Darren W Logan
Affiliation: Wellcome Trust Genome Campus
Hargreaves A, Swain M, Logan D, Mulley J. Testing the Toxicofera: comparative transcriptomics casts doubt on the single, early evolution of the reptile venom system. Toxicon. 2014;92:140-56 pubmed publisher
..The apparent conservation of gene complements across the Toxicofera therefore reflects an artefact of incomplete tissue sampling. We therefore conclude that venom has evolved multiple times in reptiles. ..
Sanchez Andrade G, Logan D. Deconstructing pheromone-mediated behavior one layer at a time. BMC Biol. 2014;12:33 pubmed publisher
..Work recently published in this journal found female mice with one layer genetically inactivated are deficient in a surprisingly wide range of reproductive behaviors, providing new insights into how the nose can influence the brain. ..
Oboti L, Ibarra Soria X, PÃ©rez GÃ³mez A, Schmid A, Pyrski M, Paschek N, et al
. Pregnancy and estrogen enhance neural progenitor-cell proliferation in the vomeronasal sensory epithelium. BMC Biol. 2015;13:104 pubmed publisher
..Peripheral olfactory neurogenesis driven by estrogen may contribute to modulate sensory perception and adaptive VNO-dependent behaviors during pregnancy and early motherhood. ..
Dias C, Estruch S, Graham S, McRae J, Sawiak S, Hurst J, et al
. BCL11A Haploinsufficiency Causes an Intellectual Disability Syndrome and Dysregulates Transcription. Am J Hum Genet. 2016;99:253-74 pubmed publisher
..Thus, our work implicates BCL11A haploinsufficiency in neurodevelopmental disorders and defines additional targets regulated by this gene, with broad relevance for our understanding of ID and related syndromes. ..
Wynn E, Sanchez Andrade G, Carss K, Logan D. Genomic variation in the vomeronasal receptor gene repertoires of inbred mice. BMC Genomics. 2012;13:415 pubmed
..Our dataset has expanded over nine fold the known number of mouse VR alleles, and will enable mechanistic analyses into the genetics of innate behavioural differences in mice. ..
Nakahara T, Cardozo L, Ibarra Soria X, Bard A, Carvalho V, Trintinalia G, et al
. Detection of pup odors by non-canonical adult vomeronasal neurons expressing an odorant receptor gene is influenced by sex and parenting status. BMC Biol. 2016;14:12 pubmed publisher
..Our data suggest that the Olfr692 population is involved in mediating pup-oriented behaviors in mice. ..