Matthew Tg Holden

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. pmc Complete genome of acute rheumatic fever-associated serotype M5 Streptococcus pyogenes strain manfredo
    Matthew T G Holden
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK
    J Bacteriol 189:1473-7. 2007
  2. pmc Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW)
    Matthew T G Holden
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom
    J Bacteriol 192:888-92. 2010
  3. pmc Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis
    Matthew T G Holden
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS ONE 4:e6072. 2009
  4. pmc The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients
    Matthew T G Holden
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom
    J Bacteriol 191:261-77. 2009
  5. pmc Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis
    Rachaneeporn Tiyawisutsri
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    BMC Microbiol 7:19. 2007
  6. pmc Gene expression changes linked to antimicrobial resistance, oxidative stress, iron depletion and retained motility are observed when Burkholderia cenocepacia grows in cystic fibrosis sputum
    Pavel Drevinek
    Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    BMC Infect Dis 8:121. 2008
  7. pmc The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay
    Erik Hjerde
    Department of Molecular Biotechnology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, N 9037 Tromsø, Norway
    BMC Genomics 9:616. 2008
  8. pmc Re-annotation and re-analysis of the Campylobacter jejuni NCTC11168 genome sequence
    Ozan Gundogdu
    Pathogen Molecular Department, London School of Hygiene and Tropical Medicine, UK
    BMC Genomics 8:162. 2007
  9. pmc Burkholderia pseudomallei genome plasticity associated with genomic island variation
    Sarinna Tumapa
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    BMC Genomics 9:190. 2008
  10. pmc Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis
    Philip N Ward
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    BMC Genomics 10:54. 2009

Collaborators

Detail Information

Publications11

  1. pmc Complete genome of acute rheumatic fever-associated serotype M5 Streptococcus pyogenes strain manfredo
    Matthew T G Holden
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK
    J Bacteriol 189:1473-7. 2007
    ..pyogenes and the close relationship between strain Manfredo and MGAS8232, another acute rheumatic fever-associated strain...
  2. pmc Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW)
    Matthew T G Holden
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom
    J Bacteriol 192:888-92. 2010
    ..The strain is resistant to a wide range of antibiotics, antiseptics, and heavy metals due to resistance genes encoded on mobile genetic elements and also mutations in housekeeping genes...
  3. pmc Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis
    Matthew T G Holden
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS ONE 4:e6072. 2009
    ..suis infections occur sporadically in human Europe and North America, but a recent major outbreak has been described in China with high levels of mortality. The mechanisms of S. suis pathogenesis in humans and pigs are poorly understood...
  4. pmc The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients
    Matthew T G Holden
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom
    J Bacteriol 191:261-77. 2009
    ..The J2315 genome contains evidence that its unique and highly adapted genetic content has played a significant role in its success as an epidemic CF pathogen...
  5. pmc Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis
    Rachaneeporn Tiyawisutsri
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    BMC Microbiol 7:19. 2007
    ..Genomic and epidemiological studies have shown that B. mallei is a recently emerged, host restricted clone of B. pseudomallei...
  6. pmc Gene expression changes linked to antimicrobial resistance, oxidative stress, iron depletion and retained motility are observed when Burkholderia cenocepacia grows in cystic fibrosis sputum
    Pavel Drevinek
    Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    BMC Infect Dis 8:121. 2008
    ..Their large genome (> 7000 genes) and multiple pathways encoding the same putative functions make virulence factor identification difficult in these bacteria...
  7. pmc The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay
    Erik Hjerde
    Department of Molecular Biotechnology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, N 9037 Tromsø, Norway
    BMC Genomics 9:616. 2008
    ..The fish pathogen Aliivibrio salmonicida is the causative agent of cold-water vibriosis in marine aquaculture. The Gram-negative bacterium causes tissue degradation, hemolysis and sepsis in vivo...
  8. pmc Re-annotation and re-analysis of the Campylobacter jejuni NCTC11168 genome sequence
    Ozan Gundogdu
    Pathogen Molecular Department, London School of Hygiene and Tropical Medicine, UK
    BMC Genomics 8:162. 2007
    ..We now describe the complete re-annotation and re-analysis of the C. jejuni NCTC11168 genome using current database information, novel tools and annotation techniques not used during the original annotation...
  9. pmc Burkholderia pseudomallei genome plasticity associated with genomic island variation
    Sarinna Tumapa
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    BMC Genomics 9:190. 2008
    ..pseudomallei isolates, little is known about the extent of variation between related strains or their association with disease or environmental survival...
  10. pmc Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis
    Philip N Ward
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    BMC Genomics 10:54. 2009
    ..Comparative analysis of the complete genome sequence of S. uberis strain 0140J was undertaken to help elucidate the biology of this effective bovine pathogen...
  11. pmc Whole-genome sequencing for analysis of an outbreak of meticillin-resistant Staphylococcus aureus: a descriptive study
    Simon R Harris
    Wellcome Trust Sanger Institute, Cambridge, UK
    Lancet Infect Dis 13:130-6. 2013
    ..We assessed the use of whole-genome sequencing to enhance detection of MRSA transmission between these settings...