essential as the field of proteomics grows and matures...
  29. ncbi Proteomics and Beyond: a report on the 3rd Annual Spring Workshop of the HUPO-PSI 21-23 April 2006, San Francisco, CA, USA
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK
    Proteomics 6:4439-43. 2006
    ....
  30. ncbi Advances in the development of common interchange standards for proteomic data
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 4:2363-5. 2004
    ..At a recent workshop in Nice, participants gathered to review the progress made to date and assist in pushing the process still further forward...
  31. ncbi The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data
    Henning Hermjakob
    European Bioinformatics Institute, EBI Hinxton, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nat Biotechnol 22:177-83. 2004
    ....
  32. ncbi New developments in the InterPro database
    Nicola J Mulder
    EMBL Outstation European Bioinformatics Institute Hinxton, Cambridge, UK
    Nucleic Acids Res 35:D224-8. 2007
    ..ebi.ac.uk/interpro), and for download by anonymous FTP (ftp://ftp.ebi.ac.uk/pub/databases/interpro). The InterProScan search tool is now also available via a web service at http://www.ebi.ac.uk/Tools/webservices/WSInterProScan.html...
  33. ncbi IntAct: an open source molecular interaction database
    Henning Hermjakob
    European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK
    Nucleic Acids Res 32:D452-5. 2004
    ..All IntAct software, data and controlled vocabularies are available at http://www.ebi.ac.uk/intact...
  34. ncbi Broadening the horizon--level 2.5 of the HUPO-PSI format for molecular interactions
    Samuel Kerrien
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    BMC Biol 5:44. 2007
    ....
  35. ncbi Rintact: enabling computational analysis of molecular interaction data from the IntAct repository
    Tony Chiang
    EBI EMBL, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Bioinformatics 24:1100-1. 2008
    ..These datasets need to be analyzed by computational methods. Software packages in the statistical environment R provide powerful tools for conducting such analyses...
  36. ncbi InterPro, progress and status in 2005
    Nicola J Mulder
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nucleic Acids Res 33:D201-5. 2005
    ..The database is available for text- and sequence-based searches via a webserver (http://www.ebi.ac.uk/interpro), and for download by anonymous FTP (ftp://ftp.ebi.ac.uk/pub/databases/interpro)...
  37. ncbi Proteomic data exchange and storage: the need for common standards and public repositories
    Sandra Orchard
    EMBL Outstation Hinxton, European Bioinformatics Institute, Cambridge, UK
    Methods Mol Biol 367:261-70. 2007
    ..Accompanying controlled vocabularies allow the accurate, while systematic, representation of metadata throughout both schema...
  38. ncbi Human Proteome Organization Proteomics Standards Initiative: data standardization, a view on developments and policy
    Lennart Martens
    European Molecular Biology Laboratory Outstation, The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Mol Cell Proteomics 6:1666-7. 2007
  39. ncbi The publication and database deposition of molecular interaction data
    Sandra Orchard
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
    Curr Protoc Protein Sci . 2010
    ..Which method the author selects is largely dictated by the amount of data to be deposited. In addition, two support protocols describe assignment of unambiguous accession numbers and use of controlled vocabulary terms...
  40. ncbi The Protein Feature Ontology: a tool for the unification of protein feature annotations
    Gabrielle A Reeves
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
    Bioinformatics 24:2767-72. 2008
    ..Integration of these methods is needed and so far this has not been possible as there was no common vocabulary available that could be used as a standard language...
  41. ncbi Ten years of standardizing proteomic data: a report on the HUPO-PSI Spring Workshop: April 12-14th, 2012, San Diego, USA
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 12:2767-72. 2012
    ....
  42. ncbi From proteomics data representation to public data flow: a report on the HUPO-PSI workshop September 2011, Geneva, Switzerland
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 12:351-5. 2012
    ..Finally, the ProteomeXchange Consortium, which will supply a single entry point for the submission of MS proteomics data to multiple data resources including PRIDE and PeptideAtlas, is currently being established...
  43. ncbi implementing data standards: a report on the HUPOPSI workshop September 2009, Toronto, Canada
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 10:1895-8. 2010
    ..Finally, the audience participated in a lively debate, discussing both the benefits of these standard formats and issues with their adoption and use in a research environment...
  44. ncbi Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project
    Chris F Taylor
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK
    Nat Biotechnol 26:889-96. 2008
  45. ncbi The IntAct molecular interaction database in 2012
    Samuel Kerrien
    EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD, UK
    Nucleic Acids Res 40:D841-6. 2012
    ..IntAct is an active contributor to the IMEx consortium (http://www.imexconsortium.org). IntAct source code and data are freely available at http://www.ebi.ac.uk/intact...
  46. ncbi Enabling BioSharing - a report on the Annual Spring Workshop of the HUPO-PSI April 11-13, 2011, EMBL-Heidelberg, Germany
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 11:4284-90. 2011
    ....
  47. ncbi InterPro: an integrated documentation resource for protein families, domains and functional sites
    Nicola J Mulder
    EMBL Outstation, European Bioinformatics Institute, Hinxton, Cambridge, UK
    Brief Bioinform 3:225-35. 2002
    ..Each InterPro entry lists all the matches against SWISS-PROT and TrEMBL (2,141,621 InterPro hits from 586,124 SWISS-PROT and TrEMBL protein sequences). The database is freely accessible for text- and sequence-based searches...
  48. ncbi Molecular interactions and data standardisation
    Sandra Orchard
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Methods Mol Biol 604:309-18. 2010
    ..Finally, tools and frameworks have been created based on PSI-MI standards to facilitate the visualisation and analysis of molecular interaction data...
  49. ncbi Annotating the human proteome
    Sandra Orchard
    EMBL-The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom
    Mol Cell Proteomics 4:435-40. 2005
    ..Public domain databases are required to manage and collate this information and present it to the user community in both a human and machine readable manner...
  50. ncbi Tackling quantitation: a report on the annual Spring Workshop of the HUPO-PSI 28-30 March 2010, Seoul, South Korea
    Sandra Orchard
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 10:3062-6. 2010
    ..Work was also undertaken to update the MIAPE guidelines, in response to feedback from the editors of a number of proteomic journals...
  51. ncbi Data standardization by the HUPO-PSI: how has the community benefitted?
    Sandra Orchard
    European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK
    Methods Mol Biol 696:149-60. 2011
    ....
  52. ncbi The proteomics standards initiative
    Sandra Orchard
    EMBL Outstation, European Bioinformatics Institute, Wellcome Trust, Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Proteomics 3:1374-6. 2003
    ..The Protein-Protein Interactions group expects to publish the Level 1 PSI data exchange format for protein-protein interactions soon and discussions as to the content of Level 2 have been initiated...
  53. ncbi A community standard format for the representation of protein affinity reagents
    David E Gloriam
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
    Mol Cell Proteomics 9:1-10. 2010
    ..Further information and documentation are available on the PSI-PAR web site...
  54. ncbi Preparing molecular interaction data for publication
    Sandra Orchard
    EMBL Outstation, European Bioinformatics Institute EBI, Cambridge, UK
    Methods Mol Biol 694:229-36. 2011
    ..This chapter acts as a brief guide to preparing both large- and small-scale data for publication and gives a range of different submission options...
  55. ncbi Omics technologies, data and bioinformatics principles
    Maria V Schneider
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Methods Mol Biol 719:3-30. 2011
    ..Finally we address the integration of Omics data, and provide several useful links for bioinformatics and Omics...
  56. ncbi Charting plant interactomes: possibilities and challenges
    Mustafa Morsy
    Department of Biochemistry and Molecular Biology, MS200, University of Nevada, Reno, NV 89557, USA
    Trends Plant Sci 13:183-91. 2008
    ..Bioinformatics approaches for curating and assessing the confidence of these datasets through inter-species comparisons will be crucial in achieving a complete understanding of protein interaction networks in plants...
  57. ncbi The annotation of both human and mouse kinomes in UniProtKB/Swiss-Prot: one small step in manual annotation, one giant leap for full comprehension of genomes
    Silvia Braconi Quintaje
    Swiss Prot group, Swiss Institute of Bioinformatics, CMU, 1 Michel Servet, 1211 Geneva 4, Switzerland
    Mol Cell Proteomics 7:1409-19. 2008
    ....
  58. ncbi The implications of alternative splicing in the ENCODE protein complement
    Michael L Tress
    Structural Computational Biology Programme, Spanish National Cancer Research Centre, E 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 104:5495-500. 2007
    ....