Ville Mustonen

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. pmc Germline fitness-based scoring of cancer mutations
    Andrej Fischer
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    Genetics 188:383-93. 2011
  2. pmc Distinguishing driver and passenger mutations in an evolutionary history categorized by interference
    Christopher J R Illingworth
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
    Genetics 189:989-1000. 2011
  3. pmc Quantifying selection acting on a complex trait using allele frequency time series data
    Christopher J R Illingworth
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    Mol Biol Evol 29:1187-97. 2012
  4. pmc A method to infer positive selection from marker dynamics in an asexual population
    Christopher J R Illingworth
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Bioinformatics 28:831-7. 2012
  5. pmc Inferring genome-wide recombination landscapes from advanced intercross lines: application to yeast crosses
    Christopher J R Illingworth
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS ONE 8:e62266. 2013
  6. pmc GraphAlignment: Bayesian pairwise alignment of biological networks
    Michal Kolar
    Institut fur Theoretische Physik, Universitat zu Koln, Zülpicher Straße 77, D 50937 Koln, Germany
    BMC Syst Biol 6:144. 2012
  7. pmc High-definition reconstruction of clonal composition in cancer
    Andrej Fischer
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK Electronic address
    Cell Rep 7:1740-52. 2014
  8. pmc Components of selection in the evolution of the influenza virus: linkage effects beat inherent selection
    Christopher J R Illingworth
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS Pathog 8:e1003091. 2012

Collaborators

  • Gianni Liti
  • Leopold Parts
  • Christopher J R Illingworth
  • Andrej Fischer
  • Michal Kolar
  • Ignacio Vázquez-García
  • Anders Bergström
  • Johannes Berg
  • Michael Lässig
  • Stephan Schiffels
  • Jörn Meier
  • Chris Greenman

Detail Information

Publications8

  1. pmc Germline fitness-based scoring of cancer mutations
    Andrej Fischer
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    Genetics 188:383-93. 2011
    ..These results help to inform how to exploit germline fitness predictions in discovering new genes and mutations responsible for cancer...
  2. pmc Distinguishing driver and passenger mutations in an evolutionary history categorized by interference
    Christopher J R Illingworth
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
    Genetics 189:989-1000. 2011
    ..95 across a range of numbers of driver loci. The potential application of our model, either in full or in part, to a range of biological systems, is discussed...
  3. pmc Quantifying selection acting on a complex trait using allele frequency time series data
    Christopher J R Illingworth
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    Mol Biol Evol 29:1187-97. 2012
    ..Our approach is applicable to study adaptation in a range of systems under different evolutionary pressures...
  4. pmc A method to infer positive selection from marker dynamics in an asexual population
    Christopher J R Illingworth
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Bioinformatics 28:831-7. 2012
    ..We here describe a method to estimate the establishment times and fitnesses of beneficial mutations from neutral marker frequency data...
  5. pmc Inferring genome-wide recombination landscapes from advanced intercross lines: application to yeast crosses
    Christopher J R Illingworth
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS ONE 8:e62266. 2013
    ..Our method has general applicability to other crossing experiments, including a variety of experimental designs...
  6. pmc GraphAlignment: Bayesian pairwise alignment of biological networks
    Michal Kolar
    Institut fur Theoretische Physik, Universitat zu Koln, Zülpicher Straße 77, D 50937 Koln, Germany
    BMC Syst Biol 6:144. 2012
    ..With increased experimental availability and accuracy of bio-molecular networks, tools for their comparative and evolutionary analysis are needed. A key component for such studies is the alignment of networks...
  7. pmc High-definition reconstruction of clonal composition in cancer
    Andrej Fischer
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK Electronic address
    Cell Rep 7:1740-52. 2014
    ..Our work provides new opportunities for tracking cancer development. ..
  8. pmc Components of selection in the evolution of the influenza virus: linkage effects beat inherent selection
    Christopher J R Illingworth
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS Pathog 8:e1003091. 2012
    ..However, on average, the fate of a polymorphism was determined more by the combined influence of interference effects than by its inherent selection coefficient...