P E Kuwabara

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. ncbi It ain't over till it's ova: germline sex determination in C. elegans
    P E Kuwabara
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, UK
    Bioessays 23:596-604. 2001
  2. ncbi RNAi--prospects for a general technique for determining gene function
    P E Kuwabara
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK CB10 1SA
    Parasitol Today 16:347-9. 2000
  3. ncbi A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis
    P E Kuwabara
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Genes Dev 14:1933-44. 2000
  4. ncbi The use of functional genomics in C. elegans for studying human development and disease
    P E Kuwabara
    The Sanger Centre, Hinxton, UK
    J Inherit Metab Dis 24:127-38. 2001
  5. ncbi The sterol-sensing domain: multiple families, a unique role?
    Patricia E Kuwabara
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Trends Genet 18:193-201. 2002
  6. ncbi Gametogenesis: keeping the male element under control
    P E Kuwabara
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Curr Biol 8:R278-81. 1998
  7. ncbi RNA-mediated interference as a tool for identifying drug targets
    N J O'Neil
    Sanger Centre, Wellcome Trust Genome Campus, Hinxton, England
    Am J Pharmacogenomics 1:45-53. 2001
  8. ncbi Worming your way through the genome
    P E Kuwabara
    MRC Laboratory of Molecular Biology, Division of Cell Biology, Cambridge, UK
    Trends Genet 13:455-60. 1997
  9. ncbi iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
    Daniele Bergamaschi
    Ludwig Institute for Cancer Research, Imperial College School of Medicine, St Mary s Campus, Norfolk Place, London, W2 1PG, UK
    Nat Genet 33:162-7. 2003
  10. ncbi The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics
    Lincoln D Stein
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Biol 1:E45. 2003

Collaborators

Detail Information

Publications11

  1. ncbi It ain't over till it's ova: germline sex determination in C. elegans
    P E Kuwabara
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, UK
    Bioessays 23:596-604. 2001
    ....
  2. ncbi RNAi--prospects for a general technique for determining gene function
    P E Kuwabara
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK CB10 1SA
    Parasitol Today 16:347-9. 2000
    ....
  3. ncbi A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis
    P E Kuwabara
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Genes Dev 14:1933-44. 2000
    ..elegans and other phyla. These results suggest that the PTC superfamily has multiple functions in animal development...
  4. ncbi The use of functional genomics in C. elegans for studying human development and disease
    P E Kuwabara
    The Sanger Centre, Hinxton, UK
    J Inherit Metab Dis 24:127-38. 2001
    ..Here we discuss how C. elegans can contribute to understanding of the function of genes involved in human development and disease...
  5. ncbi The sterol-sensing domain: multiple families, a unique role?
    Patricia E Kuwabara
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Trends Genet 18:193-201. 2002
    ..This article discusses how the SSD appears to function as a regulatory domain involved in linking vesicle trafficking and protein localization with such varied processes as cholesterol homeostasis, cell signalling and cytokinesis...
  6. ncbi Gametogenesis: keeping the male element under control
    P E Kuwabara
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Curr Biol 8:R278-81. 1998
    ..This switch involves repression of fem-3 mRNA, mediated by a protein that binds RNA through a conserved motif; a similar motif mediates RNA binding by the Drosophila pattern-regulatory protein Pumilio...
  7. ncbi RNA-mediated interference as a tool for identifying drug targets
    N J O'Neil
    Sanger Centre, Wellcome Trust Genome Campus, Hinxton, England
    Am J Pharmacogenomics 1:45-53. 2001
    ..RNAi can also help to identify the biochemical mode of action of a drug or pesticide and to identify other genes encoding products that may respond or interact with specific compounds...
  8. ncbi Worming your way through the genome
    P E Kuwabara
    MRC Laboratory of Molecular Biology, Division of Cell Biology, Cambridge, UK
    Trends Genet 13:455-60. 1997
    ..This review highlights the resources available for analysing a C. elegans homologue, starting from the gene sequence and proceeding to the biological function...
  9. ncbi iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
    Daniele Bergamaschi
    Ludwig Institute for Cancer Research, Imperial College School of Medicine, St Mary s Campus, Norfolk Place, London, W2 1PG, UK
    Nat Genet 33:162-7. 2003
    ..iASPP expression is upregulated in human breast carcinomas expressing wild-type p53 and normal levels of ASPP. Inhibition of iASPP could provide an important new strategy for treating tumors expressing wild-type p53...
  10. ncbi The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics
    Lincoln D Stein
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Biol 1:E45. 2003
    ..elegans genome. Based on similarity to C. briggsae, we found strong evidence for 1,300 new C. elegans genes. In addition, comparisons of the two genomes will help to understand the evolutionary forces that mold nematode genomes...
  11. ncbi The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans
    Olivier Zugasti
    University of Bristol, Department of Biochemistry, School of Medical Sciences, Bristol BS8 1TD, United Kingdom
    Genome Res 15:1402-10. 2005
    ..Moreover, a subset of the PTC, PTR, and Hh-r proteins have the same RNAi phenotypes, indicating that they have the potential to participate in the same processes...