William McLaren

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. pmc Locus Reference Genomic sequences: an improved basis for describing human DNA variants
    Raymond Dalgleish
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
    Genome Med 2:24. 2010
  2. pmc Ensembl variation resources
    Yuan Chen
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    BMC Genomics 11:293. 2010
  3. pmc A database and API for variation, dense genotyping and resequencing data
    Daniel Rios
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
    BMC Bioinformatics 11:238. 2010
  4. pmc Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor
    William McLaren
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Bioinformatics 26:2069-70. 2010
  5. pmc Ensembl 2012
    Paul Flicek
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton Cambridge CB10 1SD, UK
    Nucleic Acids Res 40:D84-90. 2012
  6. pmc Ensembl 2011
    Paul Flicek
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Nucleic Acids Res 39:D800-6. 2011
  7. pmc Ensembl's 10th year
    Paul Flicek
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Nucleic Acids Res 38:D557-62. 2010
  8. pmc A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose
    Fumihiko Takeuchi
    Wellcome Trust Sanger Institute, Hinxton, UK
    PLoS Genet 5:e1000433. 2009
  9. pmc Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
    Jeffrey C Barrett
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 41:703-7. 2009

Collaborators

Detail Information

Publications9

  1. pmc Locus Reference Genomic sequences: an improved basis for describing human DNA variants
    Raymond Dalgleish
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
    Genome Med 2:24. 2010
    ..Further information can be found on the LRG web site: http://www.lrg-sequence.org...
  2. pmc Ensembl variation resources
    Yuan Chen
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    BMC Genomics 11:293. 2010
    ..Maximising the utility of the data requires that it be stored in an accessible manner that facilitates the integration of variation data with other genome resources such as gene annotation and comparative genomics...
  3. pmc A database and API for variation, dense genotyping and resequencing data
    Daniel Rios
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
    BMC Bioinformatics 11:238. 2010
    ..The 1000 Genomes Project and similar efforts in other species are challenging the methods previously used for storage and manipulation of such data necessitating the redesign of existing genome-wide bioinformatics resources...
  4. pmc Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor
    William McLaren
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Bioinformatics 26:2069-70. 2010
    ..In Ensembl, a web-based tool (the SNP Effect Predictor) and API interface can now functionally annotate variants in all Ensembl and Ensembl Genomes supported species...
  5. pmc Ensembl 2012
    Paul Flicek
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton Cambridge CB10 1SD, UK
    Nucleic Acids Res 40:D84-90. 2012
    ..Of these, 55 species appear on the main Ensembl website and six species are provided on the Ensembl preview site (Pre!Ensembl; http://pre.ensembl.org) with preliminary support. The past year has also seen improvements across the project...
  6. pmc Ensembl 2011
    Paul Flicek
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Nucleic Acids Res 39:D800-6. 2011
    ..Since our previous report, we have substantially improved the presentation and integration of both data of disease relevance and the regulatory state of different cell types...
  7. pmc Ensembl's 10th year
    Paul Flicek
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Nucleic Acids Res 38:D557-62. 2010
    ....
  8. pmc A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose
    Fumihiko Takeuchi
    Wellcome Trust Sanger Institute, Hinxton, UK
    PLoS Genet 5:e1000433. 2009
    ..5% of dose variance. These GWAS results provide further impetus for conducting large-scale trials assessing patient benefit from genotype-based forecasting of warfarin dose...
  9. pmc Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
    Jeffrey C Barrett
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 41:703-7. 2009
    ..01; overall P < 5 × 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27...