Pentao Liu

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. pmc A recombineering based approach for high-throughput conditional knockout targeting vector construction
    Waiin Chan
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Nucleic Acids Res 35:e64. 2007
  2. pmc Bcl11a is essential for lymphoid development and negatively regulates p53
    Yong Yu
    Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China
    J Exp Med 209:2467-83. 2012
  3. doi request reprint Critical roles of Bcl11b in T-cell development and maintenance of T-cell identity
    Pentao Liu
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Immunol Rev 238:138-49. 2010
  4. pmc Large-scale identification of microRNA targets in murine Dgcr8-deficient embryonic stem cell lines
    Matthew P A Davis
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
    PLoS ONE 7:e41762. 2012
  5. pmc PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice
    Roland Rad
    Wellcome Trust Sanger Institute, Genome Campus, Hinxton Cambridge CB10 1SA, UK
    Science 330:1104-7. 2010
  6. pmc A DNA transposon-based approach to validate oncogenic mutations in the mouse
    Qin Su
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, England
    Proc Natl Acad Sci U S A 105:19904-9. 2008
  7. pmc The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development
    Yong Yu
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, England, UK
    J Exp Med 212:865-74. 2015
  8. pmc Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion
    Peng Li
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Science 329:85-9. 2010
  9. pmc Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1
    Wei Wang
    Wellcome Trust Sanger Institute, Hinxton CB10 1HH, United Kingdom
    Proc Natl Acad Sci U S A 108:18283-8. 2011
  10. pmc Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells
    Jason C H Tsang
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
    Genome Biol 16:178. 2015

Collaborators

Detail Information

Publications25

  1. pmc A recombineering based approach for high-throughput conditional knockout targeting vector construction
    Waiin Chan
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Nucleic Acids Res 35:e64. 2007
    ..Our new recombineering system makes it a reality to generate large numbers of precisely engineered DNA constructs for functional genomics studies...
  2. pmc Bcl11a is essential for lymphoid development and negatively regulates p53
    Yong Yu
    Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China
    J Exp Med 209:2467-83. 2012
    ..Bcl11a is therefore essential for lymphopoiesis and negatively regulates p53 activities. Deletion of Bcl11a may represent a new approach for generating a mouse model that completely lacks an adaptive immune system...
  3. doi request reprint Critical roles of Bcl11b in T-cell development and maintenance of T-cell identity
    Pentao Liu
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Immunol Rev 238:138-49. 2010
    ..These reprogrammed cells have unique properties in proliferation, cytokine dependency and killing target cells, and may therefore provide a new cell source for some cell-based therapies...
  4. pmc Large-scale identification of microRNA targets in murine Dgcr8-deficient embryonic stem cell lines
    Matthew P A Davis
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
    PLoS ONE 7:e41762. 2012
    ..Additionally, our experiments have revealed a novel candidate for Dgcr8-independent microRNA genesis and highlighted the challenges currently facing miRNA annotation...
  5. pmc PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice
    Roland Rad
    Wellcome Trust Sanger Institute, Genome Campus, Hinxton Cambridge CB10 1SA, UK
    Science 330:1104-7. 2010
    ..Mice with different transposon types, copy numbers, and chromosomal locations support wide applicability...
  6. pmc A DNA transposon-based approach to validate oncogenic mutations in the mouse
    Qin Su
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, England
    Proc Natl Acad Sci U S A 105:19904-9. 2008
    ..Consequently, these mice developed a broad spectrum of tumors at very early postnatal stages. This technology thus complements the large-scale cancer genome projects...
  7. pmc The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development
    Yong Yu
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, England, UK
    J Exp Med 212:865-74. 2015
    ..Inactivation of Bcl11b causes a complete loss of ILC2 development from hematopoietic progenitors, which is confirmed upon immune challenge with either papain administration or influenza virus infection...
  8. pmc Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion
    Peng Li
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Science 329:85-9. 2010
    ..Therefore, ITNKs may represent a new cell source for cell-based therapies...
  9. pmc Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1
    Wei Wang
    Wellcome Trust Sanger Institute, Hinxton CB10 1HH, United Kingdom
    Proc Natl Acad Sci U S A 108:18283-8. 2011
    ..The human iPSCs described here should facilitate functional analysis of the human genome...
  10. pmc Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells
    Jason C H Tsang
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
    Genome Biol 16:178. 2015
    ..We previously discovered that the transcription factor Bcl11a has critical functions in the lymphoid development of the HSC compartment...
  11. pmc Construction of gene-targeting vectors by recombineering
    Song Choon Lee
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Methods Mol Biol 530:15-27. 2009
    ..We describe here an efficient recombineering-based protocol for making mouse conditional knockout targeting vectors...
  12. doi request reprint Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells
    Jian Yang
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    Stem Cells 33:1390-404. 2015
    ..These results highlight the important functions of RA signalling in reprogramming somatic cells and primed stem cells to naïve pluripotency. Stem Cells 2015;33:1390-1404. ..
  13. pmc Chromosomal transposition of PiggyBac in mouse embryonic stem cells
    Wei Wang
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
    Proc Natl Acad Sci U S A 105:9290-5. 2008
    ..The comprehensive information from this study should facilitate further exploration of the potential of PB and SB DNA transposons in mammalian genetics...
  14. pmc Single Cell RNA-Sequencing of Pluripotent States Unlocks Modular Transcriptional Variation
    Aleksandra A Kolodziejczyk
    European Molecular Biology Laboratory, European Bioinformatics Institute EMBL EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Cell Stem Cell 17:471-85. 2015
    ..Mining of our dataset for correlations in gene expression allowed us to identify additional components of the pluripotency network, including Ptma and Zfp640, illustrating its value as a resource for future discovery. ..
  15. doi request reprint Cellular reprogramming by transcription factor engineering
    Jason C H Tsang
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Curr Opin Genet Dev 28:1-9. 2014
    ..Here, we provide a concise review on the latest progress in studying cellular reprogramming by transcription factor engineering. ..
  16. pmc Genetic screens using the piggyBac transposon
    Su Kit Chew
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK
    Methods 53:366-71. 2011
    ..We also describe the design of the piggyBac resources that we have developed for both forward and reverse genetic screens, and the protocols we use in these experiments...
  17. pmc Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers
    Xuefei Gao
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK
    Nucleic Acids Res 42:e155. 2014
    ....
  18. pmc Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice
    George S Vassiliou
    Mouse Genomics Team, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nat Genet 43:470-5. 2011
    ..We also identified recurrent integrations in known and newly discovered leukemia genes including Nf1, Bach2, Dleu2 and Nup98. Our results provide new pathogenetic insights and identify possible therapeutic targets in NPM1c+ AML...
  19. doi request reprint A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer
    Roland Rad
    1 Department of Medicine II, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany 2 German Cancer Consortium DKTK, German Cancer Research Center DKFZ, Heidelberg, Germany 3 The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire, UK
    Nat Genet 47:47-56. 2015
    ..These piggyBac resources are universally applicable in any tissue context and provide unique experimental access to the genetic complexity of cancer. ..
  20. ncbi request reprint A genome-wide, end-sequenced 129Sv BAC library resource for targeting vector construction
    David J Adams
    The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK
    Genomics 86:753-8. 2005
    ..Furthermore, we show that targeting vectors containing DNA recombineered from this BAC library can be used to target genes efficiently in several 129-derived ES cell lines...
  21. pmc Reprogramming to pluripotency using designer TALE transcription factors targeting enhancers
    Xuefei Gao
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Stem Cell Reports 1:183-97. 2013
    ..This study indicates that dTFs targeting specific enhancers can be used to study other biological processes such as transdifferentiation or directed differentiation of stem cells. ..
  22. pmc MiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse fibroblast cells to iPSCs
    Dong Lu
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS ONE 7:e40938. 2012
    ..Recent studies also demonstrate that some miRNAs have important roles in reprogramming somatic cells to induced pluripotent stem cells (iPSCs)...
  23. pmc BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells
    Walid T Khaled
    1 Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK 2 Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK 3
    Nat Commun 6:5987. 2015
    ..Thus, BCL11A has an important role in TNBC and normal mammary epithelial cells. This study highlights the importance of further investigation of BCL11A in TNBC-targeted therapies. ..
  24. doi request reprint Delineating nuclear reprogramming
    Jolene Ooi
    Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
    Protein Cell 3:329-45. 2012
    ..This review describes the effervescent changes in this field, addresses bottlenecks hindering its advancement and in conclusion, applies the latest findings to overcome these issues...
  25. ncbi request reprint Construction of gene-targeting vectors by recombineering
    Song Choon Lee
    Mouse Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, United Kingdom
    CSH Protoc 2009:pdb.prot5291. 2009
    ..The conditional targeting vectors described in this protocol generate a flexible reporter/null/conditional allele in the mouse...