Genomes and Genes
P E Kuwabara
Affiliation: Wellcome Trust Genome Campus
- It ain't over till it's ova: germline sex determination in C. elegansP E Kuwabara
The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, UK
Bioessays 23:596-604. 2001....
- RNAi--prospects for a general technique for determining gene functionP E Kuwabara
The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK CB10 1SA
Parasitol Today 16:347-9. 2000....
- A C. elegans patched gene, ptc-1, functions in germ-line cytokinesisP E Kuwabara
The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Genes Dev 14:1933-44. 2000..elegans and other phyla. These results suggest that the PTC superfamily has multiple functions in animal development...
- The use of functional genomics in C. elegans for studying human development and diseaseP E Kuwabara
The Sanger Centre, Hinxton, UK
J Inherit Metab Dis 24:127-38. 2001..Here we discuss how C. elegans can contribute to understanding of the function of genes involved in human development and disease...
- The sterol-sensing domain: multiple families, a unique role?Patricia E Kuwabara
The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Trends Genet 18:193-201. 2002..This article discusses how the SSD appears to function as a regulatory domain involved in linking vesicle trafficking and protein localization with such varied processes as cholesterol homeostasis, cell signalling and cytokinesis...
- Gametogenesis: keeping the male element under controlP E Kuwabara
Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
Curr Biol 8:R278-81. 1998..This switch involves repression of fem-3 mRNA, mediated by a protein that binds RNA through a conserved motif; a similar motif mediates RNA binding by the Drosophila pattern-regulatory protein Pumilio...
- RNA-mediated interference as a tool for identifying drug targetsN J O'Neil
Sanger Centre, Wellcome Trust Genome Campus, Hinxton, England
Am J Pharmacogenomics 1:45-53. 2001..RNAi can also help to identify the biochemical mode of action of a drug or pesticide and to identify other genes encoding products that may respond or interact with specific compounds...
- Worming your way through the genomeP E Kuwabara
MRC Laboratory of Molecular Biology, Division of Cell Biology, Cambridge, UK
Trends Genet 13:455-60. 1997..This review highlights the resources available for analysing a C. elegans homologue, starting from the gene sequence and proceeding to the biological function...
- iASPP oncoprotein is a key inhibitor of p53 conserved from worm to humanDaniele Bergamaschi
Ludwig Institute for Cancer Research, Imperial College School of Medicine, St Mary s Campus, Norfolk Place, London, W2 1PG, UK
Nat Genet 33:162-7. 2003..iASPP expression is upregulated in human breast carcinomas expressing wild-type p53 and normal levels of ASPP. Inhibition of iASPP could provide an important new strategy for treating tumors expressing wild-type p53...
- The genome sequence of Caenorhabditis briggsae: a platform for comparative genomicsLincoln D Stein
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
PLoS Biol 1:E45. 2003..elegans genome. Based on similarity to C. briggsae, we found strong evidence for 1,300 new C. elegans genes. In addition, comparisons of the two genomes will help to understand the evolutionary forces that mold nematode genomes...
- The function and expansion of the Patched- and Hedgehog-related homologs in C. elegansOlivier Zugasti
University of Bristol, Department of Biochemistry, School of Medical Sciences, Bristol BS8 1TD, United Kingdom
Genome Res 15:1402-10. 2005..Moreover, a subset of the PTC, PTR, and Hh-r proteins have the same RNAi phenotypes, indicating that they have the potential to participate in the same processes...