Andrew P Jackson

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. pmc Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS)
    Jennifer Lawton
    Division of Parasitology, MRC National Institute for Medical Research, London, UK
    BMC Genomics 13:125. 2012
  2. pmc Evolutionary consequences of a large duplication event in Trypanosoma brucei: chromosomes 4 and 8 are partial duplicons
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    BMC Genomics 8:432. 2007
  3. pmc Origins of amino acid transporter loci in trypanosomatid parasites
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
    BMC Evol Biol 7:26. 2007
  4. pmc Evolution of tubulin gene arrays in Trypanosomatid parasites: genomic restructuring in Leishmania
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
    BMC Genomics 7:261. 2006
  5. pmc Comparative genomics and concerted evolution of beta-tubulin paralogs in Leishmania spp
    Andrew P Jackson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    BMC Genomics 7:137. 2006
  6. pmc Insights into the genome sequence of a free-living Kinetoplastid: Bodo saltans (Kinetoplastida: Euglenozoa)
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK
    BMC Genomics 9:594. 2008
  7. pmc Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans
    Andrew P Jackson
    Pathogen Genomics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
    Genome Res 19:2231-44. 2009
  8. pmc The evolution of amastin surface glycoproteins in trypanosomatid parasites
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, United Kingdom
    Mol Biol Evol 27:33-45. 2010
  9. pmc Evolutionary diversification of an ancient gene family (rhs) through C-terminal displacement
    Andrew P Jackson
    The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    BMC Genomics 10:584. 2009
  10. pmc Tandem gene arrays in Trypanosoma brucei: comparative phylogenomic analysis of duplicate sequence variation
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK
    BMC Evol Biol 7:54. 2007

Collaborators

Detail Information

Publications23

  1. pmc Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS)
    Jennifer Lawton
    Division of Parasitology, MRC National Institute for Medical Research, London, UK
    BMC Genomics 13:125. 2012
    ..In order to fully understand the role(s) of CIR proteins during P. chabaudi infection, a detailed characterization of the cir gene family was required...
  2. pmc Evolutionary consequences of a large duplication event in Trypanosoma brucei: chromosomes 4 and 8 are partial duplicons
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    BMC Genomics 8:432. 2007
    ..The duplicated region may be browsed online at http://www.genedb.org/genedb/tryp/48dup_image.jsp..
  3. pmc Origins of amino acid transporter loci in trypanosomatid parasites
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
    BMC Evol Biol 7:26. 2007
    ..This study provides a comprehensive phylogenetic account of the origins of these genes, redefining each locus according to a positional criterion, through the integration of phyletic identity with comparative gene order information...
  4. pmc Evolution of tubulin gene arrays in Trypanosomatid parasites: genomic restructuring in Leishmania
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
    BMC Genomics 7:261. 2006
    ..brucei. Polycistronic transcription in these organisms makes the chromosomal arrangement of tubulin genes important with respect to gene expression...
  5. pmc Comparative genomics and concerted evolution of beta-tubulin paralogs in Leishmania spp
    Andrew P Jackson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    BMC Genomics 7:137. 2006
    ..infantum and L. braziliensis. Untranscribed regions and coding sequences for each isoform were compared within and between species in relation to the known diversity of beta-tubulin transcripts in Leishmania spp...
  6. pmc Insights into the genome sequence of a free-living Kinetoplastid: Bodo saltans (Kinetoplastida: Euglenozoa)
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK
    BMC Genomics 9:594. 2008
    ..Various coding regions were sequenced to provide a preliminary insight into the bodonid genome sequence, relative to trypanosomatid sequences...
  7. pmc Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans
    Andrew P Jackson
    Pathogen Genomics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
    Genome Res 19:2231-44. 2009
    ..albicans, C. dubliniensis has lost genomic capacity and key pathogenic functions. This could explain why C. albicans is a more potent pathogen in humans than C. dubliniensis...
  8. pmc The evolution of amastin surface glycoproteins in trypanosomatid parasites
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, United Kingdom
    Mol Biol Evol 27:33-45. 2010
    ....
  9. pmc Evolutionary diversification of an ancient gene family (rhs) through C-terminal displacement
    Andrew P Jackson
    The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    BMC Genomics 10:584. 2009
    ..coli. By comparing rhs repertoires across the Enterobacteriaceae, this study provides a robust explanation of rhs diversification and evolution, and a mechanistic model of how rhs diversity is gained and lost...
  10. pmc Tandem gene arrays in Trypanosoma brucei: comparative phylogenomic analysis of duplicate sequence variation
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK
    BMC Evol Biol 7:54. 2007
    ..This report presents the first account of the tandem gene arrays in the T. brucei genome, employing several related genome sequences to establish how variation is created and removed...
  11. pmc A cell-surface phylome for African trypanosomes
    Andrew P Jackson
    Pathogen Genomics Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, England, United Kingdom
    PLoS Negl Trop Dis 7:e2121. 2013
    ..All data can be accessed at: http://www.genedb.org/Page/trypanosoma_surface_phylome...
  12. pmc Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    Proc Natl Acad Sci U S A 109:3416-21. 2012
    ....
  13. pmc The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human african trypanosomiasis
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
    PLoS Negl Trop Dis 4:e658. 2010
    ..b. gambiense and the reference genome. We sought to identify features that were uniquely associated with T. b. gambiense and its ability to infect humans...
  14. ncbi request reprint Order within a mosaic distribution of mitochondrial c-type cytochrome biogenesis systems?
    James W A Allen
    Department of Biochemistry, University of Oxford, UK
    FEBS J 275:2385-402. 2008
    ....
  15. ncbi request reprint Cophylogeny of the Ficus microcosm
    Andrew P Jackson
    Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
    Biol Rev Camb Philos Soc 79:751-68. 2004
    ....
  16. pmc A novel nonsense CDK5RAP2 mutation in a Somali child with primary microcephaly and sensorineural hearing loss
    Alistair T Pagnamenta
    NIHR Biomedical Research Centre, Oxford and Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Am J Med Genet A 158:2577-82. 2012
    ..This study also highlights the utility of SNP-array testing to guide disease gene identification where an autosomal recessive condition is plausible...
  17. ncbi request reprint Evolution of primary microcephaly genes and the enlargement of primate brains
    Chris Ponting
    MRC Functional Genetics, University of Oxford, Department of Human Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK
    Curr Opin Genet Dev 15:241-8. 2005
    ..Further functional characterisation of their proteins will contribute to an understanding of the molecular and evolutionary processes that have determined human brain size...
  18. ncbi request reprint A reconciliation analysis of host switching in plant-fungal symbioses
    Andrew P Jackson
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
    Evolution 58:1909-23. 2004
    ....
  19. ncbi request reprint A cophylogenetic perspective of RNA-virus evolution
    Andrew P Jackson
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    Mol Biol Evol 21:45-57. 2004
    ....
  20. ncbi request reprint The first missense alteration in the MCPH1 gene causes autosomal recessive microcephaly with an extremely mild cellular and clinical phenotype
    Marc Trimborn
    Institut fur Humangenetik, Charite Universitatsmedizin Berlin, Germany
    Hum Mutat 26:496. 2005
    ..Additionally, head circumference was less severely affected, being -2.4 SD at birth and -3 SD at the age of six years. This justifies reconsideration and widening of the clinical phenotype definition of MCPH1...
  21. pmc Mutations in microcephalin cause aberrant regulation of chromosome condensation
    Marc Trimborn
    Institute of Human Genetics, Charité Universitary Medicine Berlin, Campus Virchow, Humboldt University, Berlin, Germany
    Am J Hum Genet 75:261-6. 2004
    ..Further characterization of MCPH1 is thus likely to lead to fundamental insights into both the regulation of chromosome condensation and neurodevelopment...
  22. pmc Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling
    Elen Griffith
    Medical Research Council MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Nat Genet 40:232-6. 2008
    ..These findings also suggest that other known microcephaly genes implicated in either DNA repair responses or centrosomal function may act in common developmental pathways determining human brain and body size...
  23. pmc Identification of microcephalin, a protein implicated in determining the size of the human brain
    Andrew P Jackson
    Molecular Medicine Unit, University of Leeds, United Kingdom
    Am J Hum Genet 71:136-42. 2002
    ..This gene, microcephalin, is expressed in the developing cerebral cortex of the fetal brain. Further study of this and related genes may provide important new insights into neocortical development and evolution...