Affiliation: Wellcome Trust Genome Campus
- Widespread duplications in the genomes of laboratory stocks of Dictyostelium discoideumGareth Bloomfield
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Genome Biol 9:R75. 2008..Duplications of stretches of the genome are an important source of individual genetic variation, but their unrecognized presence in laboratory organisms would be a confounding variable for genetic analysis...
- Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosaCarol J Loscher
Smurfit Institute of Genetics, Trinity College Dublin, College Green, Dublin 2, Ireland
Genome Biol 8:R248. 2007..Little is known about the cellular mechanisms that connect mutations within RHO to eventual photoreceptor cell death by apoptosis...
- Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common and specific effects from PAO1 and PA14 strainsSergio Carilla-Latorre
Instituto de Investigaciones Biomedicas Alberto Sols, Universidad Autónoma de Madrid Consejo Superior de Investigaciones Científicas, Madrid, Spain
BMC Microbiol 8:109. 2008..aeruginosa and other pathogens, we used available genomic tools in this model system to study the transcriptional host response to P. aeruginosa infection...
- Gene copy number variation throughout the Plasmodium falciparum genomeIan H Cheeseman
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
BMC Genomics 10:353. 2009..Despite the known effects of CNV, little is known about its extent throughout the genome...
- Detection of genome-wide polymorphisms in the AT-rich Plasmodium falciparum genome using a high-density microarrayHongying Jiang
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
BMC Genomics 9:398. 2008..Here we evaluate polymorphism detection accuracy of a high-density 'tiling' microarray with 2.56 million probes by comparing single feature polymorphisms (SFP) calls from the microarray with known SNP among parasite isolates...
- A software framework for microarray and gene expression object model (MAGE-OM) array design annotationMatloob Qureshi
Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, UK
BMC Genomics 9:133. 2008..However, although the MAGE object model is flexible enough to support different annotation strategies, the annotation of array descriptions can be complex...
- Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in DictyosteliumAlessio Sillo
Department of Clinical and Biological Sciences, University of Turin, Ospedale S, Luigi, 10043 Orbassano, Torino, Italy
BMC Genomics 9:291. 2008..We have investigated Dictyostelium differential gene expression during phagocytosis of non-pathogenic bacteria, using DNA microarrays, in order to identify molecular functions and novel genes involved in phagocytosis...
- The genome of the kinetoplastid parasite, Leishmania majorAlasdair C Ivens
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
Science 309:436-42. 2005..Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression...
- The Leishmania genome comes of AgeA C Ivens
The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
Parasitol Today 15:225-31. 1999....
- The genome of the simian and human malaria parasite Plasmodium knowlesiA Pain
Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
Nature 455:799-803. 2008..One of these families, the KIRs, contains sequences that collectively match over one-half of the host CD99 extracellular domain, which may represent an unusual form of molecular mimicry...
- (Beta alpha)8-barrel proteins of tryptophan biosynthesis in the hyperthermophile Thermotoga maritimaR Sterner
Abteilung fur Biophysikalische Chemie, Universitat Basel, Switzerland
EMBO J 14:4395-402. 1995..Another notable feature is the predicted lack of the N-terminal helix alpha 0 in the alpha-subunit of tryptophan synthase...
- Structure and sequence of the human homeobox gene HOX7J E Hewitt
Department of Biochemistry and Molecular Genetics, St Mary s Hospital Medical School, Imperial College of Science, Technology, and Medicine, London, United Kingdom
Genomics 11:670-8. 1991..The region encompassing the promoter region, exon 1, and the 5' region of exon 2 have a higher than expected frequency of CpG dinucleotides; numerous sites for rare-cutter restriction enzymes are present, a characteristic of HTF islands...