Andrew P Jackson

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. Jackson A. Tandem gene arrays in Trypanosoma brucei: comparative phylogenomic analysis of duplicate sequence variation. BMC Evol Biol. 2007;7:54 pubmed
    ..In describing dynamics of sequence variation that have consequences beyond gene dosage, this survey provides a basis for uncovering the hidden functionality within tandem gene arrays in trypanosomatids. ..
  2. Jackson A. Evolutionary consequences of a large duplication event in Trypanosoma brucei: chromosomes 4 and 8 are partial duplicons. BMC Genomics. 2007;8:432 pubmed
    ..brucei relative to other trypanosomatids. ..
  3. Jackson A, Vaughan S, Gull K. Evolution of tubulin gene arrays in Trypanosomatid parasites: genomic restructuring in Leishmania. BMC Genomics. 2006;7:261 pubmed
    ..This fundamental reorganisation accounted for the dissimilar genomic architectures of T. brucei and L. major tubulin repertoires. ..
  4. Jackson A, Quail M, Berriman M. Insights into the genome sequence of a free-living Kinetoplastid: Bodo saltans (Kinetoplastida: Euglenozoa). BMC Genomics. 2008;9:594 pubmed publisher
    ..Various coding regions were sequenced to provide a preliminary insight into the bodonid genome sequence, relative to trypanosomatid sequences...
  5. Jackson A, Gamble J, Yeomans T, Moran G, Saunders D, Harris D, et al. Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans. Genome Res. 2009;19:2231-44 pubmed publisher
    ..albicans, C. dubliniensis has lost genomic capacity and key pathogenic functions. This could explain why C. albicans is a more potent pathogen in humans than C. dubliniensis. ..
  6. Jackson A. The evolution of amastin surface glycoproteins in trypanosomatid parasites. Mol Biol Evol. 2010;27:33-45 pubmed publisher
    ....
  7. Jackson A, Thomas G, Parkhill J, Thomson N. Evolutionary diversification of an ancient gene family (rhs) through C-terminal displacement. BMC Genomics. 2009;10:584 pubmed publisher
    ..Hence, we predict that a large pool of dissociated rhs C-terminal tips exists episomally and these are potentially transmitted across taxonomic boundaries. ..
  8. Jackson A, Vaughan S, Gull K. Comparative genomics and concerted evolution of beta-tubulin paralogs in Leishmania spp. BMC Genomics. 2006;7:137 pubmed
    ..infantum and L. braziliensis. Untranscribed regions and coding sequences for each isoform were compared within and between species in relation to the known diversity of beta-tubulin transcripts in Leishmania spp...
  9. Jackson A. Origins of amino acid transporter loci in trypanosomatid parasites. BMC Evol Biol. 2007;7:26 pubmed
    ..Not least in T. brucei, which seems to have retained fewer ancestral loci and has acquired novel loci through a complex mix of tandem and transpositive duplication. ..

Detail Information

Publications9

  1. Jackson A. Tandem gene arrays in Trypanosoma brucei: comparative phylogenomic analysis of duplicate sequence variation. BMC Evol Biol. 2007;7:54 pubmed
    ..In describing dynamics of sequence variation that have consequences beyond gene dosage, this survey provides a basis for uncovering the hidden functionality within tandem gene arrays in trypanosomatids. ..
  2. Jackson A. Evolutionary consequences of a large duplication event in Trypanosoma brucei: chromosomes 4 and 8 are partial duplicons. BMC Genomics. 2007;8:432 pubmed
    ..brucei relative to other trypanosomatids. ..
  3. Jackson A, Vaughan S, Gull K. Evolution of tubulin gene arrays in Trypanosomatid parasites: genomic restructuring in Leishmania. BMC Genomics. 2006;7:261 pubmed
    ..This fundamental reorganisation accounted for the dissimilar genomic architectures of T. brucei and L. major tubulin repertoires. ..
  4. Jackson A, Quail M, Berriman M. Insights into the genome sequence of a free-living Kinetoplastid: Bodo saltans (Kinetoplastida: Euglenozoa). BMC Genomics. 2008;9:594 pubmed publisher
    ..Various coding regions were sequenced to provide a preliminary insight into the bodonid genome sequence, relative to trypanosomatid sequences...
  5. Jackson A, Gamble J, Yeomans T, Moran G, Saunders D, Harris D, et al. Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans. Genome Res. 2009;19:2231-44 pubmed publisher
    ..albicans, C. dubliniensis has lost genomic capacity and key pathogenic functions. This could explain why C. albicans is a more potent pathogen in humans than C. dubliniensis. ..
  6. Jackson A. The evolution of amastin surface glycoproteins in trypanosomatid parasites. Mol Biol Evol. 2010;27:33-45 pubmed publisher
    ....
  7. Jackson A, Thomas G, Parkhill J, Thomson N. Evolutionary diversification of an ancient gene family (rhs) through C-terminal displacement. BMC Genomics. 2009;10:584 pubmed publisher
    ..Hence, we predict that a large pool of dissociated rhs C-terminal tips exists episomally and these are potentially transmitted across taxonomic boundaries. ..
  8. Jackson A, Vaughan S, Gull K. Comparative genomics and concerted evolution of beta-tubulin paralogs in Leishmania spp. BMC Genomics. 2006;7:137 pubmed
    ..infantum and L. braziliensis. Untranscribed regions and coding sequences for each isoform were compared within and between species in relation to the known diversity of beta-tubulin transcripts in Leishmania spp...
  9. Jackson A. Origins of amino acid transporter loci in trypanosomatid parasites. BMC Evol Biol. 2007;7:26 pubmed
    ..Not least in T. brucei, which seems to have retained fewer ancestral loci and has acquired novel loci through a complex mix of tandem and transpositive duplication. ..